Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

Research output: Contribution to journalJournal articlepeer-review

  • Givskov, Michael
  • R de Nys
  • M Manefield
  • L Gram
  • R Maximilien
  • Leo Eberl
  • Søren Molin
  • P D Steinberg
  • S Kjelleberg
Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.
Original languageEnglish
JournalJournal of Bacteriology
Volume178
Issue number22
Pages (from-to)6618-22
Number of pages5
ISSN0021-9193
Publication statusPublished - 1996
Externally publishedYes

ID: 44309661