Process for the manufacture of ajoene derivatives

Research output: Patent

Standard

Process for the manufacture of ajoene derivatives. / Bjarnsholt, Thomas (Inventor); Hoeiby, Niels (Inventor); Jensen, Peter Østrup (Inventor); Phipps, Richard (Inventor); Shanmugham, Meenakshi, Sundaram (Inventor); Alhede, Maria (Inventor); Hultqvist, Louise Dahl (Inventor); Jakobsen, Tim Holm (Inventor); Tanner, David (Inventor); Larsen, Thomas, Ostenfeld (Inventor); Givskov, Michael (Inventor).

Patent No.: WO2012076016. Jun 14, 2012.

Research output: Patent

Harvard

Bjarnsholt, T, Hoeiby, N, Jensen, PØ, Phipps, R, Shanmugham, Meenakshi, S, Alhede, M, Hultqvist, LD, Jakobsen, TH, Tanner, D, Larsen, Thomas, O & Givskov, M Jun. 14 2012, Process for the manufacture of ajoene derivatives, Patent No. WO2012076016.

APA

Bjarnsholt, T., Hoeiby, N., Jensen, P. Ø., Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, L. D., Jakobsen, T. H., Tanner, D., Larsen, Thomas, O., & Givskov, M. (2012). Process for the manufacture of ajoene derivatives. (Patent No. WO2012076016).

Vancouver

Bjarnsholt T, Hoeiby, N, Jensen PØ, Phipps R, Shanmugham, Meenakshi S, Alhede M et al, inventors. Process for the manufacture of ajoene derivatives. WO2012076016. 2012 Jun 14.

Author

Bjarnsholt, Thomas (Inventor) ; Hoeiby, Niels (Inventor) ; Jensen, Peter Østrup (Inventor) ; Phipps, Richard (Inventor) ; Shanmugham, Meenakshi, Sundaram (Inventor) ; Alhede, Maria (Inventor) ; Hultqvist, Louise Dahl (Inventor) ; Jakobsen, Tim Holm (Inventor) ; Tanner, David (Inventor) ; Larsen, Thomas, Ostenfeld (Inventor) ; Givskov, Michael (Inventor). / Process for the manufacture of ajoene derivatives. Patent No.: WO2012076016. Jun 14, 2012.

Bibtex

@misc{58e3ab7e6e49447d8bdbb0a4bfda21ac,
title = "Process for the manufacture of ajoene derivatives",
abstract = "The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.",
author = "Thomas Bjarnsholt and Niels Hoeiby, and Jensen, {Peter {\O}strup} and Richard Phipps and {Shanmugham, Meenakshi}, Sundaram and Maria Alhede and Hultqvist, {Louise Dahl} and Jakobsen, {Tim Holm} and David Tanner and {Larsen, Thomas}, Ostenfeld and Michael Givskov,",
year = "2012",
month = jun,
day = "14",
language = "English",
type = "Patent",
note = "WO2012076016; C07C 323/ 65 A I",

}

RIS

TY - PAT

T1 - Process for the manufacture of ajoene derivatives

AU - Bjarnsholt, Thomas

AU - Hoeiby,, Niels

AU - Jensen, Peter Østrup

AU - Phipps, Richard

AU - Shanmugham, Meenakshi, Sundaram

AU - Alhede, Maria

AU - Hultqvist, Louise Dahl

AU - Jakobsen, Tim Holm

AU - Tanner, David

AU - Larsen, Thomas, Ostenfeld

AU - Givskov,, Michael

PY - 2012/6/14

Y1 - 2012/6/14

N2 - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

AB - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

M3 - Patent

M1 - WO2012076016

ER -

ID: 180365289