Michael Givskov
Professor
Bacteriology
Blegdamsvej 3B, 2200 København N, 22 Bygning 22, Building: 22-2-22
Member of:
- Published
A mouse ear skin model to study the dynamics of innate immune responses against Staphylococcus aureus biofilms
Abdul Hamid, A. I., Nakusi, L., Givskov, Michael, Chang, Y. T., Marquès, C. & Gueirard, P., 2020, In: BMC Microbiology. 20, 1, 12 p., 22.Research output: Contribution to journal › Journal article › Research › peer-review
The identification of a tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group
Agersø, Y., Jensen, L. B., Givskov, Michael & Roberts, M. C., 2002, In: FEMS Microbiology Letters. 214, 2, p. 251-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion
Alhede, M., Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., 2014, In: Advances in Applied Microbiology. 86, p. 1-40 40 p.Research output: Contribution to journal › Journal article › Research
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Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacterial biofilm formation and treatment in soft tissue fillers
Alhede, M., Er, O., Eickhardt, S., Kragh, K., Alhede, M., Hultqvist, Louise Dahl, Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.Research output: Contribution to journal › Journal article › Research
- Published
Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes
Alhede, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Phipps, R. K., Moser, Claus Ernst, Christophersen, L., Hultqvist, Louise Dahl, van Gennip, M., Parsek, M., Høiby, Niels, Rasmussen, T. B. & Givskov, Michael, 2009, In: Microbiology. 155, 11, p. 3500-3508 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition
Alhede, M., Qvortrup, Klaus, Liebrechts, R., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 335-342 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel and future treatment strategies
Alhede, M., Jakobsen, Tim Holm & Givskov, Michael, 1 Dec 2011, Biofilm Infections. Springer, p. 231-249 19 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms
Allesen-Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, Michael & Tolker-Nielsen, T., 2006, In: Molecular Microbiology. 59, 4, p. 1114-28 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content
Almblad, H., Rybtke, Morten Levin, Hendiani, S., Andersen, Jens Bo, Givskov, Michael & Tolker-Nielsen, Tim, Mar 2019, In: Microbiology. 165, 3, p. 324-333 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP
Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Jul 2015, In: Journal of Bacteriology. 197, 13, p. 2190-200 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP
Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Aug 2015, In: Journal of Bacteriology. 197, 16, p. 2731 1 p.Research output: Contribution to journal › Comment/debate › Research
Serratia liquefaciens swarm cells exhibit enhanced resistance to predation by Tetrahymena sp
Ammendola, A., Geisenberger, O., Andersen, J. B., Givskov, Michael, Schleifer, K. H. & Eberl, L., 1998, In: F E M S Microbiology Letters. 164, 1, p. 69-75 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are toxic to Lucilia sericata maggots
Andersen, A. S., Joergensen, B., Bjarnsholt, Thomas, Johansen, H., Karlsmark, T., Givskov, Michael, Krogfelt, K. A., Andersen, A. S., Jørgensen, B., Bjarnsholt, T., Johansen, H., Karlsmark, Tonny, Givskov, M. & Krogfelt, K. A., 1 Feb 2010, In: Microbiology. 156, Pt 2, p. 400-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication
Andersen, J. B., Heydorn, A., Hentzer, M., Eberl, L., Geisenberger, O., Christensen, B. B., Molin, S. & Givskov, Michael, 2001, In: Applied and Environmental Microbiology. 67, 2, p. 575-85 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria
Andersen, J. B., Sternberg, C., Poulsen, L. K., Bjorn, S. P., Givskov, Michael & Molin, S., 1998, In: Applied and Environmental Microbiology. 64, 6, p. 2240-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Surface motility in Pseudomonas sp. DSS73 is required for efficient biological containment of the root-pathogenic microfungi Rhizoctonia solani and Pythium ultimum
Andersen, Jens Bo, Koch, B., Nielsen, T. H., Sørensen, D., Hansen, M., Nybroe, O., Christophersen, C., Sørensen, J., Molin, S. & Givskov, Michael, 2003, In: Microbiology. 149, Pt 1, p. 37-46 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms
Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms
Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics
Arevalo-Ferro, C., Hentzer, M., Reil, G., Görg, A., Kjelleberg, S., Givskov, Michael, Riedel, K. & Eberl, L., 2003, In: Environmental Microbiology. 5, 12, p. 1350-69 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilms of pathogenic nontuberculous mycobacteria targeted by new therapeutic approaches
Aung, T. T., Yam, J. K. H., Lin, S., Salleh, S. M., Givskov, Michael, Liu, S., Lwin, N. C., Yang, L. & Beuerman, R. W., 1 Jan 2016, In: Antimicrobial Agents and Chemotherapy. 60, 1, p. 24-35 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of novel antimycobacterial drug therapy in biofilm of pathogenic nontuberculous mycobacterial keratitis
Aung, T. T., Chor, W. H. J., Yam, J. K. H., Givskov, Michael, Yang, L. & Beuerman, R. W., 2017, In: Ocular Surface. 15, 4, p. 770-783 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD.
Bagge, N., Ciofu, Oana, Hentzer, M., Campbell, J. I. A., Givskov, Michael & Høiby, Niels, 2002, In: Antimicrobial Agents and Chemotherapy. 46, 11, p. 3406-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.
Bagge, N., Hentzer, M., Andersen, Jens Bo, Ciofu, Oana, Givskov, Michael & Høiby, Niels, 2004, In: Antimicrobial Agents and Chemotherapy. 48, 4, p. 1168-74 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.
Bagge, N., Schuster, M., Hentzer, M., Ciofu, Oana, Givskov, Michael, Greenberg, E. P. & Høiby, Niels, 2004, In: Antimicrobial Agents and Chemotherapy. 48, 4, p. 1175-87 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors
Bang, C. G., Jensen, J. F., O'Hanlon Cohrt, E., Olsen, L. B., Siyum, S. G., Mortensen, K. T., Skovgaard, T., Berthelsen, J., Yang, L., Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, Oct 2017, In: ACS Combinatorial Science. 19, 10, p. 657-669 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms
Barken, K. B., Pamp, S. J., Yang, L., Gjermansen, M., Bertrand, J. J., Klausen, M., Givskov, Michael, Whitchurch, C. B., Engel, J. N. & Tolker-Nielsen, Tim, 2008, In: Environmental Microbiology. 10, 9, p. 2331-2343 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative effects of medium hardness and nutrient availability on the swarming motility of Serratia liquefaciens
Bees, M. A., Andresén, P., Mosekilde, E. & Givskov, Michael, 2002, In: Bulletin of Mathematical Biology. 64, 3, p. 565-87 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
The interaction of thin-film flow, bacterial swarming and cell differentiation in colonies of Serratia liquefaciens
Bees, M. A., Andresén, P., Mosekilde, E. & Givskov, Michael, 2000, In: Journal of Mathematical Biology. 40, 1, p. 27-63 37 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional Activity of Predominant Streptococcus Species at Multiple Oral Sites Associate With Periodontal Status
Midjord-Belstrøm, Daniel, Constancias, F., Markvart, Merete, Sikora, Martin, Sørensen, Christiane Elisabeth & Givskov, Michael, 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 13 p., 752664.Research output: Contribution to journal › Journal article › Research › peer-review
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Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries
Midjord-Belstrøm, Daniel, Constancias, F., Liu, Y., Yang, L., Drautz-Moses, D. I., Schuster, S. C., Kohli, G. S., Jakobsen, Tim Holm, Holmstrup, Palle & Givskov, Michael, 2017, In: npj Biofilms and Microbiomes. 3, 8 p., 23.Research output: Contribution to journal › Journal article › Research › peer-review
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Periodontitis associates with species-specific gene expression of the oral microbiota
Midjord-Belstrøm, Daniel, Constancias, F., Drautz-Moses, D. I., Schuster, S. C., Veleba, M., Mahé, F. & Givskov, Michael, 2021, In: npj Biofilms and Microbiomes. 7, 76.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control
Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients
Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115Research output: Contribution to journal › Journal article › Research › peer-review
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Why chronic wounds will not heal: a novel hypothesis
Bjarnsholt, Thomas, Kirketerp-Møller, K., Jensen, Peter Østrup, Madsen, K. G., Phipps, R. K., Krogfelt, K., Høiby, Niels & Givskov, Michael, 2008, In: Wound Repair and Regeneration. 16, 1, p. 2-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interfering with bacterial gossip.
Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Quorum sensing inhibitors disable bacterial biofilms.
Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Emerging trends in in antibacterial discovery.. Miller, A. A. & Miller, P. F. (eds.). 1 ed. Norvich UK: HorizonBioscience, p. 211-224 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections
Bjarnsholt, T., Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H., Rygaard, J., Moser, C., Eberl, L., Høiby, N. & Givskov, Michael, 2005, In: Microbiology. 151, Pt 12, p. 3873-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent
Bjarnsholt, Thomas, Jensen, Peter Østrup, Burmølle, Mette, Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, Claus Ernst, Molin, S., Høiby, Niels & Givskov, Michael, Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Process for the manufacture of ajoene derivatives
Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154Research output: Patent
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Silver against Pseudomonas aeruginosa biofilms
Bjarnsholt, Thomas, Kirketerp-Møller, K., Kristiansen, S., Phipps, R., Nielsen, A. K., Jensen, Peter Østrup, Høiby, Niels & Givskov, Michael, 2007, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 115, 8, p. 921-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions
Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Givskov, Michael, Janssen, M. & Christensen, L. H., 2009, In: Dermatologic Surgery. 35 Suppl 2, p. 1620-1624 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens
Bjarnsholt, T. & Givskov, Michael, 2007, In: Philosophical Transactions of the Royal Society of London. Biological Sciences. 362, 1483, p. 1213-22 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Applying insights from biofilm biology to drug development - can a new approach be developed?
Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?
Bjarnsholt, Thomas & Givskov, Michael, 2008, In: Current Infectious Disease Reports. 10, 1, p. 22-28 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibiofilm Properties of Acetic Acid
Bjarnsholt, Thomas, Alhede, M., Jensen, Peter Østrup, Nielsen, Anne Kirstine, Johansen, Helle Krogh, Homøe, Preben, Høiby, Niels, Givskov, Michael & Kirketerp-Moller, K., Jun 2015, In: Advances in Wound Care. 4, 7, p. 363-372 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients
Bjarnsholt, Thomas, Jensen, Peter Østrup, Fiandaca, M. J., Pedersen, J., Hansen, C. R., Andersen, C. B., Pressler, T., Givskov, Michael & Høiby, Niels, 1 Jun 2009, In: Pediatric Pulmonology. 44, 6, p. 547-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudo-monas aeruginosa infections.
Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christoffersen, L., Calum, Henrik Pierre, Hentzer, M., Hougen, H. P., Rygaard, J., Moser, Claus Ernst, Eberl, L., Høiby, Niels & Givskov, Michael, 2005, In: F E M S Microbiology. 151, p. 3873-3880 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect
Bjarnsholt, Thomas, van Gennip, M., Jakobsen, Tim Holm, Hultqvist, Louise Dahl, Jensen, Peter Østrup & Givskov, Michael, 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protoanemonin: a natural quorum sensing inhibitor that selectively activates iron starvation response
Bobadilla Fazzini, R. A., Skindersoe, M. E., Bielecki, P., Puchalka, J., Givskov, Michael & Martins sos Santos, V. A. P., 2013, In: Environmental Microbiology Reports. 15, 1, p. 111-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5838523
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
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C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth
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Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
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