Thomas Bjarnsholt
Professor
Bacteriology
Nørre Allé 14
2200 København N
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Interfering with bacterial gossip.
Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Summary and perspectives
Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, 2011, Biofilm Infections. Springer New York, p. 291-294 4 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections
Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H. P., Rygaard, J., Moser, C., Eberl, L., Høiby, Niels & Givskov, M. C., 1 Dec 2005, In: Microbiology. 151, Pt 12, p. 3873-80 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing inhibitors disable bacterial biofilms.
Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Emerging trends in in antibacterial discovery.. Miller, A. A. & Miller, P. F. (eds.). 1 ed. Norvich UK: HorizonBioscience, p. 211-224 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent
Bjarnsholt, Thomas, Jensen, Peter Østrup, Burmølle, Mette, Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, Claus Ernst, Molin, S., Høiby, Niels & Givskov, Michael, Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Process for the manufacture of ajoene derivatives
Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154Research output: Patent
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Silver against Pseudomonas aeruginosa biofilms
Bjarnsholt, Thomas, Kirketerp-Møller, K., Kristiansen, S., Phipps, R., Nielsen, A. K., Jensen, Peter Østrup, Høiby, Niels & Givskov, Michael, 2007, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 115, 8, p. 921-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions
Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Givskov, Michael, Janssen, M. & Christensen, L. H., 2009, In: Dermatologic Surgery. 35 Suppl 2, p. 1620-1624 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of mental models on the treatment and research of chronic infections due to biofilms
Bjarnsholt, Thomas, Mastroianni, E., Kirketerp-Møller, K., Stewart, P. S., Mähr, A. M., Domínguez Cabañes, A. & Nørager, R., 2021, In: APMIS. 129, 10, p. 598-606Research output: Contribution to journal › Journal article › Research › peer-review
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The role of bacterial biofilms in chronic infections
Bjarnsholt, Thomas, May 2013, In: APMIS Supplementum. 121, s136, p. 1-58 58 p.Research output: Contribution to journal › Journal article › Research
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Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?
Bjarnsholt, Thomas & Givskov, Michael, 2008, In: Current Infectious Disease Reports. 10, 1, p. 22-28 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The importance of understanding the infectious microenvironment
Bjarnsholt, Thomas, Whiteley, M., Rumbaugh, K. P., Stewart, P. S., Jensen, Peter Østrup & Frimodt-Møller, N., 2022, In: The Lancet Infectious Diseases. 22, 3, p. e88-e92Research output: Contribution to journal › Review › Research › peer-review
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Applying insights from biofilm biology to drug development - can a new approach be developed?
Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The in vivo biofilm
Bjarnsholt, Thomas, Alhede, M., Alhede, M., Eickhardt-Sørensen, S. R., Moser, Claus Ernst, Kühl, Michael, Jensen, Peter Østrup & Høiby, Niels, 2013, In: Trends in Microbiology. 21, 9, p. 466-474 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Methods to classify bacterial pathogens in cystic fibrosis
Bjarnsholt, Thomas, Nielsen, X. C., Johansen, U., Nørgaard, L. & Høiby, Niels, 2011, In: Methods in Molecular Biology. 742, p. 143-71 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections
Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H., Rygaard, J., Moser, C., Eberl, L., Høiby, N. & Givskov, M., 2005, In: Microbiology. 151, Pt 12, p. 3873-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients
Bjarnsholt, Thomas, Jensen, Peter Østrup, Fiandaca, M. J., Pedersen, J., Hansen, C. R., Andersen, C. B., Pressler, T., Givskov, Michael & Høiby, Niels, 1 Jun 2009, In: Pediatric Pulmonology. 44, 6, p. 547-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Revival of Krebs-Ringer balanced salt solution for the investigation of polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilm interaction
Bjarnsholt, Thomas, Jensen, Peter Østrup & Alhede, M., 2019, In: Pathogens and Disease. 77, 5, ftz052.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibiofilm Properties of Acetic Acid
Bjarnsholt, Thomas, Alhede, M., Jensen, Peter Østrup, Nielsen, Anne Kirstine, Johansen, Helle Krogh, Homøe, Preben, Høiby, Niels, Givskov, Michael & Kirketerp-Moller, K., Jun 2015, In: Advances in Wound Care. 4, 7, p. 363-372 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent
Bjarnsholt, Thomas, Jensen, P. Ø., Burmølle, M., Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, C., Molin, S., Høiby, Niels & Givskov, M. C., 1 Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa
Bjarnsholt, Thomas & Givskov, M., 2006, In: Analytical and Bioanalytical Chemistry. 387, 2, p. 409-14 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Understanding biofilms - Are we there yet?
Bjarnsholt, Thomas, Høiby, Niels, Donelli, G., Imbert, C. & Försberg, A., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 125-126 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudo-monas aeruginosa infections.
Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christoffersen, L., Calum, Henrik Pierre, Hentzer, M., Hougen, H. P., Rygaard, J., Moser, Claus Ernst, Eberl, L., Høiby, Niels & Givskov, Michael, 2005, In: F E M S Microbiology. 151, p. 3873-3880 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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APMIS 2022 focus issue on human microbiome in disease and pathology
Bjarnsholt, Thomas, Ralfkiaer, U. & Malone, M., 2022, In: APMIS. 130, 12, p. 689 1 p.Research output: Contribution to journal › Editorial › Research › peer-review
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Introduction to Biofilm Infections
Bjarnsholt, Thomas, 2010, Biofilm Infections. New YorkResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Introduction to biofilms
Bjarnsholt, Thomas, 2011, Biofilm Infections. Springer New York, p. 1-9 9 p.Research output: Chapter in Book/Report/Conference proceeding › Preface/postscript › Research › peer-review
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Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control
Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect
Bjarnsholt, Thomas, van Gennip, M., Jakobsen, Tim Holm, Hultqvist, Louise Dahl, Jensen, Peter Østrup & Givskov, Michael, 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biofilm formation – what we can learn from recent developments
Bjarnsholt, Thomas, Buhlin, K., Dufrêne, Y. F., Gomelsky, M., Moroni, A., Ramstedt, M., Rumbaugh, K. P., Schulte, T., Sun, L., Åkerlund, B. & Römling, U., 2018, In: Journal of Internal Medicine. 284, 4, p. 332-345 14 p.Research output: Contribution to journal › Review › Research › peer-review
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The gut microbiota can orchestrate the signaling pathways in colorectal cancer
Bennedsen, A. L. B., Furbo, S., Bjarnsholt, Thomas, Raskov, H., Gögenur, Ismail & Kvich, Lasse Andersson, 2022, In: APMIS. 130, 3, p. 121-139 19 p.Research output: Contribution to journal › Review › Research › peer-review
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Protocol to assess metabolic activity of Pseudomonas aeruginosa by measuring heat flow using isothermal calorimetry
Beilharz, K., Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim, Bjarnsholt, Thomas & Lichtenberg, Mads, 2023, In: STAR Protocols. 4, 2, 102269.Research output: Contribution to journal › Journal article › Research › peer-review
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Universal Dermal Microbiome in Human Skin
Bay, Lene, Barnes, Christopher James, Fritz, Blaine Gabriel, Thorsen, Jonathan Jan Ilve, Restrup, M. E. M., Rasmussen, Linett, Sørensen, J. K., Hesselvig, A. B., Odgaard, Anders, Hansen, Anders Johannes & Bjarnsholt, Thomas, 2020, In: mBio. 11, 1, 13 p., e02945-19.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial Aggregates Establish at the Edges of Acute Epidermal Wounds
Bay, Lene, Kragh, K. N., Eickhardt, S. R., Poulsen, Steen Seier, Gjerdrum, Lise Mette Rahbek, Ghathian, K., Calum, Henrik Pierre, Ågren, Magnus & Bjarnsholt, Thomas, Apr 2018, In: Advances in Wound Care. 7, 4, p. 105-113Research output: Contribution to journal › Journal article › Research › peer-review
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HUMAN SKIN MICROORGANISMS ARE DISTRIBUTED IN BIOFILM AGGREGATES AT WOUND EDGES
Bay, Lene, Agren, M. S., Poulsen, Steen Seier, Ghathian, K. S. A., Calum, H. & Bjarnsholt, Thomas, 2015, In: Wound Repair and Regeneration. 23, 4, p. A3-A3 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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A simplified bacterial community found within the epidermis than at the epidermal surface of atopic dermatitis patients and healthy controls
Barnes, Christopher James, Asplund, M., Clausen, M., Rasmussen, Linett, Olesen, C. M., Yüksel, Y. T., Andersen, P. S., Litman, Thomas, Holmstrøm, K., Bay, Lene, Fritz, Blaine Gabriel, Bjarnsholt, Thomas, Agner, Tove & Hansen, Anders Johannes, 2023, In: BMC Microbiology. 23, 12 p., 273.Research output: Contribution to journal › Journal article › Research › peer-review
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A UVC device for intra-luminal disinfection of catheters: In vitro tests on soft polymer tubes contaminated with Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Candida albicans
Bak, J., Begovic, T., Bjarnsholt, Thomas & Nielsen, A., 2011, In: Photochemistry and Photobiology. 87, 5, p. 1123-1128 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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UV light assisted antibiotics for eradication of in vitro biofilms
Argyraki, A., Markvart, Merete, Stavnsbjerg, Camilla, Kragh, K. N., Ou, Y., Bjørndal, Lars, Bjarnsholt, Thomas & Petersen, P. M., 2018, In: Scientific Reports. 8, p. 1-9 16360.Research output: Contribution to journal › Journal article › Research › peer-review
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Inactivation of Pseudomonas aeruginosa biofilm after ultraviolet light-emitting diode treatment: a comparative study between ultraviolet C and ultraviolet B
Argyraki, A., Markvart, Merete, Bjørndal, Lars, Bjarnsholt, Thomas & Petersen, P. M., 2017, In: Journal of Biomedical Optics. 22, 6, 7 p., 65004.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of UVB and UVC irradiation disinfection efficacies on Pseudomonas Aeruginosa (P. aeruginosa) biofilm
Argyraki, A., Markvart, Merete, Nielsen, Anne Kirstine, Bjarnsholt, Thomas, Bjørndal, Lars & Petersen, P. M., 2016, Biophotonics: Photonic Solutions for Better Health Care V. SPIE - International Society for Optical Engineering, Vol. 9887. 7 p. 988730. (Proceedings of S P I E - International Society for Optical Engineering, Vol. 9887).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are toxic to Lucilia sericata maggots
Andersen, A. S., Joergensen, B., Bjarnsholt, Thomas, Johansen, H., Karlsmark, T., Givskov, Michael, Krogfelt, K. A., Andersen, A. S., Jørgensen, B., Bjarnsholt, T., Johansen, H., Karlsmark, Tonny, Givskov, M. & Krogfelt, K. A., 1 Feb 2010, In: Microbiology. 156, Pt 2, p. 400-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Minimum information guideline for spectrophotometric and fluorometric methods to assess biofilm formation in microplates
Allkja, J., Bjarnsholt, Thomas, Coenye, T., Cos, P., Fallarero, A., Harrison, J. J., Lopes, S. P., Oliver, A., Pereira, M. O., Ramage, G., Shirtliff, M. E., Stoodley, P., Webb, J. S., Zaat, S. A. J., Goeres, D. M. & Azevedo, N. F., 2020, In: Biofilm. 2, 8 p., 100010.Research output: Contribution to journal › Journal article › Research › peer-review
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Are biofilms responsible for the adverse effects experienced following soft-tissue fillers?
Alhede, M. & Bjarnsholt, Thomas, 2014, In: Future Microbiology. 9, 8, p. 931-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Targets for Treatment of Pseudomonas aeruginosa Biofilms
Alhede, M., Alhede, M. & Bjarnsholt, Thomas, 1 Jan 2014, Antibiofilm Agents. Rumbaugh, K. (ed.). Springer Publishing Company, Vol. 8. p. 257-272 16 p. (Springer Series on Biofilms, Vol. 8).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
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Bacterial biofilm formation and treatment in soft tissue fillers
Alhede, M., Er, O., Eickhardt, S., Kragh, K., Alhede, M., Hultqvist, Louise Dahl, Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.Research output: Contribution to journal › Journal article › Research
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Phenotype of non-attached Pseudomonas aeruginosa microclonies resembles attached biofilm, including reversible antibiotic tolerance
Alhede, M., Qvortrup, K., Allesen-Holm, M., van Gennip, M., Christensen, L., Jensen, Peter Østrup, Nielsen, A., Tolker-Nielsen, T., Høiby, Niels, Givskov, M. C. & Bjarnsholt, Thomas, 2010. 0 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes
Alhede, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Phipps, R. K., Moser, Claus Ernst, Christophersen, L., Hultqvist, Louise Dahl, van Gennip, M., Parsek, M., Høiby, Niels, Rasmussen, T. B. & Givskov, Michael, 2009, In: Microbiology. 155, 11, p. 3500-3508 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition
Alhede, M., Qvortrup, Klaus, Liebrechts, R., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 335-342 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9755066
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Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
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Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
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