Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils. / Fexby, Sara; Bjarnsholt, Thomas; Jensen, Peter Østrup; Roos, Viktoria; Høiby, Niels; Givskov, Michael; Klemm, Per.

In: Infection and Immunity, Vol. 75, No. 1, 2006, p. 30-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fexby, S, Bjarnsholt, T, Jensen, PØ, Roos, V, Høiby, N, Givskov, M & Klemm, P 2006, 'Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils', Infection and Immunity, vol. 75, no. 1, pp. 30-4. https://doi.org/10.1128/IAI.01117-06

APA

Fexby, S., Bjarnsholt, T., Jensen, P. Ø., Roos, V., Høiby, N., Givskov, M., & Klemm, P. (2006). Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils. Infection and Immunity, 75(1), 30-4. https://doi.org/10.1128/IAI.01117-06

Vancouver

Fexby S, Bjarnsholt T, Jensen PØ, Roos V, Høiby N, Givskov M et al. Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils. Infection and Immunity. 2006;75(1):30-4. https://doi.org/10.1128/IAI.01117-06

Author

Fexby, Sara ; Bjarnsholt, Thomas ; Jensen, Peter Østrup ; Roos, Viktoria ; Høiby, Niels ; Givskov, Michael ; Klemm, Per. / Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils. In: Infection and Immunity. 2006 ; Vol. 75, No. 1. pp. 30-4.

Bibtex

@article{d4507dc0fce811ddb219000ea68e967b,
title = "Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils",
abstract = "Escherichia coli is a versatile pathogen causing millions of infections in humans every year. This bacterium can form multicellular aggregates when it expresses a self-associating protein, antigen 43 (Ag43), on its surface. We have discovered that Ag43-expressing E. coli cells are efficiently taken up by human defense cells, polymorphonuclear neutrophils (PMNs), in an opsonin-independent manner. Surprisingly, the phagocytosed bacteria were not immediately killed but resided as tight aggregates within the PMNs. Our observations indicate that Ag43-mediated uptake and survival in PMNs constitute a mechanism to subvert one of the primary defense mechanisms of the human body.",
author = "Sara Fexby and Thomas Bjarnsholt and Jensen, {Peter {\O}strup} and Viktoria Roos and Niels H{\o}iby and Michael Givskov and Per Klemm",
note = "Keywords: Adhesins, Bacterial; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Cells, Cultured; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Humans; Neutrophils; Phagocytosis",
year = "2006",
doi = "10.1128/IAI.01117-06",
language = "English",
volume = "75",
pages = "30--4",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "1",

}

RIS

TY - JOUR

T1 - Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils

AU - Fexby, Sara

AU - Bjarnsholt, Thomas

AU - Jensen, Peter Østrup

AU - Roos, Viktoria

AU - Høiby, Niels

AU - Givskov, Michael

AU - Klemm, Per

N1 - Keywords: Adhesins, Bacterial; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Cells, Cultured; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Humans; Neutrophils; Phagocytosis

PY - 2006

Y1 - 2006

N2 - Escherichia coli is a versatile pathogen causing millions of infections in humans every year. This bacterium can form multicellular aggregates when it expresses a self-associating protein, antigen 43 (Ag43), on its surface. We have discovered that Ag43-expressing E. coli cells are efficiently taken up by human defense cells, polymorphonuclear neutrophils (PMNs), in an opsonin-independent manner. Surprisingly, the phagocytosed bacteria were not immediately killed but resided as tight aggregates within the PMNs. Our observations indicate that Ag43-mediated uptake and survival in PMNs constitute a mechanism to subvert one of the primary defense mechanisms of the human body.

AB - Escherichia coli is a versatile pathogen causing millions of infections in humans every year. This bacterium can form multicellular aggregates when it expresses a self-associating protein, antigen 43 (Ag43), on its surface. We have discovered that Ag43-expressing E. coli cells are efficiently taken up by human defense cells, polymorphonuclear neutrophils (PMNs), in an opsonin-independent manner. Surprisingly, the phagocytosed bacteria were not immediately killed but resided as tight aggregates within the PMNs. Our observations indicate that Ag43-mediated uptake and survival in PMNs constitute a mechanism to subvert one of the primary defense mechanisms of the human body.

U2 - 10.1128/IAI.01117-06

DO - 10.1128/IAI.01117-06

M3 - Journal article

C2 - 17030570

VL - 75

SP - 30

EP - 34

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 1

ER -

ID: 10613916