Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice
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Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice. / Petersen, Anne; Heegaard, Peter M.H.; Pedersen, Anna L.; Andersen, Jens Bo; Sørensen, Rikke B.; Frøkiær, Hanne; Lahtinen, Sampo J.; Ouwehand, Arthur C.; Poulsen, Morten; Licht, Tine Rask.
In: BMC Microbiology, Vol. 9, No. 245, 2009, p. 245.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice
AU - Petersen, Anne
AU - Heegaard, Peter M.H.
AU - Pedersen, Anna L.
AU - Andersen, Jens Bo
AU - Sørensen, Rikke B.
AU - Frøkiær, Hanne
AU - Lahtinen, Sampo J.
AU - Ouwehand, Arthur C.
AU - Poulsen, Morten
AU - Licht, Tine Rask
PY - 2009
Y1 - 2009
N2 - Prebiotics are non-digestible food ingredients believed to beneficially affect host health by selectively stimulating the growth of the beneficial bacteria residing in the gut. Such beneficial bacteria have been reported to protect against pathogenic infections. However, contradicting results on prevention of Salmonella infections with prebiotics have been published. The aim of the present study was to examine whether S. Typhimurium SL1344 infection in mice could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles. BALB/c mice were fed a diet containing 10% of either of the following carbohydrates: inulin, fructo-oligosaccharide, xylo-oligosaccharide, galacto-oligosaccharide, apple pectin, polydextrose or beta-glucan for three weeks prior to oral Salmonella challenge (107 CFU) and compared to mice fed a cornstarch-based control diet.
AB - Prebiotics are non-digestible food ingredients believed to beneficially affect host health by selectively stimulating the growth of the beneficial bacteria residing in the gut. Such beneficial bacteria have been reported to protect against pathogenic infections. However, contradicting results on prevention of Salmonella infections with prebiotics have been published. The aim of the present study was to examine whether S. Typhimurium SL1344 infection in mice could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles. BALB/c mice were fed a diet containing 10% of either of the following carbohydrates: inulin, fructo-oligosaccharide, xylo-oligosaccharide, galacto-oligosaccharide, apple pectin, polydextrose or beta-glucan for three weeks prior to oral Salmonella challenge (107 CFU) and compared to mice fed a cornstarch-based control diet.
KW - Animals
KW - Body Weight
KW - Cecum
KW - Dietary Carbohydrates
KW - Feces
KW - Fermentation
KW - Haptoglobins
KW - Hydrogen-Ion Concentration
KW - Mice
KW - Mice, Inbred BALB C
KW - Prebiotics
KW - Salmonella Infections
KW - Salmonella typhimurium
KW - Spleen
U2 - 10.1186/1471-2180-9-245
DO - 10.1186/1471-2180-9-245
M3 - Journal article
C2 - 19948011
VL - 9
SP - 245
JO - BMC Microbiology
JF - BMC Microbiology
SN - 1471-2180
IS - 245
ER -
ID: 17527633