Quorum sensing antagonism from marine organisms

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Quorum sensing antagonism from marine organisms. / Skindersoe, Mette Elena; Ettinger-Epstein, Piers; Rasmussen, Thomas Bovbjerg; Bjarnsholt, Thomas; de Nys, Rocky; Givskov, Michael.

In: Marine Biotechnology, Vol. 10, No. 1, 2007, p. 56-63.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Skindersoe, ME, Ettinger-Epstein, P, Rasmussen, TB, Bjarnsholt, T, de Nys, R & Givskov, M 2007, 'Quorum sensing antagonism from marine organisms', Marine Biotechnology, vol. 10, no. 1, pp. 56-63. https://doi.org/10.1007/s10126-007-9036-y

APA

Skindersoe, M. E., Ettinger-Epstein, P., Rasmussen, T. B., Bjarnsholt, T., de Nys, R., & Givskov, M. (2007). Quorum sensing antagonism from marine organisms. Marine Biotechnology, 10(1), 56-63. https://doi.org/10.1007/s10126-007-9036-y

Vancouver

Skindersoe ME, Ettinger-Epstein P, Rasmussen TB, Bjarnsholt T, de Nys R, Givskov M. Quorum sensing antagonism from marine organisms. Marine Biotechnology. 2007;10(1):56-63. https://doi.org/10.1007/s10126-007-9036-y

Author

Skindersoe, Mette Elena ; Ettinger-Epstein, Piers ; Rasmussen, Thomas Bovbjerg ; Bjarnsholt, Thomas ; de Nys, Rocky ; Givskov, Michael. / Quorum sensing antagonism from marine organisms. In: Marine Biotechnology. 2007 ; Vol. 10, No. 1. pp. 56-63.

Bibtex

@article{fa50cad0a2ea11df928f000ea68e967b,
title = "Quorum sensing antagonism from marine organisms",
abstract = "With the global emergence of multiresistant bacteria there is an increasing demand for development of new treatments to combat pathogens. Bacterial cell-cell communication [quorum sensing (QS)] regulates expression of virulence factors in a number of bacterial pathogens and is a new promising target for the control of infectious bacteria. We present the results of screening of 284 extracts of marine organisms from the Great Barrier Reef, Australia, for their inhibition of QS. Of the 284 extracts, 64 (23%) were active in a general, LuxR-derived QS screen, and of these 36 (56%) were also active in a specific Pseudomonas aeruginosa QS screen. Extracts of the marine sponge Luffariella variabilis proved active in both systems. The secondary metabolites manoalide, manoalide monoacetate, and secomanoalide isolated from the sponge showed strong QS inhibition of a lasB::gfp(ASV) fusion, demonstrating the potential for further identification of specific QS antagonists from marine organisms.",
author = "Skindersoe, {Mette Elena} and Piers Ettinger-Epstein and Rasmussen, {Thomas Bovbjerg} and Thomas Bjarnsholt and {de Nys}, Rocky and Michael Givskov",
note = "Keywords: Animals; Australia; Bacteria; Complex Mixtures; Dose-Response Relationship, Drug; Invertebrates; Pacific Ocean; Quorum Sensing; Terpenes",
year = "2007",
doi = "10.1007/s10126-007-9036-y",
language = "English",
volume = "10",
pages = "56--63",
journal = "Marine Biotechnology",
issn = "1436-2228",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Quorum sensing antagonism from marine organisms

AU - Skindersoe, Mette Elena

AU - Ettinger-Epstein, Piers

AU - Rasmussen, Thomas Bovbjerg

AU - Bjarnsholt, Thomas

AU - de Nys, Rocky

AU - Givskov, Michael

N1 - Keywords: Animals; Australia; Bacteria; Complex Mixtures; Dose-Response Relationship, Drug; Invertebrates; Pacific Ocean; Quorum Sensing; Terpenes

PY - 2007

Y1 - 2007

N2 - With the global emergence of multiresistant bacteria there is an increasing demand for development of new treatments to combat pathogens. Bacterial cell-cell communication [quorum sensing (QS)] regulates expression of virulence factors in a number of bacterial pathogens and is a new promising target for the control of infectious bacteria. We present the results of screening of 284 extracts of marine organisms from the Great Barrier Reef, Australia, for their inhibition of QS. Of the 284 extracts, 64 (23%) were active in a general, LuxR-derived QS screen, and of these 36 (56%) were also active in a specific Pseudomonas aeruginosa QS screen. Extracts of the marine sponge Luffariella variabilis proved active in both systems. The secondary metabolites manoalide, manoalide monoacetate, and secomanoalide isolated from the sponge showed strong QS inhibition of a lasB::gfp(ASV) fusion, demonstrating the potential for further identification of specific QS antagonists from marine organisms.

AB - With the global emergence of multiresistant bacteria there is an increasing demand for development of new treatments to combat pathogens. Bacterial cell-cell communication [quorum sensing (QS)] regulates expression of virulence factors in a number of bacterial pathogens and is a new promising target for the control of infectious bacteria. We present the results of screening of 284 extracts of marine organisms from the Great Barrier Reef, Australia, for their inhibition of QS. Of the 284 extracts, 64 (23%) were active in a general, LuxR-derived QS screen, and of these 36 (56%) were also active in a specific Pseudomonas aeruginosa QS screen. Extracts of the marine sponge Luffariella variabilis proved active in both systems. The secondary metabolites manoalide, manoalide monoacetate, and secomanoalide isolated from the sponge showed strong QS inhibition of a lasB::gfp(ASV) fusion, demonstrating the potential for further identification of specific QS antagonists from marine organisms.

U2 - 10.1007/s10126-007-9036-y

DO - 10.1007/s10126-007-9036-y

M3 - Journal article

C2 - 17952508

VL - 10

SP - 56

EP - 63

JO - Marine Biotechnology

JF - Marine Biotechnology

SN - 1436-2228

IS - 1

ER -

ID: 21258455