Thomas Bjarnsholt

Thomas Bjarnsholt

Professor

  • Bacteriology

    22, Building: 22.2.26

    2200 København N.

    Phone: +45 35 33 74 41Mobile: +45 20 65 98 88

  1. Published

    Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes

    Alhede, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Phipps, R. K., Moser, Claus Ernst, Christophersen, L., Hultqvist, L. D., van Gennip, M., Parsek, M., Høiby, Niels, Rasmussen, T. B. & Givskov, Michael, 2009, In: Microbiology. 155, 11, p. 3500-3508 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent

    Bjarnsholt, Thomas, Jensen, Peter Østrup, Burmølle, Mette, Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, Claus Ernst, Molin, S., Høiby, Niels & Givskov, Michael, Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Pseudomonas aeruginosa aggregate formation in an alginate bead model system exhibits In Vivo-like characteristics

    Sønderholm, M., Kragh, Kasper Nørskov, Koren, K., Jakobsen, Tim Holm, Darch, S., Alhede, M., Jensen, Peter Østrup, Whiteley, M., Kühl, Michael & Bjarnsholt, Thomas, May 2017, In: Applied and Environmental Microbiology. 83, 9, 15 p., e00113-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Staphylococcus aureus augments release of matrix metalloproteinase-8 from human polymorphonuclear leukocytes

    Kirketerp-Møller, K., Bjarnsholt, Thomas, Jensen, Peter Østrup & Ågren, Magnus, 2020, In: Acta Dermato-Venereologica. 100, 15, p. 1-2 2 p., adv00232.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A UVC device for intra-luminal disinfection of catheters: In vitro tests on soft polymer tubes contaminated with Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Candida albicans

    Bak, J., Begovic, T., Bjarnsholt, Thomas & Nielsen, A., 2011, In: Photochemistry and Photobiology. 87, 5, p. 1123-1128 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A non-fatal case of invasive zygomycete (Lichtheimia corymbifera) infection in an allogeneic haematopoietic cell transplant recipient

    Eickhardt, S., Braendstrup, P., Clasen-Linde, E., Jensen, K. E., Alhede, M., Bjarnsholt, Thomas, Høiby, Niels, Vindeløv, L. & Moser, Claus Ernst, May 2013, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 121, 5, p. 456-9 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    A novel in vitro wound biofilm model used to evaluate low-frequency ultrasonic-assisted wound debridement

    Crone, S., Garde, C., Bjarnsholt, Thomas & Alhede, M., Mar 2015, In: Journal of Wound Care. 24, 2, p. 64-72 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    A novel chronic wound biofilm model sustaining coexistence of Pseudomonas aeruginosa and Staphylococcus aureus suitable for testing of antibiofilm effect of antimicrobial solutions and wound dressings

    Chen, X., Lorenzen, J., Xu, Y., Jonikaite, M., Thaarup, Ida Clement, Bjarnsholt, Thomas, Kirketerp-Møller, K. & Thomsen, T. R., 2021, In: Wound Repair and Regeneration. 29, 5, p. 820-829

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    APMIS pandemic editorial

    Bjarnsholt, Thomas & Calum, Henrik Pierre, 2021, In: APMIS: Acta Pathologica, Microbiologica et Immunologica Scandinavica. 129, 7, p. 319 1 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  10. Published

    Acetic acid and a buffer

    Bjarnsholt, Thomas, Givskov, Michael, P, H., Høiby, Niels, PO, J., HK, J. & K, K., 2010, Patent No. WO2009155931, 30 Jan 2010

    Research output: Patent

  11. Published

    Achromobacter Species Isolated from Cystic Fibrosis Patients Reveal Distinctly Different Biofilm Morphotypes

    Nielsen, S. M., Nørskov-Lauritsen, N., Bjarnsholt, Thomas & Meyer, R. L., Sep 2016, In: Microorganisms. 4, 3, 16 p., 33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing

    Jakobsen, Tim Holm, van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, L. D., Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, Peter Østrup, Moser, Claus Ernst, Nielsen, K. F., Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Alveolar inflammation in cystic fibrosis

    Ulrich, M., Worlitzsch, D., Viglio, S., Siegmann, N., Iadarola, P., Shute, J. K., Geiser, M., Pier, G. B., Friedel, G., Barr, M. L., Schuster, A., Meyer, K. C., Ratjen, F., Bjarnsholt, Thomas, Gulbins, E. & Döring, G., 2010, In: Journal of Cystic Fibrosis. 9, 3, p. 217-27 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    An equine wound model to study effects of bacterial aggregates on wound healing

    Jørgensen, Elin Lisby Kastbjerg, Bay, L., Skovgaard, Lene Theil, Bjarnsholt, Thomas & Jacobsen, Stine, 2019, In: Advances in Wound Care. 8, 10, p. 487-498

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    An in vitro model of bacterial infections in wounds and other soft tissues

    Werthén, M., Henriksson, L., Jensen, Peter Østrup, Sternberg, C., Givskov, Michael & Bjarnsholt, Thomas, 2010, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 118, 2, p. 156-64 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Anaerobic bacteria in biofilm –and their tolerance to antibiotics

    Kragh, K. N., Kühl, Michael, Gregersen, A., Tvede, M., Høiby, Niels & Bjarnsholt, Thomas, 2011.

    Research output: Contribution to conferencePosterResearch

  17. Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein

    Schreiber, K., Boes, N., Eschbach, M., Jaensch, L., Wehland, J., Bjarnsholt, Thomas, Givskov, M., Hentzer, M. & Schobert, M., 2006, In: Journal of Bacteriology. 188, 2, p. 659-68 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Analysis of proximal bone margins in diabetic foot osteomyelitis by conventional culture, DNA sequencing and microscopy

    Malone, M., Fritz, Blaine Gabriel, Vickery, K., Schwarzer, S., Sharma, V., Biggs, N., Radzieta, M., Jeffries, T. T., Dickson, H. G., Jensen, S. O. & Bjarnsholt, Thomas, 2019, In: APMIS. 127, 10, p. 660-670 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils

    Thomsen, K., Christophersen, L., Jensen, Peter Østrup, Bjarnsholt, Thomas, Moser, Claus Ernst & Høiby, Niels, Jul 2016, In: Human Vaccines & Immunotherapeutics. 12, 7, p. 1690-1699 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Anti-Pseudomonas aeruginosa IgY Antibodies Induce Specific Bacterial Aggregation and Internalization in Human Polymorphonuclear Neutrophils

    Thomsen, K., Christophersen, L., Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, Jul 2015, In: Infection and Immunity. 83, 7, p. 2686-2693 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Anti-Pseudomonas aeruginosa IgY antibodies augment bacterial clearance in a murine pneumonia model

    Thomsen, K., Christophersen, L., Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, Mar 2016, In: Journal of Cystic Fibrosis. 15, 2, p. 171-178 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Antibiofilm Properties of Acetic Acid

    Bjarnsholt, Thomas, Alhede, M., Jensen, Peter Østrup, Nielsen, Anne Kirstine, Johansen, Helle Krogh, Homøe, Preben, Høiby, Niels, Givskov, Michael & Kirketerp-Moller, K., Jun 2015, In: Advances in Wound Care. 4, 7, p. 363-372 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Antibiotic penetration and bacterial killing in a Pseudomonas aeruginosa biofilm model

    Cao, B., Christophersen, L., Thomsen, K., Sønderholm, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2015, In: The Journal of antimicrobial chemotherapy. 70, 7, p. 2057-2063 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Antibiotic resistance of bacterial biofilms

    Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael, Molin, S. & Ciofu, Oana, 2010, In: International Journal of Antimicrobial Agents. 35, 4, p. 322-332 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Antibiotic susceptibility of cystic fibrosis lung microbiome members in a multispecies biofilm

    Vandeplassche, E., Sass, A., Ostyn, L., Burmølle, Mette, Kragh, Kasper Nørskov, Bjarnsholt, Thomas, Coenye, T. & Crabbé, A., 2020, In: Biofilm. 2, 9 p., 100031.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms

    Crabbé, A., Jensen, Peter Østrup, Bjarnsholt, Thomas & Coenye, T., 2019, In: Trends in Microbiology. 27, 10, p. 850-863

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    Antimicrobials and Non-Healing Wounds. Evidence, controversies and suggestions-key messages

    Gottrup, F., Apelqvist, J., Bjarnsholt, Thomas, Cooper, R., Moore, Z., Peters, E. J. G. & Probst, S., 2014, In: Journal of Wound Care. 23, 10, p. 477-8, 480, 482 4 p.

    Research output: Contribution to journalJournal articleResearch

  28. Published

    Applying insights from biofilm biology to drug development - can a new approach be developed?

    Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Are biofilms responsible for the adverse effects experienced following soft-tissue fillers?

    Alhede, M. & Bjarnsholt, Thomas, 2014, In: Future Microbiology. 9, 8, p. 931-3 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa

    van Gennip, M., Moser, C., Christensen, L. D., Bjarnsholt, Thomas, Calum, H., Jensen, Peter Østrup, Christophersen, L., Hougen, H. P., Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Dec 2009, In: Journal of Antimicrobial Chemotherapy. 64, 6, p. 1241-50 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Autofluorescence in samples obtained from chronic biofilm infections – “all that glitters is not gold”

    Eickhardt-Dalbøge, S. R., Kragh, Kasper Nørskov, Schrøder, S., Poulsen, Steen Seier, Sillesen, Henrik, Givskov, Michael, Høiby, Niels, Bjarnsholt, Thomas & Alhede, M., 2015, In: Pathogens and Disease. 73, 4, 4 p., ftv012.

    Research output: Contribution to journalLetterResearchpeer-review

  32. Published

    Bacterial Aggregates Establish at the Edges of Acute Epidermal Wounds

    Bay, L., Kragh, Kasper Nørskov, Eickhardt, S. R., Poulsen, Steen Seier, Gjerdrum, Lise Mette Rahbek, Ghathian, K., Calum, Henrik Pierre, Ågren, Magnus & Bjarnsholt, Thomas, Apr 2018, In: Advances in Wound Care. 7, 4, p. 105-113

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Bacterial aggregate size determines phagocytosis efficiency of polymorphonuclear leukocytes

    Alhede, M., Lorenz, M., Fritz, Blaine Gabriel, Jensen, Peter Østrup, Ring, H. C., Bay, L. & Bjarnsholt, Thomas, 2020, In: Medical microbiology and immunology. 209, p. 669–680

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Bacterial biofilm formation and treatment in soft tissue fillers

    Alhede, M., Er, O., Eickhardt, S., Kragh, Kasper Nørskov, Alhede, M., Hultqvist, L. D., Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.

    Research output: Contribution to journalJournal articleResearch

  35. Published

    Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis

    Raskov, H., Kragh, Kasper Nørskov, Bjarnsholt, Thomas, Alamili, M. & Gögenur, Ismail, 17 Sep 2018, In: Clinical and Translational Medicine. 7, 4 p., 30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Bacterial biofilm in chronic lesions of Hidradenitis Suppurativa

    Ring, H. C., Bay, L., Nilsson, Carl Martin Peter, Kallenbach, K., Miller, I. M., Saunte, Ditte Marie, Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Jemec, Gregor, 2017, In: British Journal of Dermatology. 176, 4, p. 993–1000

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Bacterial biofilms: a possible mechanism for chronic infection in patients with lumbar disc herniation - a prospective proof-of-concept study using fluorescence in situ hybridization

    Ohrt-Nissen, S., Fritz, Blaine Gabriel, Walbom, J., Kragh, Kasper Nørskov, Bjarnsholt, Thomas, Dahl, B. & Manniche, C., 2018, In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 126, 5, p. 440-447 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Bacterial infection as a likely cause of adverse reactions to polyacrylamide hydrogel fillers in cosmetic surgery

    Christensen, L., Breiting, V., Bjarnsholt, Thomas, Eickhardt, S., Høgdall, E., Janssen, M., Pallua, N. & Zaat, S. A. J., May 2013, In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 56, 10, p. 1438-44 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation

    Brochmann, R. P., Toft, A., Ciofu, Oana, Briales, A., Kolpen, M., Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, 2014, In: International Journal of Antimicrobial Agents. 43, 2, p. 140-147 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection

    Christophersen, L. J., Trøstrup, H., Damlund, D. S. M., Bjarnsholt, Thomas, Thomsen, K., Jensen, Peter Østrup, Hougen, H. P., Høiby, Niels & Moser, Claus Ernst, 2012, In: Experimental and clinical endocrinology. 170, 2, p. 222-30 10 p., 170.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Biofilm Infections

    Bjarnsholt, Thomas (ed.), Moser, Claus Ernst (ed.), Jensen, Peter Østrup (ed.) & Høiby, Niels (ed.), 2010, Springer Publishing Company. 350 p.

    Research output: Book/ReportBookResearchpeer-review

  42. Published

    Biofilm Research in Bovine Mastitis

    Pedersen, Regitze Renee, Krömker, Volker, Bjarnsholt, Thomas, Dahl-Pedersen, Kirstin, Buhl, Rikke & Jørgensen, Elin Lisby Kastbjerg, 2021, In: Frontiers in Veterinary Science. 8, 11 p., 656810.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Biofilm and equine limb wounds

    Jørgensen, Elin Lisby Kastbjerg, Bjarnsholt, Thomas & Jacobsen, Stine, 2021, In: Animals. 11, 10, 2825.

    Research output: Contribution to journalReviewResearchpeer-review

  44. Published

    Biofilm formation – what we can learn from recent developments

    Bjarnsholt, Thomas, Buhlin, K., Dufrêne, Y. F., Gomelsky, M., Moroni, A., Ramstedt, M., Rumbaugh, K. P., Schulte, T., Sun, L., Åkerlund, B. & Römling, U., 2018, In: Journal of Internal Medicine. 284, 4, p. 332-345 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  45. Published

    Biofilms can act as plasmid reserves in the absence of plasmid specific selection

    Røder, Henriette Lyng, Trivedi, Urvish, Russel, Jakob, Kragh, Kasper Nørskov, Herschend, J., Thalsø-Madsen, I., Tolker-Nielsen, Tim, Bjarnsholt, Thomas, Burmølle, Mette & Madsen, Jonas Stenløkke, 2021, In: NPJ biofilms and microbiomes. 7, 6 p., 78.

    Research output: Contribution to journalLetterResearchpeer-review

  46. Published

    Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections

    Burmølle, Mette, Thomsen, T. R., Fazli, Mustafa, Dige, I., Christensen, L., Homøe, Preben, Tvede, M., Nyvad, B., Tolker-Nielsen, Tim, Givskov, Michael, Moser, Claus Ernst, Kirketerp-Møller, K., Johansen, Helle Krogh, Høiby, Niels, Jensen, Peter Østrup, Sørensen, Søren Johannes & Bjarnsholt, Thomas, 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 324-336 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  47. Published

    Biofilms in wounds: a review of present knowledge

    Cooper, R. A., Bjarnsholt, Thomas & Alhede, M., Nov 2014, In: Journal of Wound Care. 23, 11, p. 570, 572-4, 576-80 passim 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Biofilms of mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

    Kolpen, M., Jensen, Peter Østrup, Qvist, T., Kragh, Kasper Nørskov, Ravnholt, C., Fritz, Blaine Gabriel, Johansen, U. R., Bjarnsholt, Thomas & Høiby, Niels, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 2, e01212.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils

    Fexby, S., Bjarnsholt, Thomas, Jensen, Peter Østrup, Roos, V., Høiby, Niels, Givskov, Michael & Klemm, P., 2006, In: Infection and Immunity. 75, 1, p. 30-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Catalase protects biofilm of Staphylococcus aureus against daptomycin activity

    El Haj, C., Lichtenberg, Mads, Nielsen, K. L., Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: Antibiotics. 10, 5, 511.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 9755066