Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11
Research output: Contribution to journal › Journal article › peer-review
Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic, diagnosis of biofilm-associated infections relies heavily on culturing methods, which fail to detect nonculturable bacteria. Identification of novel fluorescent probes for biofilm imaging will greatly facilitate diagnosis of pathogenic bacterial infection. Herein, we report a novel fluorescent probe, CDy11 (compound of designation yellow 11), which targets amyloid in the Pseudomonas aeruginosa biofilm matrix through a diversity oriented fluorescent library approach (DOFLA). CDy11 was further demonstrated for in vivo imaging of P. aeruginosa in implant and corneal infection mice models.
Original language | English |
---|---|
Journal | Journal of the American Chemical Society |
Volume | 138 |
Issue number | 1 |
Pages (from-to) | 402-407 |
Number of pages | 6 |
ISSN | 0002-7863 |
DOIs | |
Publication status | Published - 13 Jan 2016 |
ID: 168876732