The in vivo biofilm

Research output: Contribution to journal › Review › Research › peer-review

Standard

The in vivo biofilm. / Bjarnsholt, Thomas; Alhede, Maria; Alhede, Morten; Eickhardt-Sørensen, Steffen R; Moser, Claus; Kühl, Michael; Jensen, Peter Østrup; Høiby, Niels.

In: Trends in Microbiology, Vol. 21, No. 9, 2013, p. 466-474.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Bjarnsholt, T, Alhede, M, Alhede, M, Eickhardt-Sørensen, SR, Moser, C, Kühl, M, Jensen, PØ & Høiby, N 2013, 'The in vivo biofilm', Trends in Microbiology, vol. 21, no. 9, pp. 466-474. https://doi.org/10.1016/j.tim.2013.06.002

APA

Bjarnsholt, T., Alhede, M., Alhede, M., Eickhardt-Sørensen, S. R., Moser, C., Kühl, M., Jensen, P. Ø., & Høiby, N. (2013). The in vivo biofilm. Trends in Microbiology, 21(9), 466-474. https://doi.org/10.1016/j.tim.2013.06.002

Vancouver

Bjarnsholt T, Alhede M, Alhede M, Eickhardt-Sørensen SR, Moser C, Kühl M et al. The in vivo biofilm. Trends in Microbiology. 2013;21(9):466-474. https://doi.org/10.1016/j.tim.2013.06.002

Author

Bjarnsholt, Thomas ; Alhede, Maria ; Alhede, Morten ; Eickhardt-Sørensen, Steffen R ; Moser, Claus ; Kühl, Michael ; Jensen, Peter Østrup ; Høiby, Niels. / The in vivo biofilm. In: Trends in Microbiology. 2013 ; Vol. 21, No. 9. pp. 466-474.

Bibtex

@article{4e678fc9f0ed4e0f8d935415a9c8d512,
title = "The in vivo biofilm",
abstract = "Bacteria can grow and proliferate either as single, independent cells or organized in aggregates commonly referred to as biofilms. When bacteria succeed in forming a biofilm within the human host, the infection often becomes very resistant to treatment and can develop into a chronic state. Biofilms have been studied for decades using various in vitro models, but it remains debatable whether such in vitro biofilms actually resemble in vivo biofilms in chronic infections. In vivo biofilms share several structural characteristics that differ from most in vitro biofilms. Additionally, the in vivo experimental time span and presence of host defenses differ from chronic infections and the chemical microenvironment of both in vivo and in vitro biofilms is seldom taken into account. In this review, we discuss why the current in vitro models of biofilms might be limited for describing infectious biofilms, and we suggest new strategies for improving this discrepancy.",
author = "Thomas Bjarnsholt and Maria Alhede and Morten Alhede and Eickhardt-S{\o}rensen, {Steffen R} and Claus Moser and Michael K{\"u}hl and Jensen, {Peter {\O}strup} and Niels H{\o}iby",
note = "Copyright {\textcopyright} 2013 Elsevier Ltd. All rights reserved.",
year = "2013",
doi = "10.1016/j.tim.2013.06.002",
language = "English",
volume = "21",
pages = "466--474",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Ltd. * Trends Journals",
number = "9",

}

RIS

TY - JOUR

T1 - The in vivo biofilm

AU - Bjarnsholt, Thomas

AU - Alhede, Maria

AU - Alhede, Morten

AU - Eickhardt-Sørensen, Steffen R

AU - Moser, Claus

AU - Kühl, Michael

AU - Jensen, Peter Østrup

AU - Høiby, Niels

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2013

Y1 - 2013

N2 - Bacteria can grow and proliferate either as single, independent cells or organized in aggregates commonly referred to as biofilms. When bacteria succeed in forming a biofilm within the human host, the infection often becomes very resistant to treatment and can develop into a chronic state. Biofilms have been studied for decades using various in vitro models, but it remains debatable whether such in vitro biofilms actually resemble in vivo biofilms in chronic infections. In vivo biofilms share several structural characteristics that differ from most in vitro biofilms. Additionally, the in vivo experimental time span and presence of host defenses differ from chronic infections and the chemical microenvironment of both in vivo and in vitro biofilms is seldom taken into account. In this review, we discuss why the current in vitro models of biofilms might be limited for describing infectious biofilms, and we suggest new strategies for improving this discrepancy.

AB - Bacteria can grow and proliferate either as single, independent cells or organized in aggregates commonly referred to as biofilms. When bacteria succeed in forming a biofilm within the human host, the infection often becomes very resistant to treatment and can develop into a chronic state. Biofilms have been studied for decades using various in vitro models, but it remains debatable whether such in vitro biofilms actually resemble in vivo biofilms in chronic infections. In vivo biofilms share several structural characteristics that differ from most in vitro biofilms. Additionally, the in vivo experimental time span and presence of host defenses differ from chronic infections and the chemical microenvironment of both in vivo and in vitro biofilms is seldom taken into account. In this review, we discuss why the current in vitro models of biofilms might be limited for describing infectious biofilms, and we suggest new strategies for improving this discrepancy.

U2 - 10.1016/j.tim.2013.06.002

DO - 10.1016/j.tim.2013.06.002

M3 - Review

C2 - 23827084

VL - 21

SP - 466

EP - 474

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 9

ER -

ID: 45102202