Quorum sensing inhibitors disable bacterial biofilms.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Quorum sensing inhibitors disable bacterial biofilms. / Bjarnsholt, Thomas; Tolker-Nielsen, Tim; Givskov, Michael.

Emerging trends in in antibacterial discovery.. ed. / A.A. Miller; P.F. Miller. 1. ed. Norvich UK : HorizonBioscience, 2011. p. 211-224.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Bjarnsholt, T, Tolker-Nielsen, T & Givskov, M 2011, Quorum sensing inhibitors disable bacterial biofilms. in AA Miller & PF Miller (eds), Emerging trends in in antibacterial discovery.. 1 edn, HorizonBioscience, Norvich UK, pp. 211-224.

APA

Bjarnsholt, T., Tolker-Nielsen, T., & Givskov, M. (2011). Quorum sensing inhibitors disable bacterial biofilms. In A. A. Miller, & P. F. Miller (Eds.), Emerging trends in in antibacterial discovery. (1 ed., pp. 211-224). HorizonBioscience.

Vancouver

Bjarnsholt T, Tolker-Nielsen T, Givskov M. Quorum sensing inhibitors disable bacterial biofilms. In Miller AA, Miller PF, editors, Emerging trends in in antibacterial discovery.. 1 ed. Norvich UK: HorizonBioscience. 2011. p. 211-224

Author

Bjarnsholt, Thomas ; Tolker-Nielsen, Tim ; Givskov, Michael. / Quorum sensing inhibitors disable bacterial biofilms. Emerging trends in in antibacterial discovery.. editor / A.A. Miller ; P.F. Miller. 1. ed. Norvich UK : HorizonBioscience, 2011. pp. 211-224

Bibtex

@inbook{98a762bd581f4225a6521a5773938fd2,
title = "Quorum sensing inhibitors disable bacterial biofilms.",
abstract = "It is now evident that bacteria assume the biofilm mode of growth during chronic infections. The important hallmarks of biofilm infections are development of local inflammations, extreme tolerance to the action of conventional antimicrobial agents and an almost infinite capacity to evade the host defence systems in particular innate immunity. In the biofilm mode, bacteria use cell to cell communication termed quorum-sensing (QS) to coordinate expression of virulence, tolerance towards a number of antimicrobial agents and shielding against the host defence system. Chemical biology approaches may allow for the development of new treatment strategies focusing on interference with cell to cell communication with the aim of primarily disabling expression of virulence, immune shielding and antibiotic tolerance. Here we present our experience with screening and testing small molecule chemistry for N-acyl homoserine lactone-dependent QS inhibition. In addition we present our thoughts with respect to advantages and potential limitations of the intervention strategies described.",
author = "Thomas Bjarnsholt and Tim Tolker-Nielsen and Michael Givskov",
year = "2011",
language = "English",
isbn = "9781904455899",
pages = "211--224",
editor = "A.A. Miller and P.F. Miller",
booktitle = "Emerging trends in in antibacterial discovery.",
publisher = "HorizonBioscience",
edition = "1",

}

RIS

TY - CHAP

T1 - Quorum sensing inhibitors disable bacterial biofilms.

AU - Bjarnsholt, Thomas

AU - Tolker-Nielsen, Tim

AU - Givskov, Michael

PY - 2011

Y1 - 2011

N2 - It is now evident that bacteria assume the biofilm mode of growth during chronic infections. The important hallmarks of biofilm infections are development of local inflammations, extreme tolerance to the action of conventional antimicrobial agents and an almost infinite capacity to evade the host defence systems in particular innate immunity. In the biofilm mode, bacteria use cell to cell communication termed quorum-sensing (QS) to coordinate expression of virulence, tolerance towards a number of antimicrobial agents and shielding against the host defence system. Chemical biology approaches may allow for the development of new treatment strategies focusing on interference with cell to cell communication with the aim of primarily disabling expression of virulence, immune shielding and antibiotic tolerance. Here we present our experience with screening and testing small molecule chemistry for N-acyl homoserine lactone-dependent QS inhibition. In addition we present our thoughts with respect to advantages and potential limitations of the intervention strategies described.

AB - It is now evident that bacteria assume the biofilm mode of growth during chronic infections. The important hallmarks of biofilm infections are development of local inflammations, extreme tolerance to the action of conventional antimicrobial agents and an almost infinite capacity to evade the host defence systems in particular innate immunity. In the biofilm mode, bacteria use cell to cell communication termed quorum-sensing (QS) to coordinate expression of virulence, tolerance towards a number of antimicrobial agents and shielding against the host defence system. Chemical biology approaches may allow for the development of new treatment strategies focusing on interference with cell to cell communication with the aim of primarily disabling expression of virulence, immune shielding and antibiotic tolerance. Here we present our experience with screening and testing small molecule chemistry for N-acyl homoserine lactone-dependent QS inhibition. In addition we present our thoughts with respect to advantages and potential limitations of the intervention strategies described.

M3 - Book chapter

SN - 9781904455899

SP - 211

EP - 224

BT - Emerging trends in in antibacterial discovery.

A2 - Miller, A.A.

A2 - Miller, P.F.

PB - HorizonBioscience

CY - Norvich UK

ER -

ID: 36061823