Morphological evidence of biofilm in chronic obstructive sialadenitis
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Morphological evidence of biofilm in chronic obstructive sialadenitis. / Schrøder, S. A.; Eickhardt, S.; Bjarnsholt, T.; Nørgaard, T.; Homøe, P.
In: Journal of Laryngology and Otology, Vol. 132, No. 7, 2018, p. 611-614.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Morphological evidence of biofilm in chronic obstructive sialadenitis
AU - Schrøder, S. A.
AU - Eickhardt, S.
AU - Bjarnsholt, T.
AU - Nørgaard, T.
AU - Homøe, P.
PY - 2018
Y1 - 2018
N2 - Objective Bacterial infection is a common finding in acute sialadenitis and may play a role in the chronicity of the condition. This study investigated if bacterial biofilm is present in submandibular chronic obstructive sialadenitis.Methods A descriptive case-control study was conducted that compared 10 histological sections of submandibular glands with chronic obstructive sialadenitis, to 10 histological sections of the healthy part of submandibular glands with pleomorphic adenoma. Fluorescence in situ hybridisation and confocal laser scanning microscopy visualised evidence of bacterial biofilm.Results In the chronic obstructive sialadenitis group, 5 out of 10 histological sections showed morphological evidence of bacterial biofilm. In the control group, there was no sign of bacterial biofilm formation.Conclusion Morphological evidence of bacterial biofilm was found in the submandibular gland sections from patients with chronic sialadenitis and suggests a role in the chronicity of submandibular chronic obstructive sialadenitis.
AB - Objective Bacterial infection is a common finding in acute sialadenitis and may play a role in the chronicity of the condition. This study investigated if bacterial biofilm is present in submandibular chronic obstructive sialadenitis.Methods A descriptive case-control study was conducted that compared 10 histological sections of submandibular glands with chronic obstructive sialadenitis, to 10 histological sections of the healthy part of submandibular glands with pleomorphic adenoma. Fluorescence in situ hybridisation and confocal laser scanning microscopy visualised evidence of bacterial biofilm.Results In the chronic obstructive sialadenitis group, 5 out of 10 histological sections showed morphological evidence of bacterial biofilm. In the control group, there was no sign of bacterial biofilm formation.Conclusion Morphological evidence of bacterial biofilm was found in the submandibular gland sections from patients with chronic sialadenitis and suggests a role in the chronicity of submandibular chronic obstructive sialadenitis.
KW - Bacteria
KW - Biofilms
KW - Salivary Gland Calculi
KW - Sialadenitis
U2 - 10.1017/S0022215118000646
DO - 10.1017/S0022215118000646
M3 - Journal article
C2 - 29986787
AN - SCOPUS:85049863656
VL - 132
SP - 611
EP - 614
JO - The Journal of laryngology and otology. Supplement
JF - The Journal of laryngology and otology. Supplement
SN - 0144-2945
IS - 7
ER -
ID: 208879894