Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Self-assessed health status and associated mortality in endocarditis : secondary findings from the POET trial. / Bundgaard, Johan S.; Iversen, Kasper; Pries-Heje, Mia; Ihlemann, Nikolaj; Gill, Sabine U.; Madsen, Trine; Elming, Hanne; Povlsen, Jonas A.; Bruun, Niels E.; Høfsten, Dan E.; Fuursted, Kurt; Christensen, Jens J.; Schultz, Martin; Rosenvinge, Flemming; Helweg‑Larsen, Jannik; Køber, Lars; Torp‑Pedersen, Christian; Fosbøl, Emil L.; Tønder, Niels; Moser, Claus; Bundgaard, Henning; Mogensen, Ulrik M.

In: Quality of Life Research, 2022.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bundgaard, JS, Iversen, K, Pries-Heje, M, Ihlemann, N, Gill, SU, Madsen, T, Elming, H, Povlsen, JA, Bruun, NE, Høfsten, DE, Fuursted, K, Christensen, JJ, Schultz, M, Rosenvinge, F, Helweg‑Larsen, J, Køber, L, Torp‑Pedersen, C, Fosbøl, EL, Tønder, N, Moser, C, Bundgaard, H & Mogensen, UM 2022, 'Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial', Quality of Life Research. https://doi.org/10.1007/s11136-022-03126-x

APA

Bundgaard, J. S., Iversen, K., Pries-Heje, M., Ihlemann, N., Gill, S. U., Madsen, T., Elming, H., Povlsen, J. A., Bruun, N. E., Høfsten, D. E., Fuursted, K., Christensen, J. J., Schultz, M., Rosenvinge, F., Helweg‑Larsen, J., Køber, L., Torp‑Pedersen, C., Fosbøl, E. L., Tønder, N., ... Mogensen, U. M. (Accepted/In press). Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial. Quality of Life Research. https://doi.org/10.1007/s11136-022-03126-x

Vancouver

Bundgaard JS, Iversen K, Pries-Heje M, Ihlemann N, Gill SU, Madsen T et al. Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial. Quality of Life Research. 2022. https://doi.org/10.1007/s11136-022-03126-x

Author

Bundgaard, Johan S. ; Iversen, Kasper ; Pries-Heje, Mia ; Ihlemann, Nikolaj ; Gill, Sabine U. ; Madsen, Trine ; Elming, Hanne ; Povlsen, Jonas A. ; Bruun, Niels E. ; Høfsten, Dan E. ; Fuursted, Kurt ; Christensen, Jens J. ; Schultz, Martin ; Rosenvinge, Flemming ; Helweg‑Larsen, Jannik ; Køber, Lars ; Torp‑Pedersen, Christian ; Fosbøl, Emil L. ; Tønder, Niels ; Moser, Claus ; Bundgaard, Henning ; Mogensen, Ulrik M. / Self-assessed health status and associated mortality in endocarditis : secondary findings from the POET trial. In: Quality of Life Research. 2022.

Bibtex

@article{0f0bfbefe4b54bf988d59f65bebcbb9f,
title = "Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial",
abstract = "Purpose: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis. Methods: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model. Results: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4–34.8) and 5.4 (95% CI 4.1–7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7–7.0, p < 0.01). Conclusion: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257. Trial registry: POET ClinicalTrials.gov number, NCT01375257.",
keywords = "Cardiovascular disease, Endocarditis, Health status, Risk factor and mortality",
author = "Bundgaard, {Johan S.} and Kasper Iversen and Mia Pries-Heje and Nikolaj Ihlemann and Gill, {Sabine U.} and Trine Madsen and Hanne Elming and Povlsen, {Jonas A.} and Bruun, {Niels E.} and H{\o}fsten, {Dan E.} and Kurt Fuursted and Christensen, {Jens J.} and Martin Schultz and Flemming Rosenvinge and Jannik Helweg‑Larsen and Lars K{\o}ber and Christian Torp‑Pedersen and Fosb{\o}l, {Emil L.} and Niels T{\o}nder and Claus Moser and Henning Bundgaard and Mogensen, {Ulrik M.}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.",
year = "2022",
doi = "10.1007/s11136-022-03126-x",
language = "English",
journal = "Quality of Life Research",
issn = "0962-9343",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Self-assessed health status and associated mortality in endocarditis

T2 - secondary findings from the POET trial

AU - Bundgaard, Johan S.

AU - Iversen, Kasper

AU - Pries-Heje, Mia

AU - Ihlemann, Nikolaj

AU - Gill, Sabine U.

AU - Madsen, Trine

AU - Elming, Hanne

AU - Povlsen, Jonas A.

AU - Bruun, Niels E.

AU - Høfsten, Dan E.

AU - Fuursted, Kurt

AU - Christensen, Jens J.

AU - Schultz, Martin

AU - Rosenvinge, Flemming

AU - Helweg‑Larsen, Jannik

AU - Køber, Lars

AU - Torp‑Pedersen, Christian

AU - Fosbøl, Emil L.

AU - Tønder, Niels

AU - Moser, Claus

AU - Bundgaard, Henning

AU - Mogensen, Ulrik M.

N1 - Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

PY - 2022

Y1 - 2022

N2 - Purpose: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis. Methods: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model. Results: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4–34.8) and 5.4 (95% CI 4.1–7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7–7.0, p < 0.01). Conclusion: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257. Trial registry: POET ClinicalTrials.gov number, NCT01375257.

AB - Purpose: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis. Methods: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model. Results: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4–34.8) and 5.4 (95% CI 4.1–7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7–7.0, p < 0.01). Conclusion: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257. Trial registry: POET ClinicalTrials.gov number, NCT01375257.

KW - Cardiovascular disease

KW - Endocarditis

KW - Health status

KW - Risk factor and mortality

U2 - 10.1007/s11136-022-03126-x

DO - 10.1007/s11136-022-03126-x

M3 - Journal article

C2 - 35349038

AN - SCOPUS:85127304001

JO - Quality of Life Research

JF - Quality of Life Research

SN - 0962-9343

ER -

ID: 305716105