Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

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Standard

Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control. / Bjarnsholt, Thomas; Tolker-Nielsen, Tim; Høiby, Niels; Givskov, Michael.

In: Expert Reviews in Molecular Medicine, Vol. 12, 2010, p. e11.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bjarnsholt, T, Tolker-Nielsen, T, Høiby, N & Givskov, M 2010, 'Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control', Expert Reviews in Molecular Medicine, vol. 12, pp. e11. https://doi.org/10.1017/S1462399410001420

APA

Bjarnsholt, T., Tolker-Nielsen, T., Høiby, N., & Givskov, M. (2010). Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control. Expert Reviews in Molecular Medicine, 12, e11. https://doi.org/10.1017/S1462399410001420

Vancouver

Bjarnsholt T, Tolker-Nielsen T, Høiby N, Givskov M. Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control. Expert Reviews in Molecular Medicine. 2010;12:e11. https://doi.org/10.1017/S1462399410001420

Author

Bjarnsholt, Thomas ; Tolker-Nielsen, Tim ; Høiby, Niels ; Givskov, Michael. / Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control. In: Expert Reviews in Molecular Medicine. 2010 ; Vol. 12. pp. e11.

Bibtex

@article{3ce933707d3c11df928f000ea68e967b,
title = "Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control",
abstract = "Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.",
author = "Thomas Bjarnsholt and Tim Tolker-Nielsen and Niels H{\o}iby and Michael Givskov",
note = "Keywords: Animals; Biofilms; Chronic Disease; Humans; Pseudomonas Infections; Pseudomonas aeruginosa; Signal Transduction",
year = "2010",
doi = "10.1017/S1462399410001420",
language = "English",
volume = "12",
pages = "e11",
journal = "Expert Reviews in Molecular Medicine",
issn = "1462-3994",
publisher = "Cambridge University Press",

}

RIS

TY - JOUR

T1 - Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

AU - Bjarnsholt, Thomas

AU - Tolker-Nielsen, Tim

AU - Høiby, Niels

AU - Givskov, Michael

N1 - Keywords: Animals; Biofilms; Chronic Disease; Humans; Pseudomonas Infections; Pseudomonas aeruginosa; Signal Transduction

PY - 2010

Y1 - 2010

N2 - Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.

AB - Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.

U2 - 10.1017/S1462399410001420

DO - 10.1017/S1462399410001420

M3 - Journal article

C2 - 20370936

VL - 12

SP - e11

JO - Expert Reviews in Molecular Medicine

JF - Expert Reviews in Molecular Medicine

SN - 1462-3994

ER -

ID: 20395015