Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
The failing eradication of bacterial biofilm by antibiotic treatment is a major clinical challenge for patients with chronic infections. The effect of re-sensitizing infectious biofilms to antibiotics by supplemental O2 has recently been explained by the pathophysiological conditions of the infectious microenvironment. In this chapter, we argue that multifactorial restrictions of O2, caused by O2 depletion within the infectious microenvironment, determine the tolerance of bacterial phenotypes ranging from the endogenous formation of persistent subpopulations within biofilms to the induction of tolerant biofilm by the host response. Consequently, we describe how reoxygenation may re-sensitize microorganisms growing in biofilms to antibiotics. To further emphasize the importance of O2 distribution we demonstrate the significance of O2 availability for the outcome of susceptibility testing.
Original language | English |
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Title of host publication | Antibiofilm Strategies : Current and Future Applications to Prevent, Control and Eradicate Biofilms |
Publisher | Springer |
Publication date | 2022 |
Pages | 201-223 |
Chapter | 9 |
ISBN (Print) | 978-3-031-10994-2 |
ISBN (Electronic) | 978-3-031-10992-8 |
DOIs | |
Publication status | Published - 2022 |
Series | Antibiofilm Strategies |
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Volume | 11 |
ISSN | 1863-9607 |
ID: 345055584