Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms
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Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms. / Crabbé, Aurélie; Jensen, Peter Østrup; Bjarnsholt, Thomas; Coenye, Tom.
In: Trends in Microbiology, Vol. 27, No. 10, 2019, p. 850-863.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms
AU - Crabbé, Aurélie
AU - Jensen, Peter Østrup
AU - Bjarnsholt, Thomas
AU - Coenye, Tom
PY - 2019
Y1 - 2019
N2 - Active bacterial metabolism is a prerequisite for optimal activity of many classes of antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic pathways to become tolerant. This review describes the tight relationship between metabolism and tolerance in bacterial biofilms, and how physicochemical properties of the microenvironment at the host–pathogen interface (such as oxygen and nutritional content) are key to this relationship. Understanding how metabolic adaptations lead to tolerance brings us to novel approaches to tackle antibiotic-tolerant biofilms. We describe the use of hyperbaric oxygen therapy, metabolism-stimulating metabolites, and alternative strategies to redirect bacterial metabolism towards an antibiotic-susceptible phenotype.
AB - Active bacterial metabolism is a prerequisite for optimal activity of many classes of antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic pathways to become tolerant. This review describes the tight relationship between metabolism and tolerance in bacterial biofilms, and how physicochemical properties of the microenvironment at the host–pathogen interface (such as oxygen and nutritional content) are key to this relationship. Understanding how metabolic adaptations lead to tolerance brings us to novel approaches to tackle antibiotic-tolerant biofilms. We describe the use of hyperbaric oxygen therapy, metabolism-stimulating metabolites, and alternative strategies to redirect bacterial metabolism towards an antibiotic-susceptible phenotype.
KW - antimicrobial tolerance
KW - biofilm
KW - metabolism
U2 - 10.1016/j.tim.2019.05.003
DO - 10.1016/j.tim.2019.05.003
M3 - Review
C2 - 31178124
AN - SCOPUS:85066779605
VL - 27
SP - 850
EP - 863
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 10
ER -
ID: 226876485