Interfering with bacterial gossip.

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Standard

Interfering with bacterial gossip. / Bjarnsholt, Thomas; Tolker-Nielsen, Tim; Givskov, Michael.

Biofilm perspectives: Biofilm highlight. ed. / H-C Flemming; J Wingender; U Szewzyk. 1. ed. Berlin : Springer Publishing Company, 2011. p. 163-188 (Springer Series on Biofilms, Vol. 5).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Harvard

Bjarnsholt, T, Tolker-Nielsen, T & Givskov, M 2011, Interfering with bacterial gossip. in H-C Flemming, J Wingender & U Szewzyk (eds), Biofilm perspectives: Biofilm highlight. 1 edn, Springer Publishing Company, Berlin, Springer Series on Biofilms, vol. 5, pp. 163-188. https://doi.org/10.1007/978-3-642-19940-0_8

APA

Bjarnsholt, T., Tolker-Nielsen, T., & Givskov, M. (2011). Interfering with bacterial gossip. In H-C. Flemming, J. Wingender, & U. Szewzyk (Eds.), Biofilm perspectives: Biofilm highlight (1 ed., pp. 163-188). Springer Publishing Company. Springer Series on Biofilms Vol. 5 https://doi.org/10.1007/978-3-642-19940-0_8

Vancouver

Bjarnsholt T, Tolker-Nielsen T, Givskov M. Interfering with bacterial gossip. In Flemming H-C, Wingender J, Szewzyk U, editors, Biofilm perspectives: Biofilm highlight. 1 ed. Berlin: Springer Publishing Company. 2011. p. 163-188. (Springer Series on Biofilms, Vol. 5). https://doi.org/10.1007/978-3-642-19940-0_8

Author

Bjarnsholt, Thomas ; Tolker-Nielsen, Tim ; Givskov, Michael. / Interfering with bacterial gossip. Biofilm perspectives: Biofilm highlight. editor / H-C Flemming ; J Wingender ; U Szewzyk. 1. ed. Berlin : Springer Publishing Company, 2011. pp. 163-188 (Springer Series on Biofilms, Vol. 5).

Bibtex

@inbook{db1e100e237242ea8f44f2df0a704a5c,
title = "Interfering with bacterial gossip.",
abstract = "Biofilm resilience poses major challenges to the development of novel antimicrobial agents. Biofilm bacteria can be considered small groups of “Special Forces” capable of infiltrating the host and destroying important components of the cellular defense system with the aim of crippling the host defense. Antibiotics exhibit a rather limited effect on biofilms. Furthermore, antibiotics have an {\textquoteleft}inherent obsolescence{\textquoteright} because they select for development of resistance. Bacterial infections with origin in bacterial biofilms have become a serious threat in developed countries. Pseudomonas aeruginosa biofilms are thought to be the dominant agent in many chronic infections including those in cystic fibrosis lungs and chronic wounds. With the present day{\textquoteright}s awareness of biofilms, the future task is to exploit this knowledge for development and application of antimicrobial intervention strategies that appropriately target bacteria in their relevant habitat with the aim of mitigating their destructive impact on patients. In this review we describe molecular mechanisms involved in “bacterial gossip” (more scientifically referred to as quorum sensing (QS) and c-di-GMP signaling), virulence, biofilm formation, resistance and QS inhibition as future antimicrobial targets, in particular those that would work to minimize selection pressures for the development of resistant bacteria.",
author = "Thomas Bjarnsholt and Tim Tolker-Nielsen and Michael Givskov",
year = "2011",
doi = "10.1007/978-3-642-19940-0_8",
language = "English",
isbn = "9783642199394",
series = "Springer Series on Biofilms",
publisher = "Springer Publishing Company",
pages = "163--188",
editor = "H-C Flemming and Wingender, {J } and U Szewzyk",
booktitle = "Biofilm perspectives",
edition = "1",

}

RIS

TY - CHAP

T1 - Interfering with bacterial gossip.

AU - Bjarnsholt, Thomas

AU - Tolker-Nielsen, Tim

AU - Givskov, Michael

PY - 2011

Y1 - 2011

N2 - Biofilm resilience poses major challenges to the development of novel antimicrobial agents. Biofilm bacteria can be considered small groups of “Special Forces” capable of infiltrating the host and destroying important components of the cellular defense system with the aim of crippling the host defense. Antibiotics exhibit a rather limited effect on biofilms. Furthermore, antibiotics have an ‘inherent obsolescence’ because they select for development of resistance. Bacterial infections with origin in bacterial biofilms have become a serious threat in developed countries. Pseudomonas aeruginosa biofilms are thought to be the dominant agent in many chronic infections including those in cystic fibrosis lungs and chronic wounds. With the present day’s awareness of biofilms, the future task is to exploit this knowledge for development and application of antimicrobial intervention strategies that appropriately target bacteria in their relevant habitat with the aim of mitigating their destructive impact on patients. In this review we describe molecular mechanisms involved in “bacterial gossip” (more scientifically referred to as quorum sensing (QS) and c-di-GMP signaling), virulence, biofilm formation, resistance and QS inhibition as future antimicrobial targets, in particular those that would work to minimize selection pressures for the development of resistant bacteria.

AB - Biofilm resilience poses major challenges to the development of novel antimicrobial agents. Biofilm bacteria can be considered small groups of “Special Forces” capable of infiltrating the host and destroying important components of the cellular defense system with the aim of crippling the host defense. Antibiotics exhibit a rather limited effect on biofilms. Furthermore, antibiotics have an ‘inherent obsolescence’ because they select for development of resistance. Bacterial infections with origin in bacterial biofilms have become a serious threat in developed countries. Pseudomonas aeruginosa biofilms are thought to be the dominant agent in many chronic infections including those in cystic fibrosis lungs and chronic wounds. With the present day’s awareness of biofilms, the future task is to exploit this knowledge for development and application of antimicrobial intervention strategies that appropriately target bacteria in their relevant habitat with the aim of mitigating their destructive impact on patients. In this review we describe molecular mechanisms involved in “bacterial gossip” (more scientifically referred to as quorum sensing (QS) and c-di-GMP signaling), virulence, biofilm formation, resistance and QS inhibition as future antimicrobial targets, in particular those that would work to minimize selection pressures for the development of resistant bacteria.

U2 - 10.1007/978-3-642-19940-0_8

DO - 10.1007/978-3-642-19940-0_8

M3 - Book chapter

SN - 9783642199394

T3 - Springer Series on Biofilms

SP - 163

EP - 188

BT - Biofilm perspectives

A2 - Flemming, H-C

A2 - Wingender, J

A2 - Szewzyk, U

PB - Springer Publishing Company

CY - Berlin

ER -

ID: 36061881