Silver against Pseudomonas aeruginosa biofilms

Research output: Contribution to journalJournal articlepeer-review

Standard

Silver against Pseudomonas aeruginosa biofilms. / Bjarnsholt, Thomas; Kirketerp-Møller, Klaus; Kristiansen, Søren; Phipps, Richard; Nielsen, Anne Kirstine; Jensen, Peter Østrup; Høiby, Niels; Givskov, Michael.

In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 115, No. 8, 2007, p. 921-8.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bjarnsholt, T, Kirketerp-Møller, K, Kristiansen, S, Phipps, R, Nielsen, AK, Jensen, PØ, Høiby, N & Givskov, M 2007, 'Silver against Pseudomonas aeruginosa biofilms', Acta Pathologica Microbiologica et Immunologica Scandinavica, vol. 115, no. 8, pp. 921-8. https://doi.org/10.1111/j.1600-0463.2007.apm_646.x

APA

Bjarnsholt, T., Kirketerp-Møller, K., Kristiansen, S., Phipps, R., Nielsen, A. K., Jensen, P. Ø., Høiby, N., & Givskov, M. (2007). Silver against Pseudomonas aeruginosa biofilms. Acta Pathologica Microbiologica et Immunologica Scandinavica, 115(8), 921-8. https://doi.org/10.1111/j.1600-0463.2007.apm_646.x

Vancouver

Bjarnsholt T, Kirketerp-Møller K, Kristiansen S, Phipps R, Nielsen AK, Jensen PØ et al. Silver against Pseudomonas aeruginosa biofilms. Acta Pathologica Microbiologica et Immunologica Scandinavica. 2007;115(8):921-8. https://doi.org/10.1111/j.1600-0463.2007.apm_646.x

Author

Bjarnsholt, Thomas ; Kirketerp-Møller, Klaus ; Kristiansen, Søren ; Phipps, Richard ; Nielsen, Anne Kirstine ; Jensen, Peter Østrup ; Høiby, Niels ; Givskov, Michael. / Silver against Pseudomonas aeruginosa biofilms. In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 2007 ; Vol. 115, No. 8. pp. 921-8.

Bibtex

@article{e0082cf0daa711df825b000ea68e967b,
title = "Silver against Pseudomonas aeruginosa biofilms",
abstract = "Silver has been recognized for its antimicrobial properties for centuries. Most studies on the antibacterial efficacy of silver, with particular emphasis on wound healing, have been performed on planktonic bacteria. Our recent studies, however, strongly suggest that colonization of wounds involves bacteria in both the planktonic and biofilm modes of growth. The action of silver on mature in vitro biofilms of Pseudomonas aeruginosa, a primary pathogen of chronic infected wounds, was investigated. The results show that silver is very effective against mature biofilms of P. aeruginosa, but that the silver concentration is important. A concentration of 5-10 mug/mL silver sulfadiazine eradicated the biofilm whereas a lower concentration (1 mug/mL) had no effect. The bactericidal concentration of silver required to eradicate the bacterial biofilm was 10-100 times higher than that used to eradicate planktonic bacteria. These observations strongly indicate that the concentration of silver in currently available wound dressings is much too low for treatment of chronic biofilm wounds. It is suggested that clinicians and manufacturers of the said wound dressings consider whether they are treating wounds primarily colonized either by biofilm-forming or planktonic bacteria.",
author = "Thomas Bjarnsholt and Klaus Kirketerp-M{\o}ller and S{\o}ren Kristiansen and Richard Phipps and Nielsen, {Anne Kirstine} and Jensen, {Peter {\O}strup} and Niels H{\o}iby and Michael Givskov",
note = "Keywords: Biofilms; Pseudomonas aeruginosa; Quorum Sensing; Silver; Silver Sulfadiazine",
year = "2007",
doi = "10.1111/j.1600-0463.2007.apm_646.x",
language = "English",
volume = "115",
pages = "921--8",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "8",

}

RIS

TY - JOUR

T1 - Silver against Pseudomonas aeruginosa biofilms

AU - Bjarnsholt, Thomas

AU - Kirketerp-Møller, Klaus

AU - Kristiansen, Søren

AU - Phipps, Richard

AU - Nielsen, Anne Kirstine

AU - Jensen, Peter Østrup

AU - Høiby, Niels

AU - Givskov, Michael

N1 - Keywords: Biofilms; Pseudomonas aeruginosa; Quorum Sensing; Silver; Silver Sulfadiazine

PY - 2007

Y1 - 2007

N2 - Silver has been recognized for its antimicrobial properties for centuries. Most studies on the antibacterial efficacy of silver, with particular emphasis on wound healing, have been performed on planktonic bacteria. Our recent studies, however, strongly suggest that colonization of wounds involves bacteria in both the planktonic and biofilm modes of growth. The action of silver on mature in vitro biofilms of Pseudomonas aeruginosa, a primary pathogen of chronic infected wounds, was investigated. The results show that silver is very effective against mature biofilms of P. aeruginosa, but that the silver concentration is important. A concentration of 5-10 mug/mL silver sulfadiazine eradicated the biofilm whereas a lower concentration (1 mug/mL) had no effect. The bactericidal concentration of silver required to eradicate the bacterial biofilm was 10-100 times higher than that used to eradicate planktonic bacteria. These observations strongly indicate that the concentration of silver in currently available wound dressings is much too low for treatment of chronic biofilm wounds. It is suggested that clinicians and manufacturers of the said wound dressings consider whether they are treating wounds primarily colonized either by biofilm-forming or planktonic bacteria.

AB - Silver has been recognized for its antimicrobial properties for centuries. Most studies on the antibacterial efficacy of silver, with particular emphasis on wound healing, have been performed on planktonic bacteria. Our recent studies, however, strongly suggest that colonization of wounds involves bacteria in both the planktonic and biofilm modes of growth. The action of silver on mature in vitro biofilms of Pseudomonas aeruginosa, a primary pathogen of chronic infected wounds, was investigated. The results show that silver is very effective against mature biofilms of P. aeruginosa, but that the silver concentration is important. A concentration of 5-10 mug/mL silver sulfadiazine eradicated the biofilm whereas a lower concentration (1 mug/mL) had no effect. The bactericidal concentration of silver required to eradicate the bacterial biofilm was 10-100 times higher than that used to eradicate planktonic bacteria. These observations strongly indicate that the concentration of silver in currently available wound dressings is much too low for treatment of chronic biofilm wounds. It is suggested that clinicians and manufacturers of the said wound dressings consider whether they are treating wounds primarily colonized either by biofilm-forming or planktonic bacteria.

U2 - 10.1111/j.1600-0463.2007.apm_646.x

DO - 10.1111/j.1600-0463.2007.apm_646.x

M3 - Journal article

C2 - 17696948

VL - 115

SP - 921

EP - 928

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 8

ER -

ID: 22568628