Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

Research output: Contribution to journal › Review › Research › peer-review

Standard

Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis. / Mauch, Renan Marrichi; Jensen, Peter Østrup; Moser, Claus; Levy, Carlos Emilio; Høiby, Niels.

In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, Vol. 17, No. 2, 2018, p. 143-152.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Mauch, RM, Jensen, PØ, Moser, C, Levy, CE & Høiby, N 2018, 'Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis', Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, vol. 17, no. 2, pp. 143-152. https://doi.org/10.1016/j.jcf.2017.08.012

APA

Mauch, R. M., Jensen, P. Ø., Moser, C., Levy, C. E., & Høiby, N. (2018). Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 17(2), 143-152. https://doi.org/10.1016/j.jcf.2017.08.012

Vancouver

Mauch RM, Jensen PØ, Moser C, Levy CE, Høiby N. Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2018;17(2):143-152. https://doi.org/10.1016/j.jcf.2017.08.012

Author

Mauch, Renan Marrichi ; Jensen, Peter Østrup ; Moser, Claus ; Levy, Carlos Emilio ; Høiby, Niels. / Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis. In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2018 ; Vol. 17, No. 2. pp. 143-152.

Bibtex

@article{380263cd27da4b04a2ed56437b4b86fb,
title = "Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis",
abstract = "P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.",
author = "Mauch, {Renan Marrichi} and Jensen, {Peter {\O}strup} and Claus Moser and Levy, {Carlos Emilio} and Niels H{\o}iby",
note = "Copyright {\textcopyright} 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.",
year = "2018",
doi = "10.1016/j.jcf.2017.08.012",
language = "English",
volume = "17",
pages = "143--152",
journal = "Journal of Cystic Fibrosis",
issn = "1569-1993",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

AU - Mauch, Renan Marrichi

AU - Jensen, Peter Østrup

AU - Moser, Claus

AU - Levy, Carlos Emilio

AU - Høiby, Niels

N1 - Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

PY - 2018

Y1 - 2018

N2 - P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.

AB - P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.

U2 - 10.1016/j.jcf.2017.08.012

DO - 10.1016/j.jcf.2017.08.012

M3 - Review

C2 - 29033275

VL - 17

SP - 143

EP - 152

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

SN - 1569-1993

IS - 2

ER -

ID: 187078876