Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort? / Bjarnsholt, Thomas; Givskov, M.

In: Current Infectious Disease Reports, Vol. 10, No. 1, 2008, p. 22-28.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bjarnsholt, T & Givskov, M 2008, 'Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?', Current Infectious Disease Reports, vol. 10, no. 1, pp. 22-28.

APA

Bjarnsholt, T., & Givskov, M. (2008). Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort? Current Infectious Disease Reports, 10(1), 22-28.

Vancouver

Bjarnsholt T, Givskov M. Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort? Current Infectious Disease Reports. 2008;10(1):22-28.

Author

Bjarnsholt, Thomas ; Givskov, M. / Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?. In: Current Infectious Disease Reports. 2008 ; Vol. 10, No. 1. pp. 22-28.

Bibtex

@article{e5563950fce011ddb219000ea68e967b,
title = "Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?",
abstract = "Bacterial resistance poses a major challenge to the development of new antimicrobial agents. Conventional antibiotics have an inherent obsolescence because they select for development of resistance. Bacterial infections have again become a serious threat in developed countries. Particularly, elderly, immunocompromised, and hospitalized patients are susceptible to infections caused by bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. These bacteria form chronic, biofilm-based infections, which are challenging because bacterial cells living as biofilms are more tolerant to antibiotics than their planktonic counterparts. Therefore, research should identify new antimicrobial agents and their corresponding targets to decrease the biofilm-forming capability or persistence of the infectious bacteria. Here, we review one such drug target: bacterial cell-to-cell communication systems, or quorum sensing.",
author = "Thomas Bjarnsholt and M. Givskov",
year = "2008",
language = "English",
volume = "10",
pages = "22--28",
journal = "Current Infectious Disease Reports",
issn = "1523-3847",
publisher = "Springer Healthcare",
number = "1",

}

RIS

TY - JOUR

T1 - Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?

AU - Bjarnsholt, Thomas

AU - Givskov, M.

PY - 2008

Y1 - 2008

N2 - Bacterial resistance poses a major challenge to the development of new antimicrobial agents. Conventional antibiotics have an inherent obsolescence because they select for development of resistance. Bacterial infections have again become a serious threat in developed countries. Particularly, elderly, immunocompromised, and hospitalized patients are susceptible to infections caused by bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. These bacteria form chronic, biofilm-based infections, which are challenging because bacterial cells living as biofilms are more tolerant to antibiotics than their planktonic counterparts. Therefore, research should identify new antimicrobial agents and their corresponding targets to decrease the biofilm-forming capability or persistence of the infectious bacteria. Here, we review one such drug target: bacterial cell-to-cell communication systems, or quorum sensing.

AB - Bacterial resistance poses a major challenge to the development of new antimicrobial agents. Conventional antibiotics have an inherent obsolescence because they select for development of resistance. Bacterial infections have again become a serious threat in developed countries. Particularly, elderly, immunocompromised, and hospitalized patients are susceptible to infections caused by bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. These bacteria form chronic, biofilm-based infections, which are challenging because bacterial cells living as biofilms are more tolerant to antibiotics than their planktonic counterparts. Therefore, research should identify new antimicrobial agents and their corresponding targets to decrease the biofilm-forming capability or persistence of the infectious bacteria. Here, we review one such drug target: bacterial cell-to-cell communication systems, or quorum sensing.

M3 - Journal article

C2 - 18377811

VL - 10

SP - 22

EP - 28

JO - Current Infectious Disease Reports

JF - Current Infectious Disease Reports

SN - 1523-3847

IS - 1

ER -

ID: 10613087