Petasis three-component coupling reactions of hydrazides for the synthesis of oxadiazolones and oxazolidinones

Research output: Contribution to journalJournal articleResearchpeer-review

  • Sebastian T Le Quement
  • Thomas Flagstad
  • Remi J T Mikkelsen
  • Mette R Hansen
  • Givskov, Michael
  • Thomas E Nielsen
An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.
Original languageEnglish
JournalOrganic Letters
Volume14
Issue number2
Pages (from-to)640-643
Number of pages4
ISSN1523-7060
DOIs
Publication statusPublished - 2012

    Research areas

  • Aldehydes, Cyclization, Hydrazines, Molecular Structure, Oxazolidinones

ID: 38230287