Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air

Research output: Contribution to journalJournal articlepeer-review

Standard

Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air. / Jensen, P.ø.; Møller, S.A.; Lerche, C.J.; Moser, C.; Bjarnsholt, T.; Ciofu, O.; Faurholt-jepsen, D.; Høiby, N.; Kolpen, M.

In: Biofilm, Vol. 1, 100008, 2019.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Jensen, PØ, Møller, SA, Lerche, CJ, Moser, C, Bjarnsholt, T, Ciofu, O, Faurholt-jepsen, D, Høiby, N & Kolpen, M 2019, 'Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air', Biofilm, vol. 1, 100008. https://doi.org/10.1016/j.bioflm.2019.100008

APA

Jensen, P. Ø., Møller, S. A., Lerche, C. J., Moser, C., Bjarnsholt, T., Ciofu, O., Faurholt-jepsen, D., Høiby, N., & Kolpen, M. (2019). Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air. Biofilm, 1, [100008]. https://doi.org/10.1016/j.bioflm.2019.100008

Vancouver

Jensen PØ, Møller SA, Lerche CJ, Moser C, Bjarnsholt T, Ciofu O et al. Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air. Biofilm. 2019;1. 100008. https://doi.org/10.1016/j.bioflm.2019.100008

Author

Jensen, P.ø. ; Møller, S.A. ; Lerche, C.J. ; Moser, C. ; Bjarnsholt, T. ; Ciofu, O. ; Faurholt-jepsen, D. ; Høiby, N. ; Kolpen, M. / Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air. In: Biofilm. 2019 ; Vol. 1.

Bibtex

@article{06244603ae994ce594171b56ef30070b,
title = "Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air",
abstract = "Bacteria and fungi show substantial increased recalcitrance when growing as infectious biofilms. Chronic infections caused by biofilm growing microorganisms is considered a major problem of modern medicine. New strategies are needed to improve antibiotic treatment of biofilms. We have improved antibiotic treatment of bacterial biofilms by reviving the dormant bacteria and thereby make them susceptible to antibiotics by means of reoxygenation. Here we review the rationale for associating lack of oxygen with low susceptibility in infectious biofilm, and how hyperbaric oxygen therapy may result in reoxygenation leading to enhanced bactericidal activity of antibiotics. We address issues of feasibility and potential adverse effects regarding patient safety and development of resistance. Finally, we propose means for supplying reoxygenation to antibiotic treatment of infectious biofilm with the potential to benefit large groups of patients.",
author = "P.{\o}. Jensen and S.A. M{\o}ller and C.J. Lerche and C. Moser and T. Bjarnsholt and O. Ciofu and D. Faurholt-jepsen and N. H{\o}iby and M. Kolpen",
year = "2019",
doi = "10.1016/j.bioflm.2019.100008",
language = "English",
volume = "1",
journal = "Biofilm",
issn = "2590-2075",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air

AU - Jensen, P.ø.

AU - Møller, S.A.

AU - Lerche, C.J.

AU - Moser, C.

AU - Bjarnsholt, T.

AU - Ciofu, O.

AU - Faurholt-jepsen, D.

AU - Høiby, N.

AU - Kolpen, M.

PY - 2019

Y1 - 2019

N2 - Bacteria and fungi show substantial increased recalcitrance when growing as infectious biofilms. Chronic infections caused by biofilm growing microorganisms is considered a major problem of modern medicine. New strategies are needed to improve antibiotic treatment of biofilms. We have improved antibiotic treatment of bacterial biofilms by reviving the dormant bacteria and thereby make them susceptible to antibiotics by means of reoxygenation. Here we review the rationale for associating lack of oxygen with low susceptibility in infectious biofilm, and how hyperbaric oxygen therapy may result in reoxygenation leading to enhanced bactericidal activity of antibiotics. We address issues of feasibility and potential adverse effects regarding patient safety and development of resistance. Finally, we propose means for supplying reoxygenation to antibiotic treatment of infectious biofilm with the potential to benefit large groups of patients.

AB - Bacteria and fungi show substantial increased recalcitrance when growing as infectious biofilms. Chronic infections caused by biofilm growing microorganisms is considered a major problem of modern medicine. New strategies are needed to improve antibiotic treatment of biofilms. We have improved antibiotic treatment of bacterial biofilms by reviving the dormant bacteria and thereby make them susceptible to antibiotics by means of reoxygenation. Here we review the rationale for associating lack of oxygen with low susceptibility in infectious biofilm, and how hyperbaric oxygen therapy may result in reoxygenation leading to enhanced bactericidal activity of antibiotics. We address issues of feasibility and potential adverse effects regarding patient safety and development of resistance. Finally, we propose means for supplying reoxygenation to antibiotic treatment of infectious biofilm with the potential to benefit large groups of patients.

U2 - 10.1016/j.bioflm.2019.100008

DO - 10.1016/j.bioflm.2019.100008

M3 - Journal article

VL - 1

JO - Biofilm

JF - Biofilm

SN - 2590-2075

M1 - 100008

ER -

ID: 238530730