Thomas Bjarnsholt

Thomas Bjarnsholt

Professor

  • Bacteriology

    22, Building: 22.2.26

    2200 København N.

    Phone: +45 35 33 74 41Mobile: +45 20 65 98 88

  1. 2015
  2. Published

    The Limitations of In Vitro Experimentation in Understanding Biofilms and Chronic Infection

    Roberts, A. E. L., Kragh, Kasper Nørskov, Bjarnsholt, Thomas & Diggle, S. P., 20 Nov 2015, In: Journal of Molecular Biology. 427, 23, p. 3646-3661 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    RE-SENSITIZATION OF ANOXIC PSEUDOMONAS AERUGINOSA BIOFILMS WITH RE-OXYGENATION USING HYPERBARIC OXYGEN TREATMENT

    Kolpen, M., Mousavi, N., Sams, T., Kragh, Kasper Nørskov, Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, P. O., Oct 2015, In: Pediatric Pulmonology. 50, S41, p. 312-312 1 p., 322.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  4. Published

    Anti-Pseudomonas aeruginosa IgY Antibodies Induce Specific Bacterial Aggregation and Internalization in Human Polymorphonuclear Neutrophils

    Thomsen, K., Christophersen, L., Bjarnsholt, Thomas, Jensen, Peter Østrup, Moser, Claus Ernst & Høiby, Niels, Jul 2015, In: Infection and Immunity. 83, 7, p. 2686-2693 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Antibiofilm Properties of Acetic Acid

    Bjarnsholt, Thomas, Alhede, M., Jensen, Peter Østrup, Nielsen, Anne Kirstine, Johansen, Helle Krogh, Homøe, Preben, Høiby, Niels, Givskov, Michael & Kirketerp-Moller, K., Jun 2015, In: Advances in Wound Care. 4, 7, p. 363-372 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Unexpected Diagnosis of Cerebral Toxoplasmosis by 16S and D2 Large-Subunit Ribosomal DNA PCR and Sequencing

    Kruse, Alexandra Yasmin Collin, Kvich, Lasse Andersson, Eickhardt-Dalbøge, S. R., Omland, L. H., Bjarnsholt, Thomas & Moser, Claus Ernst, Jun 2015, In: Journal of Clinical Microbiology. 53, 6, p. 1983-1985 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Mucosal biofilm detection in chronic otitis media: a study of middle ear biopsies from Greenlandic patients

    Wessman, M., Bjarnsholt, Thomas, Eickhardt-Sørensen, S. R., Johansen, Helle Krogh & Homøe, Preben, May 2015, In: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 272, 5, p. 1079-1085 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    A novel in vitro wound biofilm model used to evaluate low-frequency ultrasonic-assisted wound debridement

    Crone, S., Garde, C., Bjarnsholt, Thomas & Alhede, M., Mar 2015, In: Journal of Wound Care. 24, 2, p. 64-72 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The Density of Competitors in a Stratified Environment Determines the Relative Fitness of Biofilm Structures

    Gordon, V. D., Kragh, Kasper Nørskov, Hutchison, J. B., Melaugh, G., Rodesney, C. A., Irie, Y., Diggle, S., Allen, R. J. & Bjarnsholt, Thomas, 9 Feb 2015, In: Biophysical Journal. 108, 2, supplement 1, p. 313A-313A 1 p., 1568-Pos.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  10. Published

    ESCMID guideline for the diagnosis and treatment of biofilm infections 2014

    Høiby, Niels, Bjarnsholt, Thomas, Moser, C., Bassi, G. L., Coenye, T., Donelli, G., Hall-Stoodley, L., Holá, V., Imbert, C., Kirketerp-Møller, K., Lebeaux, D., Oliver, A., Ullmann, A. J., Williams, C. & ESCMID Study Group for Biofilms (ESGB) and Consulting External Expert Werner Zimmerli, E. S. G. F. B. (. A. C. E. E. W. Z., 14 Jan 2015, In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 21, Suppl. 1, p. s1-s25 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Antibiotic penetration and bacterial killing in a Pseudomonas aeruginosa biofilm model

    Cao, B., Christophersen, L., Thomsen, K., Sønderholm, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2015, In: The Journal of antimicrobial chemotherapy. 70, 7, p. 2057-2063 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Autofluorescence in samples obtained from chronic biofilm infections – “all that glitters is not gold”

    Eickhardt-Dalbøge, S. R., Kragh, Kasper Nørskov, Schrøder, S., Poulsen, Steen Seier, Sillesen, Henrik, Givskov, Michael, Høiby, Niels, Bjarnsholt, Thomas & Alhede, M., 2015, In: Pathogens and Disease. 73, 4, 4 p., ftv012.

    Research output: Contribution to journalLetterResearchpeer-review

  13. Published

    Denitrification by cystic fibrosis pathogens - Stenotrophomonas maltophilia is dormant in sputum

    Kolpen, M., Kragh, Kasper Nørskov, Bjarnsholt, Thomas, Line, L., Hansen, C. R., Dalbøge, C. S., Hansen, N., Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2015, In: International Journal of Medical Microbiology. 305, 1, p. 1-10 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Fluorescence in situ hybridization for the tissue detection of bacterial pathogens associated with porcine infections.

    Jensen, Henrik Elvang, Jensen, Louise Kruse, Barington, Kristiane, Pors, S. E., Bjarnsholt, Thomas & Boye, M., 2015, In: Methods in Molecular Biology. 1247, p. 219-134 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    HUMAN SKIN MICROORGANISMS ARE DISTRIBUTED IN BIOFILM AGGREGATES AT WOUND EDGES

    Bay, L., Agren, M. S., Poulsen, Steen Seier, Ghathian, K. S. A., Calum, H. & Bjarnsholt, Thomas, 2015, In: Wound Repair and Regeneration. 23, 4, p. A3-A3 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  16. Published

    In silico analyses of metagenomes from human atherosclerotic plaque samples

    Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Microbial biofilms and adverse reactions to gel fillers used in cosmetic surgery

    Alhede, M., Christensen, L. H. & Bjarnsholt, Thomas, 2015, In: Advances in Experimental Medicine and Biology. 831, p. 45-52 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Specific antibodies to Staphylococcus aureus  biofilm are present in serum from pigs with osteomyelitis

    Jensen, Louise Kruse, Jensen, Henrik Elvang, Koch, J., Bjarnsholt, Thomas, Eickhardt-Dalbøge, S. R. & Shirtliff, M., 2015, In: In Vivo. 29, p. 555-560 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2014
  20. Published

    Biofilms in wounds: a review of present knowledge

    Cooper, R. A., Bjarnsholt, Thomas & Alhede, M., Nov 2014, In: Journal of Wound Care. 23, 11, p. 570, 572-4, 576-80 passim 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Microbial biofilms--the coming of age of a research field

    Coenye, T., Van Dijck, P., Bjarnsholt, Thomas & Forsberg, A., Apr 2014, In: Pathogens and Disease. 70, 3, p. 203-4 2 p.

    Research output: Contribution to journalJournal articleResearch

  22. Published

    Bacterial biofilm formation and treatment in soft tissue fillers

    Alhede, M., Er, O., Eickhardt, S., Kragh, Kasper Nørskov, Alhede, M., Hultqvist, L. D., Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.

    Research output: Contribution to journalJournal articleResearch

  23. Published

    Novel Targets for Treatment of Pseudomonas aeruginosa Biofilms

    Alhede, M., Alhede, M. & Bjarnsholt, Thomas, 1 Jan 2014, Antibiofilm Agents. Rumbaugh, K. (ed.). Springer Publishing Company, Vol. 8. p. 257-272 16 p. (Springer Series on Biofilms, Vol. 8).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  24. Published

    Antimicrobials and Non-Healing Wounds. Evidence, controversies and suggestions-key messages

    Gottrup, F., Apelqvist, J., Bjarnsholt, Thomas, Cooper, R., Moore, Z., Peters, E. J. G. & Probst, S., 2014, In: Journal of Wound Care. 23, 10, p. 477-8, 480, 482 4 p.

    Research output: Contribution to journalJournal articleResearch

  25. Published

    Are biofilms responsible for the adverse effects experienced following soft-tissue fillers?

    Alhede, M. & Bjarnsholt, Thomas, 2014, In: Future Microbiology. 9, 8, p. 931-3 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation

    Brochmann, R. P., Toft, A., Ciofu, Oana, Briales, A., Kolpen, M., Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, 2014, In: International Journal of Antimicrobial Agents. 43, 2, p. 140-147 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Exhaled breath analysis using electronic nose in cystic fibrosis and primary ciliary dyskinesia patients with chronic pulmonary infections

    Joensen, O., Paff, T., Haarman, E. G., Skovgaard, I. M., Jensen, Peter Østrup, Bjarnsholt, Thomas & Nielsen, Kim G., 2014, In: PLOS ONE. 9, 12, p. 1-15 15 p., e115584.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms

    Jensen, Peter Østrup, Briales, A., Brochmann, R. P., Wang, H., Kragh, Kasper Nørskov, Kolpen, M., Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Ciofu, Oana, 2014, In: Pathogens and Disease. 70, 3, p. 440-443 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Interactions in multispecies biofilms: do they actually matter?

    Burmølle, Mette, Ren, D., Bjarnsholt, Thomas & Sørensen, Søren Johannes, 2014, In: Trends in Microbiology. 22, 2, p. 84-91 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Methods for dynamic investigations of surface-attached in vitro bacterial and fungal biofilms

    Sternberg, C., Bjarnsholt, Thomas & Shirtliff, M., 2014, In: Methods in molecular biology (Clifton, N.J.). 1147, p. 3-22 20 p.

    Research output: Contribution to journalJournal articleResearch

  31. Published

    Nitric oxide production by polymorphonuclear leukocytes in infected cystic fibrosis sputum consumes oxygen

    Kolpen, M., Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Rickelt, L. F., Kühl, Michael, Hempel, C., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Clinical and Experimental Immunology. 177, 1, p. 310–319 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection

    Kolpen, M., Kühl, Michael, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Liengaard, L., Kharazmi, A., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: PLOS ONE. 9, 1, p. e84353 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples

    Fazli, Mustafa, Bjarnsholt, Thomas, Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, 2014, In: Methods in Molecular Biology. 1211, p. 261-71 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum

    Line, L., Alhede, M., Kolpen, M., Kühl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus Ernst, Toyofuku, M., Nomura, N., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Frontiers in Microbiology. 5, 11 p., 554.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients

    Kragh, Kasper Nørskov, Alhede, M., Jensen, Peter Østrup, Moser, Claus Ernst, Scheike, Thomas, Jacobsen, C. S., Poulsen, Steen Seier, Eickhardt-Sørensen, S. R., Trostrup, H., Christoffersen, L., Hougen, H. P., Rickelt, L. F., Kühl, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2014, In: Infection and Immunity. 82, 11, p. 4477-4486 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion

    Alhede, M., Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., 2014, In: Advances in Applied Microbiology. 86, p. 1-40 40 p.

    Research output: Contribution to journalJournal articleResearch

  37. Published

    Rapid identification of Stenotrophomonas maltophilia by peptide nucleic acid fluorescence in situ hybridization

    Knudsen, N. R., Rasmussen, A. K. I., Fiandaca, M. J., Kragh, Kasper Nørskov, Bjarnsholt, Thomas, Høiby, Niels, Stender, H. & Guardabassi, Luca, 2014, In: New Microbes and New Infections. 2, 3, p. 79-81 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Sinus biofilms in patients with cystic fibrosis: is adjusted eradication therapy needed?

    Aanæs, Kasper, Eickhardt, S., Johansen, Helle Krogh, von Buchwald, Christian, Skov, M., Høiby, Niels & Bjarnsholt, Thomas, 2014, In: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. p. 1-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. 2013
  40. Published

    Applying insights from biofilm biology to drug development - can a new approach be developed?

    Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors

    Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Dietzia papillomatosis Bacteremia

    Rammer, P., Calum, Henrik Pierre, Moser, Claus Ernst, Björnsdóttir, M. K., Smedegaard, H., Høiby, Niels & Bjarnsholt, Thomas, Jun 2013, In: Journal of Clinical Microbiology. 51, 6, p. 1977-8 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    A non-fatal case of invasive zygomycete (Lichtheimia corymbifera) infection in an allogeneic haematopoietic cell transplant recipient

    Eickhardt, S., Braendstrup, P., Clasen-Linde, E., Jensen, K. E., Alhede, M., Bjarnsholt, Thomas, Høiby, Niels, Vindeløv, L. & Moser, Claus Ernst, May 2013, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 121, 5, p. 456-9 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Bacterial infection as a likely cause of adverse reactions to polyacrylamide hydrogel fillers in cosmetic surgery

    Christensen, L., Breiting, V., Bjarnsholt, Thomas, Eickhardt, S., Høgdall, E., Janssen, M., Pallua, N. & Zaat, S. A. J., May 2013, In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 56, 10, p. 1438-44 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    The role of bacterial biofilms in chronic infections

    Bjarnsholt, Thomas, May 2013, In: APMIS Supplementum. 121, s136, p. 1-58 58 p.

    Research output: Contribution to journalJournal articleResearch

  46. Published

    Direct sequencing and RipSeq interpretation as a tool for identification of polymicrobial infections

    Wolff, T. Y., Eickhardt, S., Björnsdottir, M. K., Moser, Claus Ernst, Bjarnsholt, Thomas, Høiby, Niels & Thomsen, T. R., Apr 2013, In: Journal of Clinical Microbiology. 51, 4, p. 1281-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Pseudomonas aeruginosa biofilm aggravates skin inflammatory response in BALB/c mice in a novel chronic wound model

    Trøstrup, H., Thomsen, Kim, Christophersen, L. J., Hougen, H. P., Bjarnsholt, Thomas, Jensen, Peter Østrup, Kirkby, N., Calum, H., Høiby, Niels & Moser, Claus Ernst, Mar 2013, In: Wound Repair and Regeneration. 21, 2, p. 292-299 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Identification of pathogenic microorganisms directly from positive blood vials by matrix-assisted laser desorption/ionization time of flight mass spectrometry

    Nonnemann, B., Tvede, M. & Bjarnsholt, Thomas, 18 Jan 2013, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 121, 9, p. 871-877 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes

    Jakobsen, Tim Holm, Hansen, M. A., Jensen, Peter Østrup, Hansen, L., Riber, Leise, Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, Klaus, Burmølle, Mette, Moser, Claus Ernst, Kühl, Michael, Ciofu, Oana, Givskov, Michael, Sørensen, Søren Johannes, Høiby, Niels & Bjarnsholt, Thomas, 2013, In: P L o S One. 8, 7, 17 p., e68484.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    EWMA document: Antimicrobials and non-healing wounds. Evidence, controversies and suggestions

    Gottrup, F., Apelqvist, J., Bjarnsholt, Thomas, Bjansholt, T., Cooper, R., Moore, Z., Peters, E. J. G. & Probst, S., 2013, In: Journal of Wound Care. 22, 5 Suppl, p. S1-89

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR

    Claussen, A., Jakobsen, Tim Holm, Bjarnsholt, Thomas, Givskov, Michael, Welch, M., Ferkinghoff-Borg, J. & Sams, T., 2013, In: International Journal of Molecular Sciences (Online). 14, 7, p. 13360-76 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    The in vivo biofilm

    Bjarnsholt, Thomas, Alhede, M., Alhede, M., Eickhardt-Sørensen, S. R., Moser, Claus Ernst, Kühl, Michael, Jensen, Peter Østrup & Høiby, Niels, 2013, In: Trends in Microbiology. 21, 9, p. 466-474 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  53. 2012
  54. Published

    Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo

    van Gennip, M., Hultqvist, L. D., Alhede, M., Qvortrup, Klaus, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Aug 2012, In: Infection and Immunity. 80, 8, p. 2601-2607 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 9755066