Tim Holm Jakobsen

Tim Holm Jakobsen

Associate Professor

ORCID: 0000-0002-1671-2155

Publication year:
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11 - 20 out of 45Page size: 10
  1. 2012
  2. Published

    Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

    Christensen, L., van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Process for the manufacture of ajoene derivatives

    Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154

    Research output: Patent

  4. 2013
  5. Published

    Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes

    Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J. & 2 others, Høiby, Niels & Bjarnsholt, Thomas, 2013, In: P L o S One. 8, 7, 17 p., e68484.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Identification of LasR ligands through a virtual screening approach

    Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, Tim Holm, Harmsen, M., Tolker-Nielsen, Tim, Nielsen, T. E., Givskov, Michael & Taboureau, O., 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR

    Claussen, A., Jakobsen, Tim Holm, Bjarnsholt, Thomas, Givskov, Michael, Welch, M., Ferkinghoff-Borg, J. & Sams, T., 2013, In: International Journal of Molecular Sciences (Online). 14, 7, p. 13360-76 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors

    Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2014
  10. Published

    Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

    Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa

    Tan, S. Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, Tim Holm, Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2015
  13. Published

    Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

    Hansen, M. R., Jakobsen, Tim Holm, Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T., 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2017
  15. Published

    A broad range quorum sensing inhibitor working through sRNA inhibition

    Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 9840851