Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis

Research output: Contribution to journalJournal articlepeer-review

Standard

Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis. / Ø Gadsbøll, Anne-Sofie; Jee, Mia H; Funch, Anders B; Alhede, Maria; Mraz, Veronika; Weber, Julie F; Callender, Lauren A; Carroll, Elizabeth C; Bjarnsholt, Thomas; Woetmann, Anders; Ødum, Niels; Thomsen, Allan R; Johansen, Jeanne D; Henson, Sian M; Geisler, Carsten; Bonefeld, Charlotte M.

In: The Journal of Investigative Dermatology, Vol. 140, No. 4, 2020, p. 806-815.e5.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Ø Gadsbøll, A-S, Jee, MH, Funch, AB, Alhede, M, Mraz, V, Weber, JF, Callender, LA, Carroll, EC, Bjarnsholt, T, Woetmann, A, Ødum, N, Thomsen, AR, Johansen, JD, Henson, SM, Geisler, C & Bonefeld, CM 2020, 'Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis', The Journal of Investigative Dermatology, vol. 140, no. 4, pp. 806-815.e5. https://doi.org/10.1016/j.jid.2019.07.722

APA

Ø Gadsbøll, A-S., Jee, M. H., Funch, A. B., Alhede, M., Mraz, V., Weber, J. F., Callender, L. A., Carroll, E. C., Bjarnsholt, T., Woetmann, A., Ødum, N., Thomsen, A. R., Johansen, J. D., Henson, S. M., Geisler, C., & Bonefeld, C. M. (2020). Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis. The Journal of Investigative Dermatology, 140(4), 806-815.e5. https://doi.org/10.1016/j.jid.2019.07.722

Vancouver

Ø Gadsbøll A-S, Jee MH, Funch AB, Alhede M, Mraz V, Weber JF et al. Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis. The Journal of Investigative Dermatology. 2020;140(4):806-815.e5. https://doi.org/10.1016/j.jid.2019.07.722

Author

Ø Gadsbøll, Anne-Sofie ; Jee, Mia H ; Funch, Anders B ; Alhede, Maria ; Mraz, Veronika ; Weber, Julie F ; Callender, Lauren A ; Carroll, Elizabeth C ; Bjarnsholt, Thomas ; Woetmann, Anders ; Ødum, Niels ; Thomsen, Allan R ; Johansen, Jeanne D ; Henson, Sian M ; Geisler, Carsten ; Bonefeld, Charlotte M. / Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis. In: The Journal of Investigative Dermatology. 2020 ; Vol. 140, No. 4. pp. 806-815.e5.

Bibtex

@article{fc97e0af387e4995a45a14786a8b0690,
title = "Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis",
abstract = "The skin is our interface with the outside world and consequently it is exposed to a wide range of microbes and allergens. Recent studies have indicated that allergen-specific skin-resident memory T (TRM) cells play a role in allergic contact dermatitis (ACD). However, the composition and dynamics of the epidermal T cell subsets during ACD are not known. Here we show that exposure of the skin to the experimental contact allergen 1-fluoro-2,4-dinitrobenzene (DNFB) results in a displacement of the normally occurring dendritic epidermal T cells (DETC) concomitant with an accumulation of epidermal CD8+CD69+CD103+ TRM cells in mice. By studying knock-out mice, we provide evidence that CD8+ T cells are required for the displacement of the DETC and furthermore, that DETC are not required for recruitment of CD8+ TRM cells to the epidermis following allergen exposure. We demonstrate that the magnitude of the allergic reaction correlates with the number of CD8+ epidermal TRM cells that again correlates with allergen dose and number of allergen exposures. Finally, in an attempt to elucidate why CD8+ epidermal TRM cells persist in the epidermis, we show that CD8+ epidermal TRM cells have a higher proliferative capability and are bioenergetically more stable, displaying a higher spare respiratory capacity than DETC.",
author = "{{\O} Gadsb{\o}ll}, Anne-Sofie and Jee, {Mia H} and Funch, {Anders B} and Maria Alhede and Veronika Mraz and Weber, {Julie F} and Callender, {Lauren A} and Carroll, {Elizabeth C} and Thomas Bjarnsholt and Anders Woetmann and Niels {\O}dum and Thomsen, {Allan R} and Johansen, {Jeanne D} and Henson, {Sian M} and Carsten Geisler and Bonefeld, {Charlotte M}",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2020",
doi = "10.1016/j.jid.2019.07.722",
language = "English",
volume = "140",
pages = "806--815.e5",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "nature publishing group",
number = "4",

}

RIS

TY - JOUR

T1 - Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis

AU - Ø Gadsbøll, Anne-Sofie

AU - Jee, Mia H

AU - Funch, Anders B

AU - Alhede, Maria

AU - Mraz, Veronika

AU - Weber, Julie F

AU - Callender, Lauren A

AU - Carroll, Elizabeth C

AU - Bjarnsholt, Thomas

AU - Woetmann, Anders

AU - Ødum, Niels

AU - Thomsen, Allan R

AU - Johansen, Jeanne D

AU - Henson, Sian M

AU - Geisler, Carsten

AU - Bonefeld, Charlotte M

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2020

Y1 - 2020

N2 - The skin is our interface with the outside world and consequently it is exposed to a wide range of microbes and allergens. Recent studies have indicated that allergen-specific skin-resident memory T (TRM) cells play a role in allergic contact dermatitis (ACD). However, the composition and dynamics of the epidermal T cell subsets during ACD are not known. Here we show that exposure of the skin to the experimental contact allergen 1-fluoro-2,4-dinitrobenzene (DNFB) results in a displacement of the normally occurring dendritic epidermal T cells (DETC) concomitant with an accumulation of epidermal CD8+CD69+CD103+ TRM cells in mice. By studying knock-out mice, we provide evidence that CD8+ T cells are required for the displacement of the DETC and furthermore, that DETC are not required for recruitment of CD8+ TRM cells to the epidermis following allergen exposure. We demonstrate that the magnitude of the allergic reaction correlates with the number of CD8+ epidermal TRM cells that again correlates with allergen dose and number of allergen exposures. Finally, in an attempt to elucidate why CD8+ epidermal TRM cells persist in the epidermis, we show that CD8+ epidermal TRM cells have a higher proliferative capability and are bioenergetically more stable, displaying a higher spare respiratory capacity than DETC.

AB - The skin is our interface with the outside world and consequently it is exposed to a wide range of microbes and allergens. Recent studies have indicated that allergen-specific skin-resident memory T (TRM) cells play a role in allergic contact dermatitis (ACD). However, the composition and dynamics of the epidermal T cell subsets during ACD are not known. Here we show that exposure of the skin to the experimental contact allergen 1-fluoro-2,4-dinitrobenzene (DNFB) results in a displacement of the normally occurring dendritic epidermal T cells (DETC) concomitant with an accumulation of epidermal CD8+CD69+CD103+ TRM cells in mice. By studying knock-out mice, we provide evidence that CD8+ T cells are required for the displacement of the DETC and furthermore, that DETC are not required for recruitment of CD8+ TRM cells to the epidermis following allergen exposure. We demonstrate that the magnitude of the allergic reaction correlates with the number of CD8+ epidermal TRM cells that again correlates with allergen dose and number of allergen exposures. Finally, in an attempt to elucidate why CD8+ epidermal TRM cells persist in the epidermis, we show that CD8+ epidermal TRM cells have a higher proliferative capability and are bioenergetically more stable, displaying a higher spare respiratory capacity than DETC.

U2 - 10.1016/j.jid.2019.07.722

DO - 10.1016/j.jid.2019.07.722

M3 - Journal article

C2 - 31518559

VL - 140

SP - 806-815.e5

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 4

ER -

ID: 227415252