Tim Tolker-Nielsen

Tim Tolker-Nielsen

Professor

Member of:

    ORCID: 0000-0002-9751-474X

    Publication year:
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    1 - 204 out of 204Page size: 500
    1. 2024
    2. Published

      Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump

      Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Role of extracellular matrix components in biofilm formation and adaptation of Pseudomonas ogarae F113 to the rhizosphere environment

      Blanco-Romero, E., Garrido-Sanz, D., Durán, D., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Redondo-Nieto, M., Rivilla, R. & Martín, M., 2024, In: Frontiers in Microbiology. 15, 12 p., 1341728.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. 2023
    5. Published

      A genetic switch controls Pseudomonas aeruginosa surface colonization

      Manner, C., Dias Teixeira, R., Saha, D., Kaczmarczyk, A., Zemp, R., Wyss, F., Jaeger, T., Laventie, B. J., Boyer, S., Malone, J. G., Qvortrup, K., Andersen, Jens Bo, Givskov, Michael, Tolker-Nielsen, Tim, Hiller, S., Drescher, K. & Jenal, U., 2023, In: Nature Microbiology. 8, p. 1520–1533

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Challenges in using transcriptome data to study the c-di-GMP signaling network in Pseudomonas aeruginosa clinical isolates

      Gür, M., Erdmann, J., Will, A., Liang, Z., Andersen, Jens Bo, Tolker-Nielsen, Tim & Häussler, S., 2023, In: FEMS Microbes. 4, 10 p., xtad012.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms

      Armengol, E., Kragh, K. N., Tolker-Nielsen, Tim, Sierra, J. M., Higazy, Doaa Mohamed Mohamed E, Ciofu, Oana, Viñas, M. & Høiby, Niels, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 4, e0164122.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Protocol to assess metabolic activity of Pseudomonas aeruginosa by measuring heat flow using isothermal calorimetry

      Beilharz, K., Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim, Bjarnsholt, Thomas & Lichtenberg, Mads, 2023, In: STAR Protocols. 4, 2, 102269.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      The Bep gene cluster in Burkholderia cenocepacia H111 codes for a water-insoluble exopolysaccharide essential for biofilm formation

      Bellich, B., Terán, L. C., Fazli, M. M., Berti, F., Rizzo, R., Tolker-Nielsen, Tim & Cescutti, P., 2023, In: Carbohydrate Polymers. 301, 120318.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      The non-attached biofilm aggregate

      Kragh, K. N., Tolker-Nielsen, Tim & Lichtenberg, Mads, 2023, In: Communications Biology . 6, 898.

      Research output: Contribution to journal › Review › Research › peer-review

    11. Published

      The role of individual exopolysaccharides in antibiotic tolerance of Pseudomonas aeruginosa aggregates

      Liang, Z., Nilsson, M., Kragh, K. N., Hedal, I., Alcàcer-Almansa, J., Kiilerich, R. O., Andersen, Jens Bo & Tolker-Nielsen, Tim, 2023, In: Frontiers in Microbiology. 14, 1187708.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. 2022
    13. Published

      Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections

      Kristensen, Rasmus, Tolker-Nielsen, Tim & Jakobsen, Tim Holm, 2022, Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, p. 159-179 (Springer Series on Biofilms; No. 11).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    14. Published

      Cyclic-di-GMP signaling controls metabolic activity in Pseudomonas aeruginosa

      Lichtenberg, Mads, Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2022, In: Cell Reports. 41, 3, p. 111515 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Effects of antibiotic treatment and phagocyte infiltration on development of Pseudomonas aeruginosa biofilm—Insights from the application of a novel PF hydrogel model in vitro and in vivo

      Wu, H., Song, L., Yam, J. K. H., Plotkin, M., Wang, H., Rybtke, Morten Levin, Seliktar, D., Kofidis, T., Høiby, Niels, Tolker-Nielsen, Tim, Song, Z. & Givskov, Michael, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 826450.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa

      Yam, J. K. H., Aung, T. T., Chua, S. L., Cheng, Y., Kohli, G. S., Zhou, J., Constancias, F., Liu, Y., Cai, Z., Salido, M. M. S., Drautz-Moses, D. I., Rice, S. A., Schuster, S. C., Boo, Z. Z., Wu, B., Kjelleberg, S., Tolker-Nielsen, T., Lakshminarayanan, R., Beuerman, R. W., Yang, L. & 1 others, Givskov, Michael, 2022, In: Infection and Immunity. 90, 8

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

      Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      The BDSF quorum sensing receptor RpfR regulates Bep exopolysaccharide synthesis in Burkholderia cenocepacia via interaction with the transcriptional regulator BerB

      Steiner, E., Shilling, R. E., Richter, A. M., Schmid, N., Fazli, M., Kaever, V., Jenal, U., Tolker-Nielsen, Tim & Eberl, L., 2022, In: npj Biofilms and Microbiomes. 8, 93.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Transcription of the Alginate Operon in Pseudomonas aeruginosa Is Regulated by c-di-GMP

      Liang, Z., Rybtke, Morten Levin, Kragh, K. N., Johnson, O., Schicketanz, Muriel Leandra, Zhang, Yong, Andersen, Jens Bo & Tolker-Nielsen, Tim, 2022, In: Microbiology Spectrum. 10, 4, 13 p., e00675-22.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. 2021
    21. Published

      Biofilms can act as plasmid reserves in the absence of plasmid specific selection

      Røder, Henriette Lyng, Trivedi, Urvish, Russel, J., Kragh, K. N., Herschend, J., Thalsø-Madsen, I., Tolker-Nielsen, Tim, Bjarnsholt, Thomas, Burmølle, Mette & Madsen, Jonas Stenløkke, 2021, In: npj Biofilms and Microbiomes. 7, 6 p., 78.

      Research output: Contribution to journal › Letter › Research › peer-review

    22. Published

      Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants

      Nair, H. A. S., Subramoni, S., Poh, W. H., Hasnuddin, N. T. B., Tay, M., Givskov, Michael, Tolker-Nielsen, Tim, Kjelleberg, S., McDougald, D. & Rice, S. A., 2021, In: BMC Microbiology. 21, 10 p., 255.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through loss of the Rieske cytochrome bc1 sub-unit

      Soh, E., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Camara, M., Givskov, Michael, Hardie, K. R., Tolker-Nielsen, Tim, Ize, B. & Williams, P., 2021, bioRxiv, 43 p.

      Research output: Working paper › Preprint › Research

    24. Published

      Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1sub-unit

      Soh, E. Y. C., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Cámara, M., Givskov, Michael, Hardie, K. R., Tolker-Nielsen, Tim, Ize, B. & Williams, P., 2021, In: PLOS Pathogens. 17, 8, 25 p., e1009425.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Immune Responses to Pseudomonas aeruginosa Biofilm Infections

      Moser, Claus Ernst, Jensen, Peter Østrup, Thomsen, K., Kolpen, M., Rybtke, Morten Levin, Lauland, A. S., Trøstrup, H. & Tolker-Nielsen, Tim, 2021, In: Frontiers in Immunology. 12, 625597.

      Research output: Contribution to journal › Review › Research › peer-review

    27. Published

      Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Nitric-oxide-driven oxygen release in anoxic Pseudomonas aeruginosa

      Lichtenberg, Mads, Line, L., Schrameyer, V., Jakobsen, Tim Holm, Rybtke, Morten Levin, Toyofuku, M., Nomura, N., Kolpen, Mette, Tolker-Nielsen, Tim, Kühl, Michael, Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: iScience. 24, 12, 103404.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Redox protein osar (pa0056) regulates dsbm and the oxidative stress response in pseudomonas aeruginosa

      Liu, Y., Ma, Y., Ma, Z., Han, X., Qi, H., Andersen, Jens Bo, Xu, H., Tolker-Nielsen, Tim & Qiao, M., 2021, In: Antimicrobial Agents and Chemotherapy. 65, 3, e01771-20.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

      Jansen, C. U., Uhd, J., Andersen, Jens Bo, Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      The Extracellular Polysaccharide Matrix of Pseudomonas aeruginosa Biofilms Is a Determinant of Polymorphonuclear Leukocyte Responses

      Rybtke, Morten Levin, Jensen, Peter Østrup, Nielsen, Claus Henrik & Tolker-Nielsen, Tim, 2021, In: Infection and Immunity. 89, 1

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      The biofilm of Burkholderia cenocepacia H111 contains an exopolysaccharide composed of L-rhamnose and L-mannose: Structural characterization and molecular modelling

      Bellich, B., Jou, I. A., Buriola, C., Ravenscroft, N., Brady, J. W., Fazli, M., Tolker-Nielsen, Tim, Rizzo, R. & Cescutti, P., 2021, In: Carbohydrate Research. 499, 108231.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. 2020
    34. Published

      Burkholderia cenocepacia h111 produces a water-insoluble exopolysaccharide in biofilm: Structural determination and molecular modelling

      Bellich, B., Jou, I. A., Caterino, M., Rizzo, R., Ravenscroft, N., Fazli, M., Tolker-Nielsen, Tim, Brady, J. W. & Cescutti, P., 2020, In: International Journal of Molecular Sciences . 21, 5, 1702.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. 2019
    36. Published

      High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content

      Almblad, H., Rybtke, Morten Levin, Hendiani, S., Andersen, Jens Bo, Givskov, Michael & Tolker-Nielsen, Tim, Mar 2019, In: Microbiology. 165, 3, p. 324-333 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination: —monitoring the phage–P. aeruginosa biofilms interactions

      Henriksen, K., Rørbo, N., Rybtke, Morten Levin, Martinet, M. G., Tolker-Nielsen, Tim, Høiby, Niels, Middelboe, Mathias & Ciofu, Oana, 2019, In: Pathogens and Disease. 77, 2, 11 p., ftz011.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance

      Nilsson, Carl Martin Peter, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microorganisms. 7, 9, 12 p., 310.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells

      Teh, W. K., Dramsi, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2019, In: Journal of Bacteriology. 201, 6, p. 1-16 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia

      Richter, A. M., Fazli, M., Schmid, N., Shilling, R., Suppiger, A., Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 9, 15 p., 3286.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

      Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microbiology. 165, 3, p. 334-342

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation

      Qvortrup, K., Hultqvist, Louise Dahl, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Jansen, C. U., Uhd, J., Andersen, Jens Bo, Nielsen, Thomas Eiland, Givskov, Michael & Tolker-Nielsen, Tim, 2019, In: Frontiers in Chemistry. 7, 27 p., 742.

      Research output: Contribution to journal › Review › Research › peer-review

    43. Published

      Sub-lethal antimicrobial photodynamic inactivation affects Pseudomonas aeruginosa PAO1 quorum sensing and cyclic di-GMP regulatory systems

      Hendiani, S., Rybtke, Morten Levin, Tolker-Nielsen, Tim & Kashef, N., 2019, In: Photodiagnosis and Photodynamic Therapy. 27, p. 467-473 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Tolerance and resistance of pseudomonas aeruginosabiofilms to antimicrobial agents-how P. aeruginosa Can escape antibiotics

      Ciofu, Oana & Tolker-Nielsen, Tim, 2019, In: Frontiers in Microbiology. 10, MAY, 15 p., 913.

      Research output: Contribution to journal › Review › Research › peer-review

    45. Published

      Transposon Mutagenesis in Streptococcus Species

      Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, 2019, Microbial Transposon Mutagenesis: Protocols and Applications. Humana Press, p. 39-49 11 p. (Methods in Molecular Biology, Vol. 2016).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    46. Published

      Two FtsH proteases contribute to fitness and adaptation of pseudomonas aeruginosa Clone C strains

      Kamal, S. M., Rybtke, Morten Levin, Nimtz, M., Sperlein, S., Giske, C., Trček, J., Deschamps, J., Briandet, R., Dini, L., Jänsch, L., Tolker-Nielsen, Tim, Lee, C. & Römling, U., 2019, In: Frontiers in Microbiology. 10, JULY, 18 p., 1372.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Visualizing biofilm by targeting eDNA with long wavelength probe CDr15

      Kwon, H. Y., Kim, J. Y., Liu, X., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Heo, W., Kim, J. J., Kang, N. Y., Joo, T., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2019, In: Biomaterials Science. 7, 9, p. 3594-3598 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. 2018
    49. Published

      Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α‐synuclein and modulates its effect on biofilm formation

      Andersen, K. K., Vad, B. S., Kjaer, L., Tolker-Nielsen, Tim, Christiansen, G. & Otzen, D. E., May 2018, In: FEBS Letters. 592, 9, p. 1484-1496 13 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    50. Published

      A transposon mutant library of Bacillus cereus ATCC 10987 reveals novel genes required for biofilm formation and implicates motility as an important factor for pellicle-biofilm formation

      Okshevsky, M., Louw, M. G., Lamela, E. O., Nilsson, Carl Martin Peter, Tolker-Nielsen, Tim & Meyer, R. L., 2018, In: MicrobiologyOpen. 7, 2, 17 p., e00552.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      CDy14: A novel biofilm probe targeting exopolysaccharide Psl

      Kwon, H. Y., Kim, J. Y., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Kim, J. J., Kang, N. Y., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2018, In: Chemical Communications. 54, 84, p. 11865-11868 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Inoculation method could impact the outcome of microbiological experiments

      Kragh, K. N., Alhede, M., Rybtke, Morten Levin, Stavnsbjerg, Camilla, Tolker-Nielsen, Tim, Whiteley, M. & Bjarnsholt, Thomas, 2018, In: Applied and Environmental Microbiology. 84, 5, 14 p., e02264-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. 2017
    54. Published

      Reduced intracellular c-di-GMP content increases expression of quorum sensing-regulated genes in Pseudomonas aeruginosa

      Chua, S. L., Liu, Y., Li, Y., Ting, H. J., Kohli, G. S., Cai, Z., Suwanchaikasem, P., Goh, K. K. K., Ng, S. P., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Oct 2017, In: Frontiers in Cellular and Infection Microbiology. 7, 8 p., 451.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes

      Jakobsen, Tim Holm, Tolker-Nielsen, Tim & Givskov, Michael, Sep 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.

      Research output: Contribution to journal › Review › Research › peer-review

    56. Published

      High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111

      Schmid, N., Suppiger, A., Steiner, E., Pessi, G., Kaever, V., Fazli, M., Tolker-Nielsen, Tim, Jenal, U. & Eberl, L., 1 May 2017, In: Microbiology. 163, 5, p. 754-764 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Importance of the exopolysaccharide matrix in antimicrobial tolerance of Pseudomonas aeruginosa aggregates

      Goltermann, Lise & Tolker-Nielsen, Tim, Apr 2017, In: Antimicrobial Agents and Chemotherapy. 61, 4, 7 p., e02696.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Gauging and visualizing c-di-GMP levels in pseudomonas aeruginosa using fluorescence-based biosensors

      Rybtke, Morten Levin, Chua, S. L., Yam, J. K. H., Givskov, Michael, Yang, L. & Tolker-Nielsen, Tim, Jan 2017, c-di-GMP Signaling: Methods and Protocols. Sauer, K. (ed.). Humana Press, Vol. 1657. p. 87-98 12 p. (Methods in Molecular Biology, Vol. 1657).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    59. Published

      High-throughput screening for compounds that modulate the cellular c-di-GMP level in bacteria

      Groizeleau, J., Andersen, Jens Bo, Givskov, Michael, Berthelsen, J. & Tolker-Nielsen, Tim, Jan 2017, c-di-GMP Signaling: Methods and Protocols. Sauer, K. (ed.). Humana Press, Vol. 1657. p. 455-470 16 p. (Methods in Molecular Biology, Vol. 1657).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    60. Published

      A broad range quorum sensing inhibitor working through sRNA inhibition

      Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Bacterial biofilm in chronic lesions of Hidradenitis Suppurativa

      Ring, H. C., Bay, Lene, Nilsson, Carl Martin Peter, Kallenbach, K., Miller, I. M., Saunte, Ditte Marie, Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Jemec, Gregor, 2017, In: British Journal of Dermatology. 176, 4, p. 993–1000

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Cyclic-di-GMP is required for corneal infection by Pseudomonas aeruginosa and modulates host immunity

      Hoong Yam, J. K., Aung, T. T., Chua, S. L., Cheng, Y., Kohli, G. S., Zhou, J., Constancias, F., Liu, Y., Cai, Z., Santillan Salido, M. M., Drautz-Moses, D. I., Rice, S. A., Schuster, S. C., Wu, B., Kjelleberg, S., Tolker-Nielsen, Tim, Beuerman, R. W., Givskov, Michael & Yang, L., 2017, bioRxiv, 35 p.

      Research output: Working paper › Preprint › Research

    63. Published

      Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB

      Fazli, M., Rybtke, Morten Levin, Steiner, E., Weidel, E., Berthelsen, J., Groizeleau, J. D. D., Bin, W., Zhi, B. Z., Yaming, Z., Kaever, V., Givskov, Michael, Hartmann, R. W., Eberl, L. & Tolker-Nielsen, Tim, 2017, In: MicrobiologyOpen. 6, 4, 13 p., e00480.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Selective proteomic analysis of antibiotic-tolerant cellular subpopulations in pseudomonas aeruginosa biofilms

      Babin, B. M., Atangcho, L., van Eldijk, M. B., Sweredoski, M. J., Moradian, A., Hess, S., Tolker-Nielsen, Tim, Newman, D. K. & Tirrell, D. A., 2017, In: mBio. 8, 5, 16 p., e01593-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. 2016
    66. Published

      The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation

      Groizeleau, J., Rybtke, Morten Levin, Andersen, Jens Bo, Berthelsen, J., Liu, Y., Yang, L., Nielsen, Thomas Eiland, Kaever, V., Givskov, Michael & Tolker-Nielsen, Tim, 1 Oct 2016, In: Microbiology. 162, 10, p. 1797-1807 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms

      Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Givskov, Michael, Høiby, Niels, Twetman, Svante & Tolker-Nielsen, Tim, Sep 2016, In: International Journal of Antimicrobial Agents. 48, 3, p. 298–304

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction

      Hansen, G. M., Midjord-Belstrøm, Daniel, Nilsson, Carl Martin Peter, Helqvist, S., Nielsen, Claus Henrik, Holmstrup, Palle, Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2016, In: P L o S One. 11, 12, 13 p., e0168771.

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms

      Chua, S. L., Yam, J. K. H., Hao, P., Adav, S. S., Salido, M. M., Liu, Y., Givskov, Michael, Sze, S. K., Tolker-Nielsen, Tim & Yang, L., 2016, In: Nature Communications. 7, 11 p., 10750.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. 2015
    71. Published

      Pigments influence the tolerance of Pseudomonas aeruginosa PAO1 to photodynamically induced oxidative stress

      Orlandi, V. T., Bolognese, F., Chiodaroli, L., Tolker-Nielsen, Tim & Barbieri, P., Dec 2015, In: Microbiology. 161, 12, p. 2298-309 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface

      Rybtke, Morten Levin, Berthelsen, J., Yang, L., Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, Dec 2015, In: MicrobiologyOpen. 4, 6, p. 917-930 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange

      Hmelo, L. R., Borlee, B. R., Almblad, H., Love, M. E., Randall, T. E., Tseng, B. S., Lin, C., Irie, Y., Storek, K. M., Yang, J. J., Siehnel, R. J., Howell, P. L., Singh, P. K., Tolker-Nielsen, Tim, Parsek, M. R., Schweizer, H. P. & Harrison, J. J., Nov 2015, In: Nature Protocols (Print). 10, 11, p. 1820-41 22 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Published

      The bactericidal activity of β-lactam antibiotics is increased by metabolizable sugar species

      Thorsing, M., Bentin, Thomas, Givskov, Michael, Tolker-Nielsen, Tim & Goltermann, Lise, Oct 2015, In: Microbiology. 161, 10, p. 1999-2007 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation

      Chua, S. L., Hultqvist, Louise Dahl, Yuan, M., Rybtke, Morten Levin, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Published

      Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli

      Sun, J., Marais, J. P. J., Khoo, C., LaPlante, K., Vejborg, R. M., Givskov, Michael, Tolker-Nielsen, Tim, Seeram, N. P. & Rowley, D. C., Aug 2015, In: Journal of Functional Foods. 17, p. 235-242 8 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    77. Published

      Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

      Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Aug 2015, In: Journal of Bacteriology. 197, 16, p. 2731 1 p.

      Research output: Contribution to journal › Comment/debate › Research

    78. Published

      The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

      Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Jul 2015, In: Journal of Bacteriology. 197, 13, p. 2190-200 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      Viable Bacteria Associated with Red Blood Cells and Plasma in Freshly Drawn Blood Donations

      Damgaard, Christian, Magnussen, K., Enevold, Christian, Nilsson, Carl Martin Peter, Tolker-Nielsen, Tim, Holmstrup, Palle & Nielsen, Claus Henrik, 9 Mar 2015, In: P L o S One. 10, 3, p. 1-9 9 p., e0120826.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Published

      Pseudomonas aeruginosa LysR PA4203 regulator NmoR acts as a repressor of the PA4202 nmoA gene, encoding a nitronate monooxygenase

      Vercammen, K., Wei, Q., Charlier, D., Dötsch, A., Haüssler, S., Schulz, S., Salvi, F., Gadda, G., Spain, J., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Dingemans, J., Ye, L. & Cornelis, P., Mar 2015, In: Journal of Bacteriology. 197, 6, p. 1026-39 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Published

      Biofilm Development

      Tolker-Nielsen, Tim, Mar 2015, In: Microbiology Spectrum. 3, 2, 12 p., MB-0001-2014.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Published

      Biofilm development

      Tolker-Nielsen, Tim, 1 Jan 2015, Microbial Biofilms. Wiley-Interscience, p. 51-66 16 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    83. Published

      Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response

      Rybtke, Morten Levin, Hultqvist, Louise Dahl, Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Journal of Molecular Biology. 427, 23, p. 3628-3645

      Research output: Contribution to journal › Review › Research › peer-review

    84. Published

      Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay

      Hansen, G. M., Nilsson, M., Nielsen, Claus Henrik, Holmstrup, Palle, Helqvist, S., Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2015, In: PloS one. 10, 12, p. 1-11 11 p., e0145657.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

      Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.

      Research output: Contribution to journal › Review › Research › peer-review

    86. Published

      Biofilm development

      Tolker-Nielsen, Tim, 2015, Microbial biofilms. Ghannoum, M., Parsek, M., Whiteley, M. & P. M. (eds.). 2 ed. Washington DC: ASM Press, p. 51-66 16 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    87. Published

      C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth

      Chua, S. L., Sivakumar, K., Rybtke, Morten Levin, Yuan, M., Andersen, Jens Bo, Nielsen, T. E., Givskov, Michael, Tolker-Nielsen, Tim, Cao, B., Kjelleberg, S. & Yang, L., 2015, In: Scientific Reports. 5, 13 p., 10052.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      Functional bacterial amyloid increases Pseudomonas biofilm hydrophobicity and stiffness

      Zeng, G., Vad, B. S., Dueholm, M. S., Christiansen, G., Nilsson, Carl Martin Peter, Tolker-Nielsen, Tim, Nielsen, P. H., Meyer, R. L. & Otzen, D. E., 2015, In: Frontiers in Microbiology. 6, 14 p., 1099.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Published

      In silico analyses of metagenomes from human atherosclerotic plaque samples

      Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      In-frame and unmarked gene deletions in Burkholderia cenocepacia via an allelic exchange system compatible with gateway technology

      Fazli, M., Harrison, J. J., Gambino, M., Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Applied and Environmental Microbiology. 81, 11, p. 3623-3630 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      Lipopeptide biosurfactant viscosin enhances dispersal of Pseudomonas fluorescens SBW25 biofilms

      Bonnichsen, L., Svenningsen, N. B., Rybtke, Morten Levin, de Bruijn, I., Raaijmakers, J. M., Tolker-Nielsen, Tim & Nybroe, O., 2015, In: Microbiology. 161, 12, p. 2289-2297 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa

      Chen, Y., Yuan, M., Mohanty, A., Yam, J. K. H., Liu, Y., Chua, S. L., Nielsen, T. E., Tolker-Nielsen, Tim, Givskov, Michael, Cao, B. & Yang, L., 2015, In: Environmental Microbiology Reports. 7, 3, p. 498-507 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. Published

      Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

      Hansen, M. R., Jakobsen, Tim Holm, Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T., 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. 2014
    95. Published

      Pseudomonas aeruginosa biofilm infections: From molecular biofilm biology to new treatment possibilities

      Tolker-Nielsen, Tim, Dec 2014, 51 p. (APMIS Supplementum).

      Research output: Book/Report › Doctoral thesis › Research

    96. Published

      Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa

      Tan, S. Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, Tim Holm, Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      The Pseudomonas aeruginosa Type III Translocon Is Required for Biofilm Formation at the Epithelial Barrier

      Tran, C. S., Rangel, S. M., Almblad, H., Kierbel, A., Givskov, Michael, Tolker-Nielsen, Tim, Hauser, A. R. & Engel, J. N., Nov 2014, In: P L o S Pathogens. 10, 11, p. 1-11 12 p., e1004479.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Antimicrobial and anti-biofilm effect of a novel BODIPY photosensitizer against Pseudomonas aeruginosa PAO1

      Orlandi, V. T., Rybtke, Morten Levin, Caruso, E., Banfi, S., Tolker-Nielsen, Tim & Barbieri, P., Sep 2014, In: Biofouling. 30, 8, p. 883-91 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      A mariner transposon vector adapted for mutagenesis in oral streptococci

      Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In: MicrobiologyOpen. 3, 3, p. 333-40 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. Published

      Mulig sammenhæng mellem marginal parodontitis og iskæmisk hjertesygdom

      Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, Claus Henrik, Givskov, Michael & Hansen, Peter Riis, 28 Apr 2014, In: Ugeskrift for Laeger. 176, 18, p. 1752-1754 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    101. Published

      Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

      Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    102. Published

      Bacteria-triggered release of antimicrobial agents

      Komnatnyy, V. V., Chiang, W., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 7 Jan 2014, In: Angewandte Chemie (International ed. in English). 53, 2, p. 439-41 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    103. Published

      A possible correlation between periodontitis and ischaemic heart disease

      Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, C. H., Givskov, Michael & Hansen, Peter Riis, 2014, In: Ugeskrift for Laeger.

      Research output: Contribution to journal › Journal article › Research › peer-review

    104. Published

      Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials

      Gulez, G., Altintas, A., Fazli, M., Dechesne, A., Workman, C., Tolker-Nielsen, Tim & Smets, B. F., 2014, In: MicrobiologyOpen. 3, 4, p. 457-469

      Research output: Contribution to journal › Journal article › Research › peer-review

    105. Published

      Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

      Chua, S. L., Liu, Y., Yam, J. K. H., Chen, Y., Vejborg, R. M., Tan, B. G. C., Kjelleberg, S., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Nature Communications. 5, p. 1-12 13 p., 4462.

      Research output: Contribution to journal › Journal article › Research › peer-review

    106. Published

      Draft Genome Sequence of the Model Naphthalene-Utilizing Organism Pseudomonas putida OUS82

      Tay, M., Roizman, D., Cohen, Y., Tolker-Nielsen, Tim, Givskov, Michael & Yang, L., 2014, In: Genome Announcements. 2, 1, p. 1 1 p., e01161-13.

      Research output: Contribution to journal › Journal article › Research › peer-review

    107. Published

      Methods for studying biofilm formation: flow cells and confocal laser scanning microscopy

      Tolker-Nielsen, Tim & Sternberg, C., 2014, In: Methods in Molecular Biology. 1149, p. 615-29 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    108. Published

      PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples

      Fazli, M., Bjarnsholt, Thomas, Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, 2014, In: Methods in Molecular Biology. 1211, p. 261-71 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    109. Published

      Regulation of biofilm formation in Pseudomonas and Burkholderia species

      Fazli, M., Almblad, H., Rybtke, Morten Levin, Givskov, Michael, Eberl, L. & Tolker-Nielsen, Tim, 2014, In: Environmental Microbiology. 16, 7, p. 1961-1981 21 p.

      Research output: Contribution to journal › Review › Research › peer-review

    110. 2013
    111. Published

      Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria

      Hultqvist, Louise Dahl, van Gennip, M., Rybtke, Morten Levin, Wu, H., Chiang, W., Alhede, M., Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, Aug 2013, In: Infection and Immunity. 81, 8, p. 2705-13 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    112. Published

      Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms

      Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    113. Published

      Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa

      Pihl, M., Arvidsson, A., Skepö, M., Nilsson, M., Givskov, Michael, Tolker-Nielsen, Tim, Svensäter, G. & Davies, J. R., Apr 2013, In: Pathogens and Disease. 67, 3, p. 192-198 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    114. Published

      Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation

      Dueholm, M. S., Søndergaard, M., Nilsson, M., Christiansen, G., Stensballe, A., Overgaard, M. T., Givskov, Michael, Tolker-Nielsen, Tim, Otzen, D. & Nielsen, P. H., 18 Mar 2013, In: MicrobiologyOpen. 2, p. 365-382 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    115. Published

      The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349

      Fazli, M., McCarthy, Y., Givskov, Michael, Ryan, R. P. & Tolker-Nielsen, Tim, Feb 2013, In: MicrobiologyOpen. 2, 1, p. 105-122 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    116. Published

      C-di-GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa

      Chua, S. L., Tan, S. Y., Rybtke, Morten Levin, Chen, Y., Rice, S. A., Kjelleberg, S., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2066-2075 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    117. Published

      Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in Pseudomonas aeruginosa microbial fuel cells

      Wang, V. B., Chua, S., Cao, B., Seviour, T., Nesatyy, V. J., Marsili, E., Kjelleberg, S., Givskov, Michael, Tolker-Nielsen, Tim, Song, H., Loo, J. S. C. & Yang, L., 2013, In: PLOS ONE. 8, 5, p. e63129 7 p., e63129.

      Research output: Contribution to journal › Journal article › Research › peer-review

    118. Published

      Identification of LasR ligands through a virtual screening approach

      Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, Tim Holm, Harmsen, M., Tolker-Nielsen, Tim, Nielsen, T. E., Givskov, Michael & Taboureau, O., 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    119. Published

      Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators

      Stacy, D. M., Le Quement, S. T., Hansen, C., Clausen, J. W., Tolker-Nielsen, Tim, Brummond, J. W., Givskov, Michael, Nielsen, T. E. & Blackwell, H. E., 2013, In: Organic & Biomolecular Chemistry. 11, 6, p. 938-54 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    120. 2012
    121. Published

      The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms

      Zhang, L., Chiang, W., Gao, Q., Givskov, Michael, Tolker-Nielsen, Tim, Yang, L. & Zhang, G., Dec 2012, In: Microbiology. 158, 12, p. 3014-3019 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    122. Published

      The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms

      Chiang, W., Pamp, S. J., Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 245-256 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    123. Published

      When the PilZ don't work: effectors for cyclic di-GMP action in bacteria

      Ryan, R. P., Tolker-Nielsen, Tim & Dow, J. M., May 2012, In: Current Trends in Microbiology. 20, 5, p. 235-242 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    124. Published

      Bursting the bubble on bacterial biofilms: a flow cell methodology

      Crusz, S. A., Popat, R., Rybtke, Morten Levin, Cámara, M., Givskov, Michael, Tolker-Nielsen, Tim, Diggle, S. P. & Williams, P., 2012, In: Biofouling. 28, 8, p. 835-842 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    125. Published

      Fluorescence-based reporter for gauging cyclic di-GMP Levels in Pseudomonas aeruginosa.

      Rybtke, Morten Levin, Borlee, B. R., Murakami, K., Irie, Y., Hentzer, M., Nielsen, T. E., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, 2012, In: Applied and Environmental Microbiology. 78, 15, p. 5060-5069 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    126. 2011
    127. Published

      Antibiotic tolerance and resistance in biofilms

      Ciofu, Oana & Tolker-Nielsen, Tim, 1 Dec 2011, Biofilm Infections. Springer New York, p. 215-229 15 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    128. Published

      Pattern differentiation in co-culture biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa

      Yang, L., Liu, Y., Markussen, T., Høiby, Niels, Tolker-Nielsen, Tim & Molin, S., 1 Aug 2011, In: F E M S Immunology and Medical Microbiology. 62, 3, p. 339-47 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    129. Published

      The contribution of cell-cell signaling and motility to bacterial biofilm formation

      Shrout, J. D., Tolker-Nielsen, Tim, Givskov, Michael & Parsek, M. R., May 2011, In: M R S Bulletin. 36, 5, p. 367-373 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    130. Published

      Growing and analyzing biofilms in flow chambers

      Tolker-Nielsen, Tim & Sternberg, C., 2011, In: Current Protocols in Microbiology. 21, p. 1B.2.1-1B.2.17

      Research output: Contribution to journal › Journal article › Research › peer-review

    131. Published

      Influence of putative exopolysaccharide genes on Pseudomonas putida KT2440 biofilm stability

      Nilsson, M., Chiang, W., Fazli, M., Gjermansen, M., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Environmental Microbiology. 13, 5, p. 1357-69

      Research output: Contribution to journal › Journal article › Research › peer-review

    132. Published

      Interfering with bacterial gossip.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    133. Published

      Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

      Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943

      Research output: Contribution to journal › Journal article › Research › peer-review

    134. Published

      Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds

      Fazli, M., Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, A., Andersen, C. B., Givskov, Michael & Tolker-Nielsen, Tim, 2011, In: Wound Repair and Regeneration. 19, 3, p. 387-91 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    135. Published

      Quorum sensing inhibitors disable bacterial biofilms.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Emerging trends in in antibacterial discovery.. Miller, A. A. & Miller, P. F. (eds.). 1 ed. Norvich UK: HorizonBioscience, p. 211-224 14 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    136. Published

      Report from Eurobiofilms 2011

      Jensen, Peter Østrup & Tolker-Nielsen, Tim, 2011, In: Future Microbiology. 6, 11, p. 1237-45

      Research output: Contribution to journal › Journal article › Research › peer-review

    137. Published

      The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia

      Fazli, M., O'Connell, A., Nilsson, M., Niehaus, K., Dow, J. M., Givskov, Michael, Ryan, R. P. & Tolker-Nielsen, Tim, 2011, In: Molecular Microbiology. 82, 2, p. 327-41

      Research output: Contribution to journal › Journal article › Research › peer-review

    138. Published

      The clinical impact of bacterial biofilms

      Høiby, Niels, Ciofu, Oana, Johansen, Helle Krogh, Song, Z., Moser, Claus Ernst, Jensen, Peter Østrup, Molin, S., Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: International Journal of Oral Science. 3, 2, p. 55-65

      Research output: Contribution to journal › Journal article › Research › peer-review

    139. Published

      The implication of Pseudomonas aeruginosa biofilms in infections

      Rybtke, Morten Levin, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: Inflammation & Allergy - Drug Targets. 10, 2, p. 141-57 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    140. 2010
    141. Published

      Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115

      Research output: Contribution to journal › Journal article › Research › peer-review

    142. Published

      A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia

      McCarthy, Y., Yang, L., Twomey, K. B., Sass, A., Tolker-Nielsen, Tim, Mahenthiralingam, E., Dow, J. M. & Ryan, R. P., 2010, In: Molecular Microbiology. 77, 5, p. 1220-1236 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    143. Published

      An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal

      Harmsen, M., Yang, L., Pamp, S. J. & Tolker-Nielsen, Tim, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 253-68 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    144. Published

      Antibiotic tolerance and resistance in biofilms.

      Ciofu, Oana & Tolker-Nielsen, Tim, 2010, Biofilm Infections. Bjarnsholt, T., Moser, C., Jensen, P. Ø. & Høiby, N. (eds.). New York, USA: Springer Publishing Company, p. 215-230 16 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    145. Published

      Bacteria can form interconnected microcolonies when a self-excreted product reduces their surface motility: evidence from individual-based model simulations

      Mabrouk, N., Deffuant, G., Tolker-Nielsen, Tim & Lobry, C., 2010, In: Theory in Biosciences. 129, 1, p. 1-13 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    146. Published

      Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections

      Burmølle, Mette, Thomsen, T. R., Fazli, M., Dige, I., Christensen, L., Homøe, Preben, Tvede, M., Nyvad, B., Tolker-Nielsen, Tim, Givskov, Michael, Moser, Claus Ernst, Kirketerp-Møller, K., Johansen, Helle Krogh, Høiby, Niels, Jensen, Peter Østrup, Sørensen, Søren Johannes & Bjarnsholt, Thomas, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 324-336 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    147. Published

      Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions

      Schwarz, S., West, T. E., Boyer, F., Chiang, W., Carl, M. A., Hood, R. D., Rohmer, L., Tolker-Nielsen, Tim, Skerrett, S. J. & Mougous, J. D., 2010, In: PLoS Pathogens. 6, 8

      Research output: Contribution to journal › Journal article › Research › peer-review

    148. Published

      Characterization and transfer studies of macrolide resistance genes in Streptococcus pneumoniae from Denmark

      Nielsen, K. L., Hammerum, A. M., Lambertsen, L. M., Lester, C. H., Arpi, M., Knudsen, J. D., Stegger, M., Tolker-Nielsen, Tim & Frimodt-Møller, N., 2010, In: Scandinavian Journal of Infectious Diseases. 42, 8, p. 586-93 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    149. Published

      Characterization of starvation-induced dispersion in Pseudomonas putida biofilms: genetic elements and molecular mechanisms

      Gjermansen, M., Nilsson, Carl Martin Peter, Yang, L. & Tolker-Nielsen, Tim, 2010, In: Molecular Microbiology. 75, 4, p. 815-26 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    150. Published

      Extracellular DNA as matrix component in microbial biofilms.

      Chiang, W. & Tolker-Nielsen, Tim, 2010, Extracellular Nucleic Acids.. Kikuchi, Y. & Rykova, E. (eds.). Springer Publishing Company, p. 1-14 14 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    151. Published

      Influence of silver additions to type 316 stainless steels on bacterial inhibition, mechanical properties, and corrosion resistance.

      Chiang, W., Tseng, I., Møller, P., Rischel Hilbert, L., Tolker-Nielsen, Tim & Wu, J., 2010, In: Materials Chemistry and Physics. 119, p. 123–130 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    152. Published

      Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    153. 2009
    154. Published

      Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

      Van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Phipps, R., Jensen, Peter Østrup, Christophersen, L., Pamp, S. J., Moser, C., Mikkelsen, P. J., Koh, A. Y., Tolker-Nielsen, Tim, Pier, G. B., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Jul 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 7, p. 537-46 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    155. Published

      Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors

      Yang, L., Rybtke, Morten Levin, Jakobsen, Tim Holm, Hentzer, M., Bjarnsholt, Thomas, Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2432-43 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    156. Published

      Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Givskov, Michael, Janssen, M. & Christensen, L. H., 2009, In: Dermatologic Surgery. 35 Suppl 2, p. 1620-1624 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    157. Published

      Extracellular DNA and F-actin as targets in antibiofilm cystic fibrosis therapy

      Tolker-Nielsen, Tim & Høiby, Niels, 2009, In: Future Microbiology. 4, p. 645-7 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    158. Published

      HD-GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa

      Ryan, R. P., Lucey, J., O'Donovan, K., McCarthy, Y., Yang, L., Tolker-Nielsen, Tim & Dow, J. M., 2009, In: Environmental Microbiology. 11, 5, p. 1126-36 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    159. Published

      Insight into the microbial multicellular lifestyle via flow-cell technology and confocal microscopy

      Pamp, S. J., Sternberg, C. & Tolker-Nielsen, Tim, 2009, In: Cytometry. Part A. 75, 2, p. 90-103 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    160. Published

      Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds

      Fazli, M., Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, B., Andersen, A. S., Krogfelt, K. A., Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Journal of Clinical Microbiology. 47, 12, p. 4084-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    161. Published

      Pseudomonas aeruginosa extracellular products inhibit staphylococcal growth, and disrupt established biofilms produced by Staphylococcus epidermidis

      Qin, Z., Yang, L., Qu, D., Molin, S. & Tolker-Nielsen, Tim, 2009, In: Microbiology. 155, Pt 7, p. 2148-56 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    162. Published

      Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation

      Yang, L., Nilsson, Carl Martin Peter, Gjermansen, M., Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Molecular Microbiology. 74, 6, p. 1380-92 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    163. Published

      Silver-palladium surfaces inhibit biofilm formation

      Chiang, W., Schroll, C., Hilbert, L. R. & Tolker-Nielsen, Tim, 2009, In: Applied and Environmental Microbiology. 75, 6, p. 1674-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    164. 2008
    165. Published

      Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa

      Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 1 Oct 2008, In: Antimicrobial Agents and Chemotherapy. 52, 10, p. 3648-63 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    166. Published

      Distribution, organization, and ecology of bacteria in chronic wounds

      Kirketerp-Møller, K., Jensen, Peter Østrup, Fazli, M., Madsen, K. G., Pedersen, J., Moser, C., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Aug 2008, In: Journal of Clinical Microbiology. 46, 8, p. 2717-22 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    167. Published

      Architecture and spatial organization in a triple-species bacterial biofilm synergistically degrading the phenylurea herbicide linuron

      Breugelmans, P., Barken, K. B., Tolker-Nielsen, Tim, Hofkens, J., Dejonghe, W. & Springael, D., May 2008, In: F E M S Microbiology Ecology. 64, 2, p. 271-82 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    168. Bacterial inhibiting surfaces caused by the effects of silver release and/or electrical field

      Chiang, W. C., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Electrochimica Acta. 54, 1, p. 108-115 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    169. Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm formation and polymyxin tolerance in Pseudomonas aeruginosa.

      Ryan, R. P., Fouhy, Y., Garcia, B. F., Watt, S. A., Niehaus, K., Yang, L., Tolker-Nielsen, Tim & Dow, J. M., 2008, In: Molecular Microbiology. 68, 1, p. 75-86 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    170. Pattern formation in Pseudomonas aeruginosa biofilms.

      Parsek, M. R. & Tolker-Nielsen, Tim, 2008, In: Current Opinion in Microbiology. 11, p. 560-566 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    171. Pseudomonas aeruginosa: A Model for Biofilm Formation

      McDougald, D., Klebensberger, J., Tolker-Nielsen, Tim, Webb, J. S., Conibear, T., Rice, S. A., Kirov, S. M., Matz, C. & Kjelleberg, S., 2008,   Pseudomonas. Model Organism, Pathogen, Cell Factory.. Rehm, B. H. A. (ed.). Wiley-VCH, p. 215-254 40 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    172. Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms

      Barken, K. B., Pamp, S. J., Yang, L., Gjermansen, M., Bertrand, J. J., Klausen, M., Givskov, Michael, Whitchurch, C. B., Engel, J. N. & Tolker-Nielsen, Tim, 2008, In: Environmental Microbiology. 10, 9, p. 2331-2343 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    173. Published

      Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes

      Pamp, S. J., Gjermansen, M., Johansen, Helle Krogh & Tolker-Nielsen, Tim, 2008, In: Molecular Microbiology. 68, 1, p. 223-40 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    174. z A study of electroplated silver-palladium biofouling inhibiting coating.

      Chang, W., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Corrosion Engineering, Science and Technology. 43, 2, p. 142-148 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    175. z Bacteria inhibiting surfaces caused by the effects of silver release and/or electrical field.

      Chang, W., Hilbert, L. R., Schroll, C., Tolker-Nielsen, Tim & Møller, P., 2008, In: Electrochimica Acta. 54, p. 108–115 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    176. 2007

    177. Advances in nucleic acid-based diagnostics of bacterial infections.

      Barken, K. B., Haagensen, J. A. J. & Tolker-Nielsen, Tim, 2007, In: Clinica Chimica Acta. 384, 1-2, p. 1-11 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    178. Characterization of a Pseudomonas putida rough variant evolved in a mixed-species biofilm with Acinetobacter sp. strain C6.

      Hansen, S. K., Haagensen, J. A. J., Gjermansen, M., Jørgensen, T. M., Tolker-Nielsen, Tim & Molin, S., 2007, In: Journal of Bacteriology. 189, 13, p. 4932-43 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    179. DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus.

      Eckhart, L., Fischer, H., Barken, K. B., Tolker-Nielsen, Tim & Tschachler, E., 2007, In: British Journal of Dermatology. 156, 6, p. 1342-5 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    180. Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa.

      Yang, L., Barken, K. B., Skindersoe, M. E., Christensen, A. B., Givskov, M. & Tolker-Nielsen, Tim, 2007, In: Microbiology. 153, Pt 5, p. 1318-28 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    181. Identification of a new gene PA5017 involved in flagella-mediated motility, chemotaxis and biofilm formation in Pseudomonas aeruginosa.

      Li, Y., Xia, H., Bai, F., Xu, H., Yang, L., Yao, H., Zhang, L., Zhang, X., Bai, Y., Saris, P. E. J., Tolker-Nielsen, Tim & Qiao, M., 2007, In: FEMS Microbiology Letters. 272, 2, p. 188-95 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    182. Microbial motility involvement in biofilm structure formation--a 3D modelling study.

      Picioreanu, C., Kreft, J. U., Klausen, M., Haagensen, J. A. J., Tolker-Nielsen, Tim & Molin, S., 2007, In: Water Science and Technology. 55, 8-9, p. 337-43 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    183. Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa.

      Pamp, S. J. & Tolker-Nielsen, Tim, 2007, In: Journal of Bacteriology. 189, 6, p. 2531-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    184. Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis.

      Qin, Z., Ou, Y., Yang, L., Zhu, Y., Tolker-Nielsen, Tim, Molin, S. & Qu, D., 2007, In: Microbiology. 153, Pt 7, p. 2083-92 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    185. The biofilm matrix - A sticky framework.

      Pamp, S., Gjermansen, M. & Tolker-Nielsen, Tim, 2007, The biofilm mode of life - Mechanisms and adaptations.. Kjelleberg, S. & Givskov, M. (eds.). HorizonBioscience, p. 37-69

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    186. 2006

    187. A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms.

      Allesen-Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, M. & Tolker-Nielsen, Tim, 2006, In: Molecular Microbiology. 59, 4, p. 1114-28 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    188. Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms.

      Haagensen, J. A. J., Klausen, M., Ernst, R. K., Miller, S. I., Folkesson, A., Tolker-Nielsen, Tim & Molin, S., 2006, In: Journal of Bacteriology. 189, 1, p. 28-37 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    189. Dynamics of development and dispersal in sessile microbial communities: examples from Pseudomonas aeruginosa and Pseudomonas putida model biofilms.

      Klausen, M., Gjermansen, M., Kreft, J. & Tolker-Nielsen, Tim, 2006, In: FEMS Microbiology Letters. 261, 1, p. 1-11 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    190. Growing and analyzing biofilms in flow cells.

      Sternberg, C. & Tolker-Nielsen, Tim, 2006, In: Current Protocols in Microbiology. Chapter 1, p. Unit 1B.2

      Research output: Contribution to journal › Journal article › Research › peer-review

    191. Proteins with GGDEF and EAL domains regulate Pseudomonas putida biofilm formation and dispersal.

      Gjermansen, M., Ragas, P. & Tolker-Nielsen, Tim, 2006, In: FEMS Microbiology Letters. 265, 2, p. 215-24 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    192. 2005

    193. Characterization of starvation-induced dispersion in Pseudomonas putida biofilms.

      Gjermansen, M., Ragas, P., Sternberg, C., Molin, S. & Tolker-Nielsen, Tim, 2005, In: Environmental Microbiology. 7, 6, p. 894-906 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    194. Microbial pathogenesis and biofilm development.

      Reisner, A., Høiby, N., Tolker-Nielsen, Tim & Molin, S., 2005, In: Contributions to Microbiology. 12, p. 114-31 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    195. Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways.

      Whitchurch, C. B., Beatson, S. A., Comolli, J. C., Jakobsen, T., Sargent, J. L., Bertrand, J. J., West, J., Klausen, M., Waite, L. L., Kang, P. J., Tolker-Nielsen, Tim, Mattick, J. S. & Engel, J. N., 2005, In: Molecular Microbiology. 55, 5, p. 1357-78 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    196. 2004

    197. Biofilm development by pseudomonads.

      Tolker-Nielsen, Tim & Molin, S., 2004, Environmental Biotechnology. Verstraete, W. (ed.). CRC Press/Balkema, p. 27-32

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    198. Microbial interactions in mixed-species biofilms.

      Molin, S., Tolker-Nielsen, Tim & Hansen, S. K., 2004, Microbial biofilms.. Ghannoum, M. & O’Toole, G. A. (eds.). ASM International, p. 206-221

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    199. The biofilm lifestyle of pseudomonads.

      Tolker-Nielsen, Tim & Molin, S., 2004, Pseudomonas. Ramos, J. (ed.). Kluwer Academic Publishers, p. 547-571

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    200. 2003

    201. Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants.

      Klausen, M., Heydorn, A., Ragas, P., Lambertsen, L., Aaes-Jørgensen, A., Molin, S. & Tolker-Nielsen, Tim, 2003, In: Molecular Microbiology. 48, 6, p. 1511-24 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    202. Cell death in Pseudomonas aeruginosa biofilm development.

      Webb, J. S., Thompson, L. S., James, S., Charlton, T., Tolker-Nielsen, Tim, Koch, B., Givskov, M. & Kjelleberg, S., 2003, In: Journal of Bacteriology. 185, 15, p. 4585-92 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    203. Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilisation of the biofilm structure.

      Molin, S. & Tolker-Nielsen, Tim, 2003, In: Current Opinion in Biotechnology. 14, 3, p. 255-61 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    204. Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms.

      Klausen, M., Aaes-Jørgensen, A., Molin, S. & Tolker-Nielsen, Tim, 2003, In: Molecular Microbiology. 50, 1, p. 61-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    205. 2002

    206. Extracellular DNA required for bacterial biofilm formation.

      Whitchurch, C. B., Tolker-Nielsen, Tim, Ragas, P. C. & Mattick, J. S., 2002, In: Science. 295, 5559, p. 1487

      Research output: Contribution to journal › Journal article › Research › peer-review

    207. Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression.

      Heydorn, A., Ersbøll, B., Kato, J., Hentzer, M., Parsek, M. R., Tolker-Nielsen, Tim, Givskov, M. & Molin, S., 2002, In: Applied and Environmental Microbiology. 68, 4, p. 2008-17 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    208. 2000

    209. Assessment of flhDC mRNA levels in Serratia liquefaciens swarm cells.

      Tolker-Nielsen, Tim, Christensen, A. B., Holmstrøm, K., Eberl, L., Rasmussen, T. B., Sternberg, C., Heydorn, A., Molin, S. & Givskov, M., 2000, In: Journal of Bacteriology. 182, 10, p. 2680-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    210. Crystal ball: leading scientists in the field of environmental microbiology consider the technical and conceptual developments that they believe will drive innovative research during the first years of the new millennium.

      Caldwell, D. E., Colwell, R. R., Harayama, S., Kjelleberg, S., Givskov, M., Molin, S., Nielsen, A. T., Heydorn, A., Tolker-Nielsen, Tim, Sternberg, C., Nealson, K., Pace, N. R., Rainey, P., Stackebrandt, E., Tindall, B. J. & Stahl, D. A., 2000, In: Environmental Microbiology. 2, 1, p. 3-10 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    211. Development and dynamics of Pseudomonas sp. biofilms.

      Tolker-Nielsen, Tim, Brinch, U. C., Ragas, P. C., Andersen, J. B., Jacobsen, C. S. & Molin, S., 2000, In: Journal of Bacteriology. 182, 22, p. 6482-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    212. In situ reverse transcription-PCR for monitoring gene expression in individual Methanosarcina mazei S-6 cells.

      Lange, M., Tolker-Nielsen, Tim, Molin, S. & Ahring, B. K., 2000, In: Applied and Environmental Microbiology. 66, 5, p. 1796-800 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    213. Molecular ecology of biofilms.

      Molin, S., Nielsen, A. T., Christensen, B. B., Andersen, J. B., Licht, T. R., Tolker-Nielsen, Tim, Sternberg, C., Hansen, M. C., Ramos, C. & Givskov, M., 2000, Biofilms.. Wiley, p. 89-120

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    214. Role of commensal relationships on the spatial structure of a surface-attached microbial consortium.

      Nielsen, A. T., Tolker-Nielsen, Tim, Barken, K. B. & Molin, S., 2000, In: Environmental Microbiology. 2, 1, p. 59-68 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    215. Spatial Organization of Microbial Biofilm Communities.

      Tolker-Nielsen, Tim & Molin, S., 2000, In: Microbial Ecology. 40, 2, p. 75-84 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    216. 1999

    217. Inhibition of Escherichia coli precursor-16S rRNA processing by mouse intestinal contents.

      Licht, T. R., Tolker-Nielsen, Tim, Holmstrøm, K., Krogfelt, K. & Molin, S., 1999, In: Environmental Microbiology. 1, 1, p. 23-32 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    218. Physiological states of individual Salmonella typhimurium cells monitored by in situ reverse transcription-PCR.

      Hølmstrom, K., Tolker-Nielsen, Tim & Molin, S., 1999, In: Journal of Bacteriology. 181, 6, p. 1733-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    219. 1998

    220. Biased 16S rDNA PCR amplification caused by interference from DNA flanking the template region.

      Hansen, M. C., Tolker-Nielsen, Tim, Givskov, M. & Molin, S., 1998, In: FEMS Microbiology Ecology. 26, p. 141-149 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    221. Non-genetic population heterogeneity studied by in situ polymerase chain reaction.

      Tolker-Nielsen, Tim, Holmstrøm, K., Boe, L. & Molin, S., 1998, In: Molecular Microbiology. 27, 6, p. 1099-105 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    222. 1997

    223. Effects of stress treatments on the detection of Salmonella typhimurium by in situ hybridization.

      Tolker-Nielsen, Tim, Larsen, M. H., Kyed, H. & Molin, S., 1997, In: International Journal of Food Microbiology. 35, 3, p. 251-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    224. Plasmid stability: comments on the dimer catastrophe hypothesis.

      Boe, L. & Tolker-Nielsen, Tim, 1997, In: Molecular Microbiology. 23, 2, p. 247-53 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    225. Visualization of specific gene expression in individual Salmonella typhimurium cells by in situ PCR.

      Tolker-Nielsen, Tim, Holmstrøm, K. & Molin, S., 1997, In: Applied and Environmental Microbiology. 63, 11, p. 4196-203 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    226. 1996

    227. Role of ribosome degradation in the death of heat-stressed Salmonella typhimurium.

      Tolker-Nielsen, Tim & Molin, S., 1996, In: FEMS Microbiology Letters. 142, 2-3, p. 155-60 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    228. 1994
    229. Published

      Erratum: Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli (Journal of Bacteriology 176:10 (2785))

      Boe, L., Tolker-Nielsen, Tim, Eegholm, K. M., Spliid, H. & Vrang, A., 1 Jan 1994, In: Journal of Bacteriology. 176, 14, 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    230. A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli.

      Tolker-Nielsen, Tim & Boe, L., 1994, In: Journal of Bacteriology. 176, 14, p. 4306-10 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    231. Fluctuation analysis of mutations to nalidixic acid resistance in Escherichia coli.

      Boe, L., Tolker-Nielsen, Tim, Eegholm, K. M., Spliid, H. & Vrang, A., 1994, In: Journal of Bacteriology. 176, 10, p. 2781-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    232. 1991

    233. Cloning and characterization of two plasmids from Bacillus thuringiensis in Bacillus subtilis.

      Boe, L., Tolker-Nielsen, Tim, Madsen, S. M., Andrup, L. & Bolander, G., 1991, In: Plasmid. 25, 3, p. 190-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    234. Identification of a gene (mob14-3) encoding a mobilization protein from the Bacillus thuringiensis subsp. israelensis plasmid pTX14-3.

      Andrup, L., Bolander, G., Boe, L., Madsen, S. M., Tolker-Nielsen, Tim & Wassermann, K., 1991, In: Nucleic Acids Research. 19, 10, p. 2780

      Research output: Contribution to journal › Journal article › Research › peer-review

    ID: 8656938