Tim Holm Jakobsen

Tim Holm Jakobsen

Associate Professor


  1. 2024
  2. Published

    Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump

    Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2

    Research output: Contribution to journalJournal articlepeer-review

  3. E-pub ahead of print

    Novel sampling technique maintaining the two-dimensional organization of microbes during cultivation from chronic wounds: The Imprint method

    Iversen, A. K. S., Fritz, Blaine Gabriel, Hansen, M. J., Kirketerp-Møller, K., Jakobsen, Tim Holm, Bjarnsholt, Thomas & Lichtenberg, Mads, 2024, (E-pub ahead of print) In: APMIS.

    Research output: Contribution to journalJournal articlepeer-review

  4. E-pub ahead of print

    Single cells and bacterial biofilm populations in chronic wound infections

    Lichtenberg, Mads, Kirketerp-Møller, K., Kvich, Lasse Andersson, Christensen, Mads Holm, Fritz, Blaine Gabriel, Jakobsen, Tim Holm & Bjarnsholt, Thomas, 2024, (E-pub ahead of print) In: APMIS.

    Research output: Contribution to journalJournal articlepeer-review

  5. 2023
  6. Published

    Synergistic bactericidal effect of nisin and phytic acid against Escherichia coli O157:H7

    Zhao, G., Kempen, Paul Joseph, Zheng, T., Jakobsen, Tim Holm, Zhao, S., Gu, L., Solem, C. & Ruhdal Jensen, P., 2023, In: Food Control. 144, 109324.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    What's in a name? Characteristics of clinical biofilms

    Lichtenberg, Mads, Coenye, T., Parsek, M. R., Bjarnsholt, Thomas & Jakobsen, Tim Holm, 2023, In: FEMS Microbiology Reviews. 47, 5, p. 1-8 fuad050.

    Research output: Contribution to journalReviewpeer-review

  8. 2022
  9. Published

    Biofilm Survival Strategies in Chronic Wounds

    Thaarup, Ida Clement, Iversen, A. K. S., Lichtenberg, Mads, Bjarnsholt, Thomas & Jakobsen, Tim Holm, 2022, In: Microorganisms. 10, 4, 775.

    Research output: Contribution to journalReviewpeer-review

  10. Published

    Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections

    Kristensen, Rasmus, Tolker-Nielsen, Tim & Jakobsen, Tim Holm, 2022, Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, p. 159-179 (Springer Series on Biofilms; No. 11).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  11. Published

    Inoculum Concentration Influences Pseudomonas aeruginosa Phenotype and Biofilm Architecture

    Lichtenberg, Mads, Kvich, Lasse Andersson, Larsen, S. L. B., Jakobsen, Tim Holm & Bjarnsholt, Thomas, 2022, In: Microbiology Spectrum. 10, 6

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

    Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, T. E., 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment

    Lichtenberg, Mads, Jakobsen, Tim Holm, Kühl, Michael, Kolpen, Mette, Jensen, Peter Østrup & Bjarnsholt, Thomas, 2022, In: FEMS Microbiology Reviews. 46, 5, 13 p., fuac018.

    Research output: Contribution to journalJournal articlepeer-review

  14. 2021
  15. Published

    Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

    Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, T. E., Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms

    Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Nitric-oxide-driven oxygen release in anoxic Pseudomonas aeruginosa

    Lichtenberg, Mads, Line, L., Schrameyer, V., Jakobsen, Tim Holm, Rybtke, Morten Levin, Toyofuku, M., Nomura, N., Kolpen, Mette, Tolker-Nielsen, Tim, Kühl, Michael, Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: iScience. 24, 12, 103404.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

    Jansen, C. U., Uhd, J., Andersen, Jens Bo, Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Nielsen, T. E., Givskov, Michael, Tolker-Nielsen, Tim & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Sampling challenges in diagnosis of chronic bacterial infections

    Jakobsen, Tim Holm, Xu, Y., Bay, Lene, Schønheyder, H. C., Jakobsen, T., Bjarnsholt, Thomas & Thomsen, T. R., 2021, In: Journal of Medical Microbiology. 70, 3

    Research output: Contribution to journalReviewpeer-review

  20. 2019
  21. Published

    Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

    Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microbiology. 165, 3, p. 334-342

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation

    Qvortrup, K., Hultqvist, Louise Dahl, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Jansen, C. U., Uhd, J., Andersen, Jens Bo, Nielsen, T. E., Givskov, Michael & Tolker-Nielsen, Tim, 2019, In: Frontiers in Chemistry. 7, 27 p., 742.

    Research output: Contribution to journalReviewpeer-review

  23. 2018
  24. Published

    Implants induce a new niche for microbiomes

    Jakobsen, Tim Holm, Eickhardt, S. R., Gheorghe, Alexandra Gabriella, Stenqvist, C., Sønderholm, M., Stavnsberg, C., Jensen, Peter Østrup, Odgaard, Anders, Whiteley, M., Moser, Claus Ernst, Hvolris, J., Hougen, H. P. & Bjarnsholt, Thomas, 1 Aug 2018, In: APMIS - Journal of Pathology, Microbiology and Immunology. 126, 8, p. 685-692 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    Imaging N-acyl homoserine lactone quorum sensing in vivo

    Hultqvist, Louise Dahl, Alhede, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 2018, Quorum Sensing: Methods and Protocols. Leoni, L. & Rampion, G. (eds.). Humana Press, Vol. 1673. p. 203-212 10 p. (Methods in Molecular Biology; No. 1673).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  26. Published

    Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro

    Jakobsen, Tim Holm, Alhede, M., Hultqvist, Louise Dahl, Bjarnsholt, Thomas & Givskov, Michael, 2018, Quorum Sensing: Methods and Protocols. Springer, Vol. 1673. p. 275-285 11 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  27. 2017
  28. Published

    Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes

    Jakobsen, Tim Holm, Tolker-Nielsen, Tim & Givskov, Michael, Sep 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.

    Research output: Contribution to journalReviewpeer-review

  29. Published

    Pseudomonas aeruginosa aggregate formation in an alginate bead model system exhibits In Vivo-like characteristics

    Sønderholm, M., Kragh, K. N., Koren, K., Jakobsen, Tim Holm, Darch, S., Alhede, M., Jensen, Peter Østrup, Whiteley, M., Kühl, Michael & Bjarnsholt, Thomas, May 2017, In: Applied and Environmental Microbiology. 83, 9, 15 p., e00113-17.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

    Fong, J., Yuan, M., Jakobsen, Tim Holm, Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, T. E. & Givskov, Michael, 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    A broad range quorum sensing inhibitor working through sRNA inhibition

    Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, T. E., Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors

    Thanh Tung, T., Jakobsen, Tim Holm, Dao, T. T., Fuglsang, Anja Thoe, Givskov, Michael, Christensen, Søren Brøgger & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.

    Research output: Contribution to journalJournal articlepeer-review

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