Michael Givskov

Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump

Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2

Research output: Contribution to journal › Journal article › Research › peer-review

The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture

Eilers, K., Hoong Yam, J. K., Liu, X., Goh, Y. F., To, K. N., Paracuellos, P., Morton, R., Brizuela, J., Hui Yong, A. M., Givskov, Michael, Freibert, S. A., Bange, G., Rice, S. A., Steinchen, W. & Filloux, A., 2024, In: Journal of Biological Chemistry. 300, 2, 105659.

Research output: Contribution to journal › Journal article › Research › peer-review

Auranofin inhibits virulence pathways in Pseudomonas aeruginosa

Yam, J. K. H., Tan, L. Z. W., Hong, Z., Salido, M. M. S., Woo, B. Y., Yong, A. M. H., Tan, C. A. Z., Li, S. F. Y., Yang, L., Givskov, Michael & Chng, S. S., 2023, In: Bioorganic and Medicinal Chemistry. 79, 117167.

Research output: Contribution to journal › Journal article › Research › peer-review

A genetic switch controls Pseudomonas aeruginosa surface colonization

Manner, C., Dias Teixeira, R., Saha, D., Kaczmarczyk, A., Zemp, R., Wyss, F., Jaeger, T., Laventie, B. J., Boyer, S., Malone, J. G., Qvortrup, K., Andersen, Jens Bo, Givskov, Michael, Tolker-Nielsen, Tim, Hiller, S., Drescher, K. & Jenal, U., 2023, In: Nature Microbiology. 8, p. 1520–1533

Research output: Contribution to journal › Journal article › Research › peer-review

Associational Resistance to Predation by Protists in a Mixed Species Biofilm

Goh, Y. F., Røder, Henriette Lyng, Chan, S. H., Ismail, M. H., Madsen, Jonas Stenløkke, Lee, K. W. K., Sørensen, Søren Johannes, Givskov, Michael, Burmølle, Mette, Rice, S. A. & McDougald, D., 2023, In: Applied and Environmental Microbiology. 89, 2, 16 p., e0174122.

Research output: Contribution to journal › Journal article › Research › peer-review

Characterization of TelE, a T7SS LXG Effector Exhibiting a Conserved C-Terminal Glycine Zipper Motif Required for Toxicity

Teh, W. K., Ding, Y., Gubellini, F., Filloux, A., Poyart, C., Givskov, Michael & Dramsi, S., 2023, In: Microbiology Spectrum. 11, 4, e0148123.

Research output: Contribution to journal › Journal article › Research › peer-review

A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

Miettinen, Karel, Leelahakorn, Nattawat, Almeida Robles, A. R., Zhao, Yong, Hansen, L. R., Nikolajsen, I. E., Andersen, Jens Bo, Givskov, Michael, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 3664.

Research output: Contribution to journal › Journal article › Research › peer-review

Adaptation to an Amoeba Host Leads to Pseudomonas aeruginosa Isolates with Attenuated Virulence

Leong, W., Poh, W. H., Williams, J., Lutz, C., Mozammel Hoque, M., Poh, Y. H., Yee, B. Y. K., Chua, C., Givskov, Michael, Sanderson-Smith, M., Rice, S. A. & McDougald, D., 2022, In: Applied and Environmental Microbiology. 88, 5, e02322.

Research output: Contribution to journal › Journal article › Research › peer-review

Effects of antibiotic treatment and phagocyte infiltration on development of Pseudomonas aeruginosa biofilm—Insights from the application of a novel PF hydrogel model in vitro and in vivo

Wu, H., Song, L., Yam, J. K. H., Plotkin, M., Wang, H., Rybtke, Morten Levin, Seliktar, D., Kofidis, T., Høiby, Niels, Tolker-Nielsen, Tim, Song, Z. & Givskov, Michael, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 826450.

Research output: Contribution to journal › Journal article › Research › peer-review

Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa

Yam, J. K. H., Aung, T. T., Chua, S. L., Cheng, Y., Kohli, G. S., Zhou, J., Constancias, F., Liu, Y., Cai, Z., Salido, M. M. S., Drautz-Moses, D. I., Rice, S. A., Schuster, S. C., Boo, Z. Z., Wu, B., Kjelleberg, S., Tolker-Nielsen, T., Lakshminarayanan, R., Beuerman, R. W., Yang, L. & 1 others, Givskov, Michael, 2022, In: Infection and Immunity. 90, 8

Research output: Contribution to journal › Journal article › Research › peer-review

Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes

Eilers, K., Kuok Hoong Yam, J., Morton, R., Mei Hui Yong, A., Brizuela, J., Hadjicharalambous, C., Liu, X., Givskov, Michael, Rice, S. A. & Filloux, A., 2022, In: Frontiers in Microbiology. 13, 949597.

Research output: Contribution to journal › Journal article › Research › peer-review

Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, T. E., 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.

Research output: Contribution to journal › Journal article › Research › peer-review

Bacterial genotoxins induce T cell senescence

Mathiasen, S. L., Gall Mas, Laura, Pateras, I. S., Theodorou, S. D. P., Namini, Martin Rich Javadi, Hansen, Morten Bagge, Martin, O. C. B., Vadivel, Chella Krishna, Ntostoglou, K., Butter, D., Givskov, Michael, Geisler, Carsten, Akbar, A. N., Gorgoulis, V. G., Frisan, T., Ødum, Niels & Krejsgaard, T., 2021, In: Cell Reports. 35, 10, 109220.

Research output: Contribution to journal › Journal article › Research › peer-review

Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants

Nair, H. A. S., Subramoni, S., Poh, W. H., Hasnuddin, N. T. B., Tay, M., Givskov, Michael, Tolker-Nielsen, Tim, Kjelleberg, S., McDougald, D. & Rice, S. A., 2021, In: BMC Microbiology. 21, 10 p., 255.

Research output: Contribution to journal › Journal article › Research › peer-review

Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc₁sub-unit

Soh, E. Y. C., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Cámara, M., Givskov, Michael, Hardie, K. R., Tolker-Nielsen, Tim, Ize, B. & Williams, P., 2021, In: PLOS Pathogens. 17, 8, 25 p., e1009425.

Research output: Contribution to journal › Journal article › Research › peer-review

Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, T. E., Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

Research output: Contribution to journal › Journal article › Research › peer-review

Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms

Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.

Research output: Contribution to journal › Journal article › Research › peer-review

Periodontitis associates with species-specific gene expression of the oral microbiota

Midjord-Belstrøm, Daniel, Constancias, F., Drautz-Moses, D. I., Schuster, S. C., Veleba, M., Mahé, F. & Givskov, Michael, 2021, In: npj Biofilms and Microbiomes. 7, 76.

Research output: Contribution to journal › Journal article › Research › peer-review

SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

Jansen, C. U., Uhd, J., Andersen, Jens Bo, Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Nielsen, T. E., Givskov, Michael, Tolker-Nielsen, Tim & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Transcriptional Activity of Predominant Streptococcus Species at Multiple Oral Sites Associate With Periodontal Status

Midjord-Belstrøm, Daniel, Constancias, F., Markvart, Merete, Sikora, Martin, Sørensen, Christiane Elisabeth & Givskov, Michael, 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 13 p., 752664.

Research output: Contribution to journal › Journal article › Research › peer-review

A mouse ear skin model to study the dynamics of innate immune responses against Staphylococcus aureus biofilms

Abdul Hamid, A. I., Nakusi, L., Givskov, Michael, Chang, Y. T., Marquès, C. & Gueirard, P., 2020, In: BMC Microbiology. 20, 1, 12 p., 22.

Research output: Contribution to journal › Journal article › Research › peer-review

Early IL-2 treatment of mice with Pseudomonas aeruginosa pneumonia induced PMN-dominating response and reduced lung pathology

Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Bjarnsholt, Thomas, Givskov, Michael & Høiby, Niels, 2020, In: APMIS - Journal of Pathology, Microbiology and Immunology. 128, 12, p. 647-653

Research output: Contribution to journal › Journal article › Research › peer-review

Antibiotics inhibit tumor and disease activity in cutaneous T cell lymphoma

Lindahl, L. M., Willerslev-Olsen, A., Gjerdrum, L. M. R., Nielsen, P. R., Blümel, E., Rittig, A. H., Celis, P., Herpers, B., Becker, J. C., Stausbøl-Grøn, B., Wasik, M. A., Gluud, M., Fredholm, S., Buus, T. B., Johansen, C., Nastasi, C., Peiffer, L., Kubat, L., Bzorek, M., Eriksen, J. O. & 11 others, Krejsgaard, T., Bonefeld, Charlotte Menne, Geisler, Carsten, Mustelin, T., Langhoff, E., Givskov, Michael, Woetmann, Anders , Kilian, M., Litman, Thomas, Iversen, L. & Ødum, Niels, 26 Sep 2019, In: Blood. 134, 13, p. 1072-1083

Research output: Contribution to journal › Journal article › Research › peer-review

High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content

Almblad, H., Rybtke, Morten Levin, Hendiani, S., Andersen, Jens Bo, Givskov, Michael & Tolker-Nielsen, Tim, Mar 2019, In: Microbiology. 165, 3, p. 324-333 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance

Nilsson, Carl Martin Peter, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microorganisms. 7, 9, 12 p., 310.

Research output: Contribution to journal › Journal article › Research › peer-review

Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells

Teh, W. K., Dramsi, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2019, In: Journal of Bacteriology. 201, 6, p. 1-16 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

Fong, J., Mortensen, K. T., Nørskov, A., Qvortrup, K., Yang, L., Tan, C. H., Nielsen, T. E. & Givskov, Michael, 2019, In: Frontiers in Cellular and Infection Microbiology. 11, 11 p., 433.

Research output: Contribution to journal › Journal article › Research › peer-review

Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia

Richter, A. M., Fazli, M., Schmid, N., Shilling, R., Suppiger, A., Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 9, 15 p., 3286.

Research output: Contribution to journal › Journal article › Research › peer-review

Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microbiology. 165, 3, p. 334-342

Research output: Contribution to journal › Journal article › Research › peer-review

Reactivity and Synthetic Applications of Multicomponent Petasis Reactions

Wu, P., Givskov, Michael & Nielsen, T. E., 2019, In: Chemical Reviews. 119, 20, p. 11245-11290 46 p.

Research output: Contribution to journal › Review › Research › peer-review

Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation

Qvortrup, K., Hultqvist, Louise Dahl, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Jansen, C. U., Uhd, J., Andersen, Jens Bo, Nielsen, T. E., Givskov, Michael & Tolker-Nielsen, Tim, 2019, In: Frontiers in Chemistry. 7, 27 p., 742.

Research output: Contribution to journal › Review › Research › peer-review

Visualizing biofilm by targeting eDNA with long wavelength probe CDr15

Kwon, H. Y., Kim, J. Y., Liu, X., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Heo, W., Kim, J. J., Kang, N. Y., Joo, T., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2019, In: Biomaterials Science. 7, 9, p. 3594-3598 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa

Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, T. E., Givskov, Michael, Liu, X., Bin, W., Su, H. & Yang, L., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 1155.

Research output: Contribution to journal › Journal article › Research › peer-review

Acquisition of resistance to carbapenem and macrolide-mediated quorum sensing inhibition by Pseudomonas aeruginosa via ICE_Tn4371 6385

Ding, Y., Teo, J. W. P., Drautz-Moses, D. I., Schuster, S. C., Givskov, Michael & Yang, L., 2018, In: Communications Biology. 1, 10 p., 57.

Research output: Contribution to journal › Journal article › Research › peer-review

CDy14: A novel biofilm probe targeting exopolysaccharide Psl

Kwon, H. Y., Kim, J. Y., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Kim, J. J., Kang, N. Y., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2018, In: Chemical Communications. 54, 84, p. 11865-11868 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Characterization of a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul

Ding, Y., Zwe, Y. H., Chin, S. F., Kohli, G. S., Drautz-Moses, D. I., Givskov, Michael, Schlundt, J., Schuster, S. C., Yuk, H. G. & Yang, L., 2018, In: Gut Pathogens. 10, 5 p., 20.

Research output: Contribution to journal › Journal article › Research › peer-review

Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin

Woetmann, Anders , Alhede, M., Dabelsteen, Sally, Bjarnsholt, Thomas, Rybtke, Morten Levin, Nastasi, C., Krejsgaard, T., Andersen, Mads Hald, Bonefeld, Charlotte Menne, Geisler, Carsten, Givskov, Michael & Ødum, Niels, 2018, In: OncoTarget. 9, 28, p. 19481-19489 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus

Chew, S. C., Yam, J. K. H., Matysik, A., Seng, Z. J., Klebensberger, J., Givskov, Michael, Doyle, P., Rice, S. A., Yang, L. & Kjelleberg, S., 2018, In: mBio. 9, 6, 16 p., e00585-18.

Research output: Contribution to journal › Journal article › Research › peer-review

Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents

Yuan, M., Chua, S. L., Liu, Y., Drautz-Moses, D. I., Hoong Yam, J. K., Aung, T. T., Beuerman, R. W., Santillan Salido, M. M., Schuster, S. C., Tan, C. H., Givskov, Michael, Yang, L. & Nielsen, T. E., 2018, In: Beilstein Journal of Organic Chemistry. 14, p. 3059-3069 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells

Gall Mas, Laura, Fabbri, A., Namini, Martin Rich Javadi, Givskov, Michael, Fiorentini, C. & Krejsgaard, T., 2018, In: International Journal of Molecular Sciences . 19, 5, 11 p., 1408.

Research output: Contribution to journal › Journal article › Research › peer-review

A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors

Bang, C. G., Jensen, J. F., O'Hanlon Cohrt, E., Olsen, L. B., Siyum, S. G., Mortensen, K. T., Skovgaard, T., Berthelsen, J., Yang, L., Givskov, Michael, Qvortrup, K. & Nielsen, T. E., Oct 2017, In: ACS Combinatorial Science. 19, 10, p. 657-669 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Reduced intracellular c-di-GMP content increases expression of quorum sensing-regulated genes in Pseudomonas aeruginosa

Chua, S. L., Liu, Y., Li, Y., Ting, H. J., Kohli, G. S., Cai, Z., Suwanchaikasem, P., Goh, K. K. K., Ng, S. P., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Oct 2017, In: Frontiers in Cellular and Infection Microbiology. 7, 8 p., 451.

Research output: Contribution to journal › Journal article › Research › peer-review

Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes

Jakobsen, Tim Holm, Tolker-Nielsen, Tim & Givskov, Michael, Sep 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.

Research output: Contribution to journal › Review › Research › peer-review

Cholesterol crystals enhance TLR2-and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis

Køllgaard, T. M. S., Enevold, Christian, Bendtzen, K., Hansen, Peter Riis, Givskov, Michael, Holmstrup, Palle & Nielsen, Claus Henrik, 24 Feb 2017, In: P L o S One. 12, 2, 14 p., 0172773.

Research output: Contribution to journal › Journal article › Research › peer-review

Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

Fong, J., Yuan, M., Jakobsen, Tim Holm, Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, T. E. & Givskov, Michael, 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227

Research output: Contribution to journal › Journal article › Research › peer-review

A broad range quorum sensing inhibitor working through sRNA inhibition

Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, T. E., Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

Research output: Contribution to journal › Journal article › Research › peer-review

Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors

Thanh Tung, T., Jakobsen, Tim Holm, Dao, T. T., Fuglsang, Anja Thoe, Givskov, Michael, Christensen, Søren Brøgger & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy

Roizman, D., Vidaillac, C., Givskov, Michael & Yang, L., 2017, In: Antimicrobial Agents and Chemotherapy. 61, 10, 5 p., e01088-17.

Research output: Contribution to journal › Journal article › Research › peer-review

In vitro and In vivo efficacy of an LpxC inhibitor, CHIR-090, alone or combined with colistin against Pseudomonas aeruginosa biofilm

Tan, J. H., Vidaillac, C., Yam, J. K. H., Chua, S. L., Givskov, Michael & Yang, L., 2017, In: Antimicrobial Agents and Chemotherapy. 61, 7, 9 p., e02223-16.

Research output: Contribution to journal › Journal article › Research › peer-review

Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries

Midjord-Belstrøm, Daniel, Constancias, F., Liu, Y., Yang, L., Drautz-Moses, D. I., Schuster, S. C., Kohli, G. S., Jakobsen, Tim Holm, Holmstrup, Palle & Givskov, Michael, 2017, In: npj Biofilms and Microbiomes. 3, 8 p., 23.

Research output: Contribution to journal › Journal article › Research › peer-review

Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB

Fazli, M., Rybtke, Morten Levin, Steiner, E., Weidel, E., Berthelsen, J., Groizeleau, J. D. D., Bin, W., Zhi, B. Z., Yaming, Z., Kaever, V., Givskov, Michael, Hartmann, R. W., Eberl, L. & Tolker-Nielsen, Tim, 2017, In: MicrobiologyOpen. 6, 4, 13 p., e00480.

Research output: Contribution to journal › Journal article › Research › peer-review

Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels

Chua, S. L., Ding, Y., Liu, Y., Cai, Z., Zhou, J., Swarup, S., Drautz-Moses, D. I., Schuster, S. C., Kjelleberg, S., Givskov, Michael & Yang, L., Nov 2016, In: Open Biology. 6, 13 p., 160162.

Research output: Contribution to journal › Journal article › Research › peer-review

The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation

Groizeleau, J., Rybtke, Morten Levin, Andersen, Jens Bo, Berthelsen, J., Liu, Y., Yang, L., Nielsen, T. E., Kaever, V., Givskov, Michael & Tolker-Nielsen, Tim, 1 Oct 2016, In: Microbiology. 162, 10, p. 1797-1807 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms

Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Givskov, Michael, Høiby, Niels, Twetman, Svante & Tolker-Nielsen, Tim, Sep 2016, In: International Journal of Antimicrobial Agents. 48, 3, p. 298–304

Research output: Contribution to journal › Journal article › Research › peer-review

Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11

Kim, J. Y., Sahu, S., Yau, Y. H., Wang, X., Shochat, S. G., Nielsen, P. H., Dueholm, M. S., Otzen, D. E., Lee, J., Delos Santos, M. M. S., Yam, J. K. H., Kang, N. Y., Park, S. J., Kwon, H., Seviour, T., Yang, L., Givskov, Michael & Chang, Y. T., 13 Jan 2016, In: Journal of the American Chemical Society. 138, 1, p. 402-407 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Biofilms of pathogenic nontuberculous mycobacteria targeted by new therapeutic approaches

Aung, T. T., Yam, J. K. H., Lin, S., Salleh, S. M., Givskov, Michael, Liu, S., Lwin, N. C., Yang, L. & Beuerman, R. W., 1 Jan 2016, In: Antimicrobial Agents and Chemotherapy. 60, 1, p. 24-35 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction

Hansen, G. M., Midjord-Belstrøm, Daniel, Nilsson, Carl Martin Peter, Helqvist, S., Nielsen, Claus Henrik, Holmstrup, Palle, Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2016, In: P L o S One. 11, 12, 13 p., e0168771.

Research output: Contribution to journal › Journal article › Research › peer-review

Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms

Chua, S. L., Yam, J. K. H., Hao, P., Adav, S. S., Salido, M. M., Liu, Y., Givskov, Michael, Sze, S. K., Tolker-Nielsen, Tim & Yang, L., 2016, In: Nature Communications. 7, 11 p., 10750.

Research output: Contribution to journal › Journal article › Research › peer-review

RpoN Regulates Virulence Factors of Pseudomonas aeruginosa via Modulating the PqsR Quorum Sensing Regulator

Cai, Z., Liu, Y., Chen, Y., Yam, J. K. H., Chew, S. C., Chua, S. L., Wang, K., Givskov, Michael & Yang, L., Dec 2015, In: International Journal of Molecular Sciences. 16, 12, p. 28311-28319 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface

Rybtke, Morten Levin, Berthelsen, J., Yang, L., Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, Dec 2015, In: MicrobiologyOpen. 4, 6, p. 917-930 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Spatially extensive microbial biogeography of the Indian Ocean provides insights into the unique community structure of a pristine coral atoll

Jeffries, T. C., Ostrowski, M., Williams, R. B., Xie, C., Jensen, R. M., Grzymski, J. J., Senstius, S. J., Givskov, Michael, Hoeke, R., Philip, G. K., Neches, R. Y., Drautz-Moses, D. I., Chenard, C., Paulsen, I. T. & Lauro, F. M., 20 Oct 2015, In: Scientific Reports. 5, 13 p., 15383 .

Research output: Contribution to journal › Journal article › Research › peer-review

The bactericidal activity of β-lactam antibiotics is increased by metabolizable sugar species

Thorsing, M., Bentin, Thomas, Givskov, Michael, Tolker-Nielsen, Tim & Goltermann, Lise, Oct 2015, In: Microbiology. 161, 10, p. 1999-2007 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation

Chua, S. L., Hultqvist, Louise Dahl, Yuan, M., Rybtke, Morten Levin, Nielsen, T. E., Givskov, Michael, Tolker-Nielsen, Tim & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli

Sun, J., Marais, J. P. J., Khoo, C., LaPlante, K., Vejborg, R. M., Givskov, Michael, Tolker-Nielsen, Tim, Seeram, N. P. & Rowley, D. C., Aug 2015, In: Journal of Functional Foods. 17, p. 235-242 8 p.

Research output: Contribution to journal › Letter › Research › peer-review

Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Aug 2015, In: Journal of Bacteriology. 197, 16, p. 2731 1 p.

Research output: Contribution to journal › Comment/debate › Research

The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Jul 2015, In: Journal of Bacteriology. 197, 13, p. 2190-200 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Antibiofilm Properties of Acetic Acid

Bjarnsholt, Thomas, Alhede, M., Jensen, Peter Østrup, Nielsen, Anne Kirstine, Johansen, Helle Krogh, Homøe, Preben, Høiby, Niels, Givskov, Michael & Kirketerp-Moller, K., Jun 2015, In: Advances in Wound Care. 4, 7, p. 363-372 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Complete Genome Sequence and Transcriptomic Analysis of the Novel Pathogen Elizabethkingia anophelis in Response to Oxidative Stress

Li, Y., Liu, Y., Chew, S. C., Tay, M., Salido, M. M. S., Teo, J., Lauro, F. M., Givskov, Michael & Yang, L., Jun 2015, In: Genome Biology and Evolution. 7, 6, p. 1676-1685 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis of Substituted γ- and δ-Lactams through Mannich-Type Reactions of Solid-Supported N-Acyliminium Ions

Komnatnyy, V. V., Taveras, K. M., Nandurkar, N. S., Le Quement, S. T., Givskov, Michael & Nielsen, T. E., Jun 2015, In: European Journal of Organic Chemistry. 2015, 16, p. 3524-3530 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Functional Amyloids Keep Quorum-sensing Molecules in Check

Seviour, T., Hansen, S. H., Yang, L., Yau, Y. H., Wang, V. B., Stenvang, M. R., Christiansen, G., Marsili, E., Givskov, Michael, Chen, Y., Otzen, D. E., Nielsen, P. H., Geifman-Shochat, S., Kjelleberg, S. & Dueholm, M. S., 6 Mar 2015, In: Journal of Biological Chemistry. 290, 10, p. 6457-6469 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Combining the Petasis 3-Component Reaction with Multiple Modes of Cyclization: A Build/Couple/Pair Strategy for the Synthesis of Densely Functionalized Small Molecules

Flagstad, T., Hansen, M. R., Le Quementt, S. T., Givskov, Michael & Nielsen, T. E., Jan 2015, In: A C S Combinatorial Science. 17, 1, p. 19-23 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response

Rybtke, Morten Levin, Hultqvist, Louise Dahl, Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Journal of Molecular Biology. 427, 23, p. 3628-3645

Research output: Contribution to journal › Review › Research › peer-review

Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay

Hansen, G. M., Nilsson, M., Nielsen, Claus Henrik, Holmstrup, Palle, Helqvist, S., Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2015, In: PloS one. 10, 12, p. 1-11 11 p., e0145657.

Research output: Contribution to journal › Journal article › Research › peer-review

Autofluorescence in samples obtained from chronic biofilm infections – “all that glitters is not gold”

Eickhardt-Dalbøge, S. R., Kragh, K. N., Schrøder, S., Poulsen, Steen Seier, Sillesen, Henrik, Givskov, Michael, Høiby, Niels, Bjarnsholt, Thomas & Alhede, M., 2015, In: Pathogens and Disease. 73, 4, 4 p., ftv012.

Research output: Contribution to journal › Letter › Research › peer-review

C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth

Chua, S. L., Sivakumar, K., Rybtke, Morten Levin, Yuan, M., Andersen, Jens Bo, Nielsen, T. E., Givskov, Michael, Tolker-Nielsen, Tim, Cao, B., Kjelleberg, S. & Yang, L., 2015, In: Scientific Reports. 5, 13 p., 10052.

Research output: Contribution to journal › Journal article › Research › peer-review

Chemical biology strategies for biofilm control

Yang, L. & Givskov, Michael, 2015, In: Microbiology Spectrum. 3, 4, 7 p., MB-0019-2015.

Research output: Contribution to journal › Journal article › Research › peer-review

In silico analyses of metagenomes from human atherosclerotic plaque samples

Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.

Research output: Contribution to journal › Journal article › Research › peer-review

In-frame and unmarked gene deletions in Burkholderia cenocepacia via an allelic exchange system compatible with gateway technology

Fazli, M., Harrison, J. J., Gambino, M., Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Applied and Environmental Microbiology. 81, 11, p. 3623-3630 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa

Chen, Y., Yuan, M., Mohanty, A., Yam, J. K. H., Liu, Y., Chua, S. L., Nielsen, T. E., Tolker-Nielsen, Tim, Givskov, Michael, Cao, B. & Yang, L., 2015, In: Environmental Microbiology Reports. 7, 3, p. 498-507 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

Hansen, M. R., Jakobsen, Tim Holm, Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T., 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa

Tan, S. Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, Tim Holm, Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Pseudomonas aeruginosa Type III Translocon Is Required for Biofilm Formation at the Epithelial Barrier

Tran, C. S., Rangel, S. M., Almblad, H., Kierbel, A., Givskov, Michael, Tolker-Nielsen, Tim, Hauser, A. R. & Engel, J. N., Nov 2014, In: P L o S Pathogens. 10, 11, p. 1-11 12 p., e1004479.

Research output: Contribution to journal › Journal article › Research › peer-review

Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients

Wen, H., Wang, K., Liu, Y., Tay, M., Lauro, F. M., Huang, H., Wu, H., Liang, H., Ding, Y., Givskov, Michael, Chen, Y. & Yang, L., Sep 2014, In: Journal of clinical microbiology. 52, 9, p. 3200-3208 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics

Flagstad, T., Petersen, M. T., Hinnerfeldt, D. M., Givskov, Michael & Nielsen, T. E., 28 Aug 2014, In: Synthesis (Germany). 46, 23, p. 3263-3267 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A mariner transposon vector adapted for mutagenesis in oral streptococci

Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In: MicrobiologyOpen. 3, 3, p. 333-40 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Mulig sammenhæng mellem marginal parodontitis og iskæmisk hjertesygdom

Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, Claus Henrik, Givskov, Michael & Hansen, Peter Riis, 28 Apr 2014, In: Ugeskrift for Laeger. 176, 18, p. 1752-1754 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Effects of Radix Ginseng on microbial infections: a narrative review

Wu, H., Høiby, Niels, Yang, L., Givskov, Michael & Song, Z., Apr 2014, In: Journal of Traditional Chinese Medicine. 34, 2, p. 227-233 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Bacterial biofilm formation and treatment in soft tissue fillers

Alhede, M., Er, O., Eickhardt, S., Kragh, K., Alhede, M., Hultqvist, Louise Dahl, Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.

Research output: Contribution to journal › Journal article › Research

Bacteria-triggered release of antimicrobial agents

Komnatnyy, V. V., Chiang, W., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 7 Jan 2014, In: Angewandte Chemie (International ed. in English). 53, 2, p. 439-41 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A possible correlation between periodontitis and ischaemic heart disease

Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, C. H., Givskov, Michael & Hansen, Peter Riis, 2014, In: Ugeskrift for Laeger.

Research output: Contribution to journal › Journal article › Research › peer-review

Comparative genomic analysis of malariamosquito vector-associated novel pathogen elizabethkingia anophelis

Teo, J., Tan, S., Liu, Y., Tay, M., Ding, Y., Li, Y., Kjelleberg, S., Givskov, Michael, Lin, R. T. P. & Yang, L., 2014, In: Genome Biology and Evolution. p. 1158–1165 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

Chua, S. L., Liu, Y., Yam, J. K. H., Chen, Y., Vejborg, R. M., Tan, B. G. C., Kjelleberg, S., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Nature Communications. 5, p. 1-12 13 p., 4462.

Research output: Contribution to journal › Journal article › Research › peer-review

Draft Genome Sequence of the Model Naphthalene-Utilizing Organism Pseudomonas putida OUS82

Tay, M., Roizman, D., Cohen, Y., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Genome Announcements. 2, 1, p. 1 1 p., e01161-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Emerging frontiers in detection and control of bacterial biofilms

Tan, S. Y. E., Chew, S. C., Tan, S. Y. Y., Givskov, Michael & Yang, L., 2014, In: Current Opinion in Biotechnology. 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples

Fazli, M., Bjarnsholt, Thomas, Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, 2014, In: Methods in Molecular Biology. 1211, p. 261-71 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion

Alhede, M., Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., 2014, In: Advances in Applied Microbiology. 86, p. 1-40 40 p.

Research output: Contribution to journal › Journal article › Research

Regulation of biofilm formation in Pseudomonas and Burkholderia species

Fazli, M., Almblad, H., Rybtke, Morten Levin, Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2014, In: Environmental Microbiology. 16, 7, p. 1961-1981 21 p.

Research output: Contribution to journal › Review › Research › peer-review

The Common Oceanographer: Crowdsourcing the Collection of Oceanographic Data

Lauro, F. M., Senstius, S. J., Cullen, J., Neches, R., Jensen, R. M., Brown, M. V., Darling, A. E., Givskov, Michael, McDougald, D., Hoeke, R., Ostrowski, M., Philip, G. K., Paulsen, I. T. & Grzymski, J. J., 2014, In: PLOS Biology. 12, 9

Research output: Contribution to journal › Journal article › Research › peer-review

Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database

Tan, S. Y. Y., Chua, S. L., Chen, Y., Rice, S. A., Kjelleberg, S., Nielsen, T. E., Yang, L. & Givskov, Michael, Nov 2013, In: Antimicrobial Agents and Chemotherapy. 57, 11, p. 5629-5641 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Applying insights from biofilm biology to drug development - can a new approach be developed?

Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria

Hultqvist, Louise Dahl, van Gennip, M., Rybtke, Morten Levin, Wu, H., Chiang, W., Alhede, M., Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, Aug 2013, In: Infection and Immunity. 81, 8, p. 2705-13 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors

Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Comparative transcriptomic analysis of the Burkholderia cepacia tyrosine kinase bceF mutant reveals a role in tolerance to stress, biofilm formation, and virulence

Ferreira, A. A., Silva, I. I., Oliveira, V. V., Becker, J. J., Givskov, Michael, Ryan, R. R., Fernandes, F. & Moreira, L. M., May 2013, In: Applied and Environmental Microbiology. 79, 9, p. 3009-3020 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms

Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa

Pihl, M., Arvidsson, A., Skepö, M., Nilsson, M., Givskov, Michael, Tolker-Nielsen, Tim, Svensäter, G. & Davies, J. R., Apr 2013, In: Pathogens and Disease. 67, 3, p. 192-198 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation

Dueholm, M. S., Søndergaard, M., Nilsson, M., Christiansen, G., Stensballe, A., Overgaard, M. T., Givskov, Michael, Tolker-Nielsen, Tim, Otzen, D. & Nielsen, P. H., 18 Mar 2013, In: MicrobiologyOpen. 2, p. 365-382 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349

Fazli, M., McCarthy, Y., Givskov, Michael, Ryan, R. P. & Tolker-Nielsen, Tim, Feb 2013, In: MicrobiologyOpen. 2, 1, p. 105-122 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

C-di-GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa

Chua, S. L., Tan, S. Y., Rybtke, Morten Levin, Chen, Y., Rice, S. A., Kjelleberg, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2066-2075 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Comparative genomic analysis of rapid evolution of an extreme-drug- resistant Acinetobacter baumannii clone

Tan, S., Chua, S. L., Liu, Y., Høiby, Niels, Andersen, L. P., Givskov, Michael, Song, Z. & Yang, L., 2013, In: Genome Biology and Evolution. p. 807–818

Research output: Contribution to journal › Journal article › Research › peer-review

Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes

Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J. & 2 others, Høiby, Niels & Bjarnsholt, Thomas, 2013, In: P L o S One. 8, 7, 17 p., e68484.

Research output: Contribution to journal › Journal article › Research › peer-review

Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in Pseudomonas aeruginosa microbial fuel cells

Wang, V. B., Chua, S., Cao, B., Seviour, T., Nesatyy, V. J., Marsili, E., Kjelleberg, S., Givskov, Michael, Tolker-Nielsen, Tim, Song, H., Loo, J. S. C. & Yang, L., 2013, In: PLOS ONE. 8, 5, p. e63129 7 p., e63129.

Research output: Contribution to journal › Journal article › Research › peer-review

First case of E anophelis outbreak in an intensive-care unit

Teo, J., Tan, S. Y. Y., Tay, M., Ding, Y., Kjelleberg, S., Givskov, Michael, Lin, R. T. P. & Yang, L., 2013, In: The Lancet. 382, 9895, p. 855-856 2 p.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Identification of Burkholderia cenocepacia strain H111 virulence factors using nonmammalian infection hosts

Schwager, S., Agnoli, K., Köthe, M., Feldmann, F., Givskov, Michael, Carlier, A. & Eberl, L., 2013, In: Infection and Immunity. 81, 1, p. 143-53 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Identification of LasR ligands through a virtual screening approach

Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, Tim Holm, Harmsen, M., Tolker-Nielsen, Tim, Nielsen, T. E., Givskov, Michael & Taboureau, O., 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR

Claussen, A., Jakobsen, Tim Holm, Bjarnsholt, Thomas, Givskov, Michael, Welch, M., Ferkinghoff-Borg, J. & Sams, T., 2013, In: International Journal of Molecular Sciences (Online). 14, 7, p. 13360-76 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Protoanemonin: a natural quorum sensing inhibitor that selectively activates iron starvation response

Bobadilla Fazzini, R. A., Skindersoe, M. E., Bielecki, P., Puchalka, J., Givskov, Michael & Martins sos Santos, V. A. P., 2013, In: Environmental Microbiology Reports. 15, 1, p. 111-20 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators

Stacy, D. M., Le Quement, S. T., Hansen, C., Clausen, J. W., Tolker-Nielsen, Tim, Brummond, J. W., Givskov, Michael, Nielsen, T. E. & Blackwell, H. E., 2013, In: Organic & Biomolecular Chemistry. 11, 6, p. 938-54 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium pictet-spengler sequence

Komnatnyy, V. V., Givskov, Michael & Nielsen, T. E., Dec 2012, In: Chemistry. A European Journal. 18, 52, p. 16793-16800 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms

Zhang, L., Chiang, W., Gao, Q., Givskov, Michael, Tolker-Nielsen, Tim, Yang, L. & Zhang, G., Dec 2012, In: Microbiology. 158, 12, p. 3014-3019 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo

van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Qvortrup, Klaus, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Aug 2012, In: Infection and Immunity. 80, 8, p. 2601-2607 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition

Alhede, M., Qvortrup, Klaus, Liebrechts, R., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 335-342 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa

Yang, L., Hengzhuang, W., Wu, H., Damkiaer, S., Jochumsen, N., Song, Z., Givskov, Michael, Høiby, Niels & Molin, S., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 366-376 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms

Chiang, W., Pamp, S. J., Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 245-256 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing

Jakobsen, Tim Holm, van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, Louise Dahl, Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, Peter Østrup, Moser, Claus Ernst, Nielsen, Kristian Fog, Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

Christensen, L., van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Beyond nutrition: health-promoting foods by quorum-sensing inhibition

Givskov, Michael, 2012, In: Future Microbiology. 7, 9, p. 1025-1028 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Bursting the bubble on bacterial biofilms: a flow cell methodology

Crusz, S. A., Popat, R., Rybtke, Morten Levin, Cámara, M., Givskov, Michael, Tolker-Nielsen, Tim, Diggle, S. P. & Williams, P., 2012, In: Biofouling. 28, 8, p. 835-842 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Combating biofilms

Yang, L., Liu, Y., Wu, H., Song, Z., Høiby, Niels, Molin, S. & Givskov, Michael, 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 146–157

Research output: Contribution to journal › Journal article › Research › peer-review

Fluorescence-based reporter for gauging cyclic di-GMP Levels in Pseudomonas aeruginosa.

Rybtke, Morten Levin, Borlee, B. R., Murakami, K., Irie, Y., Hentzer, M., Nielsen, T. E., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, 2012, In: Applied and Environmental Microbiology. 78, 15, p. 5060-5069 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa

Jakobsen, Tim Holm, Bragason, S. K., Phipps, R. K., Hultqvist, Louise Dahl, van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Petasis three-component coupling reactions of hydrazides for the synthesis of oxadiazolones and oxazolidinones

Le Quement, S. T., Flagstad, T., Mikkelsen, R. J. T., Hansen, M. R., Givskov, Michael & Nielsen, T. E., 2012, In: Organic Letters. 14, 2, p. 640-643 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorom sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.

Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1198-1206 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A convenient procedure for the solid-phase synthesis of hydroxamic acids on PEGA resins

Nandurkar, N. S., Petersen, R., Qvortrup, K., Komnatnyy, V. V., Taveras, K. M., Le Quement, S. T., Frauenlob, R., Givskov, Michael & Nielsen, T. E., 28 Dec 2011, In: Tetrahedron Letters. 52, 52, p. 7121-7124 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients

Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U. R., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, Jul 2011, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 236-244 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Effects of ginseng on Pseudomonas aeruginosa motility and biofilm formation

Wu, H., Lee, B., Yang, L., Wang, H., Givskov, Michael, Molin, S., Høiby, Niels & Song, Z., 1 Jun 2011, In: F E M S Immunology and Medical Microbiology. 62, 1, p. 49-56 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The contribution of cell-cell signaling and motility to bacterial biofilm formation

Shrout, J. D., Tolker-Nielsen, Tim, Givskov, Michael & Parsek, M. R., May 2011, In: M R S Bulletin. 36, 5, p. 367-373 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Imaging N-acyl homoserine lactone quorum sensing in vivo

Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 1 Jan 2011, In: Methods in Molecular Biology. 692, 2, p. 147-157 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Qualitative and quantitative determination of quorum sensing inhibition in vitro

Jakobsen, Tim Holm, van Gennip, M., Hultqvist, Louise Dahl, Bjarnsholt, Thomas & Givskov, Michael, 1 Jan 2011, In: Methods in Molecular Biology. 692, 3, p. 253-263 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Influence of putative exopolysaccharide genes on Pseudomonas putida KT2440 biofilm stability

Nilsson, M., Chiang, W., Fazli, M., Gjermansen, M., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Environmental Microbiology. 13, 5, p. 1357-69

Research output: Contribution to journal › Journal article › Research › peer-review

Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943

Research output: Contribution to journal › Journal article › Research › peer-review

Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds

Fazli, M., Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, A., Andersen, C. B., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Wound Repair and Regeneration. 19, 3, p. 387-91 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Quorum sensing in Aeromonas salmonicida subsp. achromogenes and the effect of the autoinducer synthase AsaI on bacterial virulence

Schwenteit, J., Gram, L., Nielsen, K. F., Fridjonsson, O. H., Bornscheuer, U. T., Givskov, Michael & Gudmundsdottir, B. K., 2011, In: Veterinary Microbiology. 147, 3-4, p. 389-97

Research output: Contribution to journal › Journal article › Research › peer-review

The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia

Fazli, M., O'Connell, A., Nilsson, M., Niehaus, K., Dow, J. M., Givskov, Michael, Ryan, R. P. & Tolker-Nielsen, Tim, 2011, In: Molecular Microbiology. 82, 2, p. 327-41

Research output: Contribution to journal › Journal article › Research › peer-review

The clinical impact of bacterial biofilms

Høiby, Niels, Ciofu, Oana, Johansen, Helle Krogh, Song, Z., Moser, Claus Ernst, Jensen, Peter Østrup, Molin, S., Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: International Journal of Oral Science. 3, 2, p. 55-65

Research output: Contribution to journal › Journal article › Research › peer-review

The implication of Pseudomonas aeruginosa biofilms in infections

Rybtke, Morten Levin, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: Inflammation & Allergy - Drug Targets. 10, 2, p. 141-57 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

True microbiota involved in chronic lung infection of cystic fibrosis patients found by culturing and 16S rRNA gene analysis

Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2011, In: Journal of Clinical Microbiology. 49, 12, p. 4352-5 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review