The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment

Research output: Contribution to journalJournal articlepeer-review

Standard

The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment. / Lichtenberg, Mads; Jakobsen, Tim Holm; Kühl, Michael; Kolpen, Mette; Jensen, Peter Østrup; Bjarnsholt, Thomas.

In: FEMS Microbiology Reviews, Vol. 46, No. 5, fuac018, 2022.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Lichtenberg, M, Jakobsen, TH, Kühl, M, Kolpen, M, Jensen, PØ & Bjarnsholt, T 2022, 'The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment', FEMS Microbiology Reviews, vol. 46, no. 5, fuac018. https://doi.org/10.1093/femsre/fuac018

APA

Lichtenberg, M., Jakobsen, T. H., Kühl, M., Kolpen, M., Jensen, P. Ø., & Bjarnsholt, T. (2022). The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment. FEMS Microbiology Reviews, 46(5), [fuac018]. https://doi.org/10.1093/femsre/fuac018

Vancouver

Lichtenberg M, Jakobsen TH, Kühl M, Kolpen M, Jensen PØ, Bjarnsholt T. The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment. FEMS Microbiology Reviews. 2022;46(5). fuac018. https://doi.org/10.1093/femsre/fuac018

Author

Lichtenberg, Mads ; Jakobsen, Tim Holm ; Kühl, Michael ; Kolpen, Mette ; Jensen, Peter Østrup ; Bjarnsholt, Thomas. / The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment. In: FEMS Microbiology Reviews. 2022 ; Vol. 46, No. 5.

Bibtex

@article{95f7f51667d34fd08342d76aad2f2736,
title = "The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment",
abstract = "Pseudomonas aeruginosa is a human pathogen associated with both acute and chronic infections. While intensively studied, the basic mechanisms enabling the long-term survival of P. aeruginosa in the host, despite massive immune system attack and heavy antimicrobial treatment, remain to be identified. We argue that such infections may represent niche invasions by P. aeruginosa that influence the microenvironment by depleting host-derived substrate and activating the immune response. Bacteria embedded in cell aggregates establish a microenvironmental niche, where they endure the initial host response by slowing down their metabolism. This provides stable, lasting growth conditions with a constant, albeit slow supply of substrate and electron acceptors. Under such stable conditions, P. aeruginosa exhibits distinct adaptive traits, where its gene expression pattern reflects a life exposed to continuous attack by the host immune system and antimicrobials. Here, we review fundamental microenvironmental aspects of chronic P. aeruginosa infections and examine how their structural organization influences their in vivo microenvironment, which in turn affects the interaction of P. aeruginosa biofilm aggregates with the host immune system. We discuss how improving our knowledge about the microenvironmental ecology of P. aeruginosa in chronic infections can be used to combat persistent, hard-to-treat bacterial infections.",
keywords = "biofilm, chronic infections, host–pathogen interactions, immune response, microenvironment, quorum sensing",
author = "Mads Lichtenberg and Jakobsen, {Tim Holm} and Michael K{\"u}hl and Mette Kolpen and Jensen, {Peter {\O}strup} and Thomas Bjarnsholt",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.",
year = "2022",
doi = "10.1093/femsre/fuac018",
language = "English",
volume = "46",
journal = "F E M S Microbiology Reviews",
issn = "0168-6445",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment

AU - Lichtenberg, Mads

AU - Jakobsen, Tim Holm

AU - Kühl, Michael

AU - Kolpen, Mette

AU - Jensen, Peter Østrup

AU - Bjarnsholt, Thomas

N1 - Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.

PY - 2022

Y1 - 2022

N2 - Pseudomonas aeruginosa is a human pathogen associated with both acute and chronic infections. While intensively studied, the basic mechanisms enabling the long-term survival of P. aeruginosa in the host, despite massive immune system attack and heavy antimicrobial treatment, remain to be identified. We argue that such infections may represent niche invasions by P. aeruginosa that influence the microenvironment by depleting host-derived substrate and activating the immune response. Bacteria embedded in cell aggregates establish a microenvironmental niche, where they endure the initial host response by slowing down their metabolism. This provides stable, lasting growth conditions with a constant, albeit slow supply of substrate and electron acceptors. Under such stable conditions, P. aeruginosa exhibits distinct adaptive traits, where its gene expression pattern reflects a life exposed to continuous attack by the host immune system and antimicrobials. Here, we review fundamental microenvironmental aspects of chronic P. aeruginosa infections and examine how their structural organization influences their in vivo microenvironment, which in turn affects the interaction of P. aeruginosa biofilm aggregates with the host immune system. We discuss how improving our knowledge about the microenvironmental ecology of P. aeruginosa in chronic infections can be used to combat persistent, hard-to-treat bacterial infections.

AB - Pseudomonas aeruginosa is a human pathogen associated with both acute and chronic infections. While intensively studied, the basic mechanisms enabling the long-term survival of P. aeruginosa in the host, despite massive immune system attack and heavy antimicrobial treatment, remain to be identified. We argue that such infections may represent niche invasions by P. aeruginosa that influence the microenvironment by depleting host-derived substrate and activating the immune response. Bacteria embedded in cell aggregates establish a microenvironmental niche, where they endure the initial host response by slowing down their metabolism. This provides stable, lasting growth conditions with a constant, albeit slow supply of substrate and electron acceptors. Under such stable conditions, P. aeruginosa exhibits distinct adaptive traits, where its gene expression pattern reflects a life exposed to continuous attack by the host immune system and antimicrobials. Here, we review fundamental microenvironmental aspects of chronic P. aeruginosa infections and examine how their structural organization influences their in vivo microenvironment, which in turn affects the interaction of P. aeruginosa biofilm aggregates with the host immune system. We discuss how improving our knowledge about the microenvironmental ecology of P. aeruginosa in chronic infections can be used to combat persistent, hard-to-treat bacterial infections.

KW - biofilm

KW - chronic infections

KW - host–pathogen interactions

KW - immune response

KW - microenvironment

KW - quorum sensing

U2 - 10.1093/femsre/fuac018

DO - 10.1093/femsre/fuac018

M3 - Journal article

C2 - 35472245

AN - SCOPUS:85137165068

VL - 46

JO - F E M S Microbiology Reviews

JF - F E M S Microbiology Reviews

SN - 0168-6445

IS - 5

M1 - fuac018

ER -

ID: 320397587