Thomas Bjarnsholt
Professor
Bacteriology
Blegdamsvej 3B
2200 København N
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Interspecific bacterial interactions are reflected in multispecies biofilm spatial organization
Liu, W., Røder, Henriette Lyng, Madsen, Jonas Stenløkke, Bjarnsholt, Thomas, Sørensen, Søren Johannes & Burmølle, Mette, 2016, In: Frontiers in Microbiology. 7, 8 p., 1366.Research output: Contribution to journal › Review › peer-review
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The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data
Malone, M., Bjarnsholt, Thomas, McBain, A. J., James, G. A., Stoodley, P., Leaper, D., Tachi, M., Schultz, G., Swanson, T. & Wolcott, R. D., Jan 2017, In: Journal of Wound Care. 26, 1, p. 20-25Research output: Contribution to journal › Review › peer-review
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Analysis of proximal bone margins in diabetic foot osteomyelitis by conventional culture, DNA sequencing and microscopy
Malone, M., Fritz, Blaine Gabriel, Vickery, K., Schwarzer, S., Sharma, V., Biggs, N., Radzieta, M., Jeffries, T. T., Dickson, H. G., Jensen, S. O. & Bjarnsholt, Thomas, 2019, In: APMIS. 127, 10, p. 660-670 11 p.Research output: Contribution to journal › Journal article › peer-review
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Shaping the growth behaviour of biofilms initiated from bacterial aggregates
Melaugh, G., Hutchison, J., Kragh, K. N., Irie, Y., Roberts, A., Bjarnsholt, Thomas, Diggle, S. P., Gordon, V. D. & Allen, R. J., 2 Mar 2016, In: P L o S One. 11, 3, 18 p., e0149683.Research output: Contribution to journal › Journal article › peer-review
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In silico analyses of metagenomes from human atherosclerotic plaque samples
Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.Research output: Contribution to journal › Journal article › peer-review
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Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis
Moser, C., Gennip, M. V., Bjarnsholt, Thomas, Jensen, Peter Østrup, Lee, B., Hougen, H. P., Calum, H., Ciofu, Oana, Givskov, Michael, Molin, S. & Høiby, Niels, 1 Feb 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 2, p. 95-107 13 p.Research output: Contribution to journal › Journal article › peer-review
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Novel experimental Pseudomonas aeruginosa infection model mimicking long-term host-pathogen interactions in cystic fibrosis.
Moser, Claus Ernst, van Gennip, M., Bjarnsholt, Thomas, Jensen, P. Ø., Lee, B., Hougen, H. P., Calum, Henrik Pierre, Ciofu, Oana, Givskov, Michael & Høiby, Niels, 2009, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 117, p. 95-107 13 p.Research output: Contribution to journal › Journal article › peer-review
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Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients
Møller, S. A., Jensen, Peter Østrup, Høiby, Niels, Ciofu, Oana, Kragh, K. N., Bjarnsholt, Thomas & Kolpen, Mette, 2019, In: Journal of Cystic Fibrosis. 18, 5, p. 657–664Research output: Contribution to journal › Journal article › peer-review
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The discovery of bacterial biofilm in patients with muscle invasive bladder cancer
Nadler, N., Kvich, Lasse Andersson, Bjarnsholt, Thomas, Jensen, J. B., Gögenur, Ismail & Azawi, Nessn H., 2021, In: APMIS. 129, 5, p. 265-270Research output: Contribution to journal › Journal article › peer-review
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Achromobacter Species Isolated from Cystic Fibrosis Patients Reveal Distinctly Different Biofilm Morphotypes
Nielsen, S. M., Nørskov-Lauritsen, N., Bjarnsholt, Thomas & Meyer, R. L., Sep 2016, In: Microorganisms. 4, 3, 16 p., 33.Research output: Contribution to journal › Journal article › peer-review
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Identification of pathogenic microorganisms directly from positive blood vials by matrix-assisted laser desorption/ionization time of flight mass spectrometry
Nonnemann, B., Tvede, M. & Bjarnsholt, Thomas, 18 Jan 2013, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 121, 9, p. 871-877 7 p.Research output: Contribution to journal › Journal article › peer-review
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Heading for centennial anniversary and beyond
Norrild, B., Ralfkiaer, E., Bjarnsholt, Thomas & Jensen, Peter Østrup, Dec 2017, In: APMIS. 125, 12, p. 1133-1133Research output: Contribution to journal › Editorial
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Bacterial biofilms: a possible mechanism for chronic infection in patients with lumbar disc herniation - a prospective proof-of-concept study using fluorescence in situ hybridization
Ohrt-Nissen, S., Fritz, Blaine Gabriel, Walbom, J., Kragh, K. N., Bjarnsholt, Thomas, Dahl, Benny & Manniche, C., 2018, In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 126, 5, p. 440-447 8 p.Research output: Contribution to journal › Journal article › peer-review
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Is pseudarthrosis after spinal instrumentation caused by a chronic infection?
Ohrt-Nissen, S., Fritz, Blaine Gabriel, Valentin, L., Kragh, K. N., Manniche, C., Dahl, B. & Bjarnsholt, Thomas, 2019, In: European Spine Journal. 28, p. 2996–3002Research output: Contribution to journal › Journal article › peer-review
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Peptidoglycan-Binding Anchor Is a Pseudomonas aeruginosa OmpA Family Lipoprotein With Importance for Outer Membrane Vesicles, Biofilms, and the Periplasmic Shape
Paulsson, M., Kragh, K. N., Su, Y. C., Sandblad, L., Singh, B., Bjarnsholt, Thomas & Riesbeck, K., 2021, In: Frontiers in Microbiology. 12, 639582.Research output: Contribution to journal › Journal article › peer-review
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A novel Borrelia-specific real-time PCR assay is not suitable for diagnosing Lyme neuroborreliosis
Pedersen, Regitze Renee, Kragh, K. N., Fritz, Blaine Gabriel, Ørbæk, M., Jensen, Peter Østrup, Lebech, Anne-Mette & Bjarnsholt, Thomas, 2022, In: Ticks and Tick-borne Diseases. 13, 5, 101971.Research output: Contribution to journal › Journal article › peer-review
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Biofilm Research in Bovine Mastitis
Pedersen, Regitze Renee, Krömker, Volker, Bjarnsholt, Thomas, Dahl-Pedersen, Kirstin, Buhl, Rikke & Jørgensen, Elin Lisby Kastbjerg, 2021, In: Frontiers in Veterinary Science. 8, 11 p., 656810.Research output: Contribution to journal › Journal article › peer-review
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Delayed neutrophil recruitment allows nascent Staphylococcus aureus biofilm formation and immune evasion
Pettygrove, B. A., Kratofil, R. M., Alhede, M., Jensen, Peter Østrup, Newton, M., Qvortrup, Klaus, Pallister, K. B., Bjarnsholt, Thomas, Kubes, P., Voyich, J. M. & Stewart, P. S., Aug 2021, In: Biomaterials. 275, 13 p., 120775.Research output: Contribution to journal › Journal article › peer-review
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Effects of Photoactivated Titanium Dioxide Nanopowders and Coating on Planktonic and Biofilm Growth of Pseudomonas aeruginosa
Polo, A., Diamanti, M. V., Bjarnsholt, Thomas, Høiby, Niels, Villa, F., Pedeferri, M. P. & Cappitelli, F., 25 Jul 2011, In: Photochemistry and Photobiology.Research output: Contribution to journal › Journal article › peer-review
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Chronic pulmonary disease with Mycobacterium abscessus complex is a biofilm infection
Qvist, T., Eickhardt-Dalbøge, S. R., Kragh, K. N., Andersen, C. B., Iversen, M., Høiby, Niels & Bjarnsholt, Thomas, Dec 2015, In: European Respiratory Journal. 46, 6, p. 1823-1826 4 p.Research output: Contribution to journal › Comment/debate › peer-review
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Dietzia papillomatosis Bacteremia
Rammer, P., Calum, Henrik Pierre, Moser, Claus Ernst, Björnsdóttir, M. K., Smedegaard, H., Høiby, Niels & Bjarnsholt, Thomas, Jun 2013, In: Journal of Clinical Microbiology. 51, 6, p. 1977-8 2 p.Research output: Contribution to journal › Journal article › peer-review
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Samspillet mellem mikrobiota og immunsystemet ved kolorektal cancer
Raskov, H., Bjarnsholt, Thomas, Alamili, M., Kragh, K. N. & Gögenur, Ismail, 5 Nov 2018, In: Ugeskrift for Laeger. 180, 45, V04180253.Research output: Contribution to journal › Journal article › peer-review
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Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis
Raskov, H., Kragh, K. N., Bjarnsholt, Thomas, Alamili, M. & Gögenur, Ismail, 17 Sep 2018, In: Clinical and Translational Medicine. 7, 4 p., 30.Research output: Contribution to journal › Journal article › peer-review
Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector
Rasmussen, T. B., Bjarnsholt, Thomas, Skindersoe, M. E., Hentzer, M., Kristoffersen, P., Köte, M., Nielsen, J., Eberl, L. & Givskov, M., 2005, In: Journal of Bacteriology. 187, 5, p. 1799-814 15 p.Research output: Contribution to journal › Journal article › peer-review
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Bacterial biofilm in chronic lesions of Hidradenitis Suppurativa
Ring, H. C., Bay, Lene, Nilsson, Carl Martin Peter, Kallenbach, K., Miller, I. M., Saunte, Ditte Marie, Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Jemec, Gregor, 2017, In: British Journal of Dermatology. 176, 4, p. 993–1000Research output: Contribution to journal › Journal article › peer-review
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Moderate to severe hidradenitis suppurativa patients do not have an altered bacterial composition in peripheral blood compared to healthy controls
Ring, H. C., Thorsen, Jonathan Jan Ilve, Saunte, Ditte Marie, Lilje, B., Bay, Lene, Theut Riis, P., Larsen, N., O'Brien Andersen, L., Vedel Nielsen, H., Miller, I. M., Bjarnsholt, Thomas, Fuursted, K. & Jemec, Gregor, 2018, In: Journal of the European Academy of Dermatology and Venereology. 32, 1, p. 125-128 4 p.Research output: Contribution to journal › Journal article › peer-review
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Probiotics in hidradenitis suppurativa: a potential treatment option?
Ring, H. C., Thorsen, Jonathan Jan Ilve, Fuursted, K., Bjarnsholt, Thomas, Bay, Lene, Saunte, Ditte Marie, Thomsen, Simon Francis & Jemec, Gregor, 2022, In: Clinical and Experimental Dermatology. 47, 1, p. 139-141 2 p.Research output: Contribution to journal › Comment/debate
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Amplicon sequencing demonstrates comparable follicular mycobiomes in patients with hidradenitis suppurativa compared with healthy controls
Ring, H. C., Thorsen, Jonathan Jan Ilve, Fuursted, K., Bjarnsholt, Thomas, Bay, Lene, Egeberg, Alexander, Ingham, Andreas, Vedel Nielsen, H., Frew, J. W., Saunte, Ditte Marie, Thomsen, Simon Francis & Jemec, Gregor, 2022, In: Journal of the European Academy of Dermatology and Venereology. 36, 7, p. e580-e583 4 p.Research output: Contribution to journal › Comment/debate
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Predictive Metagenomic Analysis Reveals a Role of Cutaneous Dysbiosis in the Development of Hidradenitis Suppurativa
Ring, H. C., Thorsen, Jonathan Jan Ilve, Jørgensen, A. H., Bay, Lene, Bjarnsholt, Thomas, Fuursted, K., Thomsen, Simon Francis & Jemec, Gregor, 2020, In: Journal of Investigative Dermatology. 140, 7, p. 1473-1476Research output: Contribution to journal › Letter › peer-review
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Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa
Ring, H. C., Bay, Lene, Kallenbach, K., Miller, I. M., Prens, E., Saunte, Ditte Marie, Bjarnsholt, Thomas & Jemec, Gregor, Feb 2017, In: Acta Dermato-Venereologica. 97, 2, p. 208-213Research output: Contribution to journal › Journal article › peer-review
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Haematoxylin and eosin staining identifies medium to large bacterial aggregates with a reliable specificity: A comparative analysis of follicular bacterial aggregates in axillary biopsies using peptide nucleic acid-fluorescence in situ hybridization and haematoxylin and eosin staining
Ring, H. C., Riis, P. T., Bay, Lene, Kallenbach, K., Bjarnsholt, Thomas & Jemec, Gregor, Oct 2017, In: Experimental Dermatology. 26, 10, p. 943-945Research output: Contribution to journal › Letter › peer-review
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The follicular skin microbiome in patients with hidradenitis suppurativa and healthy controls
Ring, H. C., Thorsen, J., Saunte, Ditte Marie, Lilje, B., Bay, Lene, Riis, P. T., Larsen, N., Andersen, L. O., Nielsen, H. V., Miller, I. M., Bjarnsholt, Thomas, Fuursted, K. & Jemec, Gregor, 2017, In: JAMA Dermatology. 153, 9, p. 897-905 9 p.Research output: Contribution to journal › Journal article › peer-review
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The Limitations of In Vitro Experimentation in Understanding Biofilms and Chronic Infection
Roberts, A. E. L., Kragh, K. N., Bjarnsholt, Thomas & Diggle, S. P., 20 Nov 2015, In: Journal of Molecular Biology. 427, 23, p. 3646-3661 16 p.Research output: Contribution to journal › Review › peer-review
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Detection of microorganisms involved in airway infection of cystic fibrosis patients by standard culturing 6 molecular methods
Rudkjøbing, V., Thomsen, T. R., Nielsen, P. H., Alhede, M., Johansen, U. R., Høiby, Niels & Bjarnsholt, Thomas, 2010. 0 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients
Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U. R., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, Jul 2011, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 236-244 9 p.Research output: Contribution to journal › Journal article › peer-review
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True microbiota involved in chronic lung infection of cystic fibrosis patients found by culturing and 16S rRNA gene analysis
Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2011, In: Journal of Clinical Microbiology. 49, 12, p. 4352-5 4 p.Research output: Contribution to journal › Journal article › peer-review
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Comparing culture and molecular methods for the identification of microorganisms involved in necrotizing soft tissue infections
Rudkjøbing, V. B., Thomsen, T. R., Xu, Y., Melton-Kreft, R., Ahmed, A., Eickhardt-Dalbøge, S. R., Bjarnsholt, Thomas, Poulsen, Steen Seier, Nielsen, P. H., Earl, J. P., Ehrlich, G. D. & Moser, Claus Ernst, 8 Nov 2016, In: B M C Infectious Diseases. 16, 13 p., 652.Research output: Contribution to journal › Journal article › peer-review
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The implication of Pseudomonas aeruginosa biofilms in infections
Rybtke, Morten Levin, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: Inflammation & Allergy - Drug Targets. 10, 2, p. 141-57 17 p.Research output: Contribution to journal › Journal article › peer-review
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Biofilms can act as plasmid reserves in the absence of plasmid specific selection
Røder, Henriette Lyng, Trivedi, Urvish, Russel, J., Kragh, K. N., Herschend, J., Thalsø-Madsen, I., Tolker-Nielsen, Tim, Bjarnsholt, Thomas, Burmølle, Mette & Madsen, Jonas Stenløkke, 2021, In: npj Biofilms and Microbiomes. 7, 6 p., 78.Research output: Contribution to journal › Letter › peer-review
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Defining the temporal relationship between the skin microbiome, immune response and skin barrier function during flare and resolution of atopic dermatitis: protocol of a Danish intervention study
Rønnstad, A. T. M., Bay, Lene, Ruge, I. F., Halling, A., Fritz, Blaine Gabriel, Jakaša, I., Luiten, R., Kezic, S., Thomsen, Simon Francis, Bjarnsholt, Thomas & Thyssen, Jacob Pontoppidan, 2023, In: BMJ Open. 13, 2, 8 p., e068395.Research output: Contribution to journal › Journal article › peer-review
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The biofilm life cycle: expanding the conceptual model of biofilm formation
Sauer, K., Stoodley, P., Goeres, D. M., Hall-Stoodley, L., Burmølle, Mette, Stewart, P. S. & Bjarnsholt, Thomas, 2022, In: Nature Reviews Microbiology. 20, 10, p. 608-620 13 p.Research output: Contribution to journal › Review › peer-review
Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein
Schreiber, K., Boes, N., Eschbach, M., Jaensch, L., Wehland, J., Bjarnsholt, Thomas, Givskov, M., Hentzer, M. & Schobert, M., 2006, In: Journal of Bacteriology. 188, 2, p. 659-68 9 p.Research output: Contribution to journal › Journal article › peer-review
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Morphological evidence of biofilm in chronic obstructive sialadenitis
Schrøder, S. A., Eickhardt, S., Bjarnsholt, Thomas, Nørgaard, T. & Homøe, Preben, 2018, In: Journal of Laryngology and Otology. 132, 7, p. 611-614 4 p.Research output: Contribution to journal › Journal article › peer-review
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Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds
Schultz, G., Bjarnsholt, Thomas, James, G. A., Leaper, D. J., McBain, A. J., Malone, M., Stoodley, P., Swanson, T., Tachi, M. & Wolcott, R. D., Sep 2017, In: Wound Repair and Regeneration. 25, 5, p. 744-757 14 p.Research output: Contribution to journal › Journal article › peer-review
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The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review
Schwarzer, S., James, G. A., Goeres, D., Bjarnsholt, Thomas, Vickery, K., Percival, S. L., Stoodley, P., Schultz, G., Jensen, S. O. & Malone, M., 2020, In: Journal of Infection. 80, 3, p. 261-270Research output: Contribution to journal › Review › peer-review
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Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa
Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 1 Oct 2008, In: Antimicrobial Agents and Chemotherapy. 52, 10, p. 3648-63 16 p.Research output: Contribution to journal › Journal article › peer-review
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Quorum sensing antagonism from marine organisms
Skindersoe, M. E., Ettinger-Epstein, P., Rasmussen, T. B., Bjarnsholt, Thomas, de Nys, R. & Givskov, Michael, 2007, In: Marine Biotechnology. 10, 1, p. 56-63 7 p.Research output: Contribution to journal › Journal article › peer-review
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Comparison of two commercial broadrange PCR and sequencing assays for identification of bacteria in culture-negative clinical samples
Stavnsbjerg, Camilla, Frimodt-Moller, N., Moser, C. E. & Bjarnsholt, Thomas, 27 Mar 2017, In: B M C Infectious Diseases. 17, 7 p., 233.Research output: Contribution to journal › Journal article › peer-review
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Methods for dynamic investigations of surface-attached in vitro bacterial and fungal biofilms
Sternberg, C., Bjarnsholt, Thomas & Shirtliff, M., 2014, In: Methods in molecular biology (Clifton, N.J.). 1147, p. 3-22 20 p.Research output: Contribution to journal › Journal article
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Risk factors for chronic biofilm-related infection associated with implanted medical devices
Stewart, P. S. & Bjarnsholt, Thomas, 2020, In: Clinical Microbiology and Infection. 26, 8, p. 1034-1038Research output: Contribution to journal › Review › peer-review
ID: 9755066
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Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
Research output: Contribution to journal › Journal article › peer-review
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Research output: Contribution to journal › Journal article › peer-review
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Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Research output: Contribution to journal › Journal article › peer-review
Published