Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa
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Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa. / Yang, Liang; Hengzhuang, Wang; Wu, Hong; Damkiaer, Søren; Jochumsen, Nicholas; Song, Zhijun; Givskov, Michael; Høiby, Niels; Molin, Søren.
In: F E M S Immunology and Medical Microbiology, Vol. 65, No. 2, 07.2012, p. 366-376.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa
AU - Yang, Liang
AU - Hengzhuang, Wang
AU - Wu, Hong
AU - Damkiaer, Søren
AU - Jochumsen, Nicholas
AU - Song, Zhijun
AU - Givskov, Michael
AU - Høiby, Niels
AU - Molin, Søren
N1 - © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
PY - 2012/7
Y1 - 2012/7
N2 - Chronic lung infection by mucoid Pseudomonas aeruginosa is one of the major pathologic features in patients with cystic fibrosis. Mucoid P. aeruginosa is notorious for its biofilm forming capability and resistance to immune attacks. In this study, the roles of extracellular polymeric substances from biofilms formed by mucoid P. aeruginosa were investigated. Alginate is not an essential structure component for mucoid P. aeruginosa biofilms. Genetic studies revealed that Pel and Psl polysaccharides serve as essential scaffold and mediate macrocolony formation in mucoid P. aeruginosa biofilms. The Psl polysaccharide is more important than Pel polysaccharide in mucoid P. aeruginosa biofilm structure maintenance and phagocytosis resistance. The polysaccharides were further found to protect mucoid P. aeruginosa strain from host immune clearance in a mouse model of acute lung infection.
AB - Chronic lung infection by mucoid Pseudomonas aeruginosa is one of the major pathologic features in patients with cystic fibrosis. Mucoid P. aeruginosa is notorious for its biofilm forming capability and resistance to immune attacks. In this study, the roles of extracellular polymeric substances from biofilms formed by mucoid P. aeruginosa were investigated. Alginate is not an essential structure component for mucoid P. aeruginosa biofilms. Genetic studies revealed that Pel and Psl polysaccharides serve as essential scaffold and mediate macrocolony formation in mucoid P. aeruginosa biofilms. The Psl polysaccharide is more important than Pel polysaccharide in mucoid P. aeruginosa biofilm structure maintenance and phagocytosis resistance. The polysaccharides were further found to protect mucoid P. aeruginosa strain from host immune clearance in a mouse model of acute lung infection.
U2 - 10.1111/j.1574-695X.2012.00936.x
DO - 10.1111/j.1574-695X.2012.00936.x
M3 - Journal article
C2 - 22309122
VL - 65
SP - 366
EP - 376
JO - Pathogens and Disease
JF - Pathogens and Disease
SN - 2049-632X
IS - 2
ER -
ID: 38230325