Current in vitro biofilm-infected chronic wound models for developing new treatment possibilities
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Current in vitro biofilm-infected chronic wound models for developing new treatment possibilities. / Thaarup, Ida C.; Bjarnsholt, Thomas.
In: Advances in Wound Care, Vol. 10, No. 2, 2021, p. 91-102.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Current in vitro biofilm-infected chronic wound models for developing new treatment possibilities
AU - Thaarup, Ida C.
AU - Bjarnsholt, Thomas
PY - 2021
Y1 - 2021
N2 - Significance: The prevalence of chronic wounds is increasing worldwide. The most recent estimates suggest that up to 2% of the population in the industrialized countries is affected. Recent Advances: During the past few decades, bacterial biofilms have been elucidated as one of the primary reasons why chronic wounds fail to heal. Critical Issues: There is a lack of direct causation and evidence of the role that biofilms play in persistent wounds, which complicates research on new treatment options, since it is still unknown which factors dominate. For this reason, several different in vitro wound models that mimic the biofilm infections observed in chronic wounds and other chronic infections have been created. These different models are, among other purposes, used to test a variety of wound care products. However, chronic wounds are highly complex, and several different factors must be taken into consideration along with the infection, including physiochemical and human-supplemented factors. Furthermore, the limitations of using in vitro models, such as the lack of a responsive immune system should always be given due consideration. Future Directions: Present understandings of all the elements and interactions that take place within chronic wounds are incomplete. As our insight of in vivo chronic wounds continues to expand, so too must the in vitro models used to mimic these infections evolve and adapt to new knowledge.
AB - Significance: The prevalence of chronic wounds is increasing worldwide. The most recent estimates suggest that up to 2% of the population in the industrialized countries is affected. Recent Advances: During the past few decades, bacterial biofilms have been elucidated as one of the primary reasons why chronic wounds fail to heal. Critical Issues: There is a lack of direct causation and evidence of the role that biofilms play in persistent wounds, which complicates research on new treatment options, since it is still unknown which factors dominate. For this reason, several different in vitro wound models that mimic the biofilm infections observed in chronic wounds and other chronic infections have been created. These different models are, among other purposes, used to test a variety of wound care products. However, chronic wounds are highly complex, and several different factors must be taken into consideration along with the infection, including physiochemical and human-supplemented factors. Furthermore, the limitations of using in vitro models, such as the lack of a responsive immune system should always be given due consideration. Future Directions: Present understandings of all the elements and interactions that take place within chronic wounds are incomplete. As our insight of in vivo chronic wounds continues to expand, so too must the in vitro models used to mimic these infections evolve and adapt to new knowledge.
KW - Biofilm
KW - Chronic wounds
KW - In vitro models
U2 - 10.1089/wound.2020.1176
DO - 10.1089/wound.2020.1176
M3 - Journal article
C2 - 32496982
AN - SCOPUS:85098601058
VL - 10
SP - 91
EP - 102
JO - Advances in Wound Care
JF - Advances in Wound Care
SN - 2162-1918
IS - 2
ER -
ID: 254988040