Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils

Research output: Contribution to journalJournal articlepeer-review

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Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils. / Thomsen, Kim; Christophersen, Lars; Jensen, Peter Østrup; Bjarnsholt, Thomas; Moser, Claus; Høiby, Niels.

In: Human Vaccines & Immunotherapeutics, Vol. 12, No. 7, 07.2016, p. 1690-1699.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Thomsen, K, Christophersen, L, Jensen, PØ, Bjarnsholt, T, Moser, C & Høiby, N 2016, 'Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils', Human Vaccines & Immunotherapeutics, vol. 12, no. 7, pp. 1690-1699. https://doi.org/10.1080/21645515.2016.1145848

APA

Thomsen, K., Christophersen, L., Jensen, P. Ø., Bjarnsholt, T., Moser, C., & Høiby, N. (2016). Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils. Human Vaccines & Immunotherapeutics, 12(7), 1690-1699. https://doi.org/10.1080/21645515.2016.1145848

Vancouver

Thomsen K, Christophersen L, Jensen PØ, Bjarnsholt T, Moser C, Høiby N. Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils. Human Vaccines & Immunotherapeutics. 2016 Jul;12(7):1690-1699. https://doi.org/10.1080/21645515.2016.1145848

Author

Thomsen, Kim ; Christophersen, Lars ; Jensen, Peter Østrup ; Bjarnsholt, Thomas ; Moser, Claus ; Høiby, Niels. / Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils. In: Human Vaccines & Immunotherapeutics. 2016 ; Vol. 12, No. 7. pp. 1690-1699.

Bibtex

@article{a84971f1afdf4f9a82f52d9eceb431be,
title = "Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils",
abstract = "Moderation of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in non-chronically infected cystic fibrosis (CF) patients. We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. The effects on PMN phagocytic activity were observed in different Pseudomonas aeruginosa strains, including clinical isolates from non-chronically infected CF patients. Thus, oral prophylaxis with anti-Pseudomonas aeruginosa IgY may boost the innate immunity against Pseudomonas aeruginosa in the CF setting by facilitating a rapid and prompt bacterial clearance by PMNs.",
keywords = "cystic fibrosis, IgY, phagocytosis, pseudomonas aeruginosa",
author = "Kim Thomsen and Lars Christophersen and Jensen, {Peter {\O}strup} and Thomas Bjarnsholt and Claus Moser and Niels H{\o}iby",
year = "2016",
month = jul,
doi = "10.1080/21645515.2016.1145848",
language = "English",
volume = "12",
pages = "1690--1699",
journal = "Human Vaccines & Immunotherapeutics",
issn = "2164-5515",
publisher = "Taylor & Francis",
number = "7",

}

RIS

TY - JOUR

T1 - Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils

AU - Thomsen, Kim

AU - Christophersen, Lars

AU - Jensen, Peter Østrup

AU - Bjarnsholt, Thomas

AU - Moser, Claus

AU - Høiby, Niels

PY - 2016/7

Y1 - 2016/7

N2 - Moderation of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in non-chronically infected cystic fibrosis (CF) patients. We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. The effects on PMN phagocytic activity were observed in different Pseudomonas aeruginosa strains, including clinical isolates from non-chronically infected CF patients. Thus, oral prophylaxis with anti-Pseudomonas aeruginosa IgY may boost the innate immunity against Pseudomonas aeruginosa in the CF setting by facilitating a rapid and prompt bacterial clearance by PMNs.

AB - Moderation of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in non-chronically infected cystic fibrosis (CF) patients. We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. The effects on PMN phagocytic activity were observed in different Pseudomonas aeruginosa strains, including clinical isolates from non-chronically infected CF patients. Thus, oral prophylaxis with anti-Pseudomonas aeruginosa IgY may boost the innate immunity against Pseudomonas aeruginosa in the CF setting by facilitating a rapid and prompt bacterial clearance by PMNs.

KW - cystic fibrosis

KW - IgY

KW - phagocytosis

KW - pseudomonas aeruginosa

U2 - 10.1080/21645515.2016.1145848

DO - 10.1080/21645515.2016.1145848

M3 - Journal article

C2 - 26901841

AN - SCOPUS:84964077816

VL - 12

SP - 1690

EP - 1699

JO - Human Vaccines & Immunotherapeutics

JF - Human Vaccines & Immunotherapeutics

SN - 2164-5515

IS - 7

ER -

ID: 168928477