Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds

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Standard

Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds. / Wu, Peng; Nielsen, Thomas E.

In: Drug Discovery Today: Technologies, Vol. 29, 2018, p. 27-33.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wu, P & Nielsen, TE 2018, 'Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds', Drug Discovery Today: Technologies, vol. 29, pp. 27-33. https://doi.org/10.1016/j.ddtec.2018.06.010

APA

Wu, P., & Nielsen, T. E. (2018). Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds. Drug Discovery Today: Technologies, 29, 27-33. https://doi.org/10.1016/j.ddtec.2018.06.010

Vancouver

Wu P, Nielsen TE. Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds. Drug Discovery Today: Technologies. 2018;29:27-33. https://doi.org/10.1016/j.ddtec.2018.06.010

Author

Wu, Peng ; Nielsen, Thomas E. / Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds. In: Drug Discovery Today: Technologies. 2018 ; Vol. 29. pp. 27-33.

Bibtex

@article{8177ae51bfb943efba145d4f0b7f21fe,
title = "Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds",
abstract = "The Petasis three-component reaction (PR) of hydroxy aldehydes, amines and boronic acids is an important multi-component reaction for the synthesis of structurally diverse scaffolds and biologically interesting small molecules. The reaction has been significantly explored in the past decade, and many new variants have emerged, such as asymmetric, traceless and four-component approaches. The excellent stereoselectivity, high yield and broad functional group tolerance altogether make this reaction ideal for fragment and compound collection synthesis, since orthogonal chemical handles can be incorporated for subsequent scaffold formation and appendage modification. Herein we present a selection of recent variations on the PR theme for the synthesis of scaffolds of relevance to medicinal chemistry.",
author = "Peng Wu and Nielsen, {Thomas E.}",
year = "2018",
doi = "10.1016/j.ddtec.2018.06.010",
language = "English",
volume = "29",
pages = "27--33",
journal = "Drug Discovery Today: Technologies",
issn = "1740-6749",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds

AU - Wu, Peng

AU - Nielsen, Thomas E.

PY - 2018

Y1 - 2018

N2 - The Petasis three-component reaction (PR) of hydroxy aldehydes, amines and boronic acids is an important multi-component reaction for the synthesis of structurally diverse scaffolds and biologically interesting small molecules. The reaction has been significantly explored in the past decade, and many new variants have emerged, such as asymmetric, traceless and four-component approaches. The excellent stereoselectivity, high yield and broad functional group tolerance altogether make this reaction ideal for fragment and compound collection synthesis, since orthogonal chemical handles can be incorporated for subsequent scaffold formation and appendage modification. Herein we present a selection of recent variations on the PR theme for the synthesis of scaffolds of relevance to medicinal chemistry.

AB - The Petasis three-component reaction (PR) of hydroxy aldehydes, amines and boronic acids is an important multi-component reaction for the synthesis of structurally diverse scaffolds and biologically interesting small molecules. The reaction has been significantly explored in the past decade, and many new variants have emerged, such as asymmetric, traceless and four-component approaches. The excellent stereoselectivity, high yield and broad functional group tolerance altogether make this reaction ideal for fragment and compound collection synthesis, since orthogonal chemical handles can be incorporated for subsequent scaffold formation and appendage modification. Herein we present a selection of recent variations on the PR theme for the synthesis of scaffolds of relevance to medicinal chemistry.

U2 - 10.1016/j.ddtec.2018.06.010

DO - 10.1016/j.ddtec.2018.06.010

M3 - Journal article

C2 - 30471670

AN - SCOPUS:85049886289

VL - 29

SP - 27

EP - 33

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

SN - 1740-6749

ER -

ID: 208888199