Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis

Research output: Contribution to journalJournal articlepeer-review

The N-acyl-L-homoserine lactones (AHLs) produced by sequential Pseudomonas aeruginosa isolates from chronically infected patients with cystic fibrosis were analyzed by thin-layer chromatography. It is demonstrated that both the amounts and the types of molecules synthesized by isolates from patients who were monitored over periods of up to 11 years do not change significantly during chronic colonization. However, in the case of a patient who became co-infected with an AHL-producing Burkholderia cepacia strain a dramatic reduction in the amounts of AHLs produced by the co-residing P. aeruginosa isolates was observed.
Original languageEnglish
JournalF E M S Microbiology Letters
Volume184
Issue number2
Pages (from-to)273-8
Number of pages6
ISSN0378-1097
Publication statusPublished - 2000

    Research areas

  • 4-Butyrolactone, Burkholderia Infections, Burkholderia cepacia, Chromatography, Thin Layer, Chronic Disease, Cystic Fibrosis, Gene Expression Regulation, Bacterial, Humans, Lung Diseases, Pseudomonas Infections, Pseudomonas aeruginosa, Signal Transduction

ID: 44305765