Michael Givskov

Michael Givskov

Professor

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    ORCID: 0000-0001-5004-8609

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    1. Published

      Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction

      Hansen, G. M., Midjord-Belstrøm, Daniel, Nilsson, Carl Martin Peter, Helqvist, S., Nielsen, Claus Henrik, Holmstrup, Palle, Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2016, In: P L o S One. 11, 12, 13 p., e0168771.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes

      Alhede, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Phipps, R. K., Moser, Claus Ernst, Christophersen, L., Hultqvist, Louise Dahl, van Gennip, M., Parsek, M., Høiby, Niels, Rasmussen, T. B. & Givskov, Michael, 2009, In: Microbiology. 155, 11, p. 3500-3508 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Auranofin inhibits virulence pathways in Pseudomonas aeruginosa

      Yam, J. K. H., Tan, L. Z. W., Hong, Z., Salido, M. M. S., Woo, B. Y., Yong, A. M. H., Tan, C. A. Z., Li, S. F. Y., Yang, L., Givskov, Michael & Chng, S. S., 2023, In: Bioorganic and Medicinal Chemistry. 79, 117167.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation

      Chua, S. L., Hultqvist, Louise Dahl, Yuan, M., Rybtke, Morten Levin, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response

      Rybtke, Morten Levin, Hultqvist, Louise Dahl, Givskov, Michael & Tolker-Nielsen, Tim, 2015, In: Journal of Molecular Biology. 427, 23, p. 3628-3645

      Research output: Contribution to journal › Review › Research › peer-review

    6. Published

      Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients

      Høiby, Niels, Johansen, Helle Krogh, Moser, Claus Ernst, Ciofu, Oana, Jensen, Peter Østrup, Kolpen, Mette, Mandsberg, L., Givskov, Michael, Molin, S. & Bjarnsholt, Thomas, 2011, Biofilm Infections. Springer, p. 167-184 18 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    7. Published

      Pseudomonas aeruginosa isolates co-incubated with Acanthamoeba castellanii exhibit phenotypes similar to chronic cystic fibrosis isolates

      Leong, W., Lutz, C., Williams, J., Poh, Y. H., Ken Yee, B. Y., Chua, C., Rice, S. A., Givskov, Michael, Sanderson-Smith, M. & McDougald, D., 2020, bioRxiv, 49 p.

      Research output: Working paper › Preprint › Research

    8. Published

      Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Burmølle, Mette, Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, Claus Ernst, Molin, S., Høiby, Niels & Givskov, Michael, Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Pseudomonas aeruginosa uses type III secretion system to kill biofilm-associated amoebae

      Matz, C., Moreno, A. M., Alhede, M., Manefield, M., Hauser, A. R., Givskov, Michael & Kjelleberg, S., 2008, In: ISME Journal. 2, 8, p. 843-852 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

      Miettinen, Karel, Leelahakorn, Nattawat, Almeida Robles, A. R., Zhao, Yong, Hansen, L. R., Nikolajsen, I. E., Andersen, Jens Bo, Givskov, Michael, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 3664.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors

      Bang, C. G., Jensen, J. F., O'Hanlon Cohrt, E., Olsen, L. B., Siyum, S. G., Mortensen, K. T., Skovgaard, T., Berthelsen, J., Yang, L., Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, Oct 2017, In: ACS Combinatorial Science. 19, 10, p. 657-669 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      A broad range quorum sensing inhibitor working through sRNA inhibition

      Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, Morten Levin, Andersen, Jens Bo, Petersen, R., Andersen, P. S., Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms

      Allesen-Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, Michael & Tolker-Nielsen, T., 2006, In: Molecular Microbiology. 59, 4, p. 1114-28 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      A convenient procedure for the solid-phase synthesis of hydroxamic acids on PEGA resins

      Nandurkar, N. S., Petersen, R., Qvortrup, K., Komnatnyy, V. V., Taveras, K. M., Le Quement, S. T., Frauenlob, R., Givskov, Michael & Nielsen, Thomas Eiland, 28 Dec 2011, In: Tetrahedron Letters. 52, 52, p. 7121-7124 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      A genetic switch controls Pseudomonas aeruginosa surface colonization

      Manner, C., Dias Teixeira, R., Saha, D., Kaczmarczyk, A., Zemp, R., Wyss, F., Jaeger, T., Laventie, B. J., Boyer, S., Malone, J. G., Qvortrup, K., Andersen, Jens Bo, Givskov, Michael, Tolker-Nielsen, Tim, Hiller, S., Drescher, K. & Jenal, U., 2023, In: Nature Microbiology. 8, p. 1520–1533

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      A mariner transposon vector adapted for mutagenesis in oral streptococci

      Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In: MicrobiologyOpen. 3, 3, p. 333-40 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      A mouse ear skin model to study the dynamics of innate immune responses against Staphylococcus aureus biofilms

      Abdul Hamid, A. I., Nakusi, L., Givskov, Michael, Chang, Y. T., Marquès, C. & Gueirard, P., 2020, In: BMC Microbiology. 20, 1, 12 p., 22.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm

      Charlton, T. S., de Nys, R., Netting, A., Kumar, N., Hentzer, M., Givskov, Michael & Kjelleberg, S., 2000, In: Environmental Microbiology. 2, 5, p. 530-41 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      A possible correlation between periodontitis and ischaemic heart disease

      Hansen, G. M., Holmstrup, Palle, Tolker-Nielsen, Tim, Køllgaard, T., Nielsen, C. H., Givskov, Michael & Hansen, Peter Riis, 2014, In: Ugeskrift for Laeger.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay

      Hansen, G. M., Nilsson, M., Nielsen, Claus Henrik, Holmstrup, Palle, Helqvist, S., Tolker-Nielsen, Tim, Givskov, Michael & Hansen, Peter Riis, 2015, In: PloS one. 10, 12, p. 1-11 11 p., e0145657.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Acetic acid and a buffer

      Bjarnsholt, Thomas, Givskov, Michael, P, H., Høiby, Niels, PO, J., HK, J. & K, K., 2010, Patent No. WO2009155931, 30 Jan 2010

      Research output: Patent

    22. Published

      Acquisition of resistance to carbapenem and macrolide-mediated quorum sensing inhibition by Pseudomonas aeruginosa via ICETn4371 6385

      Ding, Y., Teo, J. W. P., Drautz-Moses, D. I., Schuster, S. C., Givskov, Michael & Yang, L., 2018, In: Communications Biology. 1, 10 p., 57.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Adaptation to an Amoeba Host Leads to Pseudomonas aeruginosa Isolates with Attenuated Virulence

      Leong, W., Poh, W. H., Williams, J., Lutz, C., Mozammel Hoque, M., Poh, Y. H., Yee, B. Y. K., Chua, C., Givskov, Michael, Sanderson-Smith, M., Rice, S. A. & McDougald, D., 2022, In: Applied and Environmental Microbiology. 88, 5, e02322.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing

      Jakobsen, Tim Holm, van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, Louise Dahl, Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, Peter Østrup, Moser, Claus Ernst, Nielsen, Kristian Fog, Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function

      Hentzer, M., Teitzel, G. M., Balzer, G. J., Heydorn, A., Molin, S., Givskov, Michael & Parsek, M. R., 2001, In: Journal of Bacteriology. 183, 18, p. 5395-401 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. An attractive surface: gram-negative bacterial biofilms

      Schembri, M., Givskov, Michael & Klemm, P., 2002, In: Science Signaling. 2002, 132, p. re6

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      An in vitro model of bacterial infections in wounds and other soft tissues

      Werthén, M., Henriksson, L., Jensen, Peter Østrup, Sternberg, C., Givskov, Michael & Bjarnsholt, Thomas, 2010, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 118, 2, p. 156-64 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. An inhibitor of bacterial quorum sensing reduces mortalities caused by Vibriosis in rainbow trout (Oncorhynchus mykiss, Walbaum)

      Rasch, M., Buch, C., Austin, B., Slierendrecht, W. J., Ekmann, K. S., Larsen, J. L., Johansen, C., Riedel, K., Eberl, L., Givskov, Michael & Gram, L., 2004, In: Systematic and Applied Microbiology. 27, 3, p. 350-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein

      Schreiber, K., Boes, N., Eschbach, M., Jaensch, L., Wehland, J., Bjarnsholt, T., Givskov, Michael, Hentzer, M. & Schobert, M., 2006, In: Journal of Bacteriology. 188, 2, p. 659-68 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Analysis of the multimer resolution system encoded by the parCBA operon of broad-host-range plasmid RP4

      Eberl, L., Kristensen, C. S., Givskov, Michael, Grohmann, E., Gerlitz, M. & Schwab, H., 1994, In: Molecular Microbiology. 12, 1, p. 131-41 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Antibiofilm Properties of Acetic Acid

      Bjarnsholt, Thomas, Alhede, M., Jensen, Peter Østrup, Nielsen, Anne Kirstine, Johansen, Helle Krogh, Homøe, Preben, Høiby, Niels, Givskov, Michael & Kirketerp-Moller, K., Jun 2015, In: Advances in Wound Care. 4, 7, p. 363-372 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Antibiotic and biosurfactant properties of cyclic lipopeptides produced by fluorescent Pseudomonas spp. from the sugar beet rhizosphere

      Nielsen, T. H., Sørensen, D., Tobiasen, C., Andersen, Jens Bo, Christophersen, C., Givskov, Michael & Sørensen, J., 2002, In: Applied and Environmental Microbiology. 68, 7, p. 3416-23 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Antibiotic resistance of bacterial biofilms

      Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael, Molin, S. & Ciofu, Oana, 2010, In: International Journal of Antimicrobial Agents. 35, 4, p. 322-332 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    34. Published

      Antibiotics inhibit tumor and disease activity in cutaneous T cell lymphoma

      Lindahl, L. M., Willerslev-Olsen, A., Gjerdrum, L. M. R., Nielsen, P. R., Blümel, E., Rittig, A. H., Celis, P., Herpers, B., Becker, J. C., Stausbøl-Grøn, B., Wasik, M. A., Gluud, M., Fredholm, S., Buus, T. B., Johansen, C., Nastasi, C., Peiffer, L., Kubat, L., Bzorek, M., Eriksen, J. O. & 11 others, Krejsgaard, T., Bonefeld, Charlotte Menne, Geisler, Carsten, Mustelin, T., Langhoff, E., Givskov, Michael, Woetmann, Anders , Kilian, M., Litman, Thomas, Iversen, L. & Ødum, Niels, 26 Sep 2019, In: Blood. 134, 13, p. 1072-1083

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Application of molecular tools for in situ monitoring of bacterial growth activity

      Molin, S. & Givskov, Michael, 1999, In: Environmental Microbiology. 1, 5, p. 383-91 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Applying insights from biofilm biology to drug development - can a new approach be developed?

      Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Associational Resistance to Predation by Protists in a Mixed Species Biofilm

      Goh, Y. F., Røder, Henriette Lyng, Chan, S. H., Ismail, M. H., Madsen, Jonas Stenløkke, Lee, K. W. K., Sørensen, Søren Johannes, Givskov, Michael, Burmølle, Mette, Rice, S. A. & McDougald, D., 2023, In: Applied and Environmental Microbiology. 89, 2, 16 p., e0174122.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

      Hentzer, M., Wu, H., Andersen, Jens Bo, Riedel, K., Rasmussen, T. B., Bagge, N., Kumar, N., Schembri, M. A., Song, Z., Kristoffersen, P., Manefield, M., Costerton, J. W., Molin, S., Eberl, L., Steinberg, P., Kjelleberg, S., Høiby, Niels & Givskov, Michael, 2003, In: EMBO Journal. 22, 15, p. 3803-15 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa

      van Gennip, M., Moser, C., Hultqvist, Louise Dahl, Bjarnsholt, Thomas, Calum, H., Jensen, Peter Østrup, Christophersen, L., Hougen, H. P., Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Dec 2009, In: Journal of Antimicrobial Chemotherapy. 64, 6, p. 1241-50 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Autofluorescence in samples obtained from chronic biofilm infections – “all that glitters is not gold”

      Eickhardt-Dalbøge, S. R., Kragh, K. N., Schrøder, S., Poulsen, Steen Seier, Sillesen, Henrik, Givskov, Michael, Høiby, Niels, Bjarnsholt, Thomas & Alhede, M., 2015, In: Pathogens and Disease. 73, 4, 4 p., ftv012.

      Research output: Contribution to journal › Letter › Research › peer-review

    41. Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice

      Hoffmann, N., Lee, B., Hentzer, M., Rasmussen, T. B., Song, Z., Johansen, H. K., Givskov, Michael & Høiby, N., 2007, In: Antimicrobial Agents and Chemotherapy. 51, 10, p. 3677-87 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Bacteria-triggered release of antimicrobial agents

      Komnatnyy, V. V., Chiang, W., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 7 Jan 2014, In: Angewandte Chemie (International ed. in English). 53, 2, p. 439-41 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes

      Jakobsen, Tim Holm, Tolker-Nielsen, Tim & Givskov, Michael, Sep 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.

      Research output: Contribution to journal › Review › Research › peer-review

    44. Published

      Bacterial biofilm formation and treatment in soft tissue fillers

      Alhede, M., Er, O., Eickhardt, S., Kragh, K., Alhede, M., Hultqvist, Louise Dahl, Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.

      Research output: Contribution to journal › Journal article › Research

    45. Bacterial biofilms: prokaryotic adventures in multicellularity

      Webb, J. S., Givskov, Michael & Kjelleberg, S., 2003, In: Current Opinion in Microbiology. 6, 6, p. 578-85 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Bacterial genotoxins induce T cell senescence

      Mathiasen, S. L., Gall Mas, Laura, Pateras, I. S., Theodorou, S. D. P., Namini, Martin Rich Javadi, Hansen, Morten Bagge, Martin, O. C. B., Vadivel, Chella Krishna, Ntostoglou, K., Butter, D., Givskov, Michael, Geisler, Carsten, Akbar, A. N., Gorgoulis, V. G., Frisan, T., Ødum, Niels & Krejsgaard, T., 2021, In: Cell Reports. 35, 10, 109220.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Bacterial signals and antagonists: the interaction between bacteria and higher organisms

      Rice, S. A., Givskov, Michael, Steinberg, P. & Kjelleberg, S., 1999, In: Journal of Molecular Microbiology and Biotechnology. 1, 1, p. 23-31 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Beyond nutrition: health-promoting foods by quorum-sensing inhibition

      Givskov, Michael, 2012, In: Future Microbiology. 7, 9, p. 1025-1028 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa

      Pihl, M., Arvidsson, A., Skepö, M., Nilsson, M., Givskov, Michael, Tolker-Nielsen, Tim, Svensäter, G. & Davies, J. R., Apr 2013, In: Pathogens and Disease. 67, 3, p. 192-198 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Biofilms and type III secretion are not mutually exclusive in Pseudomonas aeruginosa

      Mikkelsen, H., Bond, N. J., Skindersoe, M. E., Givskov, Michael, Lilley, K. S. & Welch, M., 2009, In: Microbiology. 155, Pt 3, p. 687-98 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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