Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis. / Raskov, Hans; Kragh, Kasper Norskov; Bjarnsholt, Thomas; Alamili, Mahdi; Gogenur, Ismail.

In: Clinical and Translational Medicine, Vol. 7, 30, 17.09.2018.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Raskov, H, Kragh, KN, Bjarnsholt, T, Alamili, M & Gogenur, I 2018, 'Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis', Clinical and Translational Medicine, vol. 7, 30. https://doi.org/10.1186/s40169-018-0209-2

APA

Raskov, H., Kragh, K. N., Bjarnsholt, T., Alamili, M., & Gogenur, I. (2018). Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis. Clinical and Translational Medicine, 7, [30]. https://doi.org/10.1186/s40169-018-0209-2

Vancouver

Raskov H, Kragh KN, Bjarnsholt T, Alamili M, Gogenur I. Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis. Clinical and Translational Medicine. 2018 Sep 17;7. 30. https://doi.org/10.1186/s40169-018-0209-2

Author

Raskov, Hans ; Kragh, Kasper Norskov ; Bjarnsholt, Thomas ; Alamili, Mahdi ; Gogenur, Ismail. / Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis. In: Clinical and Translational Medicine. 2018 ; Vol. 7.

Bibtex

@article{fc303e569d484b11b8893e2f52569764,
title = "Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis",
abstract = "BackgroundResearch in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstrated by several authors indicating that biofilm not only is a key player in carcinogenesis, but also may contribute to the understanding of side-specific colon cancer—right sided colon cancer versus left sided. In this article, we briefly highlight the major findings of the research of biofilm and carcinogenesis and demonstrate our findings of colonic cancer tissue and colonic polyp examined for biofilm.Case presentationColonic cancer tissue from a patient with a right-sided colon cancer, and an adenoma tubular polyp were examined for biofilm formation by flourescens in situ hybridization. In cancer tissue we found biofilm formation on the surface epithelium but surprisingly also deep into the crypts. No biofilms were found in tubular polyp tissue.ConclusionsTo our knowledge, this is the first-time biofilm formation deep into colonic crypts are demonstrated in a patient with right-sided colon cancer. This may indicate that bacterial biofilm may have a key role in carcinogenesis.",
keywords = "Bacterial biofilm, Colonic crypts, Polyp, Colorectal cancer, Carcinogenesis",
author = "Hans Raskov and Kragh, {Kasper Norskov} and Thomas Bjarnsholt and Mahdi Alamili and Ismail Gogenur",
year = "2018",
month = sep,
day = "17",
doi = "10.1186/s40169-018-0209-2",
language = "English",
volume = "7",
journal = "Clinical and Translational Medicine",
issn = "2001-1326",
publisher = "SpringerOpen",

}

RIS

TY - JOUR

T1 - Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis

AU - Raskov, Hans

AU - Kragh, Kasper Norskov

AU - Bjarnsholt, Thomas

AU - Alamili, Mahdi

AU - Gogenur, Ismail

PY - 2018/9/17

Y1 - 2018/9/17

N2 - BackgroundResearch in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstrated by several authors indicating that biofilm not only is a key player in carcinogenesis, but also may contribute to the understanding of side-specific colon cancer—right sided colon cancer versus left sided. In this article, we briefly highlight the major findings of the research of biofilm and carcinogenesis and demonstrate our findings of colonic cancer tissue and colonic polyp examined for biofilm.Case presentationColonic cancer tissue from a patient with a right-sided colon cancer, and an adenoma tubular polyp were examined for biofilm formation by flourescens in situ hybridization. In cancer tissue we found biofilm formation on the surface epithelium but surprisingly also deep into the crypts. No biofilms were found in tubular polyp tissue.ConclusionsTo our knowledge, this is the first-time biofilm formation deep into colonic crypts are demonstrated in a patient with right-sided colon cancer. This may indicate that bacterial biofilm may have a key role in carcinogenesis.

AB - BackgroundResearch in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstrated by several authors indicating that biofilm not only is a key player in carcinogenesis, but also may contribute to the understanding of side-specific colon cancer—right sided colon cancer versus left sided. In this article, we briefly highlight the major findings of the research of biofilm and carcinogenesis and demonstrate our findings of colonic cancer tissue and colonic polyp examined for biofilm.Case presentationColonic cancer tissue from a patient with a right-sided colon cancer, and an adenoma tubular polyp were examined for biofilm formation by flourescens in situ hybridization. In cancer tissue we found biofilm formation on the surface epithelium but surprisingly also deep into the crypts. No biofilms were found in tubular polyp tissue.ConclusionsTo our knowledge, this is the first-time biofilm formation deep into colonic crypts are demonstrated in a patient with right-sided colon cancer. This may indicate that bacterial biofilm may have a key role in carcinogenesis.

KW - Bacterial biofilm

KW - Colonic crypts

KW - Polyp

KW - Colorectal cancer

KW - Carcinogenesis

U2 - 10.1186/s40169-018-0209-2

DO - 10.1186/s40169-018-0209-2

M3 - Journal article

C2 - 30221325

VL - 7

JO - Clinical and Translational Medicine

JF - Clinical and Translational Medicine

SN - 2001-1326

M1 - 30

ER -

ID: 217508907