Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils
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Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils. / Thomsen, Kim; Christophersen, Lars; Jensen, Peter Østrup; Bjarnsholt, Thomas; Moser, Claus; Høiby, Niels.
In: Human Vaccines & Immunotherapeutics, Vol. 12, No. 7, 07.2016, p. 1690-1699.Research output: Contribution to journal › Journal article › peer-review
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T1 - Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils
AU - Thomsen, Kim
AU - Christophersen, Lars
AU - Jensen, Peter Østrup
AU - Bjarnsholt, Thomas
AU - Moser, Claus
AU - Høiby, Niels
PY - 2016/7
Y1 - 2016/7
N2 - Moderation of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in non-chronically infected cystic fibrosis (CF) patients. We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. The effects on PMN phagocytic activity were observed in different Pseudomonas aeruginosa strains, including clinical isolates from non-chronically infected CF patients. Thus, oral prophylaxis with anti-Pseudomonas aeruginosa IgY may boost the innate immunity against Pseudomonas aeruginosa in the CF setting by facilitating a rapid and prompt bacterial clearance by PMNs.
AB - Moderation of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in non-chronically infected cystic fibrosis (CF) patients. We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. The effects on PMN phagocytic activity were observed in different Pseudomonas aeruginosa strains, including clinical isolates from non-chronically infected CF patients. Thus, oral prophylaxis with anti-Pseudomonas aeruginosa IgY may boost the innate immunity against Pseudomonas aeruginosa in the CF setting by facilitating a rapid and prompt bacterial clearance by PMNs.
KW - cystic fibrosis
KW - IgY
KW - phagocytosis
KW - pseudomonas aeruginosa
U2 - 10.1080/21645515.2016.1145848
DO - 10.1080/21645515.2016.1145848
M3 - Journal article
C2 - 26901841
AN - SCOPUS:84964077816
VL - 12
SP - 1690
EP - 1699
JO - Human Vaccines & Immunotherapeutics
JF - Human Vaccines & Immunotherapeutics
SN - 2164-5515
IS - 7
ER -
ID: 168928477