Tim Holm Jakobsen
Associate Professor
Bacteriology
Nørre Allé 14
2200 København N
- Published
Pseudomonas aeruginosa aggregate formation in an alginate bead model system exhibits In Vivo-like characteristics
Sønderholm, M., Kragh, K. N., Koren, K., Jakobsen, Tim Holm, Darch, S., Alhede, M., Jensen, Peter Østrup, Whiteley, M., Kühl, Michael & Bjarnsholt, Thomas, May 2017, In: Applied and Environmental Microbiology. 83, 9, 15 p., e00113-17.Research output: Contribution to journal › Journal article › Research › peer-review
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A broad range quorum sensing inhibitor working through sRNA inhibition
Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.Research output: Contribution to journal › Journal article › Research › peer-review
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Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing
Jakobsen, Tim Holm, van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, Louise Dahl, Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, Peter Østrup, Moser, Claus Ernst, Nielsen, Kristian Fog, Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
Jakobsen, Tim Holm, Tolker-Nielsen, Tim & Givskov, Michael, Sep 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.Research output: Contribution to journal › Review › Research › peer-review
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Biofilm Survival Strategies in Chronic Wounds
Thaarup, Ida Clement, Iversen, A. K. S., Lichtenberg, Mads, Bjarnsholt, Thomas & Jakobsen, Tim Holm, 2022, In: Microorganisms. 10, 4, 775.Research output: Contribution to journal › Review › Research › peer-review
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Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections
Kristensen, Rasmus, Tolker-Nielsen, Tim & Jakobsen, Tim Holm, 2022, Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, p. 159-179 (Springer Series on Biofilms; No. 11).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa
Tan, S. Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, Tim Holm, Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J. & 2 others, , 2013, In: P L o S One. 8, 7, 17 p., e68484.Research output: Contribution to journal › Journal article › Research › peer-review
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Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors
Yang, L., Rybtke, Morten Levin, Jakobsen, Tim Holm, Hentzer, M., Bjarnsholt, Thomas, Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2432-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa
Fong, J., Yuan, M., Jakobsen, Tim Holm, Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227Research output: Contribution to journal › Journal article › Research › peer-review
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Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa
Jakobsen, Tim Holm, Bragason, S. K., Phipps, R. K., Hultqvist, Louise Dahl, van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors
Thanh Tung, T., Jakobsen, Tim Holm, Dao, T. T., Fuglsang, Anja Thoe, Givskov, Michael, Christensen, Søren Brøgger & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of LasR ligands through a virtual screening approach
Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, Tim Holm, Harmsen, M., Tolker-Nielsen, Tim, Nielsen, T. E., Givskov, Michael & Taboureau, O., 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms
Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.Research output: Contribution to journal › Journal article › Research › peer-review
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Imaging N-acyl homoserine lactone quorum sensing in vivo
Hultqvist, Louise Dahl, Alhede, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 2018, Quorum Sensing: Methods and Protocols. Leoni, L. & Rampion, G. (eds.). Humana Press, Vol. 1673. p. 203-212 10 p. (Methods in Molecular Biology; No. 1673).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Imaging N-acyl homoserine lactone quorum sensing in vivo
Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 1 Jan 2011, In: Methods in Molecular Biology. 692, 2, p. 147-157 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Implants induce a new niche for microbiomes
Jakobsen, Tim Holm, Eickhardt, S. R., Gheorghe, Alexandra Gabriella, Stenqvist, C., Sønderholm, M., Stavnsberg, C., Jensen, Peter Østrup, Odgaard, Anders, Whiteley, M., Moser, Claus Ernst, Hvolris, J., Hougen, H. P. & Bjarnsholt, Thomas, 1 Aug 2018, In: APMIS - Journal of Pathology, Microbiology and Immunology. 126, 8, p. 685-692 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect
Bjarnsholt, Thomas, van Gennip, M., Jakobsen, Tim Holm, Hultqvist, Louise Dahl, Jensen, Peter Østrup & Givskov, Michael, 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms
Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump
Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2Research output: Contribution to journal › Journal article › Research › peer-review
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Inoculum Concentration Influences Pseudomonas aeruginosa Phenotype and Biofilm Architecture
Lichtenberg, Mads, Kvich, Lasse Andersson, Larsen, S. L. B., Jakobsen, Tim Holm & Bjarnsholt, Thomas, 2022, In: Microbiology Spectrum. 10, 6Research output: Contribution to journal › Journal article › Research › peer-review
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Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR
Claussen, A., Jakobsen, Tim Holm, Bjarnsholt, Thomas, Givskov, Michael, Welch, M., Ferkinghoff-Borg, J. & Sams, T., 2013, In: International Journal of Molecular Sciences (Online). 14, 7, p. 13360-76 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries
Midjord-Belstrøm, Daniel, Constancias, F., Liu, Y., Yang, L., Drautz-Moses, D. I., Schuster, S. C., Kohli, G. S., Jakobsen, Tim Holm, Holmstrup, Palle & Givskov, Michael, 2017, In: npj Biofilms and Microbiomes. 3, 8 p., 23.Research output: Contribution to journal › Journal article › Research › peer-review
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Nitric-oxide-driven oxygen release in anoxic Pseudomonas aeruginosa
Lichtenberg, Mads, Line, L., Schrameyer, V., Jakobsen, Tim Holm, Rybtke, Morten Levin, Toyofuku, M., Nomura, N., Kolpen, Mette, Tolker-Nielsen, Tim, Kühl, Michael, Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: iScience. 24, 12, 103404.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel and future treatment strategies
Alhede, M., Jakobsen, Tim Holm & Givskov, Michael, 1 Dec 2011, Biofilm Infections. Springer, p. 231-249 19 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
ID: 9840851
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2831
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
322
downloads
Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
Research output: Contribution to journal › Review › Research › peer-review
Published -
257
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Pseudomonas aeruginosa aggregate formation in an alginate bead model system exhibits In Vivo-like characteristics
Research output: Contribution to journal › Journal article › Research › peer-review
Published