The consequences of being in an infectious biofilm – microenvironmental conditions governing antibiotic tolerance

Research output: Contribution to journalReviewpeer-review

Standard

The consequences of being in an infectious biofilm – microenvironmental conditions governing antibiotic tolerance. / Sønderholm, Majken; Bjarnsholt, Thomas; Alhede, Maria; Kolpen, Mette; Jensen, Peter Østrup; Kühl, Michael; Kragh, Kasper Nørskov.

In: International Journal of Molecular Sciences, Vol. 18, No. 12, 2688, 2017.

Research output: Contribution to journalReviewpeer-review

Harvard

Sønderholm, M, Bjarnsholt, T, Alhede, M, Kolpen, M, Jensen, PØ, Kühl, M & Kragh, KN 2017, 'The consequences of being in an infectious biofilm – microenvironmental conditions governing antibiotic tolerance', International Journal of Molecular Sciences, vol. 18, no. 12, 2688. https://doi.org/10.3390/ijms18122688

APA

Sønderholm, M., Bjarnsholt, T., Alhede, M., Kolpen, M., Jensen, P. Ø., Kühl, M., & Kragh, K. N. (2017). The consequences of being in an infectious biofilm – microenvironmental conditions governing antibiotic tolerance. International Journal of Molecular Sciences, 18(12), [2688]. https://doi.org/10.3390/ijms18122688

Vancouver

Sønderholm M, Bjarnsholt T, Alhede M, Kolpen M, Jensen PØ, Kühl M et al. The consequences of being in an infectious biofilm – microenvironmental conditions governing antibiotic tolerance. International Journal of Molecular Sciences. 2017;18(12). 2688. https://doi.org/10.3390/ijms18122688

Author

Sønderholm, Majken ; Bjarnsholt, Thomas ; Alhede, Maria ; Kolpen, Mette ; Jensen, Peter Østrup ; Kühl, Michael ; Kragh, Kasper Nørskov. / The consequences of being in an infectious biofilm – microenvironmental conditions governing antibiotic tolerance. In: International Journal of Molecular Sciences. 2017 ; Vol. 18, No. 12.

Bibtex

@article{95eff88426e44210be8fcead7787f6bf,
title = "The consequences of being in an infectious biofilm – microenvironmental conditions governing antibiotic tolerance",
abstract = "The main driver behind biofilm research is the desire to understand the mechanisms governing the antibiotic tolerance of biofilm-growing bacteria found in chronic bacterial infections. Rather than genetic traits, several physical and chemical traits of the biofilm have been shown to be attributable to antibiotic tolerance. During infection, bacteria in biofilms exhibit slow growth and a low metabolic state due to O2 limitation imposed by intense O2 consumption of polymorphonuclear leukocytes or metabolically active bacteria in the biofilm periphery. Due to variable O2 availability throughout the infection, pathogen growth can involve aerobic, microaerobic and anaerobic metabolism. This has serious implications for the antibiotic treatment of infections (e.g., in chronic wounds or in the chronic lung infection of cystic fibrosis patients), as antibiotics are usually optimized for aerobic, fast-growing bacteria. This review summarizes knowledge about the links between the microenvironment of biofilms in chronic infections and their tolerance against antibiotics",
author = "Majken S{\o}nderholm and Thomas Bjarnsholt and Maria Alhede and Mette Kolpen and Jensen, {Peter {\O}strup} and Michael K{\"u}hl and Kragh, {Kasper N{\o}rskov}",
year = "2017",
doi = "10.3390/ijms18122688",
language = "English",
volume = "18",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "12",

}

RIS

TY - JOUR

T1 - The consequences of being in an infectious biofilm – microenvironmental conditions governing antibiotic tolerance

AU - Sønderholm, Majken

AU - Bjarnsholt, Thomas

AU - Alhede, Maria

AU - Kolpen, Mette

AU - Jensen, Peter Østrup

AU - Kühl, Michael

AU - Kragh, Kasper Nørskov

PY - 2017

Y1 - 2017

N2 - The main driver behind biofilm research is the desire to understand the mechanisms governing the antibiotic tolerance of biofilm-growing bacteria found in chronic bacterial infections. Rather than genetic traits, several physical and chemical traits of the biofilm have been shown to be attributable to antibiotic tolerance. During infection, bacteria in biofilms exhibit slow growth and a low metabolic state due to O2 limitation imposed by intense O2 consumption of polymorphonuclear leukocytes or metabolically active bacteria in the biofilm periphery. Due to variable O2 availability throughout the infection, pathogen growth can involve aerobic, microaerobic and anaerobic metabolism. This has serious implications for the antibiotic treatment of infections (e.g., in chronic wounds or in the chronic lung infection of cystic fibrosis patients), as antibiotics are usually optimized for aerobic, fast-growing bacteria. This review summarizes knowledge about the links between the microenvironment of biofilms in chronic infections and their tolerance against antibiotics

AB - The main driver behind biofilm research is the desire to understand the mechanisms governing the antibiotic tolerance of biofilm-growing bacteria found in chronic bacterial infections. Rather than genetic traits, several physical and chemical traits of the biofilm have been shown to be attributable to antibiotic tolerance. During infection, bacteria in biofilms exhibit slow growth and a low metabolic state due to O2 limitation imposed by intense O2 consumption of polymorphonuclear leukocytes or metabolically active bacteria in the biofilm periphery. Due to variable O2 availability throughout the infection, pathogen growth can involve aerobic, microaerobic and anaerobic metabolism. This has serious implications for the antibiotic treatment of infections (e.g., in chronic wounds or in the chronic lung infection of cystic fibrosis patients), as antibiotics are usually optimized for aerobic, fast-growing bacteria. This review summarizes knowledge about the links between the microenvironment of biofilms in chronic infections and their tolerance against antibiotics

U2 - 10.3390/ijms18122688

DO - 10.3390/ijms18122688

M3 - Review

C2 - 29231866

VL - 18

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 12

M1 - 2688

ER -

ID: 186687694