SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

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Standard

SAR study of 4-arylazo-3,5-diamino-1 : H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms. / Jansen, Charlotte U.; Uhd, Jesper; Andersen, Jens B.; Hultqvist, Louise D.; Jakobsen, Tim H.; Nilsson, Martin; Nielsen, Thomas E.; Givskov, Michael; Tolker-Nielsen, Tim; Qvortrup, Katrine M.

In: RSC Medicinal Chemistry, Vol. 12, No. 11, 2021, p. 1868-1878.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jansen, CU, Uhd, J, Andersen, JB, Hultqvist, LD, Jakobsen, TH, Nilsson, M, Nielsen, TE, Givskov, M, Tolker-Nielsen, T & Qvortrup, KM 2021, 'SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms', RSC Medicinal Chemistry, vol. 12, no. 11, pp. 1868-1878. https://doi.org/10.1039/d1md00275a

APA

Jansen, C. U., Uhd, J., Andersen, J. B., Hultqvist, L. D., Jakobsen, T. H., Nilsson, M., Nielsen, T. E., Givskov, M., Tolker-Nielsen, T., & Qvortrup, K. M. (2021). SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms. RSC Medicinal Chemistry, 12(11), 1868-1878. https://doi.org/10.1039/d1md00275a

Vancouver

Jansen CU, Uhd J, Andersen JB, Hultqvist LD, Jakobsen TH, Nilsson M et al. SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms. RSC Medicinal Chemistry. 2021;12(11):1868-1878. https://doi.org/10.1039/d1md00275a

Author

Jansen, Charlotte U. ; Uhd, Jesper ; Andersen, Jens B. ; Hultqvist, Louise D. ; Jakobsen, Tim H. ; Nilsson, Martin ; Nielsen, Thomas E. ; Givskov, Michael ; Tolker-Nielsen, Tim ; Qvortrup, Katrine M. / SAR study of 4-arylazo-3,5-diamino-1 : H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms. In: RSC Medicinal Chemistry. 2021 ; Vol. 12, No. 11. pp. 1868-1878.

Bibtex

@article{e52528c8a5344e32a5b2f718020c164c,
title = "SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms",
abstract = "By screening of a collection of 50 000 small-molecule compounds, we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of anti-biofilm agents. Here, we report a SAR study based on 60 analogues by examining ways in which the pharmacophore can be further optimized, for example, via substitutions in the aryl ring. The SAR study revealed the very potent anti-biofilm compound 4-(2-(2-fluorophenyl)hydrazineylidene)-5-imino-4,5-dihydro-1H-pyrazol-3-amine (2). This journal is ",
author = "Jansen, {Charlotte U.} and Jesper Uhd and Andersen, {Jens B.} and Hultqvist, {Louise D.} and Jakobsen, {Tim H.} and Martin Nilsson and Nielsen, {Thomas E.} and Michael Givskov and Tim Tolker-Nielsen and Qvortrup, {Katrine M.}",
note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",
year = "2021",
doi = "10.1039/d1md00275a",
language = "English",
volume = "12",
pages = "1868--1878",
journal = "RSC Medicinal Chemistry",
issn = "2040-2503",
publisher = "Royal Society of Chemistry",
number = "11",

}

RIS

TY - JOUR

T1 - SAR study of 4-arylazo-3,5-diamino-1

T2 - H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

AU - Jansen, Charlotte U.

AU - Uhd, Jesper

AU - Andersen, Jens B.

AU - Hultqvist, Louise D.

AU - Jakobsen, Tim H.

AU - Nilsson, Martin

AU - Nielsen, Thomas E.

AU - Givskov, Michael

AU - Tolker-Nielsen, Tim

AU - Qvortrup, Katrine M.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021

Y1 - 2021

N2 - By screening of a collection of 50 000 small-molecule compounds, we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of anti-biofilm agents. Here, we report a SAR study based on 60 analogues by examining ways in which the pharmacophore can be further optimized, for example, via substitutions in the aryl ring. The SAR study revealed the very potent anti-biofilm compound 4-(2-(2-fluorophenyl)hydrazineylidene)-5-imino-4,5-dihydro-1H-pyrazol-3-amine (2). This journal is

AB - By screening of a collection of 50 000 small-molecule compounds, we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of anti-biofilm agents. Here, we report a SAR study based on 60 analogues by examining ways in which the pharmacophore can be further optimized, for example, via substitutions in the aryl ring. The SAR study revealed the very potent anti-biofilm compound 4-(2-(2-fluorophenyl)hydrazineylidene)-5-imino-4,5-dihydro-1H-pyrazol-3-amine (2). This journal is

U2 - 10.1039/d1md00275a

DO - 10.1039/d1md00275a

M3 - Journal article

C2 - 34841247

AN - SCOPUS:85119990587

VL - 12

SP - 1868

EP - 1878

JO - RSC Medicinal Chemistry

JF - RSC Medicinal Chemistry

SN - 2040-2503

IS - 11

ER -

ID: 286631232