Thomas Bjarnsholt

Thomas Bjarnsholt

Professor

  • Bacteriology

    22, Building: 22.2.26

    2200 København N.

    Phone: +45 35 33 74 41Mobile: +45 20 65 98 88

  1. 2005
  2. Published

    Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudo-monas aeruginosa infections.

    Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christoffersen, L., Calum, Henrik Pierre, Hentzer, M., Hougen, H. P., Rygaard, J., Moser, Claus Ernst, Eberl, L., Høiby, Niels & Givskov, Michael, 2005, In: F E M S Microbiology. 151, p. 3873-3880 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

    Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H., Rygaard, J., Moser, C., Eberl, L., Høiby, N. & Givskov, M., 2005, In: Microbiology. 151, Pt 12, p. 3873-80 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector

    Rasmussen, T. B., Bjarnsholt, Thomas, Skindersoe, M. E., Hentzer, M., Kristoffersen, P., Köte, M., Nielsen, J., Eberl, L. & Givskov, M., 2005, In: Journal of Bacteriology. 187, 5, p. 1799-814 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent

    Bjarnsholt, Thomas, Jensen, Peter Østrup, Burmølle, Mette, Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, Claus Ernst, Molin, S., Høiby, Niels & Givskov, Michael, Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent

    Bjarnsholt, Thomas, Jensen, P. Ø., Burmølle, M., Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, C., Molin, S., Høiby, Niels & Givskov, M. C., 1 Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

    Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H. P., Rygaard, J., Moser, C., Eberl, L., Høiby, Niels & Givskov, M. C., 1 Dec 2005, In: Microbiology. 151, Pt 12, p. 3873-80 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2006
  9. Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein

    Schreiber, K., Boes, N., Eschbach, M., Jaensch, L., Wehland, J., Bjarnsholt, Thomas, Givskov, M., Hentzer, M. & Schobert, M., 2006, In: Journal of Bacteriology. 188, 2, p. 659-68 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils

    Fexby, S., Bjarnsholt, Thomas, Jensen, Peter Østrup, Roos, V., Høiby, Niels, Givskov, Michael & Klemm, P., 2006, In: Infection and Immunity. 75, 1, p. 30-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa

    Bjarnsholt, Thomas & Givskov, M., 2006, In: Analytical and Bioanalytical Chemistry. 387, 2, p. 409-14 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2007
  13. Published

    Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing.

    Høiby, Niels, Johansen, Helle Krogh, Ciofu, Oana, Jensen, Peter Østrup, Bjarnsholt, Thomas & Givskov, Michael, 2007, In: Ugeskrift for læger. 169, 48, p. 4163-6 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model

    Christensen, L. D., Moser, C., Jensen, Peter Østrup, Rasmussen, T. B., Christophersen, L., Kjelleberg, S., Kumar, N., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2007, In: Microbiology. 153, Pt 7, p. 2312-20 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Quorum sensing antagonism from marine organisms

    Skindersoe, M. E., Ettinger-Epstein, P., Rasmussen, T. B., Bjarnsholt, Thomas, de Nys, R. & Givskov, Michael, 2007, In: Marine Biotechnology. 10, 1, p. 56-63 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens

    Bjarnsholt, Thomas & Givskov, M., 2007, In: Philosophical Transactions of the Royal Society of London. Biological Sciences. 362, 1483, p. 1213-22 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa

    Jensen, Peter Østrup, Bjarnsholt, Thomas, Phipps, R., Rasmussen, T. B., Calum, H., Christoffersen, L., Moser, C., Williams, P., Pressler, T., Givskov, Michael & Høiby, Niels, 2007, In: Microbiology. 153, Pt 5, p. 1329-38 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Silver against Pseudomonas aeruginosa biofilms

    Bjarnsholt, Thomas, Kirketerp-Møller, K., Kristiansen, S., Phipps, R., Nielsen, A. K., Jensen, Peter Østrup, Høiby, Niels & Givskov, Michael, 2007, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 115, 8, p. 921-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens

    Bjarnsholt, Thomas & Givskov, M. C., 29 Jul 2007, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 362, 1483, p. 1213-22 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2008
  21. Published

    Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection

    Bohn, Y. T., Brandes, G., Rakhimova, E., Horatzek, S., Salunkhe, P., Munder, A., van Barneveld, A., Jordan, D., Bredenbruch, F., Häussler, S., Riedel, K., Eberl, L., Jensen, Peter Østrup, Bjarnsholt, Thomas, Moser, C., Høiby, Niels, Tümmler, B. & Wiehlmann, L., 2008, In: Molecular Microbiology. 71, 3, p. 730-47 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?

    Bjarnsholt, Thomas & Givskov, Michael, 2008, In: Current Infectious Disease Reports. 10, 1, p. 22-28 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The Pseudomonas aeruginosa autoinducer dodecanoyl-homoserine lactone inhibits the putrescine synthesis in human cells

    Kristiansen, S., Bjarnsholt, Thomas, Adeltoft, D., Ifversen, P. & Givskov, Michael, 2008, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 116, 5, p. 361-371 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Thermal injury induces impaired function in polymorphonuclear neutrophil granulocytes and reduced control of burn wound infection

    Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Christoffersen, L., Damlund, D. S. M., Alhede, M., Bjarnsholt, Thomas, Hougen, H. P., Givskov, Michael, Jacobsen, G. K. & Høiby, Niels, 2008, In: Clinical and Experimental Immunology. 156, 1, p. 102-110 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Why chronic wounds will not heal: a novel hypothesis

    Bjarnsholt, Thomas, Kirketerp-Møller, K., Jensen, Peter Østrup, Madsen, K. G., Phipps, R. K., Krogfelt, K., Høiby, Niels & Givskov, Michael, 2008, In: Wound Repair and Regeneration. 16, 1, p. 2-10 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Har ny teknologi overflødiggjort Grams farvemetode? Dansk Selskab for Klinisk Mikrobiologi

    Johansen, Helle Krogh, Bjarnsholt, Thomas, Høiby, Niels & Dansk Selskab for Klinisk Mikrobiologi, D. S. F. K. M., 17 Mar 2008, In: Ugeskrift for læger. 170, 12, p. 1041

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Distribution, organization, and ecology of bacteria in chronic wounds

    Kirketerp-Møller, K., Jensen, Peter Østrup, Fazli, Mustafa, Madsen, K. G., Pedersen, J., Moser, C., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Aug 2008, In: Journal of Clinical Microbiology. 46, 8, p. 2717-22 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa

    Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 1 Oct 2008, In: Antimicrobial Agents and Chemotherapy. 52, 10, p. 3648-63 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2009
  30. Published

    Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes

    Alhede, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Phipps, R. K., Moser, Claus Ernst, Christophersen, L., Hultqvist, L. D., van Gennip, M., Parsek, M., Høiby, Niels, Rasmussen, T. B. & Givskov, Michael, 2009, In: Microbiology. 155, 11, p. 3500-3508 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors

    Yang, L., Rybtke, M. T., Jakobsen, Tim Holm, Hentzer, M., Bjarnsholt, Thomas, Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2432-43 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions

    Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Givskov, Michael, Janssen, M. & Christensen, L. H., 2009, In: Dermatologic Surgery. 35 Suppl 2, p. 1620-1624 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds

    Fazli, Mustafa, Bjarnsholt, Thomas, Kirketerp-Møller, K., Jørgensen, B., Andersen, A. S., Krogfelt, K. A., Givskov, Michael & Tolker-Nielsen, Tim, 2009, In: Journal of Clinical Microbiology. 47, 12, p. 4084-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Novel experimental Pseudomonas aeruginosa infection model mimicking long-term host-pathogen interactions in cystic fibrosis.

    Moser, Claus Ernst, van Gennip, M., Bjarnsholt, Thomas, Jensen, P. Ø., Lee, B., Hougen, H. P., Calum, Henrik Pierre, Ciofu, Oana, Givskov, Michael & Høiby, Niels, 2009, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 117, p. 95-107 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis

    Moser, C., Gennip, M. V., Bjarnsholt, Thomas, Jensen, Peter Østrup, Lee, B., Hougen, H. P., Calum, H., Ciofu, Oana, Givskov, Michael, Molin, S. & Høiby, Niels, 1 Feb 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 2, p. 95-107 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients

    Bjarnsholt, Thomas, Jensen, Peter Østrup, Fiandaca, M. J., Pedersen, J., Hansen, C. R., Andersen, C. B., Pressler, T., Givskov, Michael & Høiby, Niels, 1 Jun 2009, In: Pediatric Pulmonology. 44, 6, p. 547-58 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

    Van Gennip, M., Christensen, L. D., Alhede, M., Phipps, R., Jensen, Peter Østrup, Christophersen, L., Pamp, S. J., Moser, C., Mikkelsen, P. J., Koh, A. Y., Tolker-Nielsen, Tim, Pier, G. B., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Jul 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 7, p. 537-46 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Morphological evidence of biofilm formation in Greenlanders with chronic suppurative otitis media

    Homøe, Preben, Bjarnsholt, Thomas, Wessman, M., Sørensen, H. C. F. & Johansen, Helle Krogh, 1 Oct 2009, In: European Archives of Oto-Rhino-Laryngology. 266, 10, p. 1533-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa

    van Gennip, M., Moser, C., Christensen, L. D., Bjarnsholt, Thomas, Calum, H., Jensen, Peter Østrup, Christophersen, L., Hougen, H. P., Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Dec 2009, In: Journal of Antimicrobial Chemotherapy. 64, 6, p. 1241-50 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2010
  41. Published

    Acetic acid and a buffer

    Bjarnsholt, Thomas, Givskov, Michael, P, H., Høiby, Niels, PO, J., HK, J. & K, K., 2010, Patent No. WO2009155931, 30 Jan 2010

    Research output: Patent

  42. Published

    Alveolar inflammation in cystic fibrosis

    Ulrich, M., Worlitzsch, D., Viglio, S., Siegmann, N., Iadarola, P., Shute, J. K., Geiser, M., Pier, G. B., Friedel, G., Barr, M. L., Schuster, A., Meyer, K. C., Ratjen, F., Bjarnsholt, Thomas, Gulbins, E. & Döring, G., 2010, In: Journal of Cystic Fibrosis. 9, 3, p. 217-27 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    An in vitro model of bacterial infections in wounds and other soft tissues

    Werthén, M., Henriksson, L., Jensen, Peter Østrup, Sternberg, C., Givskov, Michael & Bjarnsholt, Thomas, 2010, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 118, 2, p. 156-64 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Antibiotic resistance of bacterial biofilms

    Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael, Molin, S. & Ciofu, Oana, 2010, In: International Journal of Antimicrobial Agents. 35, 4, p. 322-332 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  45. Published

    Biofilm Infections

    Bjarnsholt, Thomas (ed.), Moser, Claus Ernst (ed.), Jensen, Peter Østrup (ed.) & Høiby, Niels (ed.), 2010, Springer Publishing Company. 350 p.

    Research output: Book/ReportBookResearchpeer-review

  46. Published

    Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections

    Burmølle, Mette, Thomsen, T. R., Fazli, Mustafa, Dige, I., Christensen, L., Homøe, Preben, Tvede, M., Nyvad, B., Tolker-Nielsen, Tim, Givskov, Michael, Moser, Claus Ernst, Kirketerp-Møller, K., Johansen, Helle Krogh, Høiby, Niels, Jensen, Peter Østrup, Sørensen, Søren Johannes & Bjarnsholt, Thomas, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 324-336 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  47. Published

    Complete genomic sequence of the CF pathogene Achromobacter xylosoxidans and in vitro biofilm formation

    Jakobsen, T. H., Hansen, M., Kerpedjiev, P., Hansen, L., Jensen, Peter Østrup, Hansen, C. R., Qvortrup, K., Givskov, M., Burmølle, M., Sørensen, S. J., Høiby, Niels & Bjarnsholt, Thomas, 2010. 0 p.

    Research output: Contribution to conferencePaperResearchpeer-review

  48. Published

    Detection of microorganisms involved in airway infection of cystic fibrosis patients by standard culturing 6 molecular methods

    Rudkjøbing, V., Thomsen, T. R., Nielsen, P. H., Alhede, M., Johansen, U. R., Høiby, Niels & Bjarnsholt, Thomas, 2010. 0 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  49. Published

    Ecology of biofilms in chronic wounds

    Bjarnsholt, Thomas & Givskov, M., 2010, WHS yearbook 2010.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  50. Published

    Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants

    Ciofu, Oana, Mandsberg, L. F., Bjarnsholt, Thomas, Wassermann, T. & Høiby, Niels, 2010, In: Microbiology. 156, p. 1108-1119 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect

    Bjarnsholt, Thomas, van Gennip, M., Jakobsen, Tim Holm, Christensen, L. D., Jensen, Peter Østrup & Givskov, Michael, 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Increased severity of chronic Pseudomonas aeruginosa biofilm infection in the smaller airways of BALB/c mice

    Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 0 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  53. Published

    Increased severity of chronic Pseuomonas aeruginosa biofilm infection in the smaller airways of BALB/C mice

    Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 0 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  54. Published

    Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

    Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Introduction to Biofilm Infections

    Bjarnsholt, Thomas, 2010, Biofilm Infections. New York

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  56. Published

    Nitric oxide production by polymorphonuclear leukocytes in sputum from CF patients with chronic lung infection

    Jensen, Peter Østrup, Kolpen, M., Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Pressler, T. & Høiby, Niels, 2010. 0 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

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