Tim Holm Jakobsen

Tim Holm Jakobsen

Associate Professor

ORCID: 0000-0002-1671-2155

Publication year:
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1 - 25 out of 37Page size: 25
  1. 2022
  2. Published

    Biofilm Survival Strategies in Chronic Wounds

    Thaarup, Ida Clement, Iversen, Anne Kristine Servais, Lichtenberg, Mads, Bjarnsholt, Thomas & Jakobsen, Tim Holm, 2022, In: Microorganisms. 10, 4, 775.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

    Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2021
  5. Published

    Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

    Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, M., Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms

    Andersen, Jens Bo, Kragh, Kasper Nørskov, Hultqvist, Louise Dahl, Rybtke, M., Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Nitric-oxide-driven oxygen release in anoxic Pseudomonas aeruginosa

    Lichtenberg, Mads, Line, L., Schrameyer, V., Jakobsen, Tim Holm, Rybtke, M. L., Toyofuku, M., Nomura, N., Kolpen, M., Tolker-Nielsen, Tim, Kühl, Michael, Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: iScience. 24, 12, 103404.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

    Jansen, C. U., Uhd, J., Andersen, Jens Bo, Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Sampling challenges in diagnosis of chronic bacterial infections

    Jakobsen, Tim Holm, Xu, Y., Bay, Lene, Schønheyder, H. C., Jakobsen, T., Bjarnsholt, Thomas & Thomsen, T. R., 2021, In: Journal of Medical Microbiology. 70, 3

    Research output: Contribution to journal › Review › Research › peer-review

  10. 2019
  11. Published

    Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

    Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael, Twetman, Svante & Tolker-Nielsen, Tim, 2019, In: Microbiology. 165, 3, p. 334-342

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation

    Qvortrup, K., Hultqvist, Louise Dahl, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Jansen, C. U., Uhd, J., Andersen, Jens Bo, Nielsen, Thomas Eiland, Givskov, Michael & Tolker-Nielsen, Tim, 2019, In: Frontiers in Chemistry. 7, 27 p., 742.

    Research output: Contribution to journal › Review › Research › peer-review

  13. 2018
  14. Published

    Implants induce a new niche for microbiomes

    Jakobsen, Tim Holm, Eickhardt, S. R., Gheorghe, Alexandra Gabriella, Stenqvist, C., Sønderholm, M., Stavnsberg, C., Jensen, Peter Østrup, Odgaard, Anders, Whiteley, M., Moser, Claus Ernst, Hvolris, J., Hougen, Hans Petter & Bjarnsholt, Thomas, 1 Aug 2018, In: APMIS - Journal of Pathology, Microbiology and Immunology. 126, 8, p. 685-692 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Imaging N-acyl homoserine lactone quorum sensing in vivo

    Hultqvist, Louise Dahl, Alhede, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 2018, Quorum Sensing: Methods and Protocols. Leoni, L. & Rampion, G. (eds.). Humana Press, Vol. 1673. p. 203-212 10 p. (Methods in Molecular Biology; No. 1673).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  16. Published

    Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro

    Jakobsen, Tim Holm, Alhede, M., Hultqvist, Louise Dahl, Bjarnsholt, Thomas & Givskov, Michael, 2018, Quorum Sensing: Methods and Protocols. Springer, Vol. 1673. p. 275-285 11 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  17. 2017
  18. Published

    Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes

    Jakobsen, Tim Holm, Tolker-Nielsen, Tim & Givskov, Michael, Sep 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.

    Research output: Contribution to journal › Review › Research › peer-review

  19. Published

    Pseudomonas aeruginosa aggregate formation in an alginate bead model system exhibits In Vivo-like characteristics

    Sønderholm, M., Kragh, Kasper Nørskov, Koren, K., Jakobsen, Tim Holm, Darch, S., Alhede, M., Jensen, Peter Østrup, Whiteley, M., Kühl, Michael & Bjarnsholt, Thomas, May 2017, In: Applied and Environmental Microbiology. 83, 9, 15 p., e00113-17.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

    Fong, J., Yuan, M., Jakobsen, Tim Holm, Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    A broad range quorum sensing inhibitor working through sRNA inhibition

    Jakobsen, Tim Holm, Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, M., Andersen, Jens Bo, Petersen, R., Andersen, Paal Skytt, Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, A., Ingmer, Hanne & Givskov, Michael, 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors

    Thanh Tung, T., Jakobsen, Tim Holm, Dao, T. T., Fuglsang, Anja Thoe, Givskov, Michael, Christensen, Søren Brøgger & Nielsen, John, 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries

    Midjord-Belstrøm, Daniel, Constancias, F., Liu, Y., Yang, L., Drautz-Moses, D. I., Schuster, S. C., Kohli, G. S., Jakobsen, Tim Holm, Holmstrup, Palle & Givskov, Michael, 2017, In: npj Biofilms and Microbiomes. 3, 8 p., 23.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. 2015
  25. Published

    Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

    Hansen, M. R., Jakobsen, Tim Holm, Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T., 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2014
  27. Published

    Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa

    Tan, S. Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, Tim Holm, Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, Tim, Yang, L. & Givskov, Michael, Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

    Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. 2013
  30. Published

    Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors

    Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes

    Jakobsen, Tim Holm, Hansen, M. A., Jensen, Peter Østrup, Hansen, L., Riber, Leise, Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, Klaus, Burmølle, Mette, Moser, Claus Ernst, Kühl, Michael, Ciofu, Oana, Givskov, Michael, Sørensen, Søren Johannes, Høiby, Niels & Bjarnsholt, Thomas, 2013, In: P L o S One. 8, 7, 17 p., e68484.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Identification of LasR ligands through a virtual screening approach

    Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, Tim Holm, Harmsen, M., Tolker-Nielsen, Tim, Nielsen, T. E., Givskov, Michael & Taboureau, O., 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR

    Claussen, A., Jakobsen, Tim Holm, Bjarnsholt, Thomas, Givskov, Michael, Welch, M., Ferkinghoff-Borg, J. & Sams, T., 2013, In: International Journal of Molecular Sciences (Online). 14, 7, p. 13360-76 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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