Niels Høiby
Professor, No job title
Bacteriology
Blegdamsvej 3B, 2200 København N, 24 Bygning 24, Building: 24-1-16
Member of:
- 2015
- Published
The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection: a pilot study
Skov, M., Pressler, T., Lykkesfeldt, Jens, Poulsen, Henrik Enghusen, Jensen, Peter Østrup, Johansen, Helle Krogh, Qvist, T., Kræmer, D., Høiby, Niels & Ciofu, Oana, Mar 2015, In: Journal of Cystic Fibrosis. 14, 2, p. 211-218 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ESCMID guideline for the diagnosis and treatment of biofilm infections 2014
Høiby, Niels, Bjarnsholt, Thomas, Moser, C., Bassi, G. L., Coenye, T., Donelli, G., Hall-Stoodley, L., Holá, V., Imbert, C., Kirketerp-Møller, K., Lebeaux, D., Oliver, A., Ullmann, A. J., Williams, C. & ESCMID Study Group for Biofilms (ESGB) and Consulting External Expert Werner Zimmerli, E. S. G. F. B. (. A. C. E. E. W. Z., 14 Jan 2015, In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 21, Suppl. 1, p. s1-s25 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Simultaneous sinus and lung infections in patients with primary ciliary dyskinesia
Alanin, M. C., Johansen, Helle Krogh, Aanaes, K., Høiby, Niels, Pressler, T., Skov, M., Nielsen, K. G. & von Buchwald, Christian, Jan 2015, In: Acta Oto-Laryngologica. 135, 1, p. 58-63 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibiotic penetration and bacterial killing in a Pseudomonas aeruginosa biofilm model
Cao, B., Christophersen, L., Thomsen, K., Sønderholm, M., Bjarnsholt, Thomas, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2015, In: The Journal of antimicrobial chemotherapy. 70, 7, p. 2057-2063 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients
Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, H. & Høiby, Niels, 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Autofluorescence in samples obtained from chronic biofilm infections – “all that glitters is not gold”
Eickhardt-Dalbøge, S. R., Kragh, K. N., Schrøder, S., Poulsen, Steen Seier, Sillesen, Henrik, Givskov, Michael, Høiby, Niels, Bjarnsholt, Thomas & Alhede, M., 2015, In: Pathogens and Disease. 73, 4, 4 p., ftv012.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Denitrification by cystic fibrosis pathogens - Stenotrophomonas maltophilia is dormant in sputum
Kolpen, Mette, Kragh, K. N., Bjarnsholt, Thomas, Line, L., Hansen, C. R., Dalbøge, C. S., Hansen, N., Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2015, In: International Journal of Medical Microbiology. 305, 1, p. 1-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PSEUDOMONAS AERUGINOSA BIOFILM INFECTION SUPPRESSES LOCAL HOST RESPONSE IN BURN WOUNDS
Trostrup, H., Lerche, C. J., Christophersen, L., Thomsen, K., Jensen, P. O., Høiby, Niels & Moser, Claus Ernst, 2015, In: Wound Repair and Regeneration. 23, 4, p. A31-A31 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
S100A8/A9 WOUND FLUID LEVELS ARE REDUCED IN NON-HEALING VENOUS LEG ULCERS COMPARED WITH NEUROPATHIC FOOT ULCERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Trostrup, H., Laursen, A. C., Holstein, P., Christophersen, L., Jorgensen, B., Karlsmark, Tonny, Høiby, Niels, Moser, Claus Ernst & Agren, M. S., 2015, In: Wound Repair and Regeneration. 23, 4, p. A31-A31 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Strategies for combating bacterial biofilm infections
Wu, H., Moser, Claus Ernst, Wang, H., Høiby, Niels & Song, Z., 2015, In: International Journal of Oral Science. 7, 1, p. 1-7 7 p.Research output: Contribution to journal › Review › Research › peer-review
- 2014
- Published
Urine lipoarabinomannan point-of-care testing in patients affected by pulmonary nontuberculous mycobacteria - experiences from the Danish Cystic Fibrosis cohort study
Qvist, T., Johansen, I. S., Pressler, T., Høiby, Niels, Andersen, A. B., Katzenstein, T. L. & Bjerrum, S., 4 Dec 2014, In: BMC Infectious Diseases. 14, p. 1-8 8 p., 655.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A mariner transposon vector adapted for mutagenesis in oral streptococci
Nilsson, M., Christiansen, N., Høiby, Niels, Twetman, Svante, Givskov, Michael & Tolker-Nielsen, Tim, Jun 2014, In: MicrobiologyOpen. 3, 3, p. 333-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A personal history of research on microbial biofilms and biofilm infections
Høiby, Niels, Apr 2014, In: Pathogens and Disease. 70, 3, p. 205-211 7 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Effects of Radix Ginseng on microbial infections: a narrative review
Wu, H., Høiby, Niels, Yang, L., Givskov, Michael & Song, Z., Apr 2014, In: Journal of Traditional Chinese Medicine. 34, 2, p. 227-233 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacokinetic variability of clarithromycin and differences in CYP3A4 activity in patients with cystic fibrosis
Dalbøge, C. S., Nielsen, X. C., Dalhoff, K., Alffenaar, J. W., Duno, M., Buchard, Anders, Uges, D. R. A., Jensen, A. G., Jürgens, G., Pressler, T., Johansen, H. K. & Høiby, Niels, Mar 2014, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 13, 2, p. 179-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacterial biofilm formation and treatment in soft tissue fillers
Alhede, M., Er, O., Eickhardt, S., Kragh, K., Alhede, M., Hultqvist, Louise Dahl, Poulsen, Steen Seier, Givskov, Michael, Christensen, L. H., Høiby, Niels, Tvede, M. & Bjarnsholt, Thomas, 30 Jan 2014, In: Pathogens and Disease. 70, p. 339-346 8 p.Research output: Contribution to journal › Journal article › Research
- Published
Staphylococcus aureus alters growth activity, autolysis and antibiotic tolerance in a human host-adapted Pseudomonas aeruginosa lineage
Michelsen, C. F., Christensen, A. J., Bojer, Martin Saxtorph, Høiby, Niels, Ingmer, Hanne & Jelsbak, L., 2014, In: Journal of Bacteriology. 196, 22, p. 3903-3911 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation
Brochmann, R. P., Toft, A., Ciofu, Oana, Briales, A., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, 2014, In: International Journal of Antimicrobial Agents. 43, 2, p. 140-147 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Environmental Heterogeneity Drives Within-Host Diversification and Evolution of Pseudomonas aeruginosa
Markussen, T., Marvig, R. L., Gómez-Lozano, M., Aanæs, K., Burleigh, A. E., Høiby, Niels, Johansen, Helle Krogh, Molin, S. & Jelsbak, L., 2014, In: mBio. 5, 5, p. 1-10 10 p., e01592-14.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms
Jensen, Peter Østrup, Briales, A., Brochmann, R. P., Wang, H., Kragh, K. N., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Ciofu, Oana, 2014, In: Pathogens and Disease. 70, 3, p. 440-443 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nitric oxide production by polymorphonuclear leukocytes in infected cystic fibrosis sputum consumes oxygen
Kolpen, Mette, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Rickelt, L. F., Kühl, Michael, Hempel, C., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Clinical and Experimental Immunology. 177, 1, p. 310–319 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Kolpen, Mette, Kühl, Michael, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Liengaard, L., Kharazmi, A., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: PLOS ONE. 9, 1, p. e84353 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples
Fazli, M., Bjarnsholt, Thomas, Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, 2014, In: Methods in Molecular Biology. 1211, p. 261-71 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacokinetics and pharmacodynamics of antibiotics in biofilm infections of Pseudomonas aeruginosa in vitro and in vivo
Hengzhuang, W., Høiby, Niels & Ciofu, Oana, 2014, In: Methods in molecular biology (Clifton, N.J.). 1147, p. 239-54 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
Line, L., Alhede, M., Kolpen, Mette, Kühl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus Ernst, Toyofuku, M., Nomura, N., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Frontiers in Microbiology. 5, 11 p., 554.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients
Kragh, K. N., Alhede, M., Jensen, Peter Østrup, Moser, Claus Ernst, Scheike, Thomas, Jacobsen, C. S., Poulsen, Steen Seier, Eickhardt-Sørensen, S. R., Trostrup, H., Christoffersen, L., Hougen, H. P., Rickelt, L. F., Kühl, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2014, In: Infection and Immunity. 82, 11, p. 4477-4486 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rapid identification of Stenotrophomonas maltophilia by peptide nucleic acid fluorescence in situ hybridization
Knudsen, N. R., Rasmussen, A. K. I., Fiandaca, M. J., Kragh, K. N., Bjarnsholt, Thomas, Høiby, Niels, Stender, H. & Guardabassi, Luca, 2014, In: New Microbes and New Infections. 2, 3, p. 79-81 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Shifting paradigms of nontuberculous mycobacteria in cystic fibrosis
Qvist, T., Pressler, T., Høiby, Niels & Katzenstein, T. L., 2014, In: Respiratory research. 15, p. 1-6 6 p., 41.Research output: Contribution to journal › Comment/debate › Research
- Published
Sinus biofilms in patients with cystic fibrosis: is adjusted eradication therapy needed?
Aanæs, Kasper, Eickhardt, S., Johansen, Helle Krogh, von Buchwald, Christian, Skov, M., Høiby, Niels & Bjarnsholt, Thomas, 2014, In: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Applying insights from biofilm biology to drug development - can a new approach be developed?
Bjarnsholt, Thomas, Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa
Jørgensen, K. M., Wassermann, T., Jensen, Peter Østrup, Hengzuang, W., Molin, S., Høiby, Niels & Ciofu, Oana, Sep 2013, In: Antimicrobial Agents and Chemotherapy. 57, 9, p. 4215-21 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria
Hultqvist, Louise Dahl, van Gennip, M., Rybtke, Morten Levin, Wu, H., Chiang, W., Alhede, M., Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, Aug 2013, In: Infection and Immunity. 81, 8, p. 2705-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors
Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms
Song, Z., Borgwardt, L., Høiby, Niels, Wu, H., Sørensen, T. S. & Borgwardt, A., 7 Jun 2013, In: Orthopedic Reviews. 5, 2, p. 65-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dietzia papillomatosis Bacteremia
Rammer, P., Calum, Henrik Pierre, Moser, Claus Ernst, Björnsdóttir, M. K., Smedegaard, H., Høiby, Niels & Bjarnsholt, Thomas, Jun 2013, In: Journal of Clinical Microbiology. 51, 6, p. 1977-8 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A non-fatal case of invasive zygomycete (Lichtheimia corymbifera) infection in an allogeneic haematopoietic cell transplant recipient
Eickhardt, S., Braendstrup, P., Clasen-Linde, E., Jensen, K. E., Alhede, M., Bjarnsholt, Thomas, Høiby, Niels, Vindeløv, L. & Moser, Claus Ernst, May 2013, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 121, 5, p. 456-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms
Chiang, W., Nilsson, M., Jensen, Peter Østrup, Høiby, Niels, Nielsen, T., Givskov, Michael & Tolker-Nielsen, Tim, May 2013, In: Antimicrobial Agents and Chemotherapy. 57, 5, p. 2352-61 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Respiratory bacterial infections in cystic fibrosis
Ciofu, Oana, Hansen, C. R. & Høiby, Niels, May 2013, In: Current Opinion in Pulmonary Medicine. 19, 3, p. 251-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct sequencing and RipSeq interpretation as a tool for identification of polymicrobial infections
Wolff, T. Y., Eickhardt, S., Björnsdottir, M. K., Moser, Claus Ernst, Bjarnsholt, Thomas, Høiby, Niels & Thomsen, T. R., Apr 2013, In: Journal of Clinical Microbiology. 51, 4, p. 1281-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs
Ciofu, Oana, Johansen, Helle Krogh, Aanæs, Kasper, Wassermann, T., Alhede, M., von Buchwald, Christian & Høiby, Niels, 8 Mar 2013, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 12, 6, p. 729-736 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pseudomonas aeruginosa biofilm aggravates skin inflammatory response in BALB/c mice in a novel chronic wound model
Trøstrup, H., Thomsen, K., Christophersen, L. J., Hougen, H. P., Bjarnsholt, Thomas, Jensen, Peter Østrup, Kirkby, N., Calum, H., Høiby, Niels & Moser, Claus Ernst, Mar 2013, In: Wound Repair and Regeneration. 21, 2, p. 292-299 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A cohort study of the Copenhagen CF Centre eradication strategy against Staphylococcus aureus in patients with CF
Dalbøge, C. S., Pressler, T., Høiby, Niels, Nielsen, Kim G. & Johansen, Helle Krogh, Jan 2013, In: Journal of Cystic Fibrosis. 12, 1, p. 42-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High β-lactamase levels change the pharmacodynamics of β-lactam antibiotics in Pseudomonas aeruginosa biofilms
Hengzhuang, W., Ciofu, Oana, Yang, L., Wu, H., Song, Z., Oliver, A. & Høiby, Niels, Jan 2013, In: Antimicrobial Agents and Chemotherapy. 57, 1, p. 196-204 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clinical effects of sinus surgery and adjuvant therapy in cystic fibrosis patients - can chronic lung infections be postponed?
Aanæs, Kasper, Johansen, Helle Krogh, Skov, M., Buchvald, F. F., Hjuler, Thomas, Pressler, T., Høiby, Niels, Nielsen, Kim G. & von Buchwald, Christian, 2013, In: Rhinology. 51, 3, p. 222-230 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative genomic analysis of rapid evolution of an extreme-drug- resistant Acinetobacter baumannii clone
Tan, S., Chua, S. L., Liu, Y., Høiby, Niels, Andersen, L. P., Givskov, Michael, Song, Z. & Yang, L., 2013, In: Genome Biology and Evolution. p. 807–818Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J. & 2 others, , 2013, In: P L o S One. 8, 7, 17 p., e68484.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of infectious dose and season on development of hemorrhagic pneumonia in mink caused by Pseudomonas aeruginosa
Salomonsen, C. M., Chriél, M., Jensen, T. H., Rangstrup-Christensen, L., Høiby, Niels & Hammer, Anne Sofie Vedsted, 2013, In: Canadian Journal of Veterinary Research. 77, 3, p. 221-225 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The in vivo biofilm
Bjarnsholt, Thomas, Alhede, M., Alhede, M., Eickhardt-Sørensen, S. R., Moser, Claus Ernst, Kühl, Michael, Jensen, Peter Østrup & Høiby, Niels, 2013, In: Trends in Microbiology. 21, 9, p. 466-474 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Typing of Pseudomonas aeruginosa from hemorrhagic pneumonia in mink (Neovison vison)
Salomonsen, C. M., Themudo, G. E., Jelsbak, L., Molin, S., Høiby, Niels & Hammer, Anne Sofie Vedsted, 2013, In: Veterinary Microbiology. 163, 1-2, p. 103-109 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective
Folkesson, A., Jelsbak, L., Yang, L., Johansen, Helle Krogh, Ciofu, Oana, Høiby, Niels & Molin, S., Dec 2012, In: Nature Reviews. Microbiology. 10, 12, p. 841-851 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 8427
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2962
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Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
2836
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
1909
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Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Research output: Contribution to journal › Journal article › Research › peer-review
Published