24, Building: 24.1.10
2200 København N.
Curriculum Vitae, Oana Ciofu 2018
Date of birth: 3rd of July 1967 Bucharest, Romania, Danish citizen, Address: Galionsvej 6, st..th.1437K, Single, live together with my two daughters (10 and 17 years old)
Education and academic degrees
8th of December 2003: Doctor of Science in medicine (Doctor medicinae) from Faculty of Health Sciences, University of Copenhagen (UCPH) with thesis title:” Pseudomonas aeruginosa chromosomal beta-lactamase in patients with cystic fibrosis and chronic lung infection. Mechanism of antibiotic resistance and target of the humoral immune response”
29th of January 1998: Authorization as Medical Doctor in Denmark, Faculty of Health Sciences, UCPH
19th of June 1996: Ph.D. from Department of Medical Microbiology and Immunology, Faculty of Health Sciences, UCPH with thesis ”Chromosomal beta-lactamase of Pseudomonas aeruginosa. Occurrence and Significance in Serum and Respiratory Secretions from Patients with Cystic Fibrosis and Chronic Pseudomonas aeruginosa Lung Infection”.
September 1991: Medical doctor, University “Carol Davila”, Bucharest, Romania
2003- until present Associate professor, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, UCPH
1998-2002: Assistant Prof. Dept. Medical Microbiology and Immunology, UCPH
1996-1998: Research assistant, Dept. Clinical Microbiology, Rigshospitalet
1993-1996: ph.D student, Dept. Medical Microbiology and Immunology, UCPH
1992-1993: Assistant professor, Department of Pediatrics, University Hospital “Sf. Pantelimon”, Bucharest, Romania
Visiting foreign research institutions
1998 June-August: University of Guelph, Ontario, Canada- preparation of outer membrane vesicles and electronomicroscopy techniques prof. Terry Beveridge
The Family Hede Nielsen Award, 2005 for “Research in prevention of development of antibiotic resistance by use of antioxidants”, 400.000 DKK
Main research interests
The main research interests are bacterial evolution and adaptation with special interest in hypermutability, antibiotic resistance and biofilm. The work has led to fundamental understanding of the bacterial adaptation processes during chronic infection in a host using Pseudomonas aeruginosa chronic lung infection in cystic fibrosis patients, as a model.
Publication summary ORCID https://orcid.org/0000-0001-5648-4858
Number of scientific publications: 87 articles in peer reviewed journals, 1 monography and contributions to eleven book chapters, several posters and lectures at international conferences. Bibliographic index ( juni 2018): Web of Science: Hirsch index 33; 4653 citation without self-citations.
Scientific management (PI)
2018-“Effect of Ceftazidime-avibactam on biofilm of AmpC hyperproducers of P. aeruginosa” Pfizer A/S 339.500 DKK
2017 ”Treatment of biofilm infections with bacteriophages” Frøken P-A. Brandt, Gunna og Einer Polanders Legat, 170.000 DKK, Brdr. Hartmann 50.000 DKK, Dansk CF Forening 40.000 DKK
2013 ”Validation of new vaccine candidates against Pseudomonas aeruginosa identified by in silico vaccine discovery platform based on artificial intelligence” Knowledge Voucher from Agency of Research and Innovation together with Evaxion ApS, 600.900 DKK, 2013
2012 “Optimization of treatment” as part of collaborative funding from KU 2016 Fond to” University of Copenhagen Research Centre for Control of Antibiotic Resistance (UC-CARE)” (total funding 32.6m DKK).
2010 “Adaptive mechanisms of P. aeruginosa during the chronic airways infection in patients with cystic fibrosis” (3 years). Funding from Copenhagen University and Danish Technical University (total funding: 1.5m DKK)
Cooperation with research groups: Antonio Oliver, Hospital Son Dureta, Palma de Mallorca, Spain; prof. Susanne Haussler, Medical School of Hannover, Germany; Prof. Carlos Argarana, Universidad Nacional de Cordoba, Argentina. Prof. Antoni Torres MD, Hospital Clínic of Barcelona, Spain.,
I have supervised or co-supervised more than 30 bachelor and master projects of medical students, 10 master projects of other biological educations and 6 PhD students.
“Medical Microbiology” course for medical students: Course leader, lectures, laboratory courses. Lectures and supervision at two ph.D courses: Medical Biofilms and Antibiotic Research. Lectures in UCPH Coursera course on “Biofilm infections”. Organizer of the first interdisciplinary course at the Health and Medical Science Faculty ”One Health: Antibiotic resistance – a threat for human and animal health” for medical and veterinary students, KU, SUND.
Reviewer for " Antimicrobial Agents and Chemotherapy", "APMIS", "American Journal of Respiratory Medicine", "Journal of Antimicrobial Chemotherapy", "The Journal of Cystic Fibrosis", "Microbes and Infections", "Biofilms" "Molecular Microbiology" and "Nature Medicine" journals.