The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa. / Bjarnsholt, Thomas; Givskov, Michael.

In: Analytical and Bioanalytical Chemistry, Vol. 387, No. 2, 2006, p. 409-14.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bjarnsholt, T & Givskov, M 2006, 'The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa', Analytical and Bioanalytical Chemistry, vol. 387, no. 2, pp. 409-14. https://doi.org/10.1007/s00216-006-0774-x

APA

Bjarnsholt, T., & Givskov, M. (2006). The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa. Analytical and Bioanalytical Chemistry, 387(2), 409-14. https://doi.org/10.1007/s00216-006-0774-x

Vancouver

Bjarnsholt T, Givskov M. The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa. Analytical and Bioanalytical Chemistry. 2006;387(2):409-14. https://doi.org/10.1007/s00216-006-0774-x

Author

Bjarnsholt, Thomas ; Givskov, Michael. / The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa. In: Analytical and Bioanalytical Chemistry. 2006 ; Vol. 387, No. 2. pp. 409-14.

Bibtex

@article{142e96c0fce911ddb219000ea68e967b,
title = "The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa",
abstract = "Recent decades have revealed that many bacterial species are capable of communicating with each other, and this observation has been largely responsible for a paradigm shift in microbiology. Whereas it was previously believed that bacteria lived as individual cells, it is now acknowledged that bacteria preferentially live in communities in the form of primitive organisms in which the behavior of individual cells is coordinated by cell-cell communication, known as quorum sensing (QS). Bacteria use QS for regulation of the processes involved in their interaction with each other, their environment, and, particularly, higher organisms We have focused on Pseudomonas aeruginosa, an opportunistic pathogen producing more than 30 QS-regulated virulence factors. P. aeruginosa causes several types of nosocomial infection, and lung infection in cystic fibrosis (CF) patients. We review the role of QS in the protective mechanisms of P. aeruginosa and show how disruption of the QS can be used as an approach to control this cunning aggressor.",
author = "Thomas Bjarnsholt and Michael Givskov",
note = "Keywords: Animals; Bacterial Physiological Phenomena; Humans; Pseudomonas Infections; Pseudomonas aeruginosa; Quorum Sensing; Virulence",
year = "2006",
doi = "10.1007/s00216-006-0774-x",
language = "English",
volume = "387",
pages = "409--14",
journal = "Analytical and Bioanalytical Chemistry",
issn = "1618-2642",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa

AU - Bjarnsholt, Thomas

AU - Givskov, Michael

N1 - Keywords: Animals; Bacterial Physiological Phenomena; Humans; Pseudomonas Infections; Pseudomonas aeruginosa; Quorum Sensing; Virulence

PY - 2006

Y1 - 2006

N2 - Recent decades have revealed that many bacterial species are capable of communicating with each other, and this observation has been largely responsible for a paradigm shift in microbiology. Whereas it was previously believed that bacteria lived as individual cells, it is now acknowledged that bacteria preferentially live in communities in the form of primitive organisms in which the behavior of individual cells is coordinated by cell-cell communication, known as quorum sensing (QS). Bacteria use QS for regulation of the processes involved in their interaction with each other, their environment, and, particularly, higher organisms We have focused on Pseudomonas aeruginosa, an opportunistic pathogen producing more than 30 QS-regulated virulence factors. P. aeruginosa causes several types of nosocomial infection, and lung infection in cystic fibrosis (CF) patients. We review the role of QS in the protective mechanisms of P. aeruginosa and show how disruption of the QS can be used as an approach to control this cunning aggressor.

AB - Recent decades have revealed that many bacterial species are capable of communicating with each other, and this observation has been largely responsible for a paradigm shift in microbiology. Whereas it was previously believed that bacteria lived as individual cells, it is now acknowledged that bacteria preferentially live in communities in the form of primitive organisms in which the behavior of individual cells is coordinated by cell-cell communication, known as quorum sensing (QS). Bacteria use QS for regulation of the processes involved in their interaction with each other, their environment, and, particularly, higher organisms We have focused on Pseudomonas aeruginosa, an opportunistic pathogen producing more than 30 QS-regulated virulence factors. P. aeruginosa causes several types of nosocomial infection, and lung infection in cystic fibrosis (CF) patients. We review the role of QS in the protective mechanisms of P. aeruginosa and show how disruption of the QS can be used as an approach to control this cunning aggressor.

U2 - 10.1007/s00216-006-0774-x

DO - 10.1007/s00216-006-0774-x

M3 - Journal article

C2 - 17019573

VL - 387

SP - 409

EP - 414

JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

SN - 1618-2642

IS - 2

ER -

ID: 10613997