Niels Høiby

Niels Høiby

Professor, No job title

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    ORCID: 0000-0002-1347-725X

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    1. Published

      Diagnosis and treatment of cystic fibrosis

      Koch, C. & Høiby, Niels, 2000, In: Tanaffos. 67, p. 239-247

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      O-2 AFFECTS THE ACTIVITY OF AMIKACIN ON MYCOBACTERIUM ABSCESSUS BIOFILM

      Kolpen, M., Ravnholt, C., Qvist, T., Kragh, K., Fritz, Blaine Gabriel, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, Sep 2017, In: Pediatric Pulmonology. 52, S47, p. S359-S360 379.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    3. Published

      RE-SENSITIZATION OF ANOXIC PSEUDOMONAS AERUGINOSA BIOFILMS WITH RE-OXYGENATION USING HYPERBARIC OXYGEN TREATMENT

      Kolpen, Mette, Mousavi, N., Sams, T., Kragh, K. N., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, P. O., Oct 2015, In: Pediatric Pulmonology. 50, S41, p. 312-312 1 p., 322.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    4. Published

      Reinforcement of the bactericidal effect of ciprofloxacin on Pseudomonas aeruginosa biofilm by hyperbaric oxygen treatment

      Kolpen, Mette, Mousavi, N., Sams, T., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2016, In: International Journal of Antimicrobial Agents. 47, 2, p. 163–167 5 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    5. Published

      Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin

      Kolpen, Mette, Lerche, C. J., Kragh, K. N., Sams, T., Koren, K., Jensen, A. S., Line, L., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, Nov 2017, In: Antimicrobial Agents and Chemotherapy. 61, 11, 9 p., e01024-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Nitric oxide production by polymorphonuclear leukocytes in sputum from cystic fibrosis patients with chronic lung infection

      Kolpen, Mette, Bjarnsholt, Thomas, Moser, C., Hansen, C. R., Kühl, Michael, Høiby, Niels & Jensen, P. Ø., 2010, In: Journal of Cystic Fibrosis. Supplement 1, p. S49 1 p.

      Research output: Contribution to journal › Conference abstract in journal › Research

    7. Published

      Nitric oxide production by polymorphonuclear leukocytes in sputum from cystic fibrosis patients with chronic lung infection

      Kolpen, M., Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Kühl, M., Høiby, Niels & Jensen, Peter Østrup, 2010. 0 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    8. Published

      Nitric oxide production by polymorphonuclear leukocytes in infected cystic fibrosis sputum consumes oxygen

      Kolpen, Mette, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Rickelt, L. F., Kühl, Michael, Hempel, C., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Clinical and Experimental Immunology. 177, 1, p. 310–319 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Denitrification by cystic fibrosis pathogens - Stenotrophomonas maltophilia is dormant in sputum

      Kolpen, Mette, Kragh, K. N., Bjarnsholt, Thomas, Line, L., Hansen, C. R., Dalbøge, C. S., Hansen, N., Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2015, In: International Journal of Medical Microbiology. 305, 1, p. 1-10 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection

      Kolpen, Mette, Kühl, Michael, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Liengaard, L., Kharazmi, A., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: PLOS ONE. 9, 1, p. e84353 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis

      Kolpen, Mette, Hansen, C. R., Bjarnsholt, Thomas, Moser, C., Hultqvist, Louise Dahl, van Gennip, M., Ciofu, Oana, Mandsberg, L., Kharazmi, A., Döring, G., Givskov, Michael, Høiby, Niels & Jensen, Peter Østrup, 1 Jan 2010, In: Thorax. 65, 1, p. 57-62 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Biofilms of mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

      Kolpen, Mette, Jensen, Peter Østrup, Qvist, T., Kragh, K. N., Ravnholt, C., Fritz, Blaine Gabriel, Johansen, U. R., Bjarnsholt, Thomas & Høiby, Niels, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 2, e01212.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Increased bactericidal activity of colistin on Pseudomonas aeruginosa biofilms in anaerobic conditions

      Kolpen, Mette, Appeldorff, C. F., Brandt, S., Mousavi, N., Kragh, K. N., Aydogan, S., Uppal, H. A., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, Peter Østrup, Feb 2016, In: Pathogens and Disease. 74, 1, 7 p., ftv086.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Anaerobic bacteria in biofilm –and their tolerance to antibiotics

      Kragh, K. N., Kühl, Michael, Gregersen, A., Tvede, M., Høiby, Niels & Bjarnsholt, Thomas, 2011.

      Research output: Contribution to conference › Poster › Research

    15. Published

      Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients

      Kragh, K. N., Alhede, M., Jensen, Peter Østrup, Moser, Claus Ernst, Scheike, Thomas, Jacobsen, C. S., Poulsen, Steen Seier, Eickhardt-Sørensen, S. R., Trostrup, H., Christoffersen, L., Hougen, H. P., Rickelt, L. F., Kühl, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2014, In: Infection and Immunity. 82, 11, p. 4477-4486 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Induction of oxidative burst response in human neutrophils by immune complexes made in vitro of lipopolysaccharide and hyperimmune serum from chronically infected patients

      Kronborg, Gitte, Fomsgaard, A., Jensen, E. T., Kharazmi, A. & Høiby, Niels, 1993, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 101, 11, p. 887-94 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Experimental chronic Pseudomonas aeruginosa lung infection in rats. Non-specific stimulation with LPS reduces lethality as efficiently as specific immunization

      Lange, Kai, Hougen, H. P., Høiby, Niels, Fomsgaard, A., Rygaard, J. & Johansen, Helle Krogh, 1995, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 103, 5, p. 367-74 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Kolera i Danmark--et importeret sygdomstilfoelde

      Lange, Kai, Pedersen, K. M., Nielsen, S. E. & Høiby, Niels, 17 Apr 1995, In: Ugeskrift for Laeger. 157, 16, p. 2325-6 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Use of cultivation-dependent and -independent techniques to assess contamination of central venous catheters: a pilot study

      Larsen, M. K., Thomsen, T. R., Moser, C., Nielsen, P. H. & Høiby, Niels, 2008, In: BMC Clinical Pathology. 8, p. 10 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Adjunctive S100A8/A9 Immunomodulation Hinders Ciprofloxacin Resistance in Pseudomonas aeruginosa in a Murine Biofilm Wound Model

      Laulund, A. S., Schwartz, F., Trøstrup, H., Thomsen, K., Christophersen, L., Calum, Henrik Pierre, Ciofu, Oana, Høiby, Niels & Moser, Claus Ernst, 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 652012.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Hyperbaric oxygen therapy augments ciprofloxacin effect against Pseudomonas aeruginosa biofilm infected chronic wounds in a mouse model

      Laulund, A. S., Schwartz, F. A., Christophersen, L., Kolpen, Mette, Jensen, Peter Østrup, Calum, Henrik Pierre, Høiby, Niels, Thomsen, K. & Moser, Claus Ernst, 2023, In: Biofilm. 5, 100100.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Hyperbaric oxygen therapy counteracts Pseudomonas aeruginosa biofilm micro-compartment phenomenon in murine thermal wounds

      Laulund, A. S., Schwartz, F. A., Høiby, Niels, Thomsen, K. & Moser, Claus Ernst, 2023, In: Biofilm. 6, 8 p., 100159.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Lactoferricin-inspired peptide AMC-109 augments the effect of ciprofloxacin against Pseudomonas aeruginosa biofilm in chronic murine wounds

      Laulund, A. S., Schwartz, F. A., Christophersen, L., Høiby, Niels, Svendsen, J. S. M., Stensen, W., Thomsen, K., Cavanagh, J. P. & Moser, Claus Ernst, 2022, In: Journal of Global Antimicrobial Resistance. 29, p. 185-193 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients

      Lee, B., Schjerling, C. K., Kirkby, N., Hoffmann, N., Borup, R., Molin, S., Høiby, Niels & Ciofu, Oana, 2011, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 119, 4-5, p. 263-74 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Heterogeneity of biofilms formed by nonmucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis.

      Lee, B., Haagensen, J. A. J., Ciofu, Oana, Andersen, Jens Bo, Høiby, Niels & Molin, S., 2005, In: Journal of Clinical Microbiology. 43, 10, p. 5247-55 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Hyperbaric oxygen treatment augments tobramycin efficacy in experimental staphylococcus aureus endocarditis

      Lerche, C. J., Christophersen, L. J., Kolpen, Mette, Nielsen, P. R., Trøstrup, H., Thomsen, K., Hyldegaard, Ole, Bundgård, Henning, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2017, In: International Journal of Antimicrobial Agents. 50, 3, p. 406-412

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Low efficacy of tobramycin in experimental Staphylococcus aureus endocarditis

      Lerche, C. J., Christophersen, L. J., Trøstrup, H., Thomsen, K., Jensen, Peter Østrup, Hougen, H. P., Bundgaard, H., Høiby, Niels & Moser, C., 1 Dec 2015, In: European Journal of Clinical Microbiology & Infectious Diseases. 34, 12, p. 2349-2357 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis

      Lerche, C. J., Christophersen, L. J., Goetze, J. P., Nielsen, P. R., Thomsen, K., Enevold, C., Høiby, Niels, Jensen, Peter Østrup, Bundgård, Henning & Moser, Claus Ernst, 2019, In: PLoS ONE. 14, 4, 16 p., e0215333.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Anti-biofilm Approach in Infective Endocarditis Exposes New Treatment Strategies for Improved Outcome

      Lerche, C. J., Schwartz, F., Theut, M., Fosbøl, E. L., Iversen, Kasper, Bundgård, Henning, Høiby, Niels & Moser, Claus Ernst, 2021, In: Frontiers in Cell and Developmental Biology. 9, 25 p., 643335.

      Research output: Contribution to journal › Review › Research › peer-review

    30. Published

      Potential Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective Endocarditis

      Lerche, C. J., Schwartz, F., Pries-Heje, M. M., Fosbøl, E. L., Iversen, Kasper, Jensen, Peter Østrup, Høiby, Niels, Hyldegaard, Ole, Bundgård, Henning & Moser, Claus Ernst, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 805964.

      Research output: Contribution to journal › Review › Research › peer-review

    31. Published

      Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum

      Line, L., Alhede, M., Kolpen, Mette, Kühl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus Ernst, Toyofuku, M., Nomura, N., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Frontiers in Microbiology. 5, 11 p., 554.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Mycobacterium avium subspecies paratuberculosis

      Lisby, J. G. & Høiby, Niels, 2003, In: Ugeskrift for læger. 165(50), p. 4865-4866

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Mutator P. aeruginosa with Impaired Oxidative Repair System (mutT) forms thicker biofilms with increased tolerance to antibiotics compared to PAO1

      Mandsberg, L. F., Sternberg, C., Molin, S., Poulsen, Henrik Enghusen, Høiby, Niels & Ciofu, O., 2010. 0 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    34. Published

      Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system

      Mandsberg, L. F., Ciofu, Oana, Kirkby, N., Christiansen, L. E., Poulsen, Henrik Enghusen, Høiby, Niels, Mandsberg, L. F., Ciofu, O., Kirkby, N., Christiansen, L. E., Poulsen, Henrik Enghusen & Høiby, N., 1 Jun 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2483-91 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM)

      Mandsberg, L. F., Maciá, M. D., Bergmann, K. R., Christiansen, L., Alhede, M., Kirkby, N., Høiby, Niels, Oliver, A. & Ciofu, Oana, 2011, In: F E M S Microbiology Letters. 324, 1, p. 28-37 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Environmental Heterogeneity Drives Within-Host Diversification and Evolution of Pseudomonas aeruginosa

      Markussen, T., Marvig, R. L., Gómez-Lozano, M., Aanæs, K., Burleigh, A. E., Høiby, Niels, Johansen, Helle Krogh, Molin, S. & Jelsbak, L., 2014, In: mBio. 5, 5, p. 1-10 10 p., e01592-14.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa

      Marvig, R. L., Søndergaard, M. S. R., Damkiær, S., Høiby, Niels, Johansen, Helle Krogh, Molin, S. & Jelsbak, L., Aug 2012, In: Antimicrobial Agents and Chemotherapy. 56, 8, p. 4519-4521 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.

      Mathee, K., Ciofu, Oana, Sternberg, C., Lindum, P. W., Campbell, J. I., Jensen, P., Johnsen, A. H., Givskov, Michael, Ohman, D. E., Molin, S., Høiby, Niels & Kharazmi, A., 1999, In: Microbiology. 145 ( Pt 6), p. 1349-57 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Role of exopolysaccharide in biofilm matrix formation: The alginate paradigm

      Mathee, K., Kharazmi, A. & Høiby, Niels, 2002, Molecular Ecology of Biofilms. Wymondham, UK: Horizon Scientific Press, p. 1-34

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    40. Published

      Antibody response against Pseudomonas aeruginosa and its relationship with immune mediators in the upper and lower airways of cystic fibrosis patients

      Mauch, R. M., Hentschel, J., Aanæs, Kasper, Barucha, A., Nolasco da Silva, M. T., Levy, C. E., Høiby, Niels & Mainz, J. G., 2020, In: Pediatric Pulmonology. 55, 4, p. 959-967

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Secretory IgA response against Pseudomonas aeruginosa in the upper airways and the link with chronic lung infection in cystic fibrosis

      Mauch, R. M., Rossi, C. L., Aiello, T. B., Ribeiro, J. D., Ribeiro, A. F., Høiby, Niels & Levy, C. E., 2017, In: Pathogens and Disease. 75, 6, 4 p., ftx069.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Secretory IgA-mediated immune response in saliva and early detection of Pseudomonas aeruginosa in the lower airways of pediatric cystic fibrosis patients

      Mauch, R. M., Rossi, C. L., Nolasco da Silva, M. T., Bianchi Aiello, T., Ribeiro, J. D., Ribeiro, A. F., Høiby, Niels & Levy, C. E., 2019, In: Medical Microbiology and Immunology. 208, 2, p. 205-213 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Adaptive Immune Response to Mycobacterium abscessus Complex (MABSC) in Cystic Fibrosis and the Implications of Cross-Reactivity

      Mauch, R. M., Jensen, Peter Østrup, Qvist, T., Kolpen, M., Moser, Claus Ernst, Pressler, T., Nolasco da Silva, M. T., Høiby, Niels & Copenhagen Study Group on Mycobacterial Infections in Cystic Fibrosis, C. S. G. O. M. I. I. C. F., 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 858398.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

      Mauch, R. M., Jensen, Peter Østrup, Moser, Claus Ernst, Levy, C. E. & Høiby, Niels, 2018, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 17, 2, p. 143-152

      Research output: Contribution to journal › Review › Research › peer-review

    45. Published

      IgG avidity to Pseudomonas aeruginosa over the course of chronic lung biofilm infection in cystic fibrosis

      Mauch, R. M., Nørregaard, L. L., Ciofu, Oana, Levy, C. E. & Høiby, Niels, 2018, In: Journal of Cystic Fibrosis. 17, 3, p. 356-359

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Bakteriel meningitis i Danmark 2002 og 2003. Landsdaekkende registrering baseret på laboratoriedata

      Meyer, Christian, Schønheyder, H. C., Bangsborg, Jette Marie, Nielsen, X. C., Møller, J. K., Mølbak, K., Korshin, A., Rønneberg, E., Køster-Rasmussen, Rasmus, Høiby, Niels & Dansk Bakteriel Meningitis Gruppe, D. B. M. G., 2007, In: Ugeskrift for Laeger. 169, 6, p. 503-6 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Bakteriel meningitis i Danmark 2002 og 2003: Landsdækkende registrering baseret pa laboratoriedata

      Meyer, Christian, Schonheyder, H. C., Bangsborg, J., Nielsen, X. C., Moller, J. K., Molbak, K., Korshin, A., Ronneberg, E., Koster-Rasmussen, R. & Høiby, Niels, 2007, In: Ugeskrift for læger. 169, 6, p. 503-506 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Staphylococcus aureus alters growth activity, autolysis and antibiotic tolerance in a human host-adapted Pseudomonas aeruginosa lineage

      Michelsen, C. F., Christensen, A. J., Bojer, Martin Saxtorph, Høiby, Niels, Ingmer, Hanne & Jelsbak, L., 2014, In: Journal of Bacteriology. 196, 22, p. 3903-3911 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients

      Miller, A. K., Brannon, M. K., Stevens, L., Johansen, Helle Krogh, Selgrade, S. E., Miller, S. I., Høiby, Niels & Moskowitz, S. M., 3 Oct 2011, In: Antimicrobial Agents and Chemotherapy. 55, 12, p. 5761-5769

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

      Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In: Frontiers in Microbiology. 10, 9 p., 275.

      Research output: Contribution to journal › Journal article › Research › peer-review

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