The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data

Research output: Contribution to journal › Review › Research › peer-review

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The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data. / Malone, M.; Bjarnsholt, T.; McBain, A. J.; James, G. A.; Stoodley, P.; Leaper, D.; Tachi, M.; Schultz, G.; Swanson, T.; Wolcott, R. D.

In: Journal of Wound Care, Vol. 26, No. 1, 01.2017, p. 20-25.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Malone, M, Bjarnsholt, T, McBain, AJ, James, GA, Stoodley, P, Leaper, D, Tachi, M, Schultz, G, Swanson, T & Wolcott, RD 2017, 'The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data', Journal of Wound Care, vol. 26, no. 1, pp. 20-25. https://doi.org/10.12968/jowc.2017.26.1.20

APA

Malone, M., Bjarnsholt, T., McBain, A. J., James, G. A., Stoodley, P., Leaper, D., Tachi, M., Schultz, G., Swanson, T., & Wolcott, R. D. (2017). The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data. Journal of Wound Care, 26(1), 20-25. https://doi.org/10.12968/jowc.2017.26.1.20

Vancouver

Malone M, Bjarnsholt T, McBain AJ, James GA, Stoodley P, Leaper D et al. The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data. Journal of Wound Care. 2017 Jan;26(1):20-25. https://doi.org/10.12968/jowc.2017.26.1.20

Author

Malone, M. ; Bjarnsholt, T. ; McBain, A. J. ; James, G. A. ; Stoodley, P. ; Leaper, D. ; Tachi, M. ; Schultz, G. ; Swanson, T. ; Wolcott, R. D. / The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data. In: Journal of Wound Care. 2017 ; Vol. 26, No. 1. pp. 20-25.

Bibtex

@article{16f283776bd8494b9a34364929b8e678,
title = "The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data",
abstract = "The presence of biofilms in chronic non-healing wounds, has been identified through in vitro model and in vivo animal data. However, human chronic wound studies are under-represented and generally report low sample sizes. For this reason we sought to ascertain the prevalence of biofilms in human chronic wounds by undertaking a systematic review and meta-analysis. Our initial search identified 554 studies from the literature databases (Cochrane Library, Embase, Medline). After removal of duplicates, and those not meeting the requirements of inclusion, nine studies involving 185 chronic wounds met the inclusion criteria. Prevalence of biofilms in chronic wounds was 78.2 % (confidence interval [CI 61.6–89, p<0.002]). The results of our meta-analysis support our clinical assumptions that biofilms are ubiquitous in human chronic non-healing wounds.",
keywords = "biofilm, systematic review, wound healing, infection, non-healing",
author = "M. Malone and T. Bjarnsholt and McBain, {A. J.} and James, {G. A.} and P. Stoodley and D. Leaper and M. Tachi and G. Schultz and T. Swanson and Wolcott, {R. D.}",
year = "2017",
month = jan,
doi = "10.12968/jowc.2017.26.1.20",
language = "English",
volume = "26",
pages = "20--25",
journal = "Journal of wound care",
issn = "0969-0700",
publisher = "Mark Allen Group",
number = "1",

}

RIS

TY - JOUR

T1 - The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data

AU - Malone, M.

AU - Bjarnsholt, T.

AU - McBain, A. J.

AU - James, G. A.

AU - Stoodley, P.

AU - Leaper, D.

AU - Tachi, M.

AU - Schultz, G.

AU - Swanson, T.

AU - Wolcott, R. D.

PY - 2017/1

Y1 - 2017/1

N2 - The presence of biofilms in chronic non-healing wounds, has been identified through in vitro model and in vivo animal data. However, human chronic wound studies are under-represented and generally report low sample sizes. For this reason we sought to ascertain the prevalence of biofilms in human chronic wounds by undertaking a systematic review and meta-analysis. Our initial search identified 554 studies from the literature databases (Cochrane Library, Embase, Medline). After removal of duplicates, and those not meeting the requirements of inclusion, nine studies involving 185 chronic wounds met the inclusion criteria. Prevalence of biofilms in chronic wounds was 78.2 % (confidence interval [CI 61.6–89, p<0.002]). The results of our meta-analysis support our clinical assumptions that biofilms are ubiquitous in human chronic non-healing wounds.

AB - The presence of biofilms in chronic non-healing wounds, has been identified through in vitro model and in vivo animal data. However, human chronic wound studies are under-represented and generally report low sample sizes. For this reason we sought to ascertain the prevalence of biofilms in human chronic wounds by undertaking a systematic review and meta-analysis. Our initial search identified 554 studies from the literature databases (Cochrane Library, Embase, Medline). After removal of duplicates, and those not meeting the requirements of inclusion, nine studies involving 185 chronic wounds met the inclusion criteria. Prevalence of biofilms in chronic wounds was 78.2 % (confidence interval [CI 61.6–89, p<0.002]). The results of our meta-analysis support our clinical assumptions that biofilms are ubiquitous in human chronic non-healing wounds.

KW - biofilm

KW - systematic review

KW - wound healing

KW - infection

KW - non-healing

U2 - 10.12968/jowc.2017.26.1.20

DO - 10.12968/jowc.2017.26.1.20

M3 - Review

C2 - 28103163

VL - 26

SP - 20

EP - 25

JO - Journal of wound care

JF - Journal of wound care

SN - 0969-0700

IS - 1

ER -

ID: 173506127