Michael Givskov

Michael Givskov

Professor

Member of:


    1. Published

      A mouse ear skin model to study the dynamics of innate immune responses against Staphylococcus aureus biofilms

      Abdul Hamid, A. I., Nakusi, L., Givskov, Michael, Chang, Y. T., Marquès, C. & Gueirard, P., 2020, In: BMC Microbiology. 20, 1, 12 p., 22.

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. The identification of a tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group

      Agersø, Y., Jensen, L. B., Givskov, Michael & Roberts, M. C., 2002, In: FEMS Microbiology Letters. 214, 2, p. 251-6 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion

      Alhede, M., Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., 2014, In: Advances in Applied Microbiology. 86, p. 1-40 40 p.

      Research output: Contribution to journalJournal articleResearch

    4. Published

      Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

      Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Bacterial biofilm formation and treatment in soft tissue fillers

      Alhede, M., Er, O., Eickhardt, S., Kragh, K., Alhede, M., Hultqvist, Louise Dahl, Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.

      Research output: Contribution to journalJournal articleResearch

    6. Published

      Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes

      Alhede, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Phipps, R. K., Moser, Claus Ernst, Christophersen, L., Hultqvist, Louise Dahl, van Gennip, M., Parsek, M., Høiby, Niels, Rasmussen, T. B. & Givskov, Michael, 2009, In: Microbiology. 155, 11, p. 3500-3508 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition

      Alhede, M., Qvortrup, Klaus, Liebrechts, R., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 335-342 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Novel and future treatment strategies

      Alhede, M., Jakobsen, Tim Holm & Givskov, Michael, 1 Dec 2011, Biofilm Infections. Springer, p. 231-249 19 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    9. A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms

      Allesen-Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, Michael & Tolker-Nielsen, T., 2006, In: Molecular Microbiology. 59, 4, p. 1114-28 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content

      Almblad, H., Rybtke, Morten Levin, Hendiani, S., Andersen, Jens Bo, Givskov, Michael & Tolker-Nielsen, Tim, Mar 2019, In: Microbiology. 165, 3, p. 324-333 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

      Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Jul 2015, In: Journal of Bacteriology. 197, 13, p. 2190-200 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

      Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Aug 2015, In: Journal of Bacteriology. 197, 16, p. 2731 1 p.

      Research output: Contribution to journalComment/debateResearch

    13. Serratia liquefaciens swarm cells exhibit enhanced resistance to predation by Tetrahymena sp

      Ammendola, A., Geisenberger, O., Andersen, J. B., Givskov, Michael, Schleifer, K. H. & Eberl, L., 1998, In: F E M S Microbiology Letters. 164, 1, p. 69-75 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are toxic to Lucilia sericata maggots

      Andersen, A. S., Joergensen, B., Bjarnsholt, Thomas, Johansen, H., Karlsmark, T., Givskov, Michael, Krogfelt, K. A., Andersen, A. S., Jørgensen, B., Bjarnsholt, T., Johansen, H., Karlsmark, Tonny, Givskov, M. & Krogfelt, K. A., 1 Feb 2010, In: Microbiology. 156, Pt 2, p. 400-7 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication

      Andersen, J. B., Heydorn, A., Hentzer, M., Eberl, L., Geisenberger, O., Christensen, B. B., Molin, S. & Givskov, Michael, 2001, In: Applied and Environmental Microbiology. 67, 2, p. 575-85 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria

      Andersen, J. B., Sternberg, C., Poulsen, L. K., Bjorn, S. P., Givskov, Michael & Molin, S., 1998, In: Applied and Environmental Microbiology. 64, 6, p. 2240-6 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Surface motility in Pseudomonas sp. DSS73 is required for efficient biological containment of the root-pathogenic microfungi Rhizoctonia solani and Pythium ultimum

      Andersen, Jens Bo, Koch, B., Nielsen, T. H., Sørensen, D., Hansen, M., Nybroe, O., Christophersen, C., Sørensen, J., Molin, S. & Givskov, Michael, 2003, In: Microbiology. 149, Pt 1, p. 37-46 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Induction of native c-di-GMP phosphodiesterases leads to dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Kragh, K. N., Hultqvist, Louise Dahl, Rybtke, Morten Levin, Nilsson, Carl Martin Peter, Jakobsen, Tim Holm, Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02431-20.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

      Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, C. U., Jakobsen, Tim Holm, Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Uhd, J., Fritz, Blaine Gabriel, Seifert, R., Berthelsen, J., Nielsen, Thomas Eiland, Qvortrup, K., Givskov, Michael & Tolker-Nielsen, Tim, 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics

      Arevalo-Ferro, C., Hentzer, M., Reil, G., Görg, A., Kjelleberg, S., Givskov, Michael, Riedel, K. & Eberl, L., 2003, In: Environmental Microbiology. 5, 12, p. 1350-69 19 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Biofilms of pathogenic nontuberculous mycobacteria targeted by new therapeutic approaches

      Aung, T. T., Yam, J. K. H., Lin, S., Salleh, S. M., Givskov, Michael, Liu, S., Lwin, N. C., Yang, L. & Beuerman, R. W., 1 Jan 2016, In: Antimicrobial Agents and Chemotherapy. 60, 1, p. 24-35 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Discovery of novel antimycobacterial drug therapy in biofilm of pathogenic nontuberculous mycobacterial keratitis

      Aung, T. T., Chor, W. H. J., Yam, J. K. H., Givskov, Michael, Yang, L. & Beuerman, R. W., 2017, In: Ocular Surface. 15, 4, p. 770-783 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD.

      Bagge, N., Ciofu, Oana, Hentzer, M., Campbell, J. I. A., Givskov, Michael & Høiby, Niels, 2002, In: Antimicrobial Agents and Chemotherapy. 46, 11, p. 3406-11 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.

      Bagge, N., Hentzer, M., Andersen, Jens Bo, Ciofu, Oana, Givskov, Michael & Høiby, Niels, 2004, In: Antimicrobial Agents and Chemotherapy. 48, 4, p. 1168-74 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.

      Bagge, N., Schuster, M., Hentzer, M., Ciofu, Oana, Givskov, Michael, Greenberg, E. P. & Høiby, Niels, 2004, In: Antimicrobial Agents and Chemotherapy. 48, 4, p. 1175-87 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors

      Bang, C. G., Jensen, J. F., O'Hanlon Cohrt, E., Olsen, L. B., Siyum, S. G., Mortensen, K. T., Skovgaard, T., Berthelsen, J., Yang, L., Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, Oct 2017, In: ACS Combinatorial Science. 19, 10, p. 657-669 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms

      Barken, K. B., Pamp, S. J., Yang, L., Gjermansen, M., Bertrand, J. J., Klausen, M., Givskov, Michael, Whitchurch, C. B., Engel, J. N. & Tolker-Nielsen, Tim, 2008, In: Environmental Microbiology. 10, 9, p. 2331-2343 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Quantitative effects of medium hardness and nutrient availability on the swarming motility of Serratia liquefaciens

      Bees, M. A., Andresén, P., Mosekilde, E. & Givskov, Michael, 2002, In: Bulletin of Mathematical Biology. 64, 3, p. 565-87 22 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. The interaction of thin-film flow, bacterial swarming and cell differentiation in colonies of Serratia liquefaciens

      Bees, M. A., Andresén, P., Mosekilde, E. & Givskov, Michael, 2000, In: Journal of Mathematical Biology. 40, 1, p. 27-63 37 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      Transcriptional Activity of Predominant Streptococcus Species at Multiple Oral Sites Associate With Periodontal Status

      Midjord-Belstrøm, Daniel, Constancias, F., Markvart, Merete, Sikora, Martin, Sørensen, Christiane Elisabeth & Givskov, Michael, 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 13 p., 752664.

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries

      Midjord-Belstrøm, Daniel, Constancias, F., Liu, Y., Yang, L., Drautz-Moses, D. I., Schuster, S. C., Kohli, G. S., Jakobsen, Tim Holm, Holmstrup, Palle & Givskov, Michael, 2017, In: npj Biofilms and Microbiomes. 3, 8 p., 23.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Periodontitis associates with species-specific gene expression of the oral microbiota

      Midjord-Belstrøm, Daniel, Constancias, F., Drautz-Moses, D. I., Schuster, S. C., Veleba, M., Mahé, F. & Givskov, Michael, 2021, In: npj Biofilms and Microbiomes. 7, 76.

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. Published

      Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Høiby, Niels & Givskov, Michael, 2010, In: Expert Reviews in Molecular Medicine. 12, p. e11 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      Why chronic wounds will not heal: a novel hypothesis

      Bjarnsholt, Thomas, Kirketerp-Møller, K., Jensen, Peter Østrup, Madsen, K. G., Phipps, R. K., Krogfelt, K., Høiby, Niels & Givskov, Michael, 2008, In: Wound Repair and Regeneration. 16, 1, p. 2-10 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      Interfering with bacterial gossip.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Biofilm perspectives: Biofilm highlight. Flemming, H-C., Wingender, J. & Szewzyk, U. (eds.). 1 ed. Berlin: Springer Publishing Company, p. 163-188 26 p. (Springer Series on Biofilms, Vol. 5).

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    37. Published

      Quorum sensing inhibitors disable bacterial biofilms.

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim & Givskov, Michael, 2011, Emerging trends in in antibacterial discovery.. Miller, A. A. & Miller, P. F. (eds.). 1 ed. Norvich UK: HorizonBioscience, p. 211-224 14 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    38. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

      Bjarnsholt, T., Jensen, P. Ø., Rasmussen, T. B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H., Rygaard, J., Moser, C., Eberl, L., Høiby, N. & Givskov, Michael, 2005, In: Microbiology. 151, Pt 12, p. 3873-80 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Burmølle, Mette, Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, Claus Ernst, Molin, S., Høiby, Niels & Givskov, Michael, Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Process for the manufacture of ajoene derivatives

      Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154

      Research output: Patent

    41. Published

      Silver against Pseudomonas aeruginosa biofilms

      Bjarnsholt, Thomas, Kirketerp-Møller, K., Kristiansen, S., Phipps, R., Nielsen, A. K., Jensen, Peter Østrup, Høiby, Niels & Givskov, Michael, 2007, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 115, 8, p. 921-8 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions

      Bjarnsholt, Thomas, Tolker-Nielsen, Tim, Givskov, Michael, Janssen, M. & Christensen, L. H., 2009, In: Dermatologic Surgery. 35 Suppl 2, p. 1620-1624 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens

      Bjarnsholt, T. & Givskov, Michael, 2007, In: Philosophical Transactions of the Royal Society of London. Biological Sciences. 362, 1483, p. 1213-22 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      Applying insights from biofilm biology to drug development - can a new approach be developed?

      Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?

      Bjarnsholt, Thomas & Givskov, Michael, 2008, In: Current Infectious Disease Reports. 10, 1, p. 22-28 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      Antibiofilm Properties of Acetic Acid

      Bjarnsholt, Thomas, Alhede, M., Jensen, Peter Østrup, Nielsen, Anne Kirstine, Johansen, Helle Krogh, Homøe, Preben, Høiby, Niels, Givskov, Michael & Kirketerp-Moller, K., Jun 2015, In: Advances in Wound Care. 4, 7, p. 363-372 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Fiandaca, M. J., Pedersen, J., Hansen, C. R., Andersen, C. B., Pressler, T., Givskov, Michael & Høiby, Niels, 1 Jun 2009, In: Pediatric Pulmonology. 44, 6, p. 547-58 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudo-monas aeruginosa infections.

      Bjarnsholt, Thomas, Jensen, P. Ø., Rasmussen, T. B., Christoffersen, L., Calum, Henrik Pierre, Hentzer, M., Hougen, H. P., Rygaard, J., Moser, Claus Ernst, Eberl, L., Høiby, Niels & Givskov, Michael, 2005, In: F E M S Microbiology. 151, p. 3873-3880 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. Published

      In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect

      Bjarnsholt, Thomas, van Gennip, M., Jakobsen, Tim Holm, Hultqvist, Louise Dahl, Jensen, Peter Østrup & Givskov, Michael, 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      Protoanemonin: a natural quorum sensing inhibitor that selectively activates iron starvation response

      Bobadilla Fazzini, R. A., Skindersoe, M. E., Bielecki, P., Puchalka, J., Givskov, Michael & Martins sos Santos, V. A. P., 2013, In: Environmental Microbiology Reports. 15, 1, p. 111-20 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

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