Tim Holm Jakobsen

Tim Holm Jakobsen

Associate Professor


  1. 2017
  2. Published

    Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries

    Midjord-Belstrøm, Daniel, Constancias, F., Liu, Y., Yang, L., Drautz-Moses, D. I., Schuster, S. C., Kohli, G. S., Jakobsen, Tim Holm, Holmstrup, Palle & Givskov, Michael, 2017, In: npj Biofilms and Microbiomes. 3, 8 p., 23.

    Research output: Contribution to journalJournal articlepeer-review

  3. 2015
  4. Published

    Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

    Hansen, M. R., Jakobsen, Tim Holm, Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T., 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. 2014
  6. Published

    Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa

    Tan, S. Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, Tim Holm, Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

    Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  8. 2013
  9. Published

    Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors

    Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes

    Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J. & 2 others, Høiby, Niels & Bjarnsholt, Thomas, 2013, In: P L o S One. 8, 7, 17 p., e68484.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Identification of LasR ligands through a virtual screening approach

    Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, Tim Holm, Harmsen, M., Tolker-Nielsen, Tim, Nielsen, T. E., Givskov, Michael & Taboureau, O., 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR

    Claussen, A., Jakobsen, Tim Holm, Bjarnsholt, Thomas, Givskov, Michael, Welch, M., Ferkinghoff-Borg, J. & Sams, T., 2013, In: International Journal of Molecular Sciences (Online). 14, 7, p. 13360-76 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. 2012
  14. Published

    Process for the manufacture of ajoene derivatives

    Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154

    Research output: Patent

  15. Published

    Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing

    Jakobsen, Tim Holm, van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, Louise Dahl, Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, Peter Østrup, Moser, Claus Ernst, Nielsen, Kristian Fog, Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

    Christensen, L., van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa

    Jakobsen, Tim Holm, Bragason, S. K., Phipps, R. K., Hultqvist, Louise Dahl, van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorom sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.

    Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1198-1206 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. 2011
  20. Published

    Novel and future treatment strategies

    Alhede, M., Jakobsen, Tim Holm & Givskov, Michael, 1 Dec 2011, Biofilm Infections. Springer, p. 231-249 19 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  21. Published

    Imaging N-acyl homoserine lactone quorum sensing in vivo

    Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 1 Jan 2011, In: Methods in Molecular Biology. 692, 2, p. 147-157 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Qualitative and quantitative determination of quorum sensing inhibition in vitro

    Jakobsen, Tim Holm, van Gennip, M., Hultqvist, Louise Dahl, Bjarnsholt, Thomas & Givskov, Michael, 1 Jan 2011, In: Methods in Molecular Biology. 692, 3, p. 253-263 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. 2010
  24. Published

    Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

    Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect

    Bjarnsholt, Thomas, van Gennip, M., Jakobsen, Tim Holm, Hultqvist, Louise Dahl, Jensen, Peter Østrup & Givskov, Michael, 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Quorum sensing regulation in Aeromonas hydrophila

    Garde, C., Bjarnsholt, Thomas, Givskov, Michael, Jakobsen, Tim Holm, Hentzer, M., Claussen, A., Sneppen, K., Ferkinghoff-Borg, J. & Sams, T., 2010, In: Journal of Molecular Biology. 396, 4, p. 849-57 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. 2009
  28. Published

    Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors

    Yang, L., Rybtke, Morten Levin, Jakobsen, Tim Holm, Hentzer, M., Bjarnsholt, Thomas, Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2432-43 12 p.

    Research output: Contribution to journalJournal articlepeer-review

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