In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy
Research output: Contribution to journal › Journal article › peer-review
As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa. Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/pBAD-yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy.
Original language | English |
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Article number | e01088-17 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 61 |
Issue number | 10 |
Number of pages | 5 |
ISSN | 0066-4804 |
DOIs | |
Publication status | Published - 2017 |
- antibiotic resistance, biofilms, cyclic di-GMP, dispersal, synergism
Research areas
Links
- http://europepmc.org/articles/pmc5610510?pdf=render
Final published version
ID: 184546017