Oana Ciofu

Oana Ciofu

Professor

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    ORCID: 0000-0001-5648-4858

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    1. Published

      Effect of long-term voluntary exercise wheel running on susceptibility to bacterial pulmonary infections in a mouse model

      van de Weert-van Leeuwen, P. B., de Vrankrijker, A. M. M., Fentz, J., Ciofu, Oana, Wojtaszewski, Jørgen F P, Arets, H. G. M., Hulzebos, H. J., van der Ent, C. K., Beekman, J. M. & Johansen, Helle Krogh, 2013, In: P L o S One. 8, 12, 7 p., e82869.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa

      van Gennip, M., Moser, C., Hultqvist, Louise Dahl, Bjarnsholt, Thomas, Calum, H., Jensen, Peter Østrup, Christophersen, L., Hougen, H. P., Ciofu, Oana, Molin, S., Givskov, Michael & Høiby, Niels, 1 Dec 2009, In: Journal of Antimicrobial Chemotherapy. 64, 6, p. 1241-50 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Respiratory syncytial virus infection facilitates acute colonization of Pseudomonas aeruginosa in mice

      de Vrankrijker, A. M. M., Wolfs, T. F. W., Ciofu, Oana, Høiby, Niels, van der Ent, C. K., Poulsen, Steen Seier & Johansen, Helle Krogh, 2009, In: Journal of Medical Virology. 81, 12, p. 2096-103 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Real-Time Monitoring of nfxB Mutant Occurrence and Dynamics in Pseudomonas aeruginosa Biofilm Exposed to Subinhibitory Concentrations of Ciprofloxacin

      Zaborskytė, G., Andersen, Jens Bo, Kragh, K. N. & Ciofu, Oana, Mar 2017, In: Antimicrobial Agents and Chemotherapy. 61, 3, 14 p., e02292-16.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Evolutionary dynamics of bacteria in a human host environment

      Yang, L., Jelsbak, L., Marvig, R. L., Damkiær, S., Workman, C., Rau, M. H., Hansen, S. K., Folkesson, A., Johansen, Helle Krogh, Ciofu, Oana, Høiby, Niels, Sommer, M. & Molin, S., 3 May 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 18, p. 7481-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      The phenotypic evolution of pseudomonas aeruginosa populations changes in the presence of subinhibitory concentrations of ciprofloxacin

      Wassermann, T., Jørgensen, K. M., Ivanyshyn, K., Bjarnsholt, Thomas, Hossein Khademi, S. M., Jelsbak, L., Høiby, Niels & Ciofu, Oana, 1 May 2016, In: Microbiology. 162, 5, p. 865-875 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      OligoG CF-5/20 disruption of mucoid Pseudomonas aeruginosa biofilm in a murine lung infection model

      Wang, H., Song, Z., Ciofu, Oana, Onsøyen, E., Rye, P. D. & Høiby, Niels, 2016, In: Antimicrobial Agents and Chemotherapy. 60, 5, p. 2620-2626 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      The clonal antibody response to Pseudomonas aeruginosa heat shock protein is highly diverse in cystic fibrosis patients.

      Ulanova, M., Petersen, T. D., Ciofu, Oana, Jensen, P., Hahn-Zoric, M., Hanson, L. A. & Høiby, Niels, 1997, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 105, 6, p. 449-56 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Initial Pseudomonas aeruginosa infection in patients with cystic fibrosis: characteristics of eradicated and persistent isolates

      Tramper-Stranders, G. A., van der Ent, C. K., Molin, S., Yang, L., Hansen, S. K., Rau, M. H., Ciofu, Oana, Johansen, Helle Krogh & Wolfs, T. F. W., Jun 2012, In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 18, 6, p. 567-74 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Immune Response to Biofilm Growing Pulmonary Pseudomonas aeruginosa Infection

      Thomsen, K., Høiby, Niels, Jensen, Peter Østrup, Ciofu, Oana & Moser, Claus Ernst, 2022, In: Biomedicines. 10, 9, 2064.

      Research output: Contribution to journal › Review › Research › peer-review

    11. Published

      Sustainable plant production in a changing world - formation of a cross-faculty network

      Strandmark, L. B., Schjoerring, Jan K., Christensen, Søren, Nybroe, O., Torp, J., Eilenberg, Jørgen, Munk, Lisa, Rønn, Regin, Ciofu, Oana, Bruun, Sander & Ørum, Jens Erik, 2009, In: IOP Conference Series: Earth and Environmental Science. 6, Session 34, 2 p., 342014.

      Research output: Contribution to journal › Conference abstract in journal › Research

    12. Published

      Sustainable plant production in a changing world - a cross Faculty research network at KU

      Strandmark, L. B., Schjoerring, Jan K., Christensen, Søren, Nybroe, O., Pedersen, J. G. T., Eilenberg, Jørgen, Munk, Lisa, Rønn, Regin, Ciofu, Oana, Bruun, Sander & Ørum, Jens Erik, 2009.

      Research output: Contribution to conference › Poster › Research

    13. Published

      Pseudomonas aeruginosa alginate is refractory to Th1 immune response and impedes host immune clearance in a mouse model of acute lung infection.

      Song, Z., Wu, H., Ciofu, Oana, Kong, K., Høiby, Niels, Rygaard, J., Kharazmi, A. & Mathee, K., 2003, In: Journal of Medical Microbiology. 52, Pt 9, p. 731-40 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection: a pilot study

      Skov, M., Pressler, T., Lykkesfeldt, Jens, Poulsen, Henrik Enghusen, Jensen, Peter Østrup, Johansen, Helle Krogh, Qvist, T., Kræmer, D., Høiby, Niels & Ciofu, Oana, Mar 2015, In: Journal of Cystic Fibrosis. 14, 2, p. 211-218 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Detection of multidrug-resistant bacteria in the occupied Palestinian territory: a cross-sectional study

      Sjolander, I., Hansen, F., Elmanama, A., Khayyat, R., Abu-Zant, A., Hussein, A., Abu Taha, A., Hammerum, A. M. & Ciofu, Oana, Aug 2017, In: Lancet Oncology. 390, S1, p. S12

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    16. Published

      A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production

      Sautter, R., Ramos, D., Schneper, L., Ciofu, Oana, Wassermann, T., Koh, C., Heydorn, A., Hentzer, M., Høiby, Niels, Kharazmi, A., Molin, S., Devries, C. A., Ohman, D. E. & Mathee, K., 1 May 2012, In: Gene. 498, 2, p. 242-253 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Proteome-wide antigen discovery of novel protective vaccine candidates against Staphylococcus aureus infection

      Rasmussen, K. J., Mattsson, A. H., Pilely, K., Asferg, C. A., Ciofu, Oana, Vitved, L., Koch, C. & Kemp, M., 31 Aug 2016, In: Vaccine. 34, 38, p. 4602-4609 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Maximum Likelihood based comparison of the specific growth rates for P. aeruginosa and four mutator strains.

      Philipsen, K. R., Christiansen, L. E., Mandsberg, L. F., Ciofu, Oana & Madsen, H., 2008, In: Journal of Microbiological Methods. 75, 3, p. 551-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Quantitative analysis of the IgG and IgG subclass immune responses to chromosomal Pseudomonas aeruginosa beta-lactamase in serum from patients with cystic fibrosis by western blotting and laser scanning densitometry.

      Petersen, T. D., Ciofu, Oana, Pressler, T., Giwercman, B., Pedersen, S. S. & Høiby, Niels, 1996, In: Thorax. 51, 7, p. 733-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Genome sequence of Pseudomonas aeruginosa strain DK1-NH57388A, a stable mucoid cystic fibrosis isolate

      Norman, A., Ciofu, Oana, Amador, C. I., Høiby, Niels & Jelsbak, L., 2016, In: Genome Announcements. 4, 1, e00008-16.

      Research output: Contribution to journal › Journal article › Research

    21. Published

      Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients

      Møller, S. A., Jensen, Peter Østrup, Høiby, Niels, Ciofu, Oana, Kragh, K. N., Bjarnsholt, Thomas & Kolpen, Mette, 2019, In: Journal of Cystic Fibrosis. 18, 5, p. 657–664

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Novel experimental Pseudomonas aeruginosa infection model mimicking long-term host-pathogen interactions in cystic fibrosis.

      Moser, Claus Ernst, van Gennip, M., Bjarnsholt, Thomas, Jensen, P. Ø., Lee, B., Hougen, H. P., Calum, Henrik Pierre, Ciofu, Oana, Givskov, Michael & Høiby, Niels, 2009, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 117, p. 95-107 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Antibiotic therapy as personalized medicine - general considerations and complicating factors

      Moser, Claus Ernst, Lerche, C. J., Thomsen, K., Hartvig, T., Schierbeck, J., Jensen, Peter Østrup, Ciofu, Oana & Høiby, Niels, 2019, In: APMIS. 127, 5, p. 361-371

      Research output: Contribution to journal › Review › Research › peer-review

    24. Published

      Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis

      Moser, C., Gennip, M. V., Bjarnsholt, Thomas, Jensen, Peter Østrup, Lee, B., Hougen, H. P., Calum, H., Ciofu, Oana, Givskov, Michael, Molin, S. & Høiby, Niels, 1 Feb 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 2, p. 95-107 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      IgG avidity to Pseudomonas aeruginosa over the course of chronic lung biofilm infection in cystic fibrosis

      Mauch, R. M., Nørregaard, L. L., Ciofu, Oana, Levy, C. E. & Høiby, Niels, 2018, In: Journal of Cystic Fibrosis. 17, 3, p. 356-359

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.

      Mathee, K., Ciofu, Oana, Sternberg, C., Lindum, P. W., Campbell, J. I., Jensen, P., Johnsen, A. H., Givskov, Michael, Ohman, D. E., Molin, S., Høiby, Niels & Kharazmi, A., 1999, In: Microbiology. 145 ( Pt 6), p. 1349-57 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients

      Marvig, R. L., Dolce, D., Sommer, L. M., Petersen, Bent, Ciofu, Oana, Campana, S., Molin, S., Taccetti, G. & Johansen, Helle Krogh, 19 Oct 2015, In: B M C Microbiology. 15, 13 p., 218.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM)

      Mandsberg, L. F., Maciá, M. D., Bergmann, K. R., Christiansen, L., Alhede, M., Kirkby, N., Høiby, Niels, Oliver, A. & Ciofu, Oana, 2011, In: F E M S Microbiology Letters. 324, 1, p. 28-37 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system

      Mandsberg, L. F., Ciofu, Oana, Kirkby, N., Christiansen, L. E., Poulsen, Henrik Enghusen, Høiby, Niels, Mandsberg, L. F., Ciofu, O., Kirkby, N., Christiansen, L. E., Poulsen, Henrik Enghusen & Høiby, N., 1 Jun 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2483-91 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Immunisation in the current management of cystic fibrosis patients.

      Malfroot, A., Adam, G., Ciofu, Oana, Döring, G., Knoop, C., Lang, A. B., Van Damme, P., Dab, I., Bush, A. & European Cystic Fibrosis Society (ECFS) Vaccination Group, E. C. F. S. (. V. G., 2005, In: Journal of Cystic Fibrosis. 4, 2, p. 77-87 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Polymicrobial infections can select against Pseudomonas aeruginosa mutators because of quorum-sensing trade-offs

      Luján, A. M., Paterson, S., Hesse, E., Sommer, L. M., Marvig, R. L., Sharma, M. D., Alseth, E. O., Ciofu, Oana, Smania, A. M., Molin, S., Johansen, Helle Krogh & Buckling, A., 2022, In: Nature Ecology and Evolution. 6, p. 979–988

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum

      Line, L., Alhede, M., Kolpen, Mette, Kühl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus Ernst, Toyofuku, M., Nomura, N., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Frontiers in Microbiology. 5, 11 p., 554.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients

      Lee, B., Schjerling, C. K., Kirkby, N., Hoffmann, N., Borup, R., Molin, S., Høiby, Niels & Ciofu, Oana, 2011, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 119, 4-5, p. 263-74 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Heterogeneity of biofilms formed by nonmucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis.

      Lee, B., Haagensen, J. A. J., Ciofu, Oana, Andersen, Jens Bo, Høiby, Niels & Molin, S., 2005, In: Journal of Clinical Microbiology. 43, 10, p. 5247-55 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Adjunctive S100A8/A9 Immunomodulation Hinders Ciprofloxacin Resistance in Pseudomonas aeruginosa in a Murine Biofilm Wound Model

      Laulund, A. S., Schwartz, F., Trøstrup, H., Thomsen, K., Christophersen, L., Calum, Henrik Pierre, Ciofu, Oana, Høiby, Niels & Moser, Claus Ernst, 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 652012.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Anvendelse af antibiotika i tandlægepraksis

      Larsen, Tove, Ciofu, Oana, Moesby, L., Kirkevang, L. & Havemose-Poulsen, A., Sep 2013, In: Tandlaegebladet. 117, 9, p. 718-729 12 p., 460.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Reinforcement of the bactericidal effect of ciprofloxacin on Pseudomonas aeruginosa biofilm by hyperbaric oxygen treatment

      Kolpen, Mette, Mousavi, N., Sams, T., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2016, In: International Journal of Antimicrobial Agents. 47, 2, p. 163–167 5 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    38. Published

      Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin

      Kolpen, Mette, Lerche, C. J., Kragh, K. N., Sams, T., Koren, K., Jensen, A. S., Line, L., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, Nov 2017, In: Antimicrobial Agents and Chemotherapy. 61, 11, 9 p., e01024-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis

      Kolpen, Mette, Hansen, C. R., Bjarnsholt, Thomas, Moser, C., Hultqvist, Louise Dahl, van Gennip, M., Ciofu, Oana, Mandsberg, L., Kharazmi, A., Döring, G., Givskov, Michael, Høiby, Niels & Jensen, Peter Østrup, 1 Jan 2010, In: Thorax. 65, 1, p. 57-62 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Increased bactericidal activity of colistin on Pseudomonas aeruginosa biofilms in anaerobic conditions

      Kolpen, Mette, Appeldorff, C. F., Brandt, S., Mousavi, N., Kragh, K. N., Aydogan, S., Uppal, H. A., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, Peter Østrup, Feb 2016, In: Pathogens and Disease. 74, 1, 7 p., ftv086.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      RE-SENSITIZATION OF ANOXIC PSEUDOMONAS AERUGINOSA BIOFILMS WITH RE-OXYGENATION USING HYPERBARIC OXYGEN TREATMENT

      Kolpen, Mette, Mousavi, N., Sams, T., Kragh, K. N., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, P. O., Oct 2015, In: Pediatric Pulmonology. 50, S41, p. 312-312 1 p., 322.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    42. Published

      Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa

      Jørgensen, K. M., Wassermann, T., Jensen, Peter Østrup, Hengzuang, W., Molin, S., Høiby, Niels & Ciofu, Oana, Sep 2013, In: Antimicrobial Agents and Chemotherapy. 57, 9, p. 4215-21 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Diversity of metabolic profiles of cystic fibrosis Pseudomonas aeruginosa during the early stages of lung infection

      Jorgensen, K. M., Wassermann, T., Johansen, Helle Krogh, Christiansen, L. E., Molin, S., Høiby, Niels & Ciofu, Oana, Jul 2015, In: Microbiology. 161, 7, p. 1447-1462 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients.

      Johansen, Helle Krogh, Moskowitz, S. M., Ciofu, Oana, Pressler, T. & Høiby, Niels, 2008, In: Journal of Cystic Fibrosis. 7, 5, p. 391-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in Guinea Pigs

      Jensen, Peter Østrup, Lykkesfeldt, Jens, Bjarnsholt, Thomas, Hougen, H. P., Høiby, Niels & Ciofu, Oana, 2012, In: Basic & Clinical Pharmacology & Toxicology. 110, 4, p. 353-358 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms

      Jensen, Peter Østrup, Briales, A., Brochmann, R. P., Wang, H., Kragh, K. N., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Ciofu, Oana, 2014, In: Pathogens and Disease. 70, 3, p. 440-443 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air

      Jensen, Peter Østrup, Møller, S. A., Lerche, C. J., Moser, Claus Ernst, Bjarnsholt, Thomas, Ciofu, Oana, Faurholt-Jepsen, Daniel, Høiby, Niels & Kolpen, Mette, 2019, In: Biofilm. 1, 4 p., 100008.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients.

      Jelsbak, L., Johansen, Helle Krogh, Frost, A., Thøgersen, R., Thomsen, Line Elnif, Ciofu, Oana, Yang, L., Haagensen, J. A. J., Høiby, Niels & Molin, S., 2007, In: Infection and Immunity. 75, 5, p. 2214-24 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Antibacterial and anti-biofilm activities of antibiotic-free phosphatidylglycerol/docosahexaenoic acid lamellar and non-lamellar liquid crystalline nanoparticles

      Jan, Habibullah, Ghayas, Sana, Higazy, Doaa Mohamed Mohamed E, Yaghmur, Anan, Yaghmur, Anan & Ciofu, Oana, 2024, In: Journal of Colloid and Interface Science. 669, p. 537-551

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.

      Jalal, S., Ciofu, Oana, Høiby, Niels, Gotoh, N. & Wretlind, B., 2000, In: Antimicrobial Agents and Chemotherapy. 44, 3, p. 710-2 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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